Using a novel computational drug-repositioning approach (DrugPredict) to rapidly identify potent drug candidates for cancer treatment

Towards precision medicine-based therapies for glioblastoma: interrogating human disease genomics and mouse phenotypes

(2016) Yang Chen et al.   BMC GENOMICS

A genomics-based systems approach towards drug repositioning for rheumatoid arthritis

(2016) Rong Xu et al.   BMC GENOMICS

Phenome-based gene discovery provides information about Parkinson’s disease drug targets

(2016) Yang Chen et al.   BMC GENOMICS

Drug repurposing for glioblastoma based on molecular subtypes

(2016) Yang Chen et al.   JOURNAL OF BIOMEDICAL INFORMATICS

Phenome-driven disease genetics prediction toward drug discovery

(2015) Yang Chen et al.   BIOINFORMATICS

Network-based gene prediction for Plasmodium falciparum malaria towards genetics-based drug discovery

(2015) Yang Chen et al.   BMC GENOMICS

A survey of current trends in computational drug repositioning

(2015) Jiao Li et al.   BRIEFINGS IN BIOINFORMATICS

PhenoPredict: A disease phenome-wide drug repositioning approach towards schizophrenia drug discovery

(2015) Rong Xu et al.   JOURNAL OF BIOMEDICAL INFORMATICS

Critical role of Wnt/β-catenin signaling in driving epithelial ovarian cancer platinum resistance

(2015) Anil Belur Nagaraj et al.   Oncotarget

Use of Fixed Dose Combination (FDC) Drugs in India: Central Regulatory Approval and Sales of FDCs Containing Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), Metformin, or Psychotropic Drugs

(2015) Patricia McGettigan et al.   PLOS MEDICINE

Celecoxib induces epithelial-mesenchymal transition in epithelial ovarian cancer cells via regulating ZEB1 expression

(2014) Ruihan Liu et al.   ARCHIVES OF GYNECOLOGY AND OBSTETRICS

Cancer statistics, 2014

(2014) Rebecca Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Non-steroidal anti-inflammatory drugs and cancer risk in women: Results from the Women's Health Initiative

(2014) Theodore M. Brasky et al.   INTERNATIONAL JOURNAL OF CANCER

Aspirin, Nonaspirin Nonsteroidal Anti-inflammatory Drug, and Acetaminophen Use and Risk of Invasive Epithelial Ovarian Cancer: A Pooled Analysis in the Ovarian Cancer Association Consortium

(2014) B. Trabert et al.   JNCI-Journal of the National Cancer Institute

A comparative encyclopedia of DNA elements in the mouse genome

(2014) Feng Yue et al.   NATURE

β-Catenin-regulated ALDH1A1 is a target in ovarian cancer spheroids

(2014) S Condello et al.   ONCOGENE

Non-steroidal anti-inflammatory drugs and risk of venous thromboembolism: a systematic review and meta-analysis

(2014) Patompong Ungprasert et al.   RHEUMATOLOGY

Mouse model phenotypes provide information about human drug targets

(2013) Robert Hoehndorf et al.   BIOINFORMATICS

NSAIDs Inhibit Tumorigenesis, but How?

(2013) Evrim Gurpinar et al.   CLINICAL CANCER RESEARCH

Computational Drug Repositioning: From Data to Therapeutics

(2013) M R Hurle et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Venous thromboembolism in ovarian cancer: incidence, risk factors and impact on survival

(2013) Feras Abu Saadeh et al.   European Journal of Obstetrics & Gynecology and Reproductive Biology

Ovarian surface epithelium at the junction area contains a cancer-prone stem cell niche

(2013) Andrea Flesken-Nikitin et al.   NATURE

Non-Steroidal Anti-inflammatory Drugs Decrease E2F1 Expression and Inhibit Cell Growth in Ovarian Cancer Cells

(2013) Blanca L. Valle et al.   PLoS One

Nonsteroidal anti-inflammatory drugs and risk of ovarian cancer: systematic review and meta-analysis of observational studies

(2012) Louise Baandrup et al.   ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA

Non-steroidal anti-inflammatory drug use and ovarian cancer risk: findings from the NIH-AARP Diet and Health Study and systematic review

(2012) Megan A. Murphy et al.   CANCER CAUSES & CONTROL

Genetic and Pharmacologic Inhibition of β-Catenin Targets Imatinib-Resistant Leukemia Stem Cells in CML

(2012) Florian H. Heidel et al.   Cell Stem Cell

Diagnosing the decline in pharmaceutical R&D efficiency

(2012) Jack W. Scannell et al.   NATURE REVIEWS DRUG DISCOVERY

Multifaceted roles of PGE2 in inflammation and cancer

(2012) Masako Nakanishi et al.   Seminars in Immunopathology

Exploiting drug-disease relationships for computational drug repositioning

(2011) J. T. Dudley et al.   BRIEFINGS IN BIOINFORMATICS

High Incidence of Thromboembolic Events in Patients Treated With Cisplatin-Based Chemotherapy: A Large Retrospective Analysis

(2011) Russell A. Moore et al.   JOURNAL OF CLINICAL ONCOLOGY

Non-steroidal anti-inflammatory drug use and risk of venous thromboembolism

(2011) M. SCHMIDT et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Evolution of platinum resistance in high-grade serous ovarian cancer

(2011) Susanna L Cooke et al.   LANCET ONCOLOGY

Integrated genomic analyses of ovarian carcinoma

(2011) D. Bell et al.   NATURE

How were new medicines discovered?

(2011) David C. Swinney et al.   NATURE REVIEWS DRUG DISCOVERY

Computational Repositioning of the Anticonvulsant Topiramate for Inflammatory Bowel Disease

(2011) J. T. Dudley et al.   Science Translational Medicine

Discovery and Preclinical Validation of Drug Indications Using Compendia of Public Gene Expression Data

(2011) M. Sirota et al.   Science Translational Medicine

Targeting Aldehyde Dehydrogenase Cancer Stem Cells in Ovarian Cancer

(2010) C. N. Landen et al.   MOLECULAR CANCER THERAPEUTICS

The Comparative Toxicogenomics Database: update 2011

(2010) A. P. Davis et al.   NUCLEIC ACIDS RESEARCH

Genetic Interaction of PGE2 and Wnt Signaling Regulates Developmental Specification of Stem Cells and Regeneration

(2009) Wolfram Goessling et al.   CELL