The Epigenomic Analysis of Human Obesity

Genetic Association of Waist-to-Hip Ratio With Cardiometabolic Traits, Type 2 Diabetes, and Coronary Heart Disease

(2017) Connor A. Emdin et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Scaling single-cell genomics from phenomenology to mechanism

(2017) Amos Tanay et al.   NATURE

Inflammation, metaflammation and immunometabolic disorders

(2017) Gökhan S. Hotamisligil   NATURE

Detecting DNA cytosine methylation using nanopore sequencing

(2017) Jared T Simpson et al.   NATURE METHODS

Mechanisms, Pathophysiology, and Management of Obesity

(2017) Steven B. Heymsfield et al.   NEW ENGLAND JOURNAL OF MEDICINE

Impact of cytosine methylation on DNA binding specificities of human transcription factors

(2017) Yimeng Yin et al.   SCIENCE

AHRR (cg05575921) hypomethylation marks smoking behaviour, morbidity and mortality

(2017) Stig E Bojesen et al.   THORAX

Epigenetics, obesity and early-life cadmium or lead exposure

(2017) Sarah S Park et al.   Epigenomics

Using Genetic Variation to Explore the Causal Effect of Maternal Pregnancy Adiposity on Future Offspring Adiposity: A Mendelian Randomisation Study

(2017) Rebecca C. Richmond et al.   PLOS MEDICINE

Association of Body Mass Index with DNA Methylation and Gene Expression in Blood Cells and Relations to Cardiometabolic Disease: A Mendelian Randomization Approach

(2017) Michael M. Mendelson et al.   PLOS MEDICINE

Epigenetic Patterns in Blood Associated With Lipid Traits Predict Incident Coronary Heart Disease Events and Are Enriched for Results From Genome-Wide Association StudiesCLINICAL PERSPECTIVE

(2017) Åsa K. Hedman et al.   Circulation-Cardiovascular Genetics

Epigenome-wide association study (EWAS) on lipids: the Rotterdam Study

(2017) Kim V. E. Braun et al.   Clinical Epigenetics

Obesity accelerates epigenetic aging in middle-aged but not in elderly individuals

(2017) Tapio Nevalainen et al.   Clinical Epigenetics

The idea of uniform change: is it time to revisit a central tenet of Rose’s “Strategy of Preventive Medicine”?

(2016) Fahad Razak et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Comparison of associations of maternal peri-pregnancy and paternal anthropometrics with child anthropometrics from birth through age 7 y assessed in the Danish National Birth Cohort

(2016) Thorkild IA Sørensen et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Genetic Drivers of Epigenetic and Transcriptional Variation in Human Immune Cells

(2016) Lu Chen et al.   CELL

Histone Acetylome-wide Association Study of Autism Spectrum Disorder

(2016) Wenjie Sun et al.   CELL

The importance of gene-environment interactions in human obesity

(2016) H. Reddon et al.   CLINICAL SCIENCE

DNA Methylation and BMI: Investigating Identified Methylation Sites atHIF3Ain a Causal Framework

(2016) Rebecca C. Richmond et al.   DIABETES

The DNA methylation profile of activated human natural killer cells

(2016) John. K. Wiencke et al.   Epigenetics

Management of obesity

(2016) George A Bray et al.   LANCET

Genome-wide associations for birth weight and correlations with adult disease

(2016) Momoko Horikoshi et al.   NATURE

Quantitative comparison of DNA methylation assays for biomarker development and clinical applications

(2016) Christoph Bock et al.   NATURE BIOTECHNOLOGY

Disease variants alter transcription factor levels and methylation of their binding sites

(2016) Marc Jan Bonder et al.   NATURE GENETICS

Specification and epigenetic programming of the human germ line

(2016) Walfred W. C. Tang et al.   NATURE REVIEWS GENETICS

Association between DNA Methylation in Whole Blood and Measures of Glucose Metabolism: KORA F4 Study

(2016) Jennifer Kriebel et al.   PLoS One

“Gap hunting” to characterize clustered probe signals in Illumina methylation array data

(2016) Shan V. Andrews et al.   Epigenetics & Chromatin

Histone macroH2A1.2 promotes metabolic health and leanness by inhibiting adipogenesis

(2016) Valerio Pazienza et al.   Epigenetics & Chromatin

Enlarged leukocyte referent libraries can explain additional variance in blood-based epigenome-wide association studies

(2016) Stephanie Kim et al.   Epigenomics

Increased DNA methylation variability in type 1 diabetes across three immune effector cell types

(2016) Dirk S. Paul et al.   Nature Communications

Multiple novel gene-by-environment interactions modify the effect of FTO variants on body mass index

(2016) Alexander I. Young et al.   Nature Communications

Integrative epigenome-wide analysis demonstrates that DNA methylation may mediate genetic risk in inflammatory bowel disease

(2016) N. T. Ventham et al.   Nature Communications

eFORGE: A Tool for Identifying Cell Type-Specific Signal in Epigenomic Data

(2016) Charles E. Breeze et al.   Cell Reports

Epigenome-wide Association Studies and the Interpretation of Disease -Omics

(2016) Ewan Birney et al.   PLoS Genetics

DNA methylation and gene expression of HIF3A: cross-tissue validation and associations with BMI and insulin resistance

(2016) Ailsa Maria Main et al.   Clinical Epigenetics

Genome- and epigenome-wide association study of hypertriglyceridemic waist in Mexican American families

(2016) Manju Mamtani et al.   Clinical Epigenetics

Epigenetic associations of type 2 diabetes and BMI in an Arab population

(2016) Wadha A. Al Muftah et al.   Clinical Epigenetics

Association of DNA Methylation at CPT1A Locus with Metabolic Syndrome in the Genetics of Lipid Lowering Drugs and Diet Network (GOLDN) Study

(2016) Mithun Das et al.   PLoS One

Distinct Epigenetic Effects of Tobacco Smoking in Whole Blood and among Leukocyte Subtypes

(2016) Dan Su et al.   PLoS One

Improving Phenotypic Prediction by Combining Genetic and Epigenetic Associations

(2015) Sonia Shah et al.   AMERICAN JOURNAL OF HUMAN GENETICS

DNA Methylation of Lipid-Related Genes Affects Blood Lipid LevelsCLINICAL PERSPECTIVE

(2015) Liliane Pfeiffer et al.   Circulation-Cardiovascular Genetics

DNA Methylation Variants atHIF3ALocus, B-Vitamin Intake, and Long-term Weight Change: Gene-Diet Interactions in Two U.S. Cohorts

(2015) Tao Huang et al.   DIABETES

Retrotransposition creates sloping shores: a graded influence of hypomethylated CpG islands on flanking CpG sites

(2015) Fiorella C. Grandi et al.   GENOME RESEARCH

Epigenome-wide association study (EWAS) of BMI, BMI change and waist circumference in African American adults identifies multiple replicated loci

(2015) Ellen W. Demerath et al.   HUMAN MOLECULAR GENETICS

Maternal pre-pregnancy BMI and gestational weight gain, offspring DNA methylation and later offspring adiposity: findings from the Avon Longitudinal Study of Parents and Children

(2015) Gemma C Sharp et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Integrative analysis of 111 reference human epigenomes

(2015) Anshul Kundaje et al.   NATURE

Integrative analysis of haplotype-resolved epigenomes across human tissues

(2015) Danny Leung et al.   NATURE

Function and information content of DNA methylation

(2015) Dirk Schübeler   NATURE

Competition between DNA methylation and transcription factors determines binding of NRF1

(2015) Silvia Domcke et al.   NATURE

NK cells link obesity-induced adipose stress to inflammation and insulin resistance

(2015) Felix M Wensveen et al.   NATURE IMMUNOLOGY

FTO Obesity Variant Circuitry and Adipocyte Browning in Humans

(2015) Melina Claussnitzer et al.   NEW ENGLAND JOURNAL OF MEDICINE

HaploReg v4: systematic mining of putative causal variants, cell types, regulators and target genes for human complex traits and disease

(2015) Lucas D. Ward et al.   NUCLEIC ACIDS RESEARCH

Epigenome-wide study identifies novel methylation loci associated with body mass index and waist circumference

(2015) Stella Aslibekyan et al.   Obesity

Adipose tissue as an immunological organ

(2015) Ryan W. Grant et al.   Obesity

DNA Methylation of Lipid-Related Genes Affects Blood Lipid LevelsCLINICAL PERSPECTIVE

(2015) Liliane Pfeiffer et al.   Circulation-Cardiovascular Genetics

A varying T cell subtype explains apparent tobacco smoking induced single CpG hypomethylation in whole blood

(2015) Mario Bauer et al.   Clinical Epigenetics

An analysis of DNA methylation in human adipose tissue reveals differential modification of obesity genes before and after gastric bypass and weight loss

(2015) Miles C Benton et al.   GENOME BIOLOGY

GeMes, Clusters of DNA Methylation under Genetic Control, Can Inform Genetic and Epigenetic Analysis of Disease

(2014) Yun Liu et al.   AMERICAN JOURNAL OF HUMAN GENETICS

What We Talk About When We Talk About Fat

(2014) Evan D. Rosen et al.   CELL

Epigenome-Wide Association Study of Fasting Blood Lipids in the Genetics of Lipid-Lowering Drugs and Diet Network Study

(2014) Marguerite R. Irvin et al.   CIRCULATION

Adiposity is associated with DNA methylation profile in adipose tissue

(2014) Golareh Agha et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Epigenetics and human obesity

(2014) S J van Dijk et al.   INTERNATIONAL JOURNAL OF OBESITY

Robust validation of methylation levels association atCPT1Alocus with lipid plasma levels

(2014) France Gagnon et al.   JOURNAL OF LIPID RESEARCH

Methylation at CPT1A locus is associated with lipoprotein subfraction profiles

(2014) Alexis C. Frazier-Wood et al.   JOURNAL OF LIPID RESEARCH

DNA methylation and body-mass index: a genome-wide analysis

(2014) Katherine J Dick et al.   LANCET

Obesity and diabetes: from genetics to epigenetics

(2014) Ernesto Burgio et al.   MOLECULAR BIOLOGY REPORTS

5mC Oxidation by Tet2 Modulates Enhancer Activity and Timing of Transcriptome Reprogramming during Differentiation

(2014) Gary C. Hon et al.   MOLECULAR CELL

Crosstalk between Adipocytes and Immune Cells in Adipose Tissue Inflammation and Metabolic Dysregulation in Obesity

(2014) Jin Young Huh et al.   MOLECULES AND CELLS

Every amino acid matters: essential contributions of histone variants to mammalian development and disease

(2014) Ian Maze et al.   NATURE REVIEWS GENETICS

Obesity accelerates epigenetic aging of human liver

(2014) S. Horvath et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Using epigenomic studies in monozygotic twins to improve our understanding of cancer

(2014) Leonie Roos et al.   Epigenomics

Maternal nutrition at conception modulates DNA methylation of human metastable epialleles

(2014) Paula Dominguez-Salas et al.   Nature Communications

Human-specific epigenetic variation in the immunological Leukotriene B4 Receptor (LTB4R/BLT1) implicated in common inflammatory diseases

(2014) Gareth A Wilson et al.   Genome Medicine

Genome-Wide Associations between Genetic and Epigenetic Variation Influence mRNA Expression and Insulin Secretion in Human Pancreatic Islets

(2014) Anders H. Olsson et al.   PLoS Genetics

Genome-Wide DNA Methylation Analysis of Human Pancreatic Islets from Type 2 Diabetic and Non-Diabetic Donors Identifies Candidate Genes That Influence Insulin Secretion

(2014) Tasnim Dayeh et al.   PLoS Genetics

Association between Class III Obesity (BMI of 40–59 kg/m2) and Mortality: A Pooled Analysis of 20 Prospective Studies

(2014) Cari M. Kitahara et al.   PLOS MEDICINE

Aging-like Phenotype and Defective Lineage Specification in SIRT1-Deleted Hematopoietic Stem and Progenitor Cells

(2014) Pauline Rimmelé et al.   Stem Cell Reports

Discovery of cross-reactive probes and polymorphic CpGs in the Illumina Infinium HumanMethylation450 microarray

(2013) Yi-an Chen et al.   Epigenetics

Epigenetics meets metabolomics: an epigenome-wide association study with blood serum metabolic traits

(2013) Ann-Kristin Petersen et al.   HUMAN MOLECULAR GENETICS

Charting a dynamic DNA methylation landscape of the human genome

(2013) Michael J. Ziller et al.   NATURE

Epigenome-wide association data implicate DNA methylation as an intermediary of genetic risk in rheumatoid arthritis

(2013) Yun Liu et al.   NATURE BIOTECHNOLOGY

Surgically Induced Interpregnancy Weight Loss and Prevalence of Overweight and Obesity in Offspring

(2013) Mikaela Willmer et al.   PLoS One

Differential methylation in glucoregulatory genes of offspring born before vs. after maternal gastrointestinal bypass surgery

(2013) F. Guenard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Extensive Variation in Chromatin States Across Humans

(2013) M. Kasowski et al.   SCIENCE

Global differences in specific histone H3 methylation are associated with overweight and type 2 diabetes

(2013) Åsa Jufvas et al.   Clinical Epigenetics

Epigenetic mechanisms linking early nutrition to long term health

(2012) Karen A. Lillycrop et al.   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

Prenatal air pollution exposure induces neuroinflammation and predisposes offspring to weight gain in adulthood in a sex-specific manner

(2012) Jessica L. Bolton et al.   FASEB JOURNAL

Commentary: The seven plagues of epigenetic epidemiology

(2012) Bastiaan T Heijmans et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Bump hunting to identify differentially methylated regions in epigenetic epidemiology studies

(2012) Andrew E Jaffe et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

An Alu Element–Associated Hypermethylation Variant of the POMC Gene Is Associated with Childhood Obesity

(2012) Peter Kuehnen et al.   PLoS Genetics

Inflammatory Mechanisms in Obesity

(2011) Margaret F. Gregor et al.   Annual Review of Immunology

Timing is everything

(2011) Christopher Faulk et al.   Epigenetics

Distinct DNA methylation changes highly correlated with chronological age in the human brain

(2011) Dena G. Hernandez et al.   HUMAN MOLECULAR GENETICS

Identification of genetic elements that autonomously determine DNA methylation states

(2011) Florian Lienert et al.   NATURE GENETICS

Identification of Type 1 Diabetes–Associated DNA Methylation Variable Positions That Precede Disease Diagnosis

(2011) Vardhman K. Rakyan et al.   PLoS Genetics

Allelic Skewing of DNA Methylation Is Widespread across the Genome

(2010) Leonard C. Schalkwyk et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Allele-specific methylation is prevalent and is contributed by CpG-SNPs in the human genome

(2010) R. Shoemaker et al.   GENOME RESEARCH

Age-dependent DNA methylation of genes that are suppressed in stem cells is a hallmark of cancer

(2010) A. E. Teschendorff et al.   GENOME RESEARCH

Charting histone modifications and the functional organization of mammalian genomes

(2010) Vicky W. Zhou et al.   NATURE REVIEWS GENETICS

Integrated Genetic and Epigenetic Analysis Identifies Haplotype-Specific Methylation in the FTO Type 2 Diabetes and Obesity Susceptibility Locus

(2010) Christopher G. Bell et al.   PLoS One

Abundant Quantitative Trait Loci Exist for DNA Methylation and Gene Expression in Human Brain

(2010) J. Raphael Gibbs et al.   PLoS Genetics

Finding distal regulatory elements in the human genome

(2009) Nathaniel D Heintzman et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Human genetics illuminates the paths to metabolic disease

(2009) Stephen O’Rahilly   NATURE

Effect of In Utero and Early-Life Conditions on Adult Health and Disease

(2008) Peter D. Gluckman et al.   NEW ENGLAND JOURNAL OF MEDICINE