Multifaceted Roles of GSK-3 in Cancer and Autophagy-Related Diseases

Treatment of Alzheimer's Disease with the GSK-3 Inhibitor Tideglusib: A Pilot Study

(2018) Teodoro del Ser et al.   JOURNAL OF ALZHEIMERS DISEASE

Efficacy of hydralazine and valproate in cutaneous T-cell lymphoma, a phase II study

(2017) Jose Ramiro Espinoza-Zamora et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Lipid Storage and Autophagy in Melanoma Cancer Cells

(2017) Claudia Giampietri et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

GSK3B-mediated phosphorylation of MCL1 regulates axonal autophagy to promote Wallerian degeneration

(2017) Shuji Wakatsuki et al.   JOURNAL OF CELL BIOLOGY

Autophagy in the liver: functions in health and disease

(2017) Takashi Ueno et al.   Nature Reviews Gastroenterology & Hepatology

Mechanisms of hepatic stellate cell activation

(2017) Takuma Tsuchida et al.   Nature Reviews Gastroenterology & Hepatology

A model of the mitochondrial basis of bipolar disorder

(2017) Gerwyn Morris et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Autophagy is a signature of a signaling network that maintains hematopoietic stem cells

(2017) Michelle Nguyen-McCarty et al.   PLoS One

A Mechanistic Review of Cell Death in Alcohol-Induced Liver Injury

(2016) Shaogui Wang et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

(2016) Daniel J Klionsky et al.   Autophagy

Randomized placebo-controlled trial of sodium valproate in progressive supranuclear palsy

(2016) Laurène Leclair-Visonneau et al.   CLINICAL NEUROLOGY AND NEUROSURGERY

Upstream regulators and downstream effectors of NF-κB in Alzheimer's disease

(2016) Zhe-Min Shi et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

A Novel Glycogen Synthase Kinase-3 Inhibitor Optimized for Acute Myeloid Leukemia Differentiation Activity

(2016) Sophia Hu et al.   MOLECULAR CANCER THERAPEUTICS

Cholangiocarcinoma: current knowledge and future perspectives consensus statement from the European Network for the Study of Cholangiocarcinoma (ENS-CCA)

(2016) Jesus M. Banales et al.   Nature Reviews Gastroenterology & Hepatology

Impairment of the autophagic flux in astrocytes intoxicated by trimethyltin

(2016) Cinzia Fabrizi et al.   NEUROTOXICOLOGY

Primary Sclerosing Cholangitis

(2016) Konstantinos N. Lazaridis et al.   NEW ENGLAND JOURNAL OF MEDICINE

Gsk3 Signalling and Redox Status in Bipolar Disorder: Evidence from Lithium Efficacy

(2016) Antonina Luca et al.   Oxidative Medicine and Cellular Longevity

Macrophage Activation in Pediatric Nonalcoholic Fatty Liver Disease (NAFLD) Correlates with Hepatic Progenitor Cell Response via Wnt3a Pathway

(2016) Guido Carpino et al.   PLoS One

Small GSK-3 Inhibitor Shows Efficacy in a Motor Neuron Disease Murine Model Modulating Autophagy

(2016) Estefanía de Munck et al.   PLoS One

Targeting Wnt/β-catenin pathway in hepatocellular carcinoma treatment

(2016) Valery Vilchez   WORLD JOURNAL OF GASTROENTEROLOGY

GSK3-mediated raptor phosphorylation supports amino-acid-dependent mTORC1-directed signalling

(2015) C. Stretton et al.   BIOCHEMICAL JOURNAL

Autophagy in malignant transformation and cancer progression

(2015) L. Galluzzi et al.   EMBO JOURNAL

The hepatic, biliary, and pancreatic network of stem/progenitor cell niches in humans: A new reference frame for disease and regeneration

(2015) Giacomo Lanzoni et al.   HEPATOLOGY

Glycogen Synthase Kinase-3 (GSK3) Inhibition Induces Prosurvival Autophagic Signals in Human Pancreatic Cancer Cells

(2015) Benoît Marchand et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation of biliary tree stem cells within peribiliary glands in primary sclerosing cholangitis

(2015) Guido Carpino et al.   JOURNAL OF HEPATOLOGY

Autophagy and senescence in fibrosing cholangiopathies

(2015) Yasuni Nakanuma et al.   JOURNAL OF HEPATOLOGY

Curcumin induces apoptotic cell death via Oct4 inhibition and GSK-3β activation in NCCIT cells

(2015) Ji Ho Yun et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Prostaglandin E2 promotes human cholangiocarcinoma cell proliferation, migration and invasion through the upregulation of β-catenin expression via EP3-4 receptor

(2015) MINGZHAN DU et al.   ONCOLOGY REPORTS

GSK-3β controls autophagy by modulating LKB1-AMPK pathway in prostate cancer cells

(2015) Aijing Sun et al.   PROSTATE

The molecular mechanism of rotenone-induced α-synuclein aggregation: Emphasizing the role of the calcium/GSK3β pathway

(2015) Yu-he Yuan et al.   TOXICOLOGY LETTERS

β-escin reverses multidrug resistance through inhibition of the GSK3β/β-catenin pathway in cholangiocarcinoma

(2015) Gui-Li Huang   WORLD JOURNAL OF GASTROENTEROLOGY

Glycogen synthase kinase-3 inhibitor AR-A014418 suppresses pancreatic cancer cell growth via inhibition of GSK-3-mediated Notch1 expression

(2015) Selvi Kunnimalaiyaan et al.   HPB

Baclofen mediates neuroprotection on hippocampal CA1 pyramidal cells through the regulation of autophagy under chronic cerebral hypoperfusion

(2015) Li Liu et al.   Scientific Reports

Regulation of autophagic cell death by glycogen synthase kinase-3β in adult hippocampal neural stem cells following insulin withdrawal

(2015) Shinwon Ha et al.   Molecular Brain

Activating the Wnt/β-Catenin Pathway for the Treatment of Melanoma – Application of LY2090314, a Novel Selective Inhibitor of Glycogen Synthase Kinase-3

(2015) Jennifer M. Atkinson et al.   PLoS One

Perspectives of TGF-β inhibition in pancreatic and hepatocellular carcinomas

(2015) Cindy Neuzillet et al.   Oncotarget

Aurora kinase a suppresses metabolic stress-induced autophagic cell death by activating mTOR signaling in breast cancer cells

(2015) Ling-Zhi Xu et al.   Oncotarget

The novel arylindolylmaleimide PDA-66 displays pronounced antiproliferative effects in acute lymphoblastic leukemia cells

(2014) Christin Kretzschmar et al.   BMC CANCER

PI3K/mTOR Inhibition Markedly Potentiates HDAC Inhibitor Activity in NHL Cells through BIM- and MCL-1-Dependent Mechanisms In Vitro and In Vivo

(2014) M. Rahmani et al.   CLINICAL CANCER RESEARCH

Oxidative stress promotes d-GalN/LPS-induced acute hepatotoxicity by increasing glycogen synthase kinase 3β activity

(2014) Linlin Wei et al.   INFLAMMATION RESEARCH

GSK-3βInhibition Attenuates CLP-Induced Liver Injury by Reducing Inflammation and Hepatic Cell Apoptosis

(2014) Hui Zhang et al.   MEDIATORS OF INFLAMMATION

A phase 2 trial of the GSK-3 inhibitor tideglusib in progressive supranuclear palsy

(2014) Eduardo Tolosa et al.   MOVEMENT DISORDERS

Combined regulation of mTORC1 and lysosomal acidification by GSK-3 suppresses autophagy and contributes to cancer cell growth

(2014) I Azoulay-Alfaguter et al.   ONCOGENE

Targeting the β-catenin nuclear transport pathway in cancer

(2014) Cara Jamieson et al.   SEMINARS IN CANCER BIOLOGY

Oxidative stress as a crucial factor in liver diseases

(2014) Halina Cichoż-Lach   WORLD JOURNAL OF GASTROENTEROLOGY

Resveratrol protects astrocytes against traumatic brain injury through inhibiting apoptotic and autophagic cell death

(2014) C-J Lin et al.   Cell Death & Disease

Pharmacological correction of obesity-induced autophagy arrest using calcium channel blockers

(2014) Hwan-Woo Park et al.   Nature Communications

Activator or inhibitor? GSK-3 as a new drug target

(2013) Fumi Takahashi-Yanaga   BIOCHEMICAL PHARMACOLOGY

Apicidin-Resistant HA22T Hepatocellular Carcinoma Cells strongly activated the Wnt/β-Catenin Signaling Pathway and MMP-2 Expression via the IGF-IR/PI3K/Akt Signaling Pathway Enhancing Cell Metastatic Effect

(2013) Cheng-Hong HSIEH et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Inhibition of Wnt/β-catenin signaling downregulates P-glycoprotein and reverses multi-drug resistance of cholangiocarcinoma

(2013) Dong-Yan Shen et al.   CANCER SCIENCE

Autophagy in Prostate Cancer and Androgen Suppression Therapy

(2013) Elio Ziparo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Pharmacological promotion of autophagy alleviates steatosis and injury in alcoholic and non-alcoholic fatty liver conditions in mice

(2013) Chih-Wen Lin et al.   JOURNAL OF HEPATOLOGY

Role of glycogen synthase kinase 3β in protective effect of propofol against hepatic ischemia–reperfusion injury

(2013) Ge Zhao et al.   JOURNAL OF SURGICAL RESEARCH

The global NAFLD epidemic

(2013) Rohit Loomba et al.   Nature Reviews Gastroenterology & Hepatology

Suppression of Cholangiocarcinoma Cell Growth by Human Umbilical Cord Mesenchymal Stem Cells: A Possible Role of Wnt and Akt Signaling

(2013) Juan Liu et al.   PLoS One

Activation of Wnt/β-Catenin Signaling Increases Apoptosis in Melanoma Cells Treated with Trail

(2013) Zachary F. Zimmerman et al.   PLoS One

Notch signalling beyond liver development: Emerging concepts in liver repair and oncogenesis

(2013) Carola Maria Morell et al.   Clinics and Research in Hepatology and Gastroenterology

Protein phosphorylation-acetylation cascade connects growth factor deprivation to autophagy

(2012) Shu-Yong Lin et al.   Autophagy

Glycogen synthase kinase 3-β phosphorylates novel S/T-P-S/T domains in Notch1 intracellular domain and induces its nuclear localization

(2012) Xiangzi Han et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Autophagy in tumor suppression and cancer therapy

(2012) Che-Pei Kung et al.   CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION

MicroRNA-26a Promotes Cholangiocarcinoma Growth by Activating β-catenin

(2012) Jinqiang Zhang et al.   GASTROENTEROLOGY

Autophagy Releases Lipid That Promotes Fibrogenesis by Activated Hepatic Stellate Cells in Mice and in Human Tissues

(2012) Virginia Hernández–Gea et al.   GASTROENTEROLOGY

TGFβ overrides HNF4α tumor suppressing activity through GSK3β inactivation: implication for hepatocellular carcinoma gene therapy

(2012) Angela Maria Cozzolino et al.   JOURNAL OF HEPATOLOGY

Identification of Glycogen Synthase Kinase-3 Inhibitors with a Selective Sting for Glycogen Synthase Kinase-3α

(2012) Fabio Lo Monte et al.   JOURNAL OF MEDICINAL CHEMISTRY

Increased expression of mitochondrial proteins associated with autophagy in biliary epithelial lesions in primary biliary cirrhosis

(2012) Motoko Sasaki et al.   LIVER INTERNATIONAL

GSK-3 Promotes Cell Survival, Growth, and PAX3 Levels in Human Melanoma Cells

(2012) J. D. Kubic et al.   MOLECULAR CANCER RESEARCH

Inhibition of Glycogen Synthase Kinase 3β Ameliorates D-GalN/LPS-Induced Liver Injury by Reducing Endoplasmic Reticulum Stress-Triggered Apoptosis

(2012) Liyan Chen et al.   PLoS One

ShRNA silencing glycogen synthase kinase-3 beta inhibits tumor growth and angiogenesis in pancreatic cancer

(2011) Wei Zhou et al.   CANCER LETTERS

Signaling pathways activated by the phytochemical nordihydroguaiaretic acid contribute to a Keap1-independent regulation of Nrf2 stability: Role of glycogen synthase kinase-3

(2011) Ana I. Rojo et al.   FREE RADICAL BIOLOGY AND MEDICINE

Distinct Molecular Regulation of Glycogen Synthase Kinase-3α Isozyme Controlled by Its N-terminal Region

(2011) Inbar Azoulay-Alfaguter et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A role for autophagy during hepatic stellate cell activation

(2011) Lien F.R. Thoen et al.   JOURNAL OF HEPATOLOGY

Glycogen synthase kinase-3 (GSK-3) inhibition induces apoptosis in leukemic cells through mitochondria-dependent pathway

(2011) Mohammad Reza Mirlashari et al.   LEUKEMIA RESEARCH

Enhancement of Canonical Wnt/β-Catenin Signaling Activity by HCV Core Protein Promotes Cell Growth of Hepatocellular Carcinoma Cells

(2011) Jiao Liu et al.   PLoS One

GSK-3 Inhibitors: Preclinical and Clinical Focus on CNS

(2011) Hagit Eldar-Finkelman et al.   Frontiers in Molecular Neuroscience

Roles of GSK3 in metabolic shift toward abnormal anabolism in cell senescence

(2010) You-Mie Kim et al.   Annals of the New York Academy of Sciences

Characterization of autophagosome formation site by a hierarchical analysis of mammalian Atg proteins

(2010) Eisuke Itakura et al.   Autophagy

Defective Hepatic Autophagy in Obesity Promotes ER Stress and Causes Insulin Resistance

(2010) Ling Yang et al.   Cell Metabolism

Autophagy: cellular and molecular mechanisms

(2010) Danielle Glick et al.   JOURNAL OF PATHOLOGY

mTORC1 controls fasting-induced ketogenesis and its modulation by ageing

(2010) Shomit Sengupta et al.   NATURE

Can autophagy promote longevity?

(2010) Frank Madeo et al.   NATURE CELL BIOLOGY

Small molecule GSK-3 inhibitors increase neurogenesis of human neural progenitor cells

(2010) Christian Lange et al.   NEUROSCIENCE LETTERS

c-Flip overexpression affects satellite cell proliferation and promotes skeletal muscle aging

(2010) C Giampietri et al.   Cell Death & Disease

Drug Development Targeting the Glycogen Synthase Kinase-3β (GSK-3β)-Mediated Signal Transduction Pathway: Role of GSK-3β in Myocardial Protection Against Ischemia/Reperfusion Injury

(2009) Tetsuji Miura et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Cadmium Toxicity toward Autophagy through ROS-Activated GSK-3β in Mesangial Cells

(2009) Sheng-Hao Wang et al.   TOXICOLOGICAL SCIENCES

The regulation of aging: does autophagy underlie longevity?

(2009) Tibor Vellai et al.   TRENDS IN CELL BIOLOGY

Abnormalities in brain structure and behavior in GSK-3alpha mutant mice

(2009) Oksana Kaidanovich-Beilin et al.   Molecular Brain

Enhanced glycogenesis is involved in cellular senescence via GSK3/GS modulation

(2008) Yong-Hak Seo et al.   AGING CELL

Glycogen synthase kinase 3β (GSK3β) in tumorigenesis and cancer chemotherapy

(2008) Jia Luo   CANCER LETTERS

ERK5/MAPK is activated by TGFβ in hepatocytes and required for the GSK-3β-mediated Snail protein stabilization

(2008) Alessandra Marchetti et al.   CELLULAR SIGNALLING

Autophagy activation by rapamycin eliminates mouse Mallory-Denk bodies and blocks their proteasome inhibitor-mediated formation

(2008) Masaru Harada et al.   HEPATOLOGY

Proapoptotic Activity and Chemosensitizing Effect of the Novel Akt Inhibitor (2S)-1-(1H-Indol-3-yl)-3-[5-(3-methyl-2H-indazol-5-yl)pyridin-3-yl]oxypropan2-amine (A443654) in T-Cell Acute Lymphoblastic Leukemia

(2008) F. Fala et al.   MOLECULAR PHARMACOLOGY