CFTR supports cell death through ROS-dependent activation of TMEM16F (anoctamin 6)

Differential effects of anoctamins on intracellular calcium signals

(2017) Inês Cabrita et al.   FASEB JOURNAL

Role of exchange protein directly activated by cAMP (EPAC1) in breast cancer cell migration and apoptosis

(2017) Naveen Kumar et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Ion channels in regulated cell death

(2016) Karl Kunzelmann   CELLULAR AND MOLECULAR LIFE SCIENCES

Ca2+ signals, cell membrane disintegration, and activation of TMEM16F during necroptosis

(2016) Jiraporn Ousingsawat et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Structural basis for phospholipid scrambling in the TMEM16 family

(2016) Janine D Brunner et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Cl− channels in apoptosis

(2016) Podchanart Wanitchakool et al.   EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

EPAC1 activation by cAMP stabilizes CFTR at the membrane by promoting its interaction with NHERF1

(2016) Miguel J. Lobo et al.   JOURNAL OF CELL SCIENCE

Non-essential contribution of LRRC8A to volume regulation

(2016) Lalida Sirianant et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Cellular volume regulation by anoctamin 6: Ca2+, phospholipase A2 and osmosensing

(2015) Lalida Sirianant et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

An Apoptotic ‘Eat Me’ Signal: Phosphatidylserine Exposure

(2015) Katsumori Segawa et al.   TRENDS IN CELL BIOLOGY

Anoctamin 6 mediates effects essential for innate immunity downstream of P2X7 receptors in macrophages

(2015) Jiraporn Ousingsawat et al.   Nature Communications

Protein Traffic Disorders: an Effective High-Throughput Fluorescence Microscopy Pipeline for Drug Discovery

(2015) Hugo M. Botelho et al.   Scientific Reports

Hydrogen peroxide stimulation of CFTR reveals an Epac-mediated, soluble AC-dependent cAMP amplification pathway common to GPCR signalling

(2014) P Ivonnet et al.   BRITISH JOURNAL OF PHARMACOLOGY

X-ray structure of a calcium-activated TMEM16 lipid scramblase

(2014) Janine D. Brunner et al.   NATURE

Anoctamin 6 differs from VRAC and VSOAC but is involved in apoptosis and supports volume regulation in the presence of Ca2+

(2014) C. A. Juul et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Structure and Function of TMEM16 Proteins (Anoctamins)

(2014) Nicoletta Pedemonte et al.   PHYSIOLOGICAL REVIEWS

TMEM16F is a component of a Ca2+-activated Cl− channel but not a volume-sensitive outwardly rectifying Cl− channel

(2013) Takahiro Shimizu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

H2O2Stimulates Cystic Fibrosis Transmembrane Conductance Regulator through an Autocrine Prostaglandin Pathway, Using Multidrug-Resistant Protein–4

(2013) Gregory E. Conner et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Apoptotic process in cystic fibrosis cells

(2013) Raffaella Soleti et al.   APOPTOSIS

TMEM16F (Anoctamin 6), an anion channel of delayed Ca2+activation

(2013) Søren Grubb et al.   JOURNAL OF GENERAL PHYSIOLOGY

TMEM16F Forms a Ca2+-Activated Cation Channel Required for Lipid Scrambling in Platelets during Blood Coagulation

(2012) Huanghe Yang et al.   CELL

Anoctamins are a family of Ca2+-activated Cl- channels

(2012) Y. Tian et al.   JOURNAL OF CELL SCIENCE

CFTR and TMEM16A are Separate but Functionally Related Cl- Channels

(2011) Jiraporn Ousingsawat et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Anoctamin 6 is an essential component of the outwardly rectifying chloride channel

(2011) J. R. Martins et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Constitutive exposure of phosphatidylserine on viable cells

(2011) K. Segawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Calcium-dependent phospholipid scrambling by TMEM16F

(2010) Jun Suzuki et al.   NATURE

Defective CFTR induces aggresome formation and lung inflammation in cystic fibrosis through ROS-mediated autophagy inhibition

(2010) Alessandro Luciani et al.   NATURE CELL BIOLOGY

Peroxiredoxin 6 Fails to Limit Phospholipid Peroxidation in Lung from Cftr-Knockout Mice Subjected to Oxidative Challenge

(2009) Stéphanie Trudel et al.   PLoS One

CFTR mediates cadmium-induced apoptosis through modulation of ROS level in mouse proximal tubule cells

(2008) Sebastien L'hoste et al.   FREE RADICAL BIOLOGY AND MEDICINE