3,4-Dihydroxyphenylacetic acid, a microbiota-derived metabolite of quercetin, attenuates acetaminophen (APAP)-induced liver injury through activation of Nrf-2

Apocynum venetumAttenuates Acetaminophen-Induced Liver Injury in Mice

(2015) Wenyan Xie et al.   AMERICAN JOURNAL OF CHINESE MEDICINE

Systemic exposure of Paracetamol (acetaminophen) was enhanced by quercetin and chrysin co-administration in Wistar rats andin vitromodel: risk of liver toxicity

(2015) Ravindra Babu Pingili et al.   DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY

3,4-dihydroxyphenylacetic acid, a microbiota-derived metabolite of quercetin, protects against pancreatic β-cells dysfunction induced by high cholesterol

(2015) Catalina Carrasco-Pozo et al.   EXPERIMENTAL CELL RESEARCH

Quercetin protects mouse liver against CCl4-induced inflammation by the TLR2/4 and MAPK/NF-κB pathway

(2015) Jie-Qiong Ma et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Therapeutic detoxification of quercetin against carbon tetrachloride-induced acute liver injury in mice and its mechanism

(2014) Jia-qi Zhang et al.   Journal of Zhejiang University-SCIENCE B

Molecular and physiological actions of quercetin: need for clinical trials to assess its benefits in human disease

(2014) Sarah L Miles et al.   NUTRITION REVIEWS

Acetaminophen-related Hepatotoxicity

(2013) Chalermrat Bunchorntavakul et al.   Clinics in Liver Disease

Identification of the major metabolites of hyperoside produced by the human intestinal bacteria using the ultra performance liquid chromatography/quadrupole-time-of-flight mass spectrometry

(2013) Jing Yang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Metabolism and Disposition of Acetaminophen: Recent Advances in Relation to Hepatotoxicity and Diagnosis

(2013) Mitchell R. McGill et al.   PHARMACEUTICAL RESEARCH

New Therapeutic Approach: Diphenyl Diselenide Reduces Mitochondrial Dysfunction in Acetaminophen-Induced Acute Liver Failure

(2013) Nélson R. Carvalho et al.   PLoS One

Bioconversion of 7-Hydroxyflavanone: Isolation, Characterization and Bioactivity Evaluation of Twenty-One Phase I and Phase II Microbial Metabolites

(2012) Julie Rakel Mikell et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

Acetaminophen administration in a patient with Gilbert's syndrome

(2012) Taku Nakagawa et al.   PEDIATRICS INTERNATIONAL

Novel protective mechanisms for S-adenosyl-l-methionine against acetaminophen hepatotoxicity: Improvement of key antioxidant enzymatic function

(2012) James Michael Brown et al.   TOXICOLOGY LETTERS

Activation of liver X receptor increases acetaminophen clearance and prevents its toxicity in mice

(2011) Simrat P.S. Saini et al.   HEPATOLOGY

Protective Effects of Hyperoside against Carbon Tetrachloride-Induced Liver Damage in Mice

(2011) Jun-Ho Choi et al.   JOURNAL OF NATURAL PRODUCTS

Route of administration determines the anxiolytic activity of the flavonols kaempferol, quercetin and myricetin — are they prodrugs?

(2011) Cica Vissiennon et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Acetaminophen overdose: a little recognized public health threat

(2011) Sofia Achaval et al.   PHARMACOEPIDEMIOLOGY AND DRUG SAFETY

Anti-inflammatory and analgesic activity of protocatechuic acid in rats and mice

(2011) Amol B. Lende et al.   INFLAMMOPHARMACOLOGY

Urinary Excretion of Phenolic Acids in Rats Fed Cranberry†

(2010) Ronald L. Prior et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Interaction between Oxidative Stress Sensor Nrf2 and Xenobiotic-activated Aryl Hydrocarbon Receptor in the Regulation of the Human Phase II Detoxifying UDP-glucuronosyltransferase 1A10

(2010) Sandra Kalthoff et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interaction between Phenolics and Gut Microbiota: Role in Human Health

(2009) María V. Selma et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

CDDO-Im protects from acetaminophen hepatotoxicity through induction of Nrf2-dependent genes

(2009) Scott A. Reisman et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Bioavailability of [2-14C]Quercetin-4′-glucoside in Rats

(2008) William Mullen et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Microbial metabolism of dietary phenolic compounds in the colon

(2008) Anna-Marja Aura   PHYTOCHEMISTRY REVIEWS