Role of Prion Protein Aggregation in Neurotoxicity

Polythiophenes Inhibit Prion Propagation by Stabilizing Prion Protein (PrP) Aggregates

(2012) Ilan Margalith et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Recombinant Human Prion Protein Fragment 90–231, a Useful Model to Study Prion Neurotoxicity

(2012) Alessandro Corsaro et al.   OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY

Highly neurotoxic monomeric  -helical prion protein

(2012) M. Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Insights into Functional and Pathological Amyloid

(2011) Frank Shewmaker et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Prions and protein-folding diseases

(2011) E. Norrby   JOURNAL OF INTERNAL MEDICINE

Prion protein polymerisation triggered by manganese-generated prion protein seeds

(2011) Shirley Hesketh et al.   JOURNAL OF NEUROCHEMISTRY

Replication Efficiency of Soil-Bound Prions Varies with Soil Type

(2011) S. E. Saunders et al.   JOURNAL OF VIROLOGY

The pathological prion protein forms ionic conductance in lipid bilayer

(2011) Daniele Paulis et al.   NEUROCHEMISTRY INTERNATIONAL

Effects of Solution Chemistry and Aging Time on Prion Protein Adsorption and Replication of Soil-Bound Prions

(2011) Samuel E. Saunders et al.   PLoS One

Human PrP90-231-induced cell death is associated with intracellular accumulation of insoluble and protease-resistant macroaggregates and lysosomal dysfunction

(2011) S Thellung et al.   Cell Death & Disease

High hydrophobic amino acid exposure is responsible of the neurotoxic effects induced by E200K or D202N disease-related mutations of the human prion protein

(2010) Alessandro Corsaro et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Endogenous Proteolytic Cleavage of Disease-associated Prion Protein to Produce C2 Fragments Is Strongly Cell- and Tissue-dependent

(2010) Michel Dron et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Properties and Dynamic Behavior of Nonfibrillar Oligomers Formed by PrP(106−126)

(2010) Patrick Walsh et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Prion-like transmission of protein aggregates in neurodegenerative diseases

(2010) Patrik Brundin et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Efficacy of Novel Acridine Derivatives in the Inhibition of hPrP90-231 Prion Protein Fragment Toxicity

(2010) Valentina Villa et al.   NEUROTOXICITY RESEARCH

Prions in the environment

(2010) Samuel E. Saunders et al.   Prion

Fragment molecular orbital calculations reveal that the E200K mutation markedly alters local structural stability in the human prion protein

(2010) Koji Hasegawa et al.   Prion

Prion transmission

(2010) Kevin C. Gough et al.   Prion

Generating a Prion with Bacterially Expressed Recombinant Prion Protein

(2010) F. Wang et al.   SCIENCE

Increased Proportions of C1 Truncated Prion Protein Protect Against Cellular M1000 Prion Infection

(2009) Victoria Lewis et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Converging concepts of protein folding in vitro and in vivo

(2009) F Ulrich Hartl et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Dual Modulation of ERK1/2 and p38 MAP Kinase Activities Induced by Minocycline Reverses the Neurotoxic Effects of the Prion Protein Fragment 90–231

(2009) Alessandro Corsaro et al.   NEUROTOXICITY RESEARCH

The consequences of pathogenic mutations to the human prion protein

(2009) Marc W. van der Kamp et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Amyloidogenic sequences in native protein structures

(2009) Susan Tzotzos et al.   PROTEIN SCIENCE

Molecular Mechanisms of Prion Pathogenesis

(2008) Adriano Aguzzi et al.   Annual Review of Pathology-Mechanisms of Disease

Organic polyanions act as complexants of prion protein in soil

(2008) Maurizio Polano et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Detection of infectious prions in urine

(2008) Dennisse Gonzalez-Romero et al.   FEBS LETTERS

Annular Protofibrils Are a Structurally and Functionally Distinct Type of Amyloid Oligomer

(2008) Rakez Kayed et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Nonfibrillar Form of the Fusogenic Prion Protein Fragment [118-135] Induces Apoptotic Cell Death in Rat Cortical Neurons

(2003) Thierry Pillot et al.   JOURNAL OF NEUROCHEMISTRY

The Role of Prion Peptide Structure and Aggregation in Toxicity and Membrane Binding

(2003) Dawn L. Rymer et al.   JOURNAL OF NEUROCHEMISTRY