Distinct single-cell signaling characteristics are conferred by the MyD88 and TRIF pathways during TLR4 activation

Single-cell variation leads to population invariance in NF-κB signaling dynamics

(2015) Jacob J. Hughey et al.   MOLECULAR BIOLOGY OF THE CELL

Network dynamics determine the autocrine and paracrine signaling functions of TNF

(2014) Andrew B. Caldwell et al.   GENES & DEVELOPMENT

Fold Change of Nuclear NF-κB Determines TNF-Induced Transcription in Single Cells

(2014) Robin E.C. Lee et al.   MOLECULAR CELL

Single-cell RNA-seq reveals dynamic paracrine control of cellular variation

(2014) Alex K. Shalek et al.   NATURE

Positive Feedback Within a Kinase Signaling Complex Functions as a Switch Mechanism for NF- B Activation

(2014) H. Shinohara et al.   SCIENCE

Accurate information transmission through dynamic biochemical signaling networks

(2014) J. Selimkhanov et al.   SCIENCE

Switching of the Relative Dominance Between Feedback Mechanisms in Lipopolysaccharide-Induced NF- B Signaling

(2014) M.-H. Sung et al.   Science Signaling

Emerging roles of recycling endosomes

(2013) T. Taguchi   JOURNAL OF BIOCHEMISTRY

Characterizing the Relationship between Steady State and Response Using Analytical Expressions for the Steady States of Mass Action Models

(2013) Paul Michael Loriaux et al.   PLoS Computational Biology

Dual Delayed Feedback Provides Sensitivity and Robustness to the NF-κB Signaling Module

(2013) Diane M. Longo et al.   PLoS Computational Biology

Allostery and the Monod-Wyman-Changeux Model After 50 Years

(2012) Jean-Pierre Changeux   Annual Review of Biophysics

Lessons from mathematically modeling the NF-κB pathway

(2012) Soumen Basak et al.   IMMUNOLOGICAL REVIEWS

NEMO Ensures Signaling Specificity of the Pleiotropic IKKβ by Directing Its Kinase Activity toward IκBα

(2012) Bärbel Schröfelbauer et al.   MOLECULAR CELL

Control of RelB during dendritic cell activation integrates canonical and noncanonical NF-κB pathways

(2012) Vincent F-S Shih et al.   NATURE IMMUNOLOGY

Structural Insights into the Assembly of Large Oligomeric Signalosomes in the Toll-Like Receptor-Interleukin-1 Receptor Superfamily

(2012) R. Ferrao et al.   Science Signaling

CD14 Controls the LPS-Induced Endocytosis of Toll-like Receptor 4

(2011) Ivan Zanoni et al.   CELL

Sources of Cell-to-cell Variability in Canonical Nuclear Factor-κB (NF-κB) Signaling Pathway Inferred from Single Cell Dynamic Images

(2011) Mridul K. Kalita et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Imaging the coordination of multiple signalling activities in living cells

(2011) Christopher M. Welch et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Origins of regulated cell-to-cell variability

(2011) Berend Snijder et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Information Transduction Capacity of Noisy Biochemical Signaling Networks

(2011) R. Cheong et al.   SCIENCE

What the Myddosome structure tells us about the initiation of innate immunity

(2011) Nicholas J. Gay et al.   TRENDS IN IMMUNOLOGY

Cellular Heterogeneity: Do Differences Make a Difference?

(2010) Steven J. Altschuler et al.   CELL

Understanding the temporal codes of intra-cellular signals

(2010) Marcelo Behar et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Localisation and trafficking of Toll-like receptors: an important mode of regulation

(2010) Anne F McGettrick et al.   CURRENT OPINION IN IMMUNOLOGY

The Rab11a GTPase Controls Toll-like Receptor 4-Induced Activation of Interferon Regulatory Factor-3 on Phagosomes

(2010) Harald Husebye et al.   IMMUNITY

Physiological levels of TNF  stimulation induce stochastic dynamics of NF- B responses in single living cells

(2010) D. A. Turner et al.   JOURNAL OF CELL SCIENCE

Helical assembly in the MyD88–IRAK4–IRAK2 complex in TLR/IL-1R signalling

(2010) Su-Chang Lin et al.   NATURE

Single-cell NF-κB dynamics reveal digital activation and analogue information processing

(2010) Savaş Tay et al.   NATURE

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

Population robustness arising from cellular heterogeneity

(2010) P. Paszek et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Quantifying E. coli Proteome and Transcriptome with Single-Molecule Sensitivity in Single Cells

(2010) Y. Taniguchi et al.   SCIENCE

Bistability in Apoptosis by Receptor Clustering

(2010) Kenneth L. Ho et al.   PLoS Computational Biology

Non-genetic origins of cell-to-cell variability in TRAIL-induced apoptosis

(2009) Sabrina L. Spencer et al.   NATURE

The stability of mRNA influences the temporal order of the induction of genes encoding inflammatory molecules

(2009) Shengli Hao et al.   NATURE IMMUNOLOGY

Stochastic modelling for quantitative description of heterogeneous biological systems

(2009) Darren J. Wilkinson   NATURE REVIEWS GENETICS

Kinetic control of negative feedback regulators of NF- B/RelA determines their pathogen- and cytokine-receptor signaling specificity

(2009) V. F.-S. Shih et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cell Signaling in Space and Time: Where Proteins Come Together and When They're Apart

(2009) J. D. Scott et al.   SCIENCE

A Noisy Paracrine Signal Determines the Cellular NF- B Response to Lipopolysaccharide

(2009) T. K. Lee et al.   Science Signaling

Roles for LPS-dependent interaction and relocation of TLR4 and TRAM in TRIF-signaling

(2008) Natsuko Tanimura et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Encoding NF- B temporal control in response to TNF: distinct roles for the negative regulators I B  and A20

(2008) S. L. Werner et al.   GENES & DEVELOPMENT

TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-β

(2008) Jonathan C Kagan et al.   NATURE IMMUNOLOGY