Differential Regulation of Cardiac Function and Intracardiac Cytokines by Rapamycin in Healthy and Diabetic Rats

Targeting metabolism in cellular senescence, a role for intervention

(2017) Timothy Nacarelli et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Damaging effects of hyperglycemia on cardiovascular function: spotlight on glucose metabolic pathways

(2016) Rudo F. Mapanga et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging

(2016) Brian K. Kennedy et al.   Cell Metabolism

Determinants and Prognostic Impact of Hyperuricemia in Hospitalization for Acute Heart Failure

(2016) Wei-Ming Huang et al.   CIRCULATION JOURNAL

Interaction of TWEAK with Fn14 leads to the progression of fibrotic liver disease by directly modulating hepatic stellate cell proliferation

(2016) Annika Wilhelm et al.   JOURNAL OF PATHOLOGY

Inhibition of the Mechanistic Target of Rapamycin (mTOR)–Rapamycin and Beyond

(2016) Dudley W. Lamming   Cold Spring Harbor Perspectives in Medicine

Interleukin-2/Anti-Interleukin-2 Immune Complex Attenuates Cardiac Remodeling after Myocardial Infarction through Expansion of Regulatory T Cells

(2016) Zhipeng Zeng et al.   Journal of Immunology Research

Alternative rapamycin treatment regimens mitigate the impact of rapamycin on glucose homeostasis and the immune system

(2015) Sebastian I. Arriola Apelo et al.   AGING CELL

mTOR activation is a biomarker and a central pathway to autoimmune disorders, cancer, obesity, and aging

(2015) Andras Perl   Annals of the New York Academy of Sciences

Cardiomyopathy and Worsened Ischemic Heart Failure in SM22-  Cre-Mediated Neuropilin-1 Null Mice: Dysregulation of PGC1  and Mitochondrial Homeostasis

(2015) Y. Wang et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Inhibition of mammalian target of rapamycin protects against reperfusion injury in diabetic heart through STAT3 signaling

(2015) Anindita Das et al.   BASIC RESEARCH IN CARDIOLOGY

Targeting Interleukin-1β Reduces Leukocyte Production After Acute Myocardial Infarction

(2015) Hendrik B. Sager et al.   CIRCULATION

TREM-1 Mediates Inflammatory Injury and Cardiac Remodeling Following Myocardial Infarction

(2015) A. Boufenzer et al.   CIRCULATION RESEARCH

Profibrotic Role for Interleukin-4 in Cardiac Remodeling and DysfunctionNovelty and Significance

(2015) Hongmei Peng et al.   HYPERTENSION

TREM-1 Signaling Promotes Host Defense during the Early Stage of Infection with Highly Pathogenic Streptococcus suis

(2015) Chao Yang et al.   INFECTION AND IMMUNITY

Rapamycin Increases Mortality indb/dbMice, a Mouse Model of Type 2 Diabetes

(2015) Kavithalakshmi Sataranatarajan et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Regulation of cardiac miR-208a, an inducer of obesity, by rapamycin and nebivolol

(2015) Rukhsana Gul et al.   Obesity

Differential Effects of β-Blockers, Angiotensin II Receptor Blockers, and a Novel AT2R Agonist NP-6A4 on Stress Response of Nutrient-Starved Cardiovascular Cells

(2015) Abuzar Mahmood et al.   PLoS One

Opposing roles of Akt and STAT3 in the protection of the maternal heart from peripartum stress

(2014) Melanie Ricke-Hoch et al.   CARDIOVASCULAR RESEARCH

Anti-Fibrotic Actions of Interleukin-10 against Hypertrophic Scarring by Activation of PI3K/AKT and STAT3 Signaling Pathways in Scar-Forming Fibroblasts

(2014) Jihong Shi et al.   PLoS One

Regulation of Cardiac Expression of the Diabetic Marker MicroRNA miR-29

(2014) Nicholas Arnold et al.   PLoS One

Late-life rapamycin treatment reverses age-related heart dysfunction

(2013) James M. Flynn et al.   AGING CELL

Could interferon-gamma be a therapeutic target for treating heart failure?

(2013) Scott P. Levick et al.   HEART FAILURE REVIEWS

Mammalian Target of Rapamycin (mTOR) Inhibition with Rapamycin Improves Cardiac Function in Type 2 Diabetic Mice

(2013) Anindita Das et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Skin and Soft Tissue Infections and Associated Complications among Commercially Insured Patients Aged 0–64 Years with and without Diabetes in the U.S.

(2013) Jose A. Suaya et al.   PLoS One

Coronary risk assessment among intermediate risk patients using a clinical and biomarker based algorithm developed and validated in two population cohorts

(2012) D.S. Cross et al.   CURRENT MEDICAL RESEARCH AND OPINION

Long-term severe diabetes only leads to mild cardiac diastolic dysfunction in Zucker diabetic fatty rats

(2012) Anneleen Daniels et al.   EUROPEAN JOURNAL OF HEART FAILURE

Notch signaling and cardiac repair

(2012) Natalie Gude et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Regulation of Overnutrition-Induced Cardiac Inflammatory Mechanisms

(2012) Rukhsana Gul et al.   CardioRenal Medicine

Adaptive mechanisms to compensate for overnutrition-induced cardiovascular abnormalities

(2011) Lakshmi Pulakat et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Prolactin Levels, Endothelial Dysfunction, and the Risk of Cardiovascular Events and Mortality in Patients with CKD

(2011) J. J. Carrero et al.   Clinical Journal of the American Society of Nephrology

Pathway Analysis Shows Association between FGFBP1 and Hypertension

(2011) M. Tomaszewski et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Rapamycin, But Not Resveratrol or Simvastatin, Extends Life Span of Genetically Heterogeneous Mice

(2010) Richard A. Miller et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Rapamycin regulates Akt and ERK phosphorylation through mTORC1 and mTORC2 signaling pathways

(2010) Xian-Guo Chen et al.   MOLECULAR CARCINOGENESIS

Regulation of the mTOR Complex 1 Pathway by Nutrients, Growth Factors, and Stress

(2010) Shomit Sengupta et al.   MOLECULAR CELL

mTOR: from growth signal integration to cancer, diabetes and ageing

(2010) Roberto Zoncu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Prostate stromal cells produce CXCL-1, CXCL-2, CXCL-3 and IL-8 in response to epithelia-secreted IL-1

(2009) Ira Kogan-Sakin et al.   CARCINOGENESIS

Prolactin Levels and the Risk of Future Coronary Artery Disease in Apparently Healthy Men and Women

(2009) Anne Q. Reuwer et al.   Circulation-Cardiovascular Genetics

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

(2009) David E. Harrison et al.   NATURE

ROLE OF ANTIFIBROTIC CYTOKINE INTERFERON-γ IN THE PREVENTION OF POSTLAMINECTOMY PERIDURAL FIBROSIS IN RATS

(2009) Hakan Emmez et al.   NEUROSURGERY