Reprogramming Interferon Regulatory Factor Signaling in Cardiometabolic Diseases

Inhibitory Effects of Hydrogen on Proliferation and Migration of Vascular Smooth Muscle Cells via Down-Regulation of Mitogen/Activated Protein Kinase and Ezrin/Radixin/Moesin Signaling Pathways

(2016) Ya-Xing Zhang   CHINESE JOURNAL OF PHYSIOLOGY

Liver capsule: IRFs in hepatocytes: Pathophysiology

(2016) Pi-Xiao Wang et al.   HEPATOLOGY

IRF6 Regulates the Expression of IL-36γ by Human Oral Epithelial Cells in Response toPorphyromonas gingivalis

(2016) Jennifer Huynh et al.   JOURNAL OF IMMUNOLOGY

The long noncoding RNA Chaer defines an epigenetic checkpoint in cardiac hypertrophy

(2016) Zhihua Wang et al.   NATURE MEDICINE

An IRF5 Decoy Peptide Reduces Myocardial Inflammation and Fibrosis and Improves Endothelial Cell Function in Tight-Skin Mice

(2016) Dorothee Weihrauch et al.   PLoS One

Long noncoding RNA Chast promotes cardiac remodeling

(2016) Janika Viereck et al.   Science Translational Medicine

Targeted inhibition of STATs and IRFs as a potential treatment strategy in cardiovascular disease

(2016) Malgorzata Szelag et al.   Oncotarget

Hydrogen (H2) Inhibits Isoproterenol-Induced Cardiac Hypertrophy via Antioxidative Pathways

(2016) Yaxing Zhang et al.   Frontiers in Pharmacology

Defective autophagy in vascular smooth muscle cells alters contractility and Ca2+ homeostasis in mice

(2015) Cédéric F. Michiels et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Innate Immune Pattern Recognition: A Cell Biological Perspective

(2015) Sky W. Brubaker et al.   Annual Review of Immunology

Hydrogen Sulfide Maintains Mitochondrial DNA Replication via Demethylation of TFAM

(2015) Shuangshuang Li et al.   ANTIOXIDANTS & REDOX SIGNALING

Adventitia and Perivascular Cells

(2015) Mark W. Majesky   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Defective autophagy in vascular smooth muscle cells accelerates senescence and promotes neointima formation and atherogenesis

(2015) Mandy OJ Grootaert et al.   Autophagy

Interferon regulatory factors: at the crossroads of immunity, metabolism, and disease

(2015) Guang-Nian Zhao et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The interferon regulatory factors as novel potential targets in the treatment of cardiovascular diseases

(2015) Xiao-Jing Zhang et al.   BRITISH JOURNAL OF PHARMACOLOGY

Muscle as a “Mediator” of Systemic Metabolism

(2015) Kedryn K. Baskin et al.   Cell Metabolism

Upregulation of Interferon Regulatory Factor 6 Promotes Neuronal Apoptosis After Traumatic Brain Injury in Adult Rats

(2015) Yuchang Lin et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Molecular characterization of three IRF1 subfamily members reveals evolutionary significance of IRF11 in miiuy croaker

(2015) Chang Shu et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Interferon Regulatory Factor Signalings in Cardiometabolic Diseases

(2015) Xiao-Jing Zhang et al.   HYPERTENSION

TLR3 drives IRF6-dependent IL-23p19 expression and p19/EBI3 heterodimer formation in keratinocytes

(2015) Divya Ramnath et al.   IMMUNOLOGY AND CELL BIOLOGY

Roles of the tacrolimus-dependent transcription factor IRF4 in acute rejection after liver transplantation

(2015) Tengqian Tang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Interferon regulatory factor 9 is a key mediator of hepatic ischemia/reperfusion injury

(2015) Pi-Xiao Wang et al.   JOURNAL OF HEPATOLOGY

IRF-1 Promotes Liver Transplant Ischemia/Reperfusion Injury via Hepatocyte IL-15/IL-15Rα Production

(2015) Shinichiro Yokota et al.   JOURNAL OF IMMUNOLOGY

An Up-regulation of IRF-1 After a Spinal Cord Injury: Implications for Neuronal Apoptosis

(2015) Jian Zhao et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Transcription factor IRF1 is responsible for IRF8-mediated IL-1β expression in reactive microglia

(2015) Takahiro Masuda et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

The transcriptional regulators IRF4, BATF and IL-33 orchestrate development and maintenance of adipose tissue–resident regulatory T cells

(2015) Ajithkumar Vasanthakumar et al.   NATURE IMMUNOLOGY

Irf5 deficiency in macrophages promotes beneficial adipose tissue expansion and insulin sensitivity during obesity

(2015) Elise Dalmas et al.   NATURE MEDICINE

NOD-Like Receptors: Versatile Cytosolic Sentinels

(2015) Vinicius Motta et al.   PHYSIOLOGICAL REVIEWS

Inhibition of Interferon Regulatory Factor 4 Attenuates Acute Liver Allograft Rejection in Mice

(2015) W. Zhao et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Innate immune recognition of DNA: A recent history

(2015) Alan Dempsey et al.   VIROLOGY

Interferon regulatory factor 9 is an essential mediator of heart dysfunction and cell death following myocardial ischemia/reperfusion injury

(2014) Yan Zhang et al.   BASIC RESEARCH IN CARDIOLOGY

Interferon regulatory factor 3 protects against adverse neo-intima formation

(2014) Shu-Min Zhang et al.   CARDIOVASCULAR RESEARCH

IRF4 Is a Key Thermogenic Transcriptional Partner of PGC-1α

(2014) Xingxing Kong et al.   CELL

IRF4 is a novel mediator for neuronal survival in ischaemic stroke

(2014) S Guo et al.   CELL DEATH AND DIFFERENTIATION

The Long Noncoding RNA CHRF Regulates Cardiac Hypertrophy by Targeting miR-489

(2014) Kun Wang et al.   CIRCULATION RESEARCH

Interferon Regulatory Factor 1 Is Required for Cardiac Remodeling in Response to Pressure Overload

(2014) Ding-Sheng Jiang et al.   HYPERTENSION

Interferon Regulatory Factor 7 Functions as a Novel Negative Regulator of Pathological Cardiac Hypertrophy

(2014) Ding-Sheng Jiang et al.   HYPERTENSION

Interferon Regulatory Factor 6 Differentially Regulates Toll-like Receptor 2-dependent Chemokine Gene Expression in Epithelial Cells

(2014) Mei Qi Kwa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rapamycin antagonizes TNF induction of VCAM-1 on endothelial cells by inhibiting mTORC2

(2014) Chen Wang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IFN Regulatory Factor 10 Is a Negative Regulator of the IFN Responses in Fish

(2014) S. Li et al.   JOURNAL OF IMMUNOLOGY

Interferon regulatory factor 8 protects against cerebral ischaemic-reperfusion injury

(2014) Mei Xiang et al.   JOURNAL OF NEUROCHEMISTRY

A Critical Role for Interferon Regulatory Factor 9 in Cerebral Ischemic Stroke

(2014) H.-Z. Chen et al.   JOURNAL OF NEUROSCIENCE

Lipopolysaccharide preconditioning facilitates M2 activation of resident microglia after spinal cord injury

(2014) Kentaro Hayakawa et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Prion-like polymerization as a signaling mechanism

(2014) Xin Cai et al.   TRENDS IN IMMUNOLOGY

Transcription factor IRF5 drives P2X4R+-reactive microglia gating neuropathic pain

(2014) Takahiro Masuda et al.   Nature Communications

Interferon regulatory factor 9 is critical for neointima formation following vascular injury

(2014) Shu-Min Zhang et al.   Nature Communications

IRF8 suppresses pathological cardiac remodelling by inhibiting calcineurin signalling

(2014) Ding-Sheng Jiang et al.   Nature Communications

Recognition of tumor cells by Dectin-1 orchestrates innate immune cells for anti-tumor responses

(2014) Shiho Chiba et al.   eLife

Interferon Regulatory Factor 7 Protects Against Vascular Smooth Muscle Cell Proliferation and Neointima Formation

(2014) Ling Huang et al.   Journal of the American Heart Association

Interferon regulatory factor 7 deficiency prevents diet-induced obesity and insulin resistance

(2013) Xin-An Wang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Shear stress modulates VCAM-1 expression in response to TNF-α and dietary lipids via interferon regulatory factor-1 in cultured endothelium

(2013) J. Sherrod DeVerse et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Interferon regulatory factor 3 is a negative regulator of pathological cardiac hypertrophy

(2013) Jing Lu et al.   BASIC RESEARCH IN CARDIOLOGY

PDGF-mediated autophagy regulates vascular smooth muscle cell phenotype and resistance to oxidative stress

(2013) Joshua K. Salabei et al.   BIOCHEMICAL JOURNAL

Distinct angiogenesis roles and surface markers of early and late endothelial progenitor cells revealed by functional group analyses

(2013) Cheng-Chung Cheng et al.   BMC GENOMICS

Interferon regulatory factor-1 together with reactive oxygen species promotes the acceleration of cell cycle progression by up-regulating the cyclin E and CDK2 genes during high glucose-induced proliferation of vascular smooth muscle cells

(2013) Xi Zhang et al.   Cardiovascular Diabetology

Pathological Ventricular Remodeling

(2013) Jana S. Burchfield et al.   CIRCULATION

Interferon Regulatory Factor 4 Regulates Obesity-Induced Inflammation Through Regulation of Adipose Tissue Macrophage Polarization

(2013) J. Eguchi et al.   DIABETES

The IκB kinase complex in NF-κB regulation and beyond

(2013) Michael Hinz et al.   EMBO REPORTS

Interferon regulatory factor 9 protects against hepatic insulin resistance and steatosis in male mice

(2013) Xin-An Wang et al.   HEPATOLOGY

Interferon regulatory factor 3 constrains IKKβ/NF-κB signaling to alleviate hepatic steatosis and insulin resistance

(2013) Xin-An Wang et al.   HEPATOLOGY

Role of Interferon Regulatory Factor 4 in the Regulation of Pathological Cardiac Hypertrophy

(2013) Ding-Sheng Jiang et al.   HYPERTENSION

Interferon Regulatory Factor 9 Protects Against Cardiac Hypertrophy by Targeting Myocardin

(2013) Ding-Sheng Jiang et al.   HYPERTENSION

Interferon-β Production via Dectin-1-Syk-IRF5 Signaling in Dendritic Cells Is Crucial for Immunity to C. albicans

(2013) Carlos del Fresno et al.   IMMUNITY

Interferon Regulatory Factor 8 Modulates Phenotypic Switching of Smooth Muscle Cells by Regulating the Activity of Myocardin

(2013) S.-M. Zhang et al.   MOLECULAR AND CELLULAR BIOLOGY

HDAC-dependent ventricular remodeling

(2013) Min Xie et al.   TRENDS IN CARDIOVASCULAR MEDICINE

MAVS recruits multiple ubiquitin E3 ligases to activate antiviral signaling cascades

(2013) Siqi Liu et al.   eLife

Interferon regulatory factor-2 is protective against hepatic ischemia-reperfusion injury

(2012) John R. Klune et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

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(2012) Yinzhong Zhang et al.   MOLECULAR MEDICINE

Molecular basis of physiological heart growth: fundamental concepts and new players

(2012) Marjorie Maillet et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

IFN Regulatory Factor 8 Is a Key Constitutive Determinant of the Morphological and Molecular Properties of Microglia in the CNS

(2012) Carsten Minten et al.   PLoS One

Splenocyte Apoptosis and Autophagy Is Mediated by Interferon Regulatory Factor 1 During Murine Endotoxemia

(2012) Lemeng Zhang et al.   SHOCK

IRF8 Is a Critical Transcription Factor for Transforming Microglia into a Reactive Phenotype

(2012) Takahiro Masuda et al.   Cell Reports

The IRF family of transcription factors

(2012) Hideyuki Yanai et al.   OncoImmunology

IRF8 and IRF3 cooperatively regulate rapid interferon-  induction in human blood monocytes

(2011) P. Li et al.   BLOOD

Interferon-gamma induces autophagy with growth inhibition and cell death in human hepatocellular carcinoma (HCC) cells through interferon-regulatory factor-1 (IRF-1)

(2011) Peiyuan Li et al.   CANCER LETTERS

Transcriptional Control of Adipose Lipid Handling by IRF4

(2011) Jun Eguchi et al.   Cell Metabolism

IRF3 regulates cardiac fibrosis but not hypertrophy in mice during angiotensin II-induced hypertension

(2011) Kensuke Tsushima et al.   FASEB JOURNAL

Galectin-9 Protein Expression in Endothelial Cells Is Positively Regulated by Histone Deacetylase 3

(2011) Saydul Alam et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Multiple Preconditioning Paradigms Converge on Interferon Regulatory Factor-Dependent Signaling to Promote Tolerance to Ischemic Brain Injury

(2011) S. L. Stevens et al.   JOURNAL OF NEUROSCIENCE

Human Fatty Liver Disease: Old Questions and New Insights

(2011) J. C. Cohen et al.   SCIENCE

Estrogen Receptor-β Prevents Cardiac Fibrosis

(2010) Ali Pedram et al.   MOLECULAR ENDOCRINOLOGY

The cytosolic nucleic acid sensor LRRFIP1 mediates the production of type I interferon via a β-catenin-dependent pathway

(2010) Pengyuan Yang et al.   NATURE IMMUNOLOGY

Aspartate-glutamate-alanine-histidine box motif (DEAH)/RNA helicase A helicases sense microbial DNA in human plasmacytoid dendritic cells

(2010) T. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interferon Regulatory Factor 1 Mediates Acetylation and Release of High Mobility Group Box 1 from Hepatocytes During Murine Liver Ischemia-Reperfusion Injury

(2010) Rajeev Dhupar et al.   SHOCK

IL-18 induction of osteopontin mediates cardiac fibrosis and diastolic dysfunction in mice

(2009) Qianli Yu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Structural insights into interferon regulatory factor activation

(2009) Weijun Chen et al.   CELLULAR SIGNALLING

Critical role of interferon regulatory factor-1 in murine liver transplant ischemia reperfusion injury

(2009) Shinya Ueki et al.   HEPATOLOGY

Dynamic Evolution of Immune System Regulators: The History of the Interferon Regulatory Factor Family

(2009) J. Nehyba et al.   MOLECULAR BIOLOGY AND EVOLUTION

Activation of innate immune antiviral responses by Nod2

(2009) Ahmed Sabbah et al.   NATURE IMMUNOLOGY

NOD2, RIP2 and IRF5 Play a Critical Role in the Type I Interferon Response to Mycobacterium tuberculosis

(2009) Amit K. Pandey et al.   PLoS Pathogens

The IRF Family Transcription Factors in Immunity and Oncogenesis

(2008) Tomohiko Tamura et al.   Annual Review of Immunology

Interferon regulatory factor family of transcription factors and regulation of oncogenesis

(2008) Akinori Takaoka et al.   CANCER SCIENCE

Interferon Regulatory Factors Are Transcriptional Regulators of Adipogenesis

(2008) Jun Eguchi et al.   Cell Metabolism

TRADD Protein Is an Essential Component of the RIG-like Helicase Antiviral Pathway

(2008) Marie-Cécile Michallet et al.   IMMUNITY

MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts

(2008) Thomas Thum et al.   NATURE