Deficiency of the Purinergic Receptor 2X7 Attenuates Nonalcoholic Steatohepatitis Induced by High-Fat Diet: Possible Role of the NLRP3 Inflammasome

NLRP3 inflammasome driven liver injury and fibrosis: Roles of IL-17 and TNF in mice

(2017) Alexander Wree et al.   HEPATOLOGY

NLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in mice

(2017) Auvro R. Mridha et al.   JOURNAL OF HEPATOLOGY

Microvesicles released from fat-laden cells promote activation of hepatocellular NLRP3 inflammasome: A pro-inflammatory link between lipotoxicity and non-alcoholic steatohepatitis

(2017) Stefania Cannito et al.   PLoS One

Nonalcoholic Fatty Liver Disease: Pathogenesis and Disease Spectrum

(2016) Timothy Hardy et al.   Annual Review of Pathology-Mechanisms of Disease

Global epidemiology of nonalcoholic fatty liver disease: Meta-analytic assessment of prevalence, incidence, and outcomes

(2016) A. Lonardo et al.   HEPATOLOGY

P2X7 Receptor as a Key Player in Oxidative Stress-Driven Cell Fate in Nonalcoholic Steatohepatitis

(2015) Saurabh Chatterjee et al.   Oxidative Medicine and Cellular Longevity

The Beneficial Effects of P2X7 Antagonism in Rats with Bile Duct Ligation-induced Cirrhosis

(2015) Hung-Chun Tung et al.   PLoS One

Protection from diabetes-induced atherosclerosis and renal disease by d-carnosine-octylester: effects of early vs late inhibition of advanced glycation end-products in Apoe-null mice

(2014) Stefano Menini et al.   DIABETOLOGIA

NLRP3 inflammasome activation is required for fibrosis development in NAFLD

(2014) Alexander Wree et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Both bone marrow-derived and non-bone marrow-derived cells contribute to AIM2 and NLRP3 inflammasome activation in a MyD88-dependent manner in dietary steatohepatitis

(2014) Timea Csak et al.   LIVER INTERNATIONAL

Protection of differentiated neuronal NG108-15 cells from P2X7 receptor-mediated toxicity by taurine

(2014) Chia-Chia Chao et al.   Pharmacological Reports

Purinergic receptor X7 is a key modulator of metabolic oxidative stress-mediated autophagy and inflammation in experimental nonalcoholic steatohepatitis

(2013) Suvarthi Das et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

NLRP3 inflammasome activation results in hepatocyte pyroptosis, liver inflammation, and fibrosis in mice

(2013) Alexander Wree et al.   HEPATOLOGY

The purinergic 2X7receptor participates in renal inflammation and injury induced by high-fat diet: possible role of NLRP3 inflammasome activation

(2013) Anna Solini et al.   JOURNAL OF PATHOLOGY

P2X7 blockade attenuates mouse liver fibrosis

(2013) CHANGSHAN HUANG et al.   Molecular Medicine Reports

Purinergic signalling in the liver in health and disease

(2013) Geoffrey Burnstock et al.   Purinergic Signalling

P2X7 receptor-mediated purinergic signaling promotes liver injury in acetaminophen hepatotoxicity in mice

(2012) Rafaz Hoque et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

The ATP-P2X7 Signaling Axis Is Dispensable for Obesity-Associated Inflammasome Activation in Adipose Tissue

(2012) S. Sun et al.   DIABETES

P2X7 receptor-NADPH oxidase axis mediates protein radical formation and Kupffer cell activation in carbon tetrachloride-mediated steatohepatitis in obese mice

(2012) Saurabh Chatterjee et al.   FREE RADICAL BIOLOGY AND MEDICINE

Inflammasomes in liver diseases

(2012) Gyongyi Szabo et al.   JOURNAL OF HEPATOLOGY

Inflammasomes in health and disease

(2012) Till Strowig et al.   NATURE

Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity

(2012) Jorge Henao-Mejia et al.   NATURE

Expression, assembly and function of novel C-terminal truncated variants of the mouse P2X7 receptor: re-evaluation of P2X7 knockouts

(2011) Marianela Masin et al.   BRITISH JOURNAL OF PHARMACOLOGY

Fatty acid and endotoxin activate inflammasomes in mouse hepatocytes that release danger signals to stimulate immune cells

(2011) Timea Csak et al.   HEPATOLOGY

NALP-3 inflammasome silencing attenuates ceramide-induced transepithelial permeability

(2011) Narasaiah Kolliputi et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Lipotoxicity in NASH

(2011) Michael Fuchs et al.   JOURNAL OF HEPATOLOGY

Fatty acid–induced NLRP3-ASC inflammasome activation interferes with insulin signaling

(2011) Haitao Wen et al.   NATURE IMMUNOLOGY

The Inflammasomes

(2010) Kate Schroder et al.   CELL

Oxidative Stress and Diabetic Complications

(2010) Ferdinando Giacco et al.   CIRCULATION RESEARCH

Hepatic lipotoxicity and the pathogenesis of nonalcoholic steatohepatitis: The central role of nontriglyceride fatty acid metabolites

(2010) Brent A. Neuschwander-Tetri   HEPATOLOGY

Galectin-3 ablation protects mice from diet-induced NASH: A major scavenging role for galectin-3 in liver

(2010) Carla Iacobini et al.   JOURNAL OF HEPATOLOGY

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

(2010) Peter Duewell et al.   NATURE

Inflammasome-mediated regulation of hepatic stellate cells

(2009) Azuma Watanabe et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Purinergic P2X7 receptors regulate secretion of interleukin-1 receptor antagonist and beta cell function and survival

(2009) R. Glas et al.   DIABETOLOGIA

A Functional P2X7 Splice Variant with an Alternative Transmembrane Domain 1 Escapes Gene Inactivation in P2X7 Knock-out Mice

(2009) Annette Nicke et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Activation of P2X7 Receptor Impairs Lysosomal Functions and Stimulates the Release of Autophagolysosomes in Microglial Cells

(2009) T. Takenouchi et al.   JOURNAL OF IMMUNOLOGY