Different Molecular Mechanisms Mediate Direct or Glia-Dependent Prion Protein Fragment 90–231 Neurotoxic Effects in Cerebellar Granule Neurons

Early involvement of lysosome dysfunction in the degeneration of cerebral cortical neurons caused by the lipid peroxidation product 4-hydroxynonenal

(2017) Shi Zhang et al.   JOURNAL OF NEUROCHEMISTRY

Inflammatory Mechanisms and Oxidative Stress as Key Factors Responsible for Progression of Neurodegeneration: Role of Brain Innate Immune System

(2016) Jerzy Leszek et al.   CNS & Neurological Disorders-Drug Targets

The amyloid hypothesis of Alzheimer's disease at 25 years

(2016) Dennis J Selkoe et al.   EMBO Molecular Medicine

Oligomeropathies and pathogenesis of Alzheimer and Parkinson's diseases

(2016) Gianluigi Forloni et al.   MOVEMENT DISORDERS

Novel celecoxib analogues inhibit glial production of prostaglandin E2, nitric oxide, and oxygen radicals reverting the neuroinflammatory responses induced by misfolded prion protein fragment 90-231 or lipopolysaccharide

(2016) Valentina Villa et al.   PHARMACOLOGICAL RESEARCH

Complement and microglia mediate early synapse loss in Alzheimer mouse models

(2016) S. Hong et al.   SCIENCE

The histone demethylase KDM5A is a key factor for the resistance to temozolomide in glioblastoma

(2015) Barbara Banelli et al.   CELL CYCLE

Prion Disease Induces Alzheimer Disease—Like Neuropathologic Changes

(2015) Thomas Tousseyn et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

The Elusive Role of the Prion Protein and the Mechanism of Toxicity in Prion Disease

(2015) Roberto Chiesa   PLoS Pathogens

Targeting microglia for the treatment of Alzheimer’s disease

(2014) Patrick L McGeer et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Celecoxib Inhibits Prion Protein 90-231-Mediated Pro-inflammatory Responses in Microglial Cells

(2014) Valentina Villa et al.   MOLECULAR NEUROBIOLOGY

The Role of the NADPH Oxidase NOX2 in Prion Pathogenesis

(2014) Silvia Sorce et al.   PLoS Pathogens

An N-terminal Fragment of the Prion Protein Binds to Amyloid-β Oligomers and Inhibits Their Neurotoxicityin Vivo

(2013) Brian R. Fluharty et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Abnormal Activation of Microglia Accompanied with Disrupted CX3CR1/CX3CL1 Pathway in the Brains of the Hamsters Infected with Scrapie Agent 263K

(2013) Wu-Ling Xie et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Self-propagation of pathogenic protein aggregates in neurodegenerative diseases

(2013) Mathias Jucker et al.   NATURE

Microglia: Scapegoat, Saboteur, or Something Else?

(2013) A. Aguzzi et al.   SCIENCE

Role of Prion Protein Aggregation in Neurotoxicity

(2012) Alessandro Corsaro et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

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(2012) Pawel P. Liberski et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Sporadic human prion diseases: molecular insights and diagnosis

(2012) Gianfranco Puoti et al.   LANCET NEUROLOGY

Excitotoxicity Through NMDA Receptors Mediates Cerebellar Granule Neuron Apoptosis Induced by Prion Protein 90-231 Fragment

(2012) Stefano Thellung et al.   NEUROTOXICITY RESEARCH

Recombinant Human Prion Protein Fragment 90–231, a Useful Model to Study Prion Neurotoxicity

(2012) Alessandro Corsaro et al.   OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY

Calcium Binding Promotes Prion Protein Fragment 90–231 Conformational Change toward a Membrane Destabilizing and Cytotoxic Structure

(2012) Sacha Sorrentino et al.   PLoS One

Prion Pathogenesis Is Faithfully Reproduced in Cerebellar Organotypic Slice Cultures

(2012) Jeppe Falsig et al.   PLoS Pathogens

Reactive Glia not only Associates with Plaques but also Parallels Tangles in Alzheimer's Disease

(2011) Alberto Serrano-Pozo et al.   AMERICAN JOURNAL OF PATHOLOGY

Neuronal Death Induced by Nanomolar Amyloid β Is Mediated by Primary Phagocytosis of Neurons by Microglia

(2011) Urte Neniskyte et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The pathological prion protein forms ionic conductance in lipid bilayer

(2011) Daniele Paulis et al.   NEUROCHEMISTRY INTERNATIONAL

Human PrP90-231-induced cell death is associated with intracellular accumulation of insoluble and protease-resistant macroaggregates and lysosomal dysfunction

(2011) S Thellung et al.   Cell Death & Disease

High hydrophobic amino acid exposure is responsible of the neurotoxic effects induced by E200K or D202N disease-related mutations of the human prion protein

(2010) Alessandro Corsaro et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Protein aggregation diseases: pathogenicity and therapeutic perspectives

(2010) Adriano Aguzzi et al.   NATURE REVIEWS DRUG DISCOVERY

New 1,5-benzodiazepine compounds: activity at native GABAA receptors

(2010) E. Gatta et al.   NEUROSCIENCE

Microglia Mediate the Clearance of Soluble A  through Fluid Phase Macropinocytosis

(2009) S. Mandrekar et al.   JOURNAL OF NEUROSCIENCE

Dual Modulation of ERK1/2 and p38 MAP Kinase Activities Induced by Minocycline Reverses the Neurotoxic Effects of the Prion Protein Fragment 90–231

(2009) Alessandro Corsaro et al.   NEUROTOXICITY RESEARCH

Nonspecific Interaction of Prefibrillar Amyloid Aggregates with Glutamatergic Receptors Results in Ca2+Increase in Primary Neuronal Cells

(2008) Francesca Pellistri et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characterization of Truncated Forms of Abnormal Prion Protein in Creutzfeldt-Jakob Disease

(2008) Silvio Notari et al.   JOURNAL OF BIOLOGICAL CHEMISTRY