Review
Oncology
Kailong Hou, Yuyang Yu, Duda Li, Yanduo Zhang, Ke Zhang, Jinkai Tong, Kunxian Yang, Shuting Jia
Summary: This article reviews the mechanisms and processes of alternative lengthening of telomeres (ALT), and identifies ALT as a potential valuable drug target for clinical telomerase-negative tumor treatment.
Article
Oncology
Banlanjo Umaru, Satarupa Sengupta, Shiva Senthil Kumar, Rachid Drissi
Summary: Pediatric high-grade gliomas (pHGGs) are aggressive tumors with a poor prognosis. This study reveals the heterogeneity of telomere maintenance mechanisms and their association with genetic alterations in pHGGs, including both ALT and telomerase activation. These findings have significant implications for the development of novel therapeutic strategies targeting ALT and telomerase in pHGGs.
Article
Multidisciplinary Sciences
Bruno Silva, Rajika Arora, Claus M. Azzalin
Summary: This study demonstrates that telomere transcription is a major trigger of alternative lengthening of telomeres (ALT) activity. Inhibiting the transcription of telomeric long noncoding RNA TERRA can suppress ALT features. Additionally, experimentally increasing TERRA transcription leads to rapid loss of telomeric DNA.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biochemistry & Molecular Biology
Mikhail Krapivin, Andrei Tikhonov, Olga A. Efimova, Anna A. Pendina, Anna A. Smirnova, Olga G. Chiryaeva, Olga E. Talantova, Lubov' Petrova, Vera S. Dudkina, Vladislav S. Baranov
Summary: The study found differences in TL in chorionic cytotrophoblast cells between karyotypically abnormal and normal samples, with higher TL observed in ongoing pregnancies with abnormal karyotypes. TL asymmetry was similar across all chorion samples but significantly different from PHA-stimulated lymphocytes. Longer telomeres were predominantly present in chromosomes with hemihydroxymethylation, indicating a potential link to telomere lengthening through recombination.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Sabine A. Hartlieb, Lina Sieverling, Michal Nadler-Holly, Matthias Ziehm, Umut H. Toprak, Carl Herrmann, Naveed Ishaque, Konstantin Okonechnikov, Moritz Gartlgruber, Young-Gyu Park, Elisa Maria Wecht, Larissa Savelyeva, Kai-Oliver Henrich, Carolina Rosswog, Matthias Fischer, Barbara Hero, David T. W. Jones, Elke Pfaff, Olaf Witt, Stefan M. Pfister, Richard Volckmann, Jan Koster, Katharina Kiesel, Karsten Rippe, Sabine Taschner-Mandl, Peter Ambros, Benedikt Brors, Matthias Selbach, Lars Feuerbach, Frank Westermann
Summary: Alternative lengthening of telomeres (ALT) is associated with poor prognosis in neuroblastoma, often linked to mutated ATRX and reduced protein abundance, as well as the presence of frequent telomeric repeat loci and heterochromatic telomeric chromatin.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Tanya Tacheva, Shanbeh Zienolddiny, Dimo Dimov, Denitsa Vlaykova, Tatyana Vlaykova
Summary: The study suggests that COPD patients may have shorter leukocyte telomere length, and the genetic variations near TERC, particularly rs12696304 and rs10936599, may independently affect the risk of developing COPD. Carriers of the common homozygous genotype of the SNPs appeared to have a higher risk of COPD.
Article
Genetics & Heredity
Cleandra Gregorio, Shefali Thakur, Raquel Camara Rivero, Simone Marcia dos Santos Machado, Cyrille Cuenin, Christine Carreira, Valerie White, Ian A. Cree, Katarina Vukojevic, Merica Glavina Durdov, Alessandro Bersch Osvaldt, Patricia Ashton-Prolla, Zdenko Herceg, Fazlur Rahman Talukdar
Summary: This study found that periampullary carcinoma (PAC) tissues have shorter telomeres, lower TERT protein expression, and DNA hypermethylation in the TERT promoter. These findings are important for understanding the molecular pathology of PAC and developing therapeutic strategies.
Article
Biochemistry & Molecular Biology
Alina Meeser, Christoph Bartenhagen, Lisa Werr, Anna-Maria Hellmann, Yvonne Kahlert, Nadine Hemstedt, Peter Nuernberg, Janine Altmueller, Sandra Ackermann, Barbara Hero, Thorsten Simon, Martin Peifer, Matthias Fischer, Carolina Rosswog
Summary: This study proposes a workflow for reliably detecting telomere maintenance mechanisms in neuroblastoma, which can be used in clinical routine for risk stratification and treatment allocation.
CELL AND BIOSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Thomas J. Brown, Lewis G. Spurgin, Hannah L. Dugdale, Jan Komdeur, Terry Burke, David S. Richardson
Summary: The length of telomeres, which are important markers of biological age, can both shorten and lengthen with age and environmental stress. This study found that telomere lengthening in females occurs in less stressful circumstances, while telomere shortening is associated with greater stress. Males, on the other hand, did not show an association between telomere dynamics and key stressors. Individuals with lengthened telomeres, both females and males, had improved subsequent survival compared to those with unchanged or shortened telomeres.
Article
Biochemistry & Molecular Biology
Matheus Fabiao de Lima, Monique Oliveira Freitas, Mohammad K. Hamedani, Aline Rangel-Pozzo, Xu-Dong Zhu, Sabine Mai
Summary: Telomere maintenance is crucial in cancer development. This study investigates the effects of inhibiting both telomerase and alternative lengthening of telomere (ALT) pathways in Hodgkin's Lymphoma (HL) cells. The results show that consecutive inhibition of telomerase followed by ALT inhibition significantly reduces cell viability in HL.
Article
Cell Biology
Ryan L. Brown, Elissa E. Epel, Jue Lin, Dena B. Dubal, Aric A. Prather
Summary: Aging biomarkers may be interconnected through direct co-regulation or common processes associated with aging or stress. Klotho, an aging regulator, is involved in regulating insulin signaling, phosphate homeostasis, oxidative stress, and age-related inflammation. This study investigated the association between klotho levels and telomere length in immune cells among mothers caregiving for children with or without autism spectrum disorder (ASD), to understand the potential impact of high caregiving stress on these aging biomarkers. Our results showed a positive association between klotho levels and telomere length in certain immune cells among high-stress mothers of children with ASD, but not among low-stress mothers of neurotypical children. There were no significant associations between klotho and telomerase activity in either group.
Article
Cell Biology
M. Donatella Semeraro, Gunter Almer, Wilfried Renner, Hans-Juergen Gruber, Markus Herrmann
Summary: This study questions the utility of RTL in PBMCs as a biomarker for individual aging assessment.
Article
Biochemistry & Molecular Biology
Zachary W. Kockler, Josep M. Comeron, Anna Malkova
Summary: Based on the calculation of ALT frequencies and ultra-long sequencing of ALT products, this study demonstrates that both RAD51-dependent and RAD51-independent mechanisms are required for a unified ALT survivor pathway. The research provides insights into a potential unified ALT pathway that may operate in various organisms, including humans.
Review
Biochemistry & Molecular Biology
Barbara Jacczak, Blazej Rubis, Ewa Toton
Summary: The stability of telomeres is crucial for cell function, and research on telomere biology and telomerase activity has been of great interest in various medical and scientific fields. Maintaining optimal telomere length and telomerase activity is an important step in anti-aging strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biology
Megan L. Power, Roger D. Ransome, Sebastien Riquier, Luke Romaine, Gareth Jones, Emma C. Teeling
Summary: This study measured the relative telomere length in long-lived bats over three winters and found variations in telomeres during hibernation. These findings highlight the beneficial effects of hibernation on telomeres and potential consequences of changing climatic conditions for bats.
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2023)
Article
Anatomy & Morphology
Rongyan Sun, Yubo Zhou, Jiao Liang, Lihong Yang, Zhengjun Fan, Huali Wang
Summary: This study found that knockdown of MDM2 can attenuate vascular endothelial dysfunction in hypertension, which may be achieved through inhibiting the activation of Notch1 and NLRP3 inflammasome.
ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER
(2024)
Article
Anatomy & Morphology
E. M. Fernandez-Rubio, R. J. Radlanski
Summary: This study investigates the development of the primary and secondary temporomandibular joints in humans, focusing on their coexistence and subsequent separation. The findings reveal that both joints develop simultaneously and remain connected for over 6 weeks before separating at around the 18th to 24th week. Understanding the precise timing and functional movements involved in the development of these joints is crucial for comprehending the overall development of the temporomandibular joint.
ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER
(2024)
Article
Anatomy & Morphology
Nawwaf Sebastian Damen, Sorin Hostiuc, Adelina Maria Jianu, Bogdan Adrian Manta, Mugurel Constantin Rusu, Mihai Adrian Dobra
Summary: This study documented the anatomical variations of the left renal vein (LRV) through a retrospective analysis of 375 computed tomography angiograms. Five different anatomical types of LRV were identified, and a new anatomical classification system for the retroaortic LRV (RLRV) was proposed.
ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER
(2024)
Article
Anatomy & Morphology
Harald Knof, Markus Berndt, Thomas Shiozawa
Summary: This study investigated the impact of online learning conditions on the oral exam performance of medical students. The results showed that students who used collaborative learning strategies were able to assess their abilities more realistically. However, the learning strategies did not have an impact on exam results.
ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER
(2024)
Review
Anatomy & Morphology
Felix Margenfeld, Adib Zendehdel, Giorgio Tamborrini, Magdalena Mueller-Gerbl
Summary: This study is the first scoping review to screen ultrasound studies on human cadaver joints and revealed a heterogeneous field. It is recommended to use a uniform method for conducting and presenting ultrasound examinations in future studies.
ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER
(2024)
Article
Anatomy & Morphology
Rafael Heiss, Svenja A. Hoeger, Michael Uder, Thilo Hotfiel, Jannis Hanspach, Frederik B. Laun, Armin M. Nagel, Frank W. Roemer
Summary: This study utilized 7 Tesla magnetic resonance imaging (MRI) to assess morphological and functional changes in skeletal muscle during exercise-induced delayed onset muscle soreness (DOMS). The results showed significant alterations in T2 signal intensity and T2 values immediately after exercise and 60 hours later. These findings suggest the potential use of ultra-high field MRI in sports medicine to monitor microstructural muscle damage and guide appropriate therapeutic strategies.
ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER
(2024)
Article
Anatomy & Morphology
Lukasz Olewnik, Nicol Zielinska, Kacper Ruzik, Michal Podgorski, Przemyslaw Kicinski, Rui Diogo, Friedrich Paulsen
Summary: This study provides the first comprehensive classification of the fibularis brevis tendon based on its insertion in human fetuses and evaluates the prevalence of fibularis digiti quinti.
ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER
(2024)
Article
Anatomy & Morphology
Denise Bonente, Virginia Barone, Vitaliano Francesco Muzii, Sara Ottolenghi, Miriam Durante, Sandra Bracco, Claudio Nicoletti, Eugenio Bertelli
Summary: This study characterizes the morphology and topography of the spina musculi recti lateralis (SMRL) and compares it to known bony landmarks. The results show that the SMRL is a process of the sphenoidal orbital plate and serves as a reliable landmark for the insertion of the tendinous ring and lateral rectus. This is an important variation for orbital surgeons to be aware of.
ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER
(2024)
Article
Anatomy & Morphology
Fatih Cicek, Selim Cinaroglu, Faruk Gazi Ceranoglu, Erkut Kucuk, Kursad Ramazan Zor
Summary: This study revealed the nerve innervation of the orbicularis oculi muscle for BoNT treatment of blepharospasm using Sihler's staining technique. It identified precise crossing points of these nerves, which can be targeted for BoNT administration, leading to more efficient outcomes and reduced expenses.
ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER
(2024)
