Journal
MOLECULES
Volume 17, Issue 12, Pages 14637-14650Publisher
MDPI
DOI: 10.3390/molecules171214637
Keywords
CAPE; caffeic acid; 3-(3,4-dihydroxyphenyl) propanoic acid esters; 2-(3,4-dihydroxyphenyl) acetic acid esters; 3,4-dihydroxybenzoic acid esters; antioxidant
Funding
- New Brunswick Health Research Foundation
- Canada Foundation for Innovation
- New Brunswick Innovation Foundation
- Canada Research Chairs program
- Universite de Moncton
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Caffeic acid phenethyl ester (CAPE) is a bioactive component isolated from propolis. A series of CAPE analogues was synthesized and their antiradical/antioxidant effects analyzed. The effect of the presence of the double bond and of the conjugated system on the antioxidant effect is evaluated with the analogues obtained from 3-(3,4-dihydroxyphenyl) propanoic acid. Those obtained from 2-(3,4-dihydroxyphenyl) acetic acid and 3,4-dihydroxybenzoic acid allow the evaluation of the effect of the presence of two carbons between the carbonyl and aromatic system.
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