Computational Drug Repositioning: From Data to Therapeutics

Drug Research and Translational Bioinformatics

(2012) L J Lesko   CLINICAL PHARMACOLOGY & THERAPEUTICS

Translational Bioinformatics: Linking the Molecular World to the Clinical World

(2012) R B Altman   CLINICAL PHARMACOLOGY & THERAPEUTICS

Novel Data-Mining Methodologies for Adverse Drug Event Discovery and Analysis

(2012) R Harpaz et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Applications of Connectivity Map in drug discovery and development

(2012) Xiaoyan A. Qu et al.   DRUG DISCOVERY TODAY

NCATS launches drug repurposing program

(2012) Malorye Allison   NATURE BIOTECHNOLOGY

Use of genome-wide association studies for drug repositioning

(2012) Philippe Sanseau et al.   NATURE BIOTECHNOLOGY

Mining electronic health records: towards better research applications and clinical care

(2012) Peter B. Jensen et al.   NATURE REVIEWS GENETICS

Data-Driven Prediction of Drug Effects and Interactions

(2012) N. P. Tatonetti et al.   Science Translational Medicine

GlaxoSmithKline grants researchers access to clinical trial data

(2012) R. Coombes   BMJ-British Medical Journal

Recycling side-effects into clinical markers for drug repositioning

(2012) Miquel Duran-Frigola et al.   Genome Medicine

A Quantitative Analysis of Adverse Events and “Overwarning” in Drug Labeling

(2011) Jon Duke   ARCHIVES OF INTERNAL MEDICINE

Editorial: Computational methods for drug repurposing

(2011) P. Sanseau et al.   BRIEFINGS IN BIOINFORMATICS

Mining small-molecule screens to repurpose drugs

(2011) S. J. Swamidass   BRIEFINGS IN BIOINFORMATICS

Exploiting drug-disease relationships for computational drug repositioning

(2011) J. T. Dudley et al.   BRIEFINGS IN BIOINFORMATICS

mRNA Expression Signatures of Human Skeletal Muscle Atrophy Identify a Natural Compound that Increases Muscle Mass

(2011) Steven D. Kunkel et al.   Cell Metabolism

Predicting Adverse Drug Reactions Using Publicly Available PubChem BioAssay Data

(2011) Y Pouliot et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Computational tools for polypharmacology and repurposing

(2011) Janosch Achenbach et al.   Future Medicinal Chemistry

Identifying potential adverse effects using the web: A new approach to medical hypothesis generation

(2011) Adrian Benton et al.   JOURNAL OF BIOMEDICAL INFORMATICS

PREDICT: a method for inferring novel drug indications with application to personalized medicine

(2011) A. Gottlieb et al.   Molecular Systems Biology

A conditional knockout resource for the genome-wide study of mouse gene function

(2011) William C. Skarnes et al.   NATURE

Accelerated clinical discovery using self-reported patient data collected online and a patient-matching algorithm

(2011) Paul Wicks et al.   NATURE BIOTECHNOLOGY

How were new medicines discovered?

(2011) David C. Swinney et al.   NATURE REVIEWS DRUG DISCOVERY

Exome sequencing as a tool for Mendelian disease gene discovery

(2011) Michael J. Bamshad et al.   NATURE REVIEWS GENETICS

NT5EMutations and Arterial Calcifications

(2011) Cynthia St. Hilaire et al.   NEW ENGLAND JOURNAL OF MEDICINE

PubChem's BioAssay Database

(2011) Y. Wang et al.   NUCLEIC ACIDS RESEARCH

Systematic Drug Repositioning Based on Clinical Side-Effects

(2011) Lun Yang et al.   PLoS One

The NCGC Pharmaceutical Collection: A Comprehensive Resource of Clinically Approved Drugs Enabling Repurposing and Chemical Genomics

(2011) R. Huang et al.   Science Translational Medicine

Computational Repositioning of the Anticonvulsant Topiramate for Inflammatory Bowel Disease

(2011) J. T. Dudley et al.   Science Translational Medicine

Discovery and Preclinical Validation of Drug Indications Using Compendia of Public Gene Expression Data

(2011) M. Sirota et al.   Science Translational Medicine

Evaluation of Phenoxybenzamine in the CFA Model of Pain following Gene Expression Studies and Connectivity Mapping

(2010) Meiping Chang et al.   Molecular Pain

Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci

(2010) Andre Franke et al.   NATURE GENETICS

Discovery of drug mode of action and drug repositioning from transcriptional responses

(2010) F. Iorio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Network-Based Elucidation of Human Disease Similarities Reveals Common Functional Modules Enriched for Pluripotent Drug Targets

(2010) Silpa Suthram et al.   PLoS Computational Biology

Systematic Evaluation of Drug–Disease Relationships to Identify Leads for Novel Drug Uses

(2009) A P Chiang et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Predicting new molecular targets for known drugs

(2009) Michael J. Keiser et al.   NATURE

A Pathway-Based View of Human Diseases and Disease Relationships

(2009) Yong Li et al.   PLoS One

Human Disease-Drug Network Based on Genomic Expression Profiles

(2009) Guanghui Hu et al.   PLoS One

Potential etiologic and functional implications of genome-wide association loci for human diseases and traits

(2009) L. A. Hindorff et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Drug Discovery Using Chemical Systems Biology: Repositioning the Safe Medicine Comtan to Treat Multi-Drug and Extensively Drug Resistant Tuberculosis

(2009) Sarah L. Kinnings et al.   PLoS Computational Biology

Translational Bioinformatics: Coming of Age

(2008) A. J. Butte   JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION

Mouse Phenome Database

(2008) S. C. Grubb et al.   NUCLEIC ACIDS RESEARCH

Drug Target Identification Using Side-Effect Similarity

(2008) M. Campillos et al.   SCIENCE

The impact of next-generation sequencing technology on genetics

(2008) Elaine R. Mardis   TRENDS IN GENETICS