Structural basis of TIR-domain-assembly formation in MAL- and MyD88-dependent TLR4 signaling

The Structure and Dynamics of Higher-Order Assemblies: Amyloids, Signalosomes, and Granules

(2016) Hao Wu et al.   CELL

Higher-Resolution Structure of the Human Insulin Receptor Ectodomain: Multi-Modal Inclusion of the Insert Domain

(2016) Tristan I. Croll et al.   STRUCTURE

Reconstructing the TIR Side of the Myddosome: a Paradigm for TIR-TIR Interactions

(2016) Laurens Vyncke et al.   STRUCTURE

Protein crystal screening and characterization for serial femtosecond nanocrystallography

(2016) Connie Darmanin et al.   Scientific Reports

The Inflammasome Adaptor ASC Induces Procaspase-8 Death Effector Domain Filaments

(2015) Parimala R. Vajjhala et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Gateway-compatible vectors for high-throughput protein expression in pro- and eukaryotic cell-free systems

(2015) Dejan Gagoski et al.   JOURNAL OF BIOTECHNOLOGY

Atomic-accuracy models from 4.5-Å cryo-electron microscopy data with density-guided iterative local refinement

(2015) Frank DiMaio et al.   NATURE METHODS

Distinct single-cell signaling characteristics are conferred by the MyD88 and TRIF pathways during TLR4 activation

(2015) Zhang Cheng et al.   Science Signaling

The Architecture of the TIR Domain Signalosome in the Toll-like Receptor-4 Signaling Pathway

(2015) Emine Guven-Maiorov et al.   Scientific Reports

Distinct single-cell signaling characteristics are conferred by the MyD88 and TRIF pathways during TLR4 activation

(2015) Zhang Cheng et al.   Science Signaling

Structure and function of Toll/interleukin-1 receptor/resistance protein (TIR) domains

(2014) Thomas Ve et al.   APOPTOSIS

Activation of lymphoma-associated MyD88 mutations via allostery-induced TIR-domain oligomerization

(2014) M. Avbelj et al.   BLOOD

A Promiscuous Lipid-Binding Protein Diversifies the Subcellular Sites of Toll-like Receptor Signal Transduction

(2014) Kevin S. Bonham et al.   CELL

A Novel Flow Cytometric Method To Assess Inflammasome Formation

(2014) David P. Sester et al.   JOURNAL OF IMMUNOLOGY

Rapid Mapping of Interactions between Human SNX-BAR Proteins MeasuredIn Vitroby AlphaScreen and Single-molecule Spectroscopy

(2014) Emma Sierecki et al.   MOLECULAR & CELLULAR PROTEOMICS

IRAK4 Dimerization and trans -Autophosphorylation Are Induced by Myddosome Assembly

(2014) Ryan Ferrao et al.   MOLECULAR CELL

Deciphering key features in protein structures with the new ENDscript server

(2014) Xavier Robert et al.   NUCLEIC ACIDS RESEARCH

Structural Basis for Assembly and Function of a Heterodimeric Plant Immune Receptor

(2014) S. J. Williams et al.   SCIENCE

Structure of the Toll/interleukin 1 receptor (TIR) domain of the immunosuppressiveBrucellaeffector BtpA/Btp1/TcpB

(2013) Burcu Kaplan-Türköz et al.   FEBS LETTERS

Identification of Binding Sites for Myeloid Differentiation Primary Response Gene 88 (MyD88) and Toll-like Receptor 4 in MyD88 Adapter-like (Mal)

(2013) Celia Bovijn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mutational Analysis Identifies Residues Crucial for Homodimerization of Myeloid Differentiation Factor 88 (MyD88) and for Its Function in Immune Cells

(2013) Maria Loiarro et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal Structures of the Toll/Interleukin-1 Receptor (TIR) Domains from theBrucellaProtein TcpB and Host Adaptor TIRAP Reveal Mechanisms of Molecular Mimicry

(2013) Greg A. Snyder et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanism of Bacterial Interference with TLR4 Signaling byBrucellaToll/Interleukin-1 Receptor Domain-containing Protein TcpB

(2013) Mohammed Alaidarous et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structures and interface mapping of the TIR domain-containing adaptor molecules involved in interferon signaling

(2013) Y. Enokizono et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High-Resolution Comparative Modeling with RosettaCM

(2013) Yifan Song et al.   STRUCTURE

Adaptors in Toll-Like Receptor Signaling and their Potential as Therapeutic Targets

(2012) Thomas Ve et al.   CURRENT DRUG TARGETS

Toll/Interleukin-1 Receptor Domain Dimers as the Platform for Activation and Enhanced Inhibition of Toll-like Receptor Signaling

(2012) Ota Fekonja et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Insights into TIR Domain Specificity of the Bridging Adaptor Mal in TLR4 Signaling

(2012) Zhijie Lin et al.   PLoS One

Identification of Interaction Sites for Dimerization and Adapter Recruitment in Toll/Interleukin-1 Receptor (TIR) Domain of Toll-like Receptor 4

(2011) Celia Bovijn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Natural Loss-of-function Mutation of Myeloid Differentiation Protein 88 Disrupts Its Ability to Form Myddosomes

(2011) Kamalpreet Nagpal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting TLR4 Signaling by TLR4 Toll/IL-1 Receptor Domain-Derived Decoy Peptides: Identification of the TLR4 Toll/IL-1 Receptor Domain Dimerization Interface

(2011) V. Y. Toshchakov et al.   JOURNAL OF IMMUNOLOGY

Leishmania cell-free protein expression system

(2011) Oleksiy Kovtun et al.   METHODS

A High-Throughput Platform for Lentiviral Overexpression Screening of the Human ORFeome

(2011) Dubravka Škalamera et al.   PLoS One

Crystal structure of Toll-like receptor adaptor MAL/TIRAP reveals the molecular basis for signal transduction and disease protection

(2011) E. Valkov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of MyD88 Aggregation and the MyD88-dependent Signaling Pathway by Sequestosome 1 and Histone Deacetylase 6

(2010) Takeshi Into et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MyD88 Adaptor-Like D96N Is a Naturally Occurring Loss-of-Function Variant of TIRAP

(2010) J. George et al.   JOURNAL OF IMMUNOLOGY

TAK-242 (Resatorvid), a Small-Molecule Inhibitor of Toll-Like Receptor (TLR) 4 Signaling, Binds Selectively to TLR4 and Interferes with Interactions between TLR4 and Its Adaptor Molecules

(2010) N. Matsunaga et al.   MOLECULAR PHARMACOLOGY

Oncogenically active MYD88 mutations in human lymphoma

(2010) Vu N. Ngo et al.   NATURE

Helical assembly in the MyD88–IRAK4–IRAK2 complex in TLR/IL-1R signalling

(2010) Su-Chang Lin et al.   NATURE

Targeting Toll-like receptors: emerging therapeutics?

(2010) Elizabeth J. Hennessy et al.   NATURE REVIEWS DRUG DISCOVERY

Dali server: conservation mapping in 3D

(2010) Liisa Holm et al.   NUCLEIC ACIDS RESEARCH

Species-independent translational leaders facilitate cell-free expression

(2009) Sergei Mureev et al.   NATURE BIOTECHNOLOGY

Structural basis for the multiple interactions of the MyD88 TIR domain in TLR4 signaling

(2009) H. Ohnishi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pyogenic Bacterial Infections in Humans with MyD88 Deficiency

(2008) H. von Bernuth et al.   SCIENCE