The histone demethylase KDM5A is a key factor for the resistance to temozolomide in glioblastoma

A transcriptomic signature mediated by HOXA9 promotes human glioblastoma initiation, aggressiveness and resistance to temozolomide

(2015) Marta Pojo et al.   Oncotarget

Temozolomide resistance in glioblastoma occurs by miRNA-9-targeted PTCH1, independent of sonic hedgehog level

(2015) Jessian L. Munoz et al.   Oncotarget

Targeting miR-381-NEFL axis sensitizes glioblastoma cells to temozolomide by regulating stemness factors and multidrug resistance factors

(2015) Zeyou Wang et al.   Oncotarget

KDM1 is a novel therapeutic target for the treatment of gliomas

(2015) Gangadhara R Sareddy et al.   Oncotarget

Reduction of MLH1 and PMS2 confers temozolomide resistance and is associated with recurrence of glioblastoma

(2015) Yoshinari Shinsato et al.   Oncotarget

EFEMP1 induces γ-secretase/Notch-mediated temozolomide resistance in glioblastoma

(2015) Lotte Hiddingh et al.   Oncotarget

Metformin repositioning as antitumoral agent: selective antiproliferative effects in human glioblastoma stem cells, via inhibition of CLIC1-mediated ion current

(2015) Marta Gritti et al.   Oncotarget

The Effects of Histone Deacetylase Inhibitors on Glioblastoma-Derived Stem Cells

(2014) Angel A. Alvarez et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Histone deacetylase inhibitors in glioblastoma: pre-clinical and clinical experience

(2014) Pavel Bezecny   MEDICAL ONCOLOGY

The Changes in MGMT Promoter Methylation Status in Initial and Recurrent Glioblastomas

(2014) Chul-Kee Park et al.   Translational Oncology

Epigenetic modulation of the drug resistance genes MGMT, ABCB1 and ABCG2 in glioblastoma multiforme

(2013) Moritz C Oberstadt et al.   BMC CANCER

Overcoming Intrinsic Multidrug Resistance in Melanoma by Blocking the Mitochondrial Respiratory Chain of Slow-Cycling JARID1Bhigh Cells

(2013) Alexander Roesch et al.   CANCER CELL

Sorafenib selectively depletes human glioblastoma tumor-initiating cells from primary cultures

(2013) Elisa Carra et al.   CELL CYCLE

Chromatin proteins and modifications as drug targets

(2013) Kristian Helin et al.   NATURE

Temozolomide downregulates P-glycoprotein expression in glioblastoma stem cells by interfering with the Wnt3a/glycogen synthase-3 kinase/ -catenin pathway

(2013) C. Riganti et al.   NEURO-ONCOLOGY

Clinical Potentials of Methylator Phenotype in Stage 4 High-Risk Neuroblastoma: An Open Challenge

(2013) Barbara Banelli et al.   PLoS One

Inhibition of CXCL12/CXCR4 autocrine/paracrine loop reduces viability of human glioblastoma stem-like cells affecting self-renewal activity

(2013) Monica Gatti et al.   TOXICOLOGY

Metformin selectively affects human glioblastoma tumor-initiating cell viability

(2012) Roberto Würth et al.   CELL CYCLE

Inhibition of Histone Deacetylation Potentiates the Evolution of Acquired Temozolomide Resistance Linked to MGMT Upregulation in Glioblastoma Xenografts

(2012) G. J. Kitange et al.   CLINICAL CANCER RESEARCH

Epigenomics and Interindividual Differences in Drug Response

(2012) M Ivanov et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

The status of the art of human malignant glioma management: the promising role of targeting tumor-initiating cells

(2012) Tullio Florio et al.   DRUG DISCOVERY TODAY

Molecular mechanisms of temozolomide resistance in glioblastoma multiforme

(2012) Tor-Christian Aase Johannessen et al.   Expert Review of Anticancer Therapy

Emerging insights into the molecular and cellular basis of glioblastoma

(2012) G. P. Dunn et al.   GENES & DEVELOPMENT

The UCSC Cancer Genomics Browser: update 2013

(2012) Mary Goldman et al.   NUCLEIC ACIDS RESEARCH

Glioma Stem Cells: Their Role in Chemoresistance

(2012) Ryosuke Yamada et al.   World Neurosurgery

Inhibitors of histone demethylation and histone deacetylation cooperate in regulating gene expression and inhibiting growth in human breast cancer cells

(2011) Yi Huang et al.   BREAST CANCER RESEARCH AND TREATMENT

Quantitative methylation analysis of HOXA3, 7, 9, and 10 genes in glioma: association with tumor WHO grade and clinical outcome

(2011) Angela Di Vinci et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

A pyrosequencing assay for the quantitative methylation analysis of the PCDHB gene cluster, the major factor in neuroblastoma methylator phenotype

(2011) Barbara Banelli et al.   LABORATORY INVESTIGATION

O6-methylguanine DNA-methyltransferase methylation status can change between first surgery for newly diagnosed glioblastoma and second surgery for recurrence: clinical implications

(2011) A. A. Brandes et al.   NEURO-ONCOLOGY

Drug-Tolerant Cancer Cells Show Reduced Tumor-Initiating Capacity: Depletion of CD44+ Cells and Evidence for Epigenetic Mechanisms

(2011) Hong Yan et al.   PLoS One

Identification of a CpG Island Methylator Phenotype that Defines a Distinct Subgroup of Glioma

(2010) Houtan Noushmehr et al.   CANCER CELL

Reversing HOXA9 Oncogene Activation by PI3K Inhibition: Epigenetic Mechanism and Prognostic Significance in Human Glioblastoma

(2010) B. M. Costa et al.   CANCER RESEARCH

Drug Combination Studies and Their Synergy Quantification Using the Chou-Talalay Method

(2010) T.-C. Chou   CANCER RESEARCH

A Chromatin-Mediated Reversible Drug-Tolerant State in Cancer Cell Subpopulations

(2010) Sreenath V. Sharma et al.   CELL

Brain tumor stem cells: The cancer stem cell hypothesis writ large

(2010) Peter B. Dirks   Molecular Oncology

MSH6 Mutations Arise in Glioblastomas during Temozolomide Therapy and Mediate Temozolomide Resistance

(2009) S. Yip et al.   CLINICAL CANCER RESEARCH

Outcome prediction and risk assessment by quantitative pyrosequencing methylation analysis of the SFN gene in advanced stage, high-risk, neuroblastic tumor patients

(2009) Barbara Banelli et al.   INTERNATIONAL JOURNAL OF CANCER

Different Response of Human Glioma Tumor-initiating Cells to Epidermal Growth Factor Receptor Kinase Inhibitors

(2009) Fabrizio Griffero et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NK Cells Recognize and Kill Human Glioblastoma Cells with Stem Cell-Like Properties

(2009) R. Castriconi et al.   JOURNAL OF IMMUNOLOGY

Temozolomide Preferentially Depletes Cancer Stem Cells in Glioblastoma

(2008) D. Beier et al.   CANCER RESEARCH

The emerging functions of histone demethylases

(2008) Karl Agger et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Erasing the methyl mark: histone demethylases at the center of cellular differentiation and disease

(2008) P. A.C. Cloos et al.   GENES & DEVELOPMENT

Stem Cell–Related “Self-Renewal” Signature and High Epidermal Growth Factor Receptor Expression Associated With Resistance to Concomitant Chemoradiotherapy in Glioblastoma

(2008) Anastasia Murat et al.   JOURNAL OF CLINICAL ONCOLOGY

SOX2Silencing in Glioblastoma Tumor-Initiating Cells Causes Stop of Proliferation and Loss of Tumorigenicity

(2008) Rosaria Maria Rita Gangemi et al.   STEM CELLS