Small GSK-3 Inhibitor Shows Efficacy in a Motor Neuron Disease Murine Model Modulating Autophagy

Therapeutic Development in Amyotrophic Lateral Sclerosis

(2015) Monica Bucchia et al.   CLINICAL THERAPEUTICS

Dysregulated miRNA biogenesis downstream of cellular stress and ALS-causing mutations: a new mechanism for ALS

(2015) A. Emde et al.   EMBO JOURNAL

Morphometric and neurochemical alterations found in l-BMAA treated rats

(2015) Estefanía de Munck et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

The Function of Autophagy in Neurodegenerative Diseases

(2015) Yoshimitsu Kiriyama et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Amyotrophic lateral sclerosis: mechanisms and therapeutics in the epigenomic era

(2015) Ximena Paez-Colasante et al.   Nature Reviews Neurology

Challenges in the Understanding and Treatment of Amyotrophic Lateral Sclerosis/Motor Neuron Disease

(2015) Jeffrey Rosenfeld et al.   Neurotherapeutics

TDP-43 Proteinopathy and ALS: Insights into Disease Mechanisms and Therapeutic Targets

(2015) Emma L. Scotter et al.   Neurotherapeutics

Analysis of β-N-methylamino- l -alanine (L-BMAA) neurotoxicity in rat cerebellum

(2015) Emma Muñoz-Sáez et al.   NEUROTOXICOLOGY

Altered macroautophagy in the spinal cord of SOD1 mutant mice

(2014) Liang Li et al.   Autophagy

Lessons Learnt from Glycogen Synthase Kinase 3 Inhibitors Development for Alzheimer’s Disease

(2014) Ana Martinez et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Protein Kinase CK-1 Inhibitors As New Potential Drugs for Amyotrophic Lateral Sclerosis

(2014) Irene G. Salado et al.   JOURNAL OF MEDICINAL CHEMISTRY

Neuroprotective effects of JGK-263 in transgenic SOD1-G93A mice of amyotrophic lateral sclerosis

(2014) Suk-Won Ahn et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Economic burden of amyotrophic lateral sclerosis: A Canadian study of out-of-pocket expenses

(2014) Matthew Gladman et al.   Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

A Small Molecule Screen in Stem-Cell-Derived Motor Neurons Identifies a Kinase Inhibitor as a Candidate Therapeutic for ALS

(2013) Yin M. Yang et al.   Cell Stem Cell

β-N-methylamino-l-alanine causes neurological and pathological phenotypes mimicking Amyotrophic Lateral Sclerosis (ALS): The first step towards an experimental model for sporadic ALS

(2013) Estefanía de Munck et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Regulation of Th1 Cells and Experimental Autoimmune Encephalomyelitis by Glycogen Synthase Kinase-3

(2013) E. Beurel et al.   JOURNAL OF IMMUNOLOGY

The role of autophagy in neurodegenerative disease

(2013) Ralph A Nixon   NATURE MEDICINE

Glycogen synthase kinase-3 inhibitors: Rescuers of cognitive impairments

(2013) Margaret K. King et al.   PHARMACOLOGY & THERAPEUTICS

Kinase Inhibitor Screening Identifies Cyclin-Dependent Kinases and Glycogen Synthase Kinase 3 as Potential Modulators of TDP-43 Cytosolic Accumulation during Cell Stress

(2013) Diane Moujalled et al.   PLoS One

Glycogen Synthase Kinase 3 Inhibition Promotes Adult Hippocampal Neurogenesis in Vitro and in Vivo

(2012) Jose A. Morales-Garcia et al.   ACS Chemical Neuroscience

The Emerging Science of BMAA: Do Cyanobacteria Contribute to Neurodegenerative Disease?

(2012) Wendee Holtcamp   ENVIRONMENTAL HEALTH PERSPECTIVES

5-Imino-1,2,4-Thiadiazoles: First Small Molecules As Substrate Competitive Inhibitors of Glycogen Synthase Kinase 3

(2012) Valle Palomo et al.   JOURNAL OF MEDICINAL CHEMISTRY

The neuroprotective effect of the GSK-3β inhibitor and influence on the extrinsic apoptosis in the ALS transgenic mice

(2012) Suk-Won Ahn et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Targeting autophagy in ALS: A complex mission

(2011) Melissa Nassif et al.   Autophagy

Rapamycin treatment augments motor neuron degeneration in SOD1G93Amouse model of amyotrophic lateral sclerosis

(2011) Xiaojie Zhang et al.   Autophagy

Cell death pathology: Perspective for human diseases

(2011) Massimiliano Agostini et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Autophagy Dysregulation in Amyotrophic Lateral Sclerosis

(2011) Sheng Chen et al.   BRAIN PATHOLOGY

The Potential Role of Glycogen Synthase Kinase 3 Inhibitors as Amyotrophic Lateral Sclerosis Pharmacological Therapy

(2011) V. Palomo et al.   CURRENT MEDICINAL CHEMISTRY

The Molecular Machinery Regulating Apoptosis Signal Transduction and its Implication in Human Physiology and Pathophysiologies

(2011) C. T. Hellwig et al.   CURRENT MOLECULAR MEDICINE

Switching Reversibility to Irreversibility in Glycogen Synthase Kinase 3 Inhibitors: Clues for Specific Design of New Compounds

(2011) Daniel I. Perez et al.   JOURNAL OF MEDICINAL CHEMISTRY

Exploring the Binding Sites of Glycogen Synthase Kinase 3. Identification and Characterization of Allosteric Modulation Cavities

(2011) Valle Palomo et al.   JOURNAL OF MEDICINAL CHEMISTRY

Autophagy in Spinal Cord Motor Neurons in Sporadic Amyotrophic Lateral Sclerosis

(2011) Shoichi Sasaki   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

GSK-3 Inhibitors: Preclinical and Clinical Focus on CNS

(2011) Hagit Eldar-Finkelman et al.   Frontiers in Molecular Neuroscience

A role of small heat shock protein B8 (HspB8) in the autophagic removal of misfolded proteins responsible for neurodegenerative diseases

(2010) Valeria Crippa et al.   Autophagy

The Cyanobacteria Derived Toxin Beta-N-Methylamino-L-Alanine and Amyotrophic Lateral Sclerosis

(2010) Sandra A. Banack et al.   Toxins

New animal models of progressive neurodegeneration: tools for identifying targets in predictive diagnostics and presymptomatic treatment

(2010) R. Andrew Tasker et al.   EPMA Journal

Cyanobacterial neurotoxin BMAA in ALS and Alzheimer’s disease

(2009) J. Pablo et al.   ACTA NEUROLOGICA SCANDINAVICA

Mechanisms of cross-talk between the ubiquitin-proteasome and autophagy-lysosome systems

(2009) Viktor I. Korolchuk et al.   FEBS LETTERS

XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagy

(2009) C. Hetz et al.   GENES & DEVELOPMENT

Upregulation of GSK3β expression in frontal and temporal cortex in ALS with cognitive impairment (ALSci)

(2008) Wencheng Yang et al.   BRAIN RESEARCH

Animal models of BMAA neurotoxicity: A critical review

(2008) Vardan T. Karamyan et al.   LIFE SCIENCES