Identification of Binding Sites for Myeloid Differentiation Primary Response Gene 88 (MyD88) and Toll-like Receptor 4 in MyD88 Adapter-like (Mal)

Adaptors in Toll-Like Receptor Signaling and their Potential as Therapeutic Targets

(2012) Thomas Ve et al.   CURRENT DRUG TARGETS

Structural Insights into TIR Domain Specificity of the Bridging Adaptor Mal in TLR4 Signaling

(2012) Zhijie Lin et al.   PLoS One

Random Mutagenesis MAPPIT Analysis Identifies Binding Sites for Vif and Gag in Both Cytidine Deaminase Domains of Apobec3G

(2012) Isabel Uyttendaele et al.   PLoS One

Identification of Interaction Sites for Dimerization and Adapter Recruitment in Toll/Interleukin-1 Receptor (TIR) Domain of Toll-like Receptor 4

(2011) Celia Bovijn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal structure of Toll-like receptor adaptor MAL/TIRAP reveals the molecular basis for signal transduction and disease protection

(2011) E. Valkov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TLR3-mediated IFN-β gene induction is negatively regulated by the TLR adaptor MyD88 adaptor-like

(2010) Jakub Siednienko et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

IRAK1 and IRAK4 Promote Phosphorylation, Ubiquitination, and Degradation of MyD88 Adaptor-like (Mal)

(2010) Aisling Dunne et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Caspase-1 targets the TLR adaptor Mal at a crucial TIR-domain interaction site

(2010) P. Ulrichts et al.   JOURNAL OF CELL SCIENCE

MyD88 Adaptor-Like D96N Is a Naturally Occurring Loss-of-Function Variant of TIRAP

(2010) J. George et al.   JOURNAL OF IMMUNOLOGY

Helical assembly in the MyD88–IRAK4–IRAK2 complex in TLR/IL-1R signalling

(2010) Su-Chang Lin et al.   NATURE

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

Targeting Toll-like receptors: emerging therapeutics?

(2010) Elizabeth J. Hennessy et al.   NATURE REVIEWS DRUG DISCOVERY

Jalview Version 2--a multiple sequence alignment editor and analysis workbench

(2009) A. M. Waterhouse et al.   BIOINFORMATICS

A TIR Domain Variant of MyD88 Adapter-like (Mal)/TIRAP Results in Loss of MyD88 Binding and Reduced TLR2/TLR4 Signaling

(2009) Kamalpreet Nagpal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An Oligomeric Signaling Platform Formed by the Toll-like Receptor Signal Transducers MyD88 and IRAK-4

(2009) Precious G. Motshwene et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MyD88 Adapter-like (Mal)/TIRAP Interaction with TRAF6 Is Critical for TLR2- and TLR4-mediated NF-κB Proinflammatory Responses

(2009) Brett Verstak et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MyD88 Adaptor-Like Is Not Essential for TLR2 Signaling and Inhibits Signaling by TLR3

(2009) E. F. Kenny et al.   JOURNAL OF IMMUNOLOGY

Phagosomal retention of Francisella tularensis results in TIRAP/Mal-independent TLR2 signaling

(2009) Leah E. Cole et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Abrogation of the Brd4-Positive Transcription Elongation Factor b Complex by Papillomavirus E2 Protein Contributes to Viral Oncogene Repression

(2009) J. Yan et al.   JOURNAL OF VIROLOGY

Structural basis for the multiple interactions of the MyD88 TIR domain in TLR4 signaling

(2009) H. Ohnishi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MAPPIT analysis of early Toll-like receptor signalling events

(2008) Peter Ulrichts et al.   IMMUNOLOGY LETTERS

Homo-oligomerization Is Essential for Toll/Interleukin-1 Receptor Domain-containing Adaptor Molecule-1-mediated NF-κB and Interferon Regulatory Factor-3 Activation

(2008) Kenji Funami et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Crystal Structure of the Human Toll-like Receptor 10 Cytoplasmic Domain Reveals a Putative Signaling Dimer

(2008) Tomas Nyman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-β

(2008) Jonathan C Kagan et al.   NATURE IMMUNOLOGY