Structure–functionality relationship and pharmacological profiles of Pseudomonas aeruginosa alkylquinolone quorum sensing modulators
Published 2017 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Structure–functionality relationship and pharmacological profiles of Pseudomonas aeruginosa alkylquinolone quorum sensing modulators
Authors
Keywords
-
Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 15, Issue 21, Pages 4620-4630
Publisher
Royal Society of Chemistry (RSC)
Online
2017-05-05
DOI
10.1039/c7ob00263g
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- The requirements at the C-3 position of alkylquinolones for signalling in Pseudomonas aeruginosa
- (2017) Rachel Shanahan et al. ORGANIC & BIOMOLECULAR CHEMISTRY
- Application of Dual Inhibition Concept within Looped Autoregulatory Systems toward Antivirulence Agents against Pseudomonas aeruginosa Infections
- (2016) Andreas Thomann et al. ACS Chemical Biology
- Designed Small-Molecule Inhibitors of the Anthranilyl-CoA Synthetase PqsA Block Quinolone Biosynthesis in Pseudomonas aeruginosa
- (2016) Cheng Ji et al. ACS Chemical Biology
- Dissecting the Multiple Roles of PqsE in Pseudomonas aeruginosa Virulence by Discovery of Small Tool Compounds
- (2016) Michael Zender et al. ACS Chemical Biology
- Structure-Activity Relationships of 2-Sufonylpyrimidines as Quorum-Sensing Inhibitors to Tackle Biofilm Formation and eDNA Release ofPseudomonas aeruginosa
- (2016) Andreas Thomann et al. ChemMedChem
- Considerations and caveats in anti-virulence drug development
- (2016) Damien Maura et al. CURRENT OPINION IN MICROBIOLOGY
- Novel Strategies for the Treatment of Pseudomonas aeruginosa Infections
- (2016) Stefanie Wagner et al. JOURNAL OF MEDICINAL CHEMISTRY
- Evidence for Direct Control of Virulence and Defense Gene Circuits by the Pseudomonas aeruginosa Quorum Sensing Regulator, MvfR
- (2016) Damien Maura et al. Scientific Reports
- Virulence-targeted Antibacterials: Concept, Promise, and Susceptibility to Resistance Mechanisms
- (2015) Ségolène Ruer et al. Chemical Biology & Drug Design
- Catechol-based substrates of chalcone synthase as a scaffold for novel inhibitors of PqsD
- (2015) Giuseppe Allegretta et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Exploring the chemical space of ureidothiophene-2-carboxylic acids as inhibitors of the quorum sensing enzyme PqsD from Pseudomonas aeruginosa
- (2015) J. Henning Sahner et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- A Comparative Analysis of Synthetic Quorum Sensing Modulators in Pseudomonas aeruginosa: New Insights into Mechanism, Active Efflux Susceptibility, Phenotypic Response, and Next-Generation Ligand Design
- (2015) Joseph D. Moore et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Benzamidobenzoic acids as potent PqsD inhibitors for the treatment of Pseudomonas aeruginosa infections
- (2014) Stefan Hinsberger et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Optimization of anti-virulence PqsR antagonists regarding aqueous solubility and biological properties resulting in new insights in structure–activity relationships
- (2014) Cenbin Lu et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- From in vitro to in cellulo: structure–activity relationship of (2-nitrophenyl)methanol derivatives as inhibitors of PqsD in Pseudomonas aeruginosa
- (2014) Michael P. Storz et al. ORGANIC & BIOMOLECULAR CHEMISTRY
- Identification of Anti-virulence Compounds That Disrupt Quorum-Sensing Regulated Acute and Persistent Pathogenicity
- (2014) Melissa Starkey et al. PLoS Pathogens
- Overcoming the Unexpected Functional Inversion of a PqsR Antagonist inPseudomonas aeruginosa: An In Vivo Potent Antivirulence Agent TargetingpqsQuorum Sensing
- (2013) Cenbin Lu et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Development of Quorum-Based Anti-Virulence Therapeutics Targeting Gram-Negative Bacterial Pathogens
- (2013) Song Tay et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Discovery and Biophysical Characterization of 2-Amino-oxadiazoles as Novel Antagonists of PqsR, an Important Regulator of Pseudomonas aeruginosa Virulence
- (2013) Michael Zender et al. JOURNAL OF MEDICINAL CHEMISTRY
- Combining in Silico and Biophysical Methods for the Development of Pseudomonas aeruginosa Quorum Sensing Inhibitors: An Alternative Approach for Structure-Based Drug Design
- (2013) J. Henning Sahner et al. JOURNAL OF MEDICINAL CHEMISTRY
- Exploiting Quorum Sensing To Confuse Bacterial Pathogens
- (2013) B. LaSarre et al. MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS
- Molecular basis of HHQ biosynthesis: molecular dynamics simulations, enzyme kinetic and surface plasmon resonance studies
- (2013) Anke Steinbach et al. BMC Biophysics
- Structural Basis for Native Agonist and Synthetic Inhibitor Recognition by the Pseudomonas aeruginosa Quorum Sensing Regulator PqsR (MvfR)
- (2013) Aravindan Ilangovan et al. PLoS Pathogens
- Identification of Small-Molecule Antagonists of the Pseudomonas aeruginosa Transcriptional Regulator PqsR: Biophysically Guided Hit Discovery and Optimization
- (2012) Tobias Klein et al. ACS Chemical Biology
- Discovery of Antagonists of PqsR, a Key Player in 2-Alkyl-4-quinolone-Dependent Quorum Sensing in Pseudomonas aeruginosa
- (2012) Cenbin Lu et al. CHEMISTRY & BIOLOGY
- Validation of PqsD as an Anti-biofilm Target in Pseudomonas aeruginosa by Development of Small-Molecule Inhibitors
- (2012) Michael P. Storz et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Structure–function analysis of the C-3 position in analogues of microbial behavioural modulators HHQ and PQS
- (2012) F. Jerry Reen et al. ORGANIC & BIOMOLECULAR CHEMISTRY
- The potential for selective pharmacological therapies through biased receptor signaling
- (2012) Terry Kenakin BMC Pharmacology & Toxicology
- Biosynthesis of 2-Alkyl-4(1H)-Quinolones in Pseudomonas aeruginosa: Potential for Therapeutic Interference with Pathogenicity
- (2011) Dominik Pistorius et al. CHEMBIOCHEM
- Cooperation and cheating in Pseudomonas aeruginosa: the roles of the las, rhl and pqs quorum-sensing systems
- (2011) Cara N Wilder et al. ISME Journal
- A Strategy for Antagonizing Quorum Sensing
- (2011) Guozhou Chen et al. MOLECULAR CELL
- Functional Selectivity and Biased Receptor Signaling
- (2010) T. Kenakin JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- Hospital-Acquired Infections Due to Gram-Negative Bacteria
- (2010) Anton Y. Peleg et al. NEW ENGLAND JOURNAL OF MEDICINE
- Antibacterial-Resistant Pseudomonas aeruginosa: Clinical Impact and Complex Regulation of Chromosomally Encoded Resistance Mechanisms
- (2009) P. D. Lister et al. CLINICAL MICROBIOLOGY REVIEWS
- Quorum sensing and social networking in the microbial world
- (2009) S. Atkinson et al. Journal of the Royal Society Interface
- Constitutive activation of G protein-coupled receptors and diseases: Insights into mechanisms of activation and therapeutics
- (2008) Y TAO PHARMACOLOGY & THERAPEUTICS
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationAdd your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload Now