A survey of current trends in computational drug repositioning

Computational and Experimental Advances in Drug Repositioning for Accelerated Therapeutic Stratification

(2015) Khader Shameer et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Scaling drug indication curation through crowdsourcing

(2015) Ritu Khare et al.   Database-The Journal of Biological Databases and Curation

Stereoselective virtual screening of the ZINC database using atom pair 3D-fingerprints

(2015) Mahendra Awale et al.   Journal of Cheminformatics

MicroRNAs and anticancer drugs

(2014) Z. Xing et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

A phenome-guided drug repositioning through a latent variable model

(2014) Halil Bisgin et al.   BMC BIOINFORMATICS

Recent Advances in Drug Repositioning for the Discovery of New Anticancer Drugs

(2014) Joong Sup Shim et al.   International Journal of Biological Sciences

Genomics-Enabled Drug Repositioning and Repurposing

(2014) Aidan Power et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

LabeledIn: Cataloging labeled indications for human drugs

(2014) Ritu Khare et al.   JOURNAL OF BIOMEDICAL INFORMATICS

Drug–Disease Association and Drug-Repositioning Predictions in Complex Diseases Using Causal Inference–Probabilistic Matrix Factorization

(2014) Jihong Yang et al.   Journal of Chemical Information and Modeling

Validating drug repurposing signals using electronic health records: a case study of metformin associated with reduced cancer mortality

(2014) H. Xu et al.   JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION

Drug repositioning by applying ‘expression profiles’ generated by integrating chemical structure similarity and gene semantic similarity

(2014) Fujian Tan et al.   Molecular BioSystems

Computational Repositioning and Preclinical Validation of Pentamidine for Renal Cell Cancer

(2014) L. F. Zerbini et al.   MOLECULAR CANCER THERAPEUTICS

Construction of Drug Network Based on Side Effects and Its Application for Drug Repositioning

(2014) Hao Ye et al.   PLoS One

Identification of Drug Combinations Containing Imatinib for Treatment of BCR-ABL+ Leukemias

(2014) Yunyi Kang et al.   PLoS One

Genomic responses in mouse models greatly mimic human inflammatory diseases

(2014) Keizo Takao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Blockade of oncogenic I B kinase activity in diffuse large B-cell lymphoma by bromodomain and extraterminal domain protein inhibitors

(2014) M. Ceribelli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Debate erupts on 'repurposed' drugs for Ebola

(2014) M. Enserink   SCIENCE

BioCreative-IV virtual issue

(2014) C. N. Arighi et al.   Database-The Journal of Biological Databases and Curation

Systematic prediction of drug combinations based on clinical side-effects

(2014) Hui Huang et al.   Scientific Reports

Deciphering miRNA transcription factor feed-forward loops to identify drug repurposing candidates for cystic fibrosis

(2014) Zhichao Liu et al.   Genome Medicine

A Hadoop-Based Method to Predict Potential Effective Drug Combination

(2014) Yifan Sun et al.   Biomed Research International

DNorm: disease name normalization with pairwise learning to rank

(2013) R. Leaman et al.   BIOINFORMATICS

Drug repositioning for orphan genetic diseases through Conserved Anticoexpressed Gene Clusters (CAGCs)

(2013) Ivan Molineris et al.   BMC BIOINFORMATICS

Meta-analysis of variables affecting mouse protection efficacy of whole organism Brucella vaccines and vaccine candidates

(2013) Thomas E Todd et al.   BMC BIOINFORMATICS

Network based elucidation of drug response: from modulators to targets

(2013) Francesco Iorio et al.   BMC Systems Biology

Computational drug repositioning through heterogeneous network clustering

(2013) Chao Wu et al.   BMC Systems Biology

Pharmaco-miR: linking microRNAs and drug effects

(2013) J. L. Rukov et al.   BRIEFINGS IN BIOINFORMATICS

Drug Repositioning for Treatment of Movement Disorders: From Serendipity to Rational Discovery Strategies

(2013) Bence Bolgár et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

The challenges, advantages and future of phenome-wide association studies

(2013) Scott J. Hebbring   IMMUNOLOGY

Repositioning of the anthelmintic drug mebendazole for the treatment for colon cancer

(2013) Peter Nygren et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

A common rejection module (CRM) for acute rejection across multiple organs identifies novel therapeutics for organ transplantation

(2013) Purvesh Khatri et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Experimental Confirmation of New Drug–Target Interactions Predicted by Drug Profile Matching

(2013) László Végner et al.   JOURNAL OF MEDICINAL CHEMISTRY

Drug Repurposing for Gastrointestinal Stromal Tumor

(2013) Z. Y. Pessetto et al.   MOLECULAR CANCER THERAPEUTICS

Genetics of rheumatoid arthritis contributes to biology and drug discovery

(2013) Yukinori Okada et al.   NATURE

Systematic comparison of phenome-wide association study of electronic medical record data and genome-wide association study data

(2013) Joshua C Denny et al.   NATURE BIOTECHNOLOGY

PubTator: a web-based text mining tool for assisting biocuration

(2013) Chih-Hsuan Wei et al.   NUCLEIC ACIDS RESEARCH

Machine Learning Prediction of Cancer Cell Sensitivity to Drugs Based on Genomic and Chemical Properties

(2013) Michael P. Menden et al.   PLoS One

SWEETLEAD: an In Silico Database of Approved Drugs, Regulated Chemicals, and Herbal Isolates for Computer-Aided Drug Discovery

(2013) Paul A. Novick et al.   PLoS One

Drug Repositioning by Kernel-Based Integration of Molecular Structure, Molecular Activity, and Phenotype Data

(2013) Yongcui Wang et al.   PLoS One

Genomic responses in mouse models poorly mimic human inflammatory diseases

(2013) Junhee Seok et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Repositioning metformin for cancer prevention and treatment

(2013) Brendan J. Quinn et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Evaluating cell lines as tumour models by comparison of genomic profiles

(2013) Silvia Domcke et al.   Nature Communications

Individualized Systems Medicine Strategy to Tailor Treatments for Patients with Chemorefractory Acute Myeloid Leukemia

(2013) T. Pemovska et al.   Cancer Discovery

A Drug Repositioning Approach Identifies Tricyclic Antidepressants as Inhibitors of Small Cell Lung Cancer and Other Neuroendocrine Tumors

(2013) N. S. Jahchan et al.   Cancer Discovery

Drug Repositioning: A Machine-Learning Approach through Data Integration

(2013) Francesco Napolitano et al.   Journal of Cheminformatics

MicroRNAs: regulators of cancer metastasis and epithelial-mesenchymal transition (EMT)

(2013) Xiang-Ming Ding   Chinese Journal of Cancer

Biomarker-Guided Repurposing of Chemotherapeutic Drugs for Cancer Therapy: A Novel Strategy in Drug Development

(2013) Jan Stenvang et al.   Frontiers in Oncology

Trifluoperazine, an Antipsychotic Agent, Inhibits Cancer Stem Cell Growth and Overcomes Drug Resistance of Lung Cancer

(2012) Chi-Tai Yeh et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

e-Drug3D: 3D structure collections dedicated to drug repurposing and fragment-based drug design

(2012) Emilie Pihan et al.   BIOINFORMATICS

DvD: An R/Cytoscape pipeline for drug repurposing using public repositories of gene expression data

(2012) Clare Pacini et al.   BIOINFORMATICS

SM2miR: a database of the experimentally validated small molecules' effects on microRNA expression

(2012) X. Liu et al.   BIOINFORMATICS

The risk of primary and contralateral breast cancer after ovarian cancer inBRCA1/BRCA2mutation carriers

(2012) Peggy M. L. H. Vencken et al.   CANCER

Transcriptional data: a new gateway to drug repositioning?

(2012) Francesco Iorio et al.   DRUG DISCOVERY TODAY

Systematic identification of pharmacogenomics information from clinical trials

(2012) Jiao Li et al.   JOURNAL OF BIOMEDICAL INFORMATICS

Systematic identification of genomic markers of drug sensitivity in cancer cells

(2012) Mathew J. Garnett et al.   NATURE

Use of genome-wide association studies for drug repositioning

(2012) Philippe Sanseau et al.   NATURE BIOTECHNOLOGY

Identification of links between small molecules and miRNAs in human cancers based on transcriptional responses

(2012) Wei Jiang et al.   Scientific Reports

Assessing Drug Target Association Using Semantic Linked Data

(2012) Bin Chen et al.   PLoS Computational Biology

Database identifies FDA-approved drugs with potential to be repurposed for treatment of orphan diseases

(2011) K. Xu et al.   BRIEFINGS IN BIOINFORMATICS

Mining small-molecule screens to repurpose drugs

(2011) S. J. Swamidass   BRIEFINGS IN BIOINFORMATICS

Literature mining, ontologies and information visualization for drug repurposing

(2011) C. Andronis et al.   BRIEFINGS IN BIOINFORMATICS

Exploiting drug-disease relationships for computational drug repositioning

(2011) J. T. Dudley et al.   BRIEFINGS IN BIOINFORMATICS

Improved survival forBRCA2-associated serous ovarian cancer compared with bothBRCA-negative andBRCA1-associated serous ovarian cancer

(2011) David M. Hyman et al.   CANCER

A Novel Method of Transcriptional Response Analysis to Facilitate Drug Repositioning for Cancer Therapy

(2011) G. Jin et al.   CANCER RESEARCH

PREDICT: a method for inferring novel drug indications with application to personalized medicine

(2011) A. Gottlieb et al.   Molecular Systems Biology

Systematic Drug Repositioning Based on Clinical Side-Effects

(2011) Lun Yang et al.   PLoS One

Computational Repositioning of the Anticonvulsant Topiramate for Inflammatory Bowel Disease

(2011) J. T. Dudley et al.   Science Translational Medicine

PubMed and beyond: a survey of web tools for searching biomedical literature

(2011) Z. Lu   Database-The Journal of Biological Databases and Curation

A side effect resource to capture phenotypic effects of drugs

(2010) Michael Kuhn et al.   Molecular Systems Biology

How to improve R&D productivity: the pharmaceutical industry's grand challenge

(2010) Steven M. Paul et al.   NATURE REVIEWS DRUG DISCOVERY

PROMISCUOUS: a database for network-based drug-repositioning

(2010) J. von Eichborn et al.   NUCLEIC ACIDS RESEARCH

Repositioning of an existing drug for the neglected tropical disease Onchocerciasis

(2010) Christian Gloeckner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Discovery of drug mode of action and drug repositioning from transcriptional responses

(2010) F. Iorio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Drug-Induced Regulation of Target Expression

(2010) Murat Iskar et al.   PLoS Computational Biology

DCDB: Drug combination database

(2009) Y. Liu et al.   BIOINFORMATICS

Molecular networks as sensors and drivers of common human diseases

(2009) Eric E. Schadt   NATURE

Predicting new molecular targets for known drugs

(2009) Michael J. Keiser et al.   NATURE

Understanding PubMed(R) user search behavior through log analysis

(2009) R. Islamaj Dogan et al.   Database-The Journal of Biological Databases and Curation

IDMap: facilitating the detection of potential leads with therapeutic targets

(2008) S. Ha et al.   BIOINFORMATICS