Non-alcoholic fatty liver disease: an emerging driving force in chronic kidney disease

The Renin Angiotensin Aldosterone System in Obesity and Hypertension

(2017) Peminda K. Cabandugama et al.   MEDICAL CLINICS OF NORTH AMERICA

Gut microbiome in chronic kidney disease: challenges and opportunities

(2017) Anitha Nallu et al.   Translational Research

Improvement in liver histology due to lifestyle modification is independently associated with improved kidney function in patients with non-alcoholic steatohepatitis

(2016) E. Vilar-Gomez et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Long-Term Pioglitazone Treatment for Patients With Nonalcoholic Steatohepatitis and Prediabetes or Type 2 Diabetes Mellitus

(2016) Kenneth Cusi et al.   ANNALS OF INTERNAL MEDICINE

2016 ESC/EAS Guidelines for the Management of Dyslipidaemias

(2016) Alberico L. Catapano et al.   ATHEROSCLEROSIS

Extrahepatic Diseases and NAFLD: The Triangular Relationship between NAFLD, Type 2-Diabetes and Dysbiosis

(2016) Eleonora Scorletti et al.   DIGESTIVE DISEASES

Medical and Surgical Treatment Options for Nonalcoholic Steatohepatitis

(2016) Kathleen E. Corey et al.   DIGESTIVE DISEASES AND SCIENCES

Role of Dietary Fructose and Hepatic De Novo Lipogenesis in Fatty Liver Disease

(2016) Samir Softic et al.   DIGESTIVE DISEASES AND SCIENCES

Perspectives on Treatment for Nonalcoholic Steatohepatitis

(2016) Guillaume Lassailly et al.   GASTROENTEROLOGY

Elafibranor, an Agonist of the Peroxisome Proliferator−Activated Receptor−α and −δ, Induces Resolution of Nonalcoholic Steatohepatitis Without Fibrosis Worsening

(2016) Vlad Ratziu et al.   GASTROENTEROLOGY

Current and upcoming pharmacotherapy for non-alcoholic fatty liver disease

(2016) Yaron Rotman et al.   GUT

Farnesoid X receptor activation increases reverse cholesterol transport by modulating bile acid composition and cholesterol absorption in mice

(2016) Yang Xu et al.   HEPATOLOGY

Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes

(2016) Zobair M. Younossi et al.   HEPATOLOGY

The severity of nonalcoholic fatty liver disease is associated with gut dysbiosis and shift in the metabolic function of the gut microbiota

(2016) Jérôme Boursier et al.   HEPATOLOGY

Mechanisms Linking the Gut Microbiome and Glucose Metabolism

(2016) Kristina M. Utzschneider et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

DKK3 expression in hepatocytes defines susceptibility to liver steatosis and obesity

(2016) Lanfeng Xie et al.   JOURNAL OF HEPATOLOGY

Noninvasive diagnosis of nonalcoholic fatty liver disease: Are we there yet?

(2016) Naim Alkhouri et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Renal, metabolic and cardiovascular considerations of SGLT2 inhibition

(2016) Ralph A. DeFronzo et al.   Nature Reviews Nephrology

Empagliflozin and Progression of Kidney Disease in Type 2 Diabetes

(2016) Christoph Wanner et al.   NEW ENGLAND JOURNAL OF MEDICINE

Fibroblast growth factor 21 attenuates hepatic fibrogenesis through TGF-β/smad2/3 and NF-κB signaling pathways

(2016) Pengfei Xu et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Nonalcoholic Steatohepatitis is the Most Rapidly Growing Indication for Simultaneous Liver Kidney Transplantation in the United States

(2016) Ashwani Kumar Singal et al.   TRANSPLANTATION

Non-alcoholic fatty liver and the gut microbiota

(2016) Stavros Bashiardes et al.   Molecular Metabolism

Renin-Angiotensin System Inhibitors, Type 2 Diabetes and Fibrosis Progression: An Observational Study in Patients with Nonalcoholic Fatty Liver Disease

(2016) Serena Pelusi et al.   PLoS One

Systematic review: microbial dysbiosis and nonalcoholic fatty liver disease

(2015) A. Wieland et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Micro-RNA 21 inhibition of SMAD7 enhances fibrogenesis via leptin-mediated NADPH oxidase in experimental and human nonalcoholic steatohepatitis

(2015) Diptadip Dattaroy et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Non-lethal Inhibition of Gut Microbial Trimethylamine Production for the Treatment of Atherosclerosis

(2015) Zeneng Wang et al.   CELL

Proprotein Convertase Subtilisin/Kexin Type 9 Inhibition

(2015) Nathalie Bergeron et al.   CIRCULATION

Omega-3 fatty acids: Mechanisms of benefit and therapeutic effects in pediatric and adult NAFLD

(2015) Valerio Nobili et al.   CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES

Intake ofLactobacillus reuteriImproves Incretin and Insulin Secretion in Glucose-Tolerant Humans: A Proof of Concept

(2015) Marie-Christine Simon et al.   DIABETES CARE

Epidemiological modifiers of non-alcoholic fatty liver disease: Focus on high-risk groups

(2015) Amedeo Lonardo et al.   DIGESTIVE AND LIVER DISEASE

Relationship between Obesity, Gut Microbiome and Hepatocellular Carcinoma Development

(2015) Eiji Hara   DIGESTIVE DISEASES

Hepatitis C Virus Infection Increases the Risk of Developing Chronic Kidney Disease: A Systematic Review and Meta-Analysis

(2015) Fabrizio Fabrizi et al.   DIGESTIVE DISEASES AND SCIENCES

Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease

(2015) Lauren E. Tebay et al.   FREE RADICAL BIOLOGY AND MEDICINE

The gut microbiota and host health: a new clinical frontier

(2015) Julian R Marchesi et al.   GUT

Plasma cholesteryl ester transfer protein is predominantly derived from Kupffer cells

(2015) Yanan Wang et al.   HEPATOLOGY

Comparative effectiveness of pharmacological interventions for nonalcoholic steatohepatitis: A systematic review and network meta-analysis

(2015) Siddharth Singh et al.   HEPATOLOGY

High FIB-4 index as an independent risk factor of prevalent chronic kidney disease in patients with nonalcoholic fatty liver disease

(2015) Huang-Wei Xu et al.   Hepatology International

Chemokine and chemokine receptor structure and interactions: implications for therapeutic strategies

(2015) Irina Kufareva et al.   IMMUNOLOGY AND CELL BIOLOGY

Statin use and non-alcoholic steatohepatitis in at risk individuals

(2015) Paola Dongiovanni et al.   JOURNAL OF HEPATOLOGY

NAFLD: A multisystem disease

(2015) Christopher D. Byrne et al.   JOURNAL OF HEPATOLOGY

Effects of n-3 fish oil on metabolic and histological parameters in NASH: A double-blind, randomized, placebo-controlled trial

(2015) Curtis K. Argo et al.   JOURNAL OF HEPATOLOGY

Treating liver fat and serum triglyceride levels in NAFLD, effects of PNPLA3 and TM6SF2 genotypes: Results from the WELCOME trial

(2015) Eleonora Scorletti et al.   JOURNAL OF HEPATOLOGY

Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial

(2015) Brent A Neuschwander-Tetri et al.   LANCET

Intrahepatic triglyceride content is independently associated with chronic kidney disease in obese adults: A cross-sectional study

(2015) Ling-Ling Pan et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

CHOP links endoplasmic reticulum stress to NF-κB activation in the pathogenesis of nonalcoholic steatohepatitis

(2015) Jeffrey A. Willy et al.   MOLECULAR BIOLOGY OF THE CELL

A double-blind, placebo-controlled randomized trial to evaluate the efficacy of docosahexaenoic acid supplementation on hepatic fat and associated cardiovascular risk factors in overweight children with nonalcoholic fatty liver disease

(2015) L. Pacifico et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

Activation of the Liver X Receptor by Agonist TO901317 Improves Hepatic Insulin Resistance via Suppressing Reactive Oxygen Species and JNK Pathway

(2015) Ying Dong et al.   PLoS One

High-throughput sequencing reveals altered expression of hepatic microRNAs in nonalcoholic fatty liver disease–related fibrosis

(2015) Fatjon Leti et al.   Translational Research

Emerging Liver–Kidney Interactions in Nonalcoholic Fatty Liver Disease

(2015) Giovanni Musso et al.   TRENDS IN MOLECULAR MEDICINE

Non-Alcoholic Fatty Liver Disease Is a Risk Factor for the Development of Diabetic Nephropathy in Patients with Type 2 Diabetes Mellitus

(2015) Guoyu Jia et al.   PLoS One

Akkermansia muciniphila inversely correlates with the onset of inflammation, altered adipose tissue metabolism and metabolic disorders during obesity in mice

(2015) Marc Schneeberger et al.   Scientific Reports

CKD and Nonalcoholic Fatty Liver Disease

(2014) Giovanni Targher et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

KDOQI US Commentary on the 2012 KDIGO Clinical Practice Guideline for the Evaluation and Management of CKD

(2014) Lesley A. Inker et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Expansion of Urease- and Uricase-Containing, Indole- and p-Cresol-Forming and Contraction of Short-Chain Fatty Acid-Producing Intestinal Microbiota in ESRD

(2014) Jakk Wong et al.   AMERICAN JOURNAL OF NEPHROLOGY

Hepatic Syndecan-1 Changes Associate With Dyslipidemia After Renal Transplantation

(2014) S. Adepu et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Lipid Management in Chronic Kidney Disease: Synopsis of the Kidney Disease: Improving Global Outcomes 2013 Clinical Practice Guideline

(2014) Marcello Tonelli et al.   ANNALS OF INTERNAL MEDICINE

Links Between Ectopic Fat and Vascular Disease in Humans

(2014) Soo Lim et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Nonalcoholic Fatty Liver Disease Is Independently Associated With an Increased Incidence of Chronic Kidney Disease in Patients With Type 1 Diabetes

(2014) Giovanni Targher et al.   DIABETES CARE

No Significant Effects of Ethyl-Eicosapentanoic Acid on Histologic Features of Nonalcoholic Steatohepatitis in a Phase 2 Trial

(2014) Arun J. Sanyal et al.   GASTROENTEROLOGY

Galectin-3: an emerging all-out player in metabolic disorders and their complications

(2014) G. Pugliese et al.   GLYCOBIOLOGY

Vitamin D counteracts fibrogenic TGF-β signalling in human hepatic stellate cells both receptor-dependently and independently

(2014) Anja Beilfuss et al.   GUT

Pharmacological inhibition of the chemokine C-C motif chemokine ligand 2 (monocyte chemoattractant protein 1) accelerates liver fibrosis regression by suppressing Ly-6C+macrophage infiltration in mice

(2014) Christer Baeck et al.   HEPATOLOGY

Effects of purified eicosapentaenoic and docosahexaenoic acids in nonalcoholic fatty liver disease: Results from the WELCOME* study

(2014) Eleonora Scorletti et al.   HEPATOLOGY

The transrepressive activity of peroxisome proliferator-activated receptor alpha is necessary and sufficient to prevent liver fibrosis in mice

(2014) Michal Pawlak et al.   HEPATOLOGY

The short chain fatty acid propionate stimulates GLP-1 and PYY secretion via free fatty acid receptor 2 in rodents

(2014) A Psichas et al.   INTERNATIONAL JOURNAL OF OBESITY

Anti–microRNA-21 oligonucleotides prevent Alport nephropathy progression by stimulating metabolic pathways

(2014) Ivan G. Gomez et al.   JOURNAL OF CLINICAL INVESTIGATION

Renin-angiotensin system and fibrosis in non-alcoholic fatty liver disease

(2014) George B Goh et al.   LIVER INTERNATIONAL

Effect of Redox Modulating NRF2 Activators on Chronic Kidney Disease

(2014) Bo-hyun Choi et al.   MOLECULES

The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes

(2014) Rachel J. Perry et al.   NATURE

MicroRNAs in kidney physiology and disease

(2014) Piera Trionfini et al.   Nature Reviews Nephrology

Gut microbiome and nonalcoholic fatty liver diseases

(2014) Lixin Zhu et al.   PEDIATRIC RESEARCH

Nonalcoholic fatty liver disease and the renin-angiotensin system blockers in the patients with chronic kidney disease

(2014) Lidija Orlic et al.   WIENER KLINISCHE WOCHENSCHRIFT

Chronic hepatitis C virus infection and atherosclerosis: Clinical impact and mechanisms

(2014) Luigi E Adinolfi   WORLD JOURNAL OF GASTROENTEROLOGY

Massive gene amplification drives paediatric hepatocellular carcinoma caused by bile salt export pump deficiency

(2014) Fabio Iannelli et al.   Nature Communications

Distinct Roles for JNK and IKK Activation in Agouti-Related Peptide Neurons in the Development of Obesity and Insulin Resistance

(2014) Eva Tsaousidou et al.   Cell Reports

Association of Non-alcoholic Fatty Liver Disease with Chronic Kidney Disease: A Systematic Review and Meta-analysis

(2014) Giovanni Musso et al.   PLOS MEDICINE

Chronic Kidney Disease Causes Disruption of Gastric and Small Intestinal Epithelial Tight Junction

(2013) Nosratola D. Vaziri et al.   AMERICAN JOURNAL OF NEPHROLOGY

Omega-3 Fatty Acids, Hepatic Lipid Metabolism, and Nonalcoholic Fatty Liver Disease

(2013) E. Scorletti et al.   Annual Review of Nutrition

Effect of intensive lipid lowering with atorvastatin on cardiovascular outcomes in coronary heart disease patients with mild-to-moderate baseline elevations in alanine aminotransferase levels

(2013) Matti J. Tikkanen et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Glucagon-Like Peptide-1 (GLP-1): Effect on Kidney Hemodynamics and Renin-Angiotensin-Aldosterone System in Healthy Men

(2013) Jeppe Skov et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Decoding cell death signals in liver inflammation

(2013) Catherine Brenner et al.   JOURNAL OF HEPATOLOGY

Chronic Kidney Disease and Nonalcoholic Fatty Liver Disease Proven by Transient Elastography

(2013) Ivana Mikolasevic et al.   KIDNEY & BLOOD PRESSURE RESEARCH

Gut metagenome in European women with normal, impaired and diabetic glucose control

(2013) Fredrik H. Karlsson et al.   NATURE

Noninvasive evaluation of NAFLD

(2013) Laurent Castera et al.   Nature Reviews Gastroenterology & Hepatology

The Gordian Knot of dysbiosis, obesity and NAFLD

(2013) Wajahat Z. Mehal   Nature Reviews Gastroenterology & Hepatology

Adipokines protecting CKD

(2013) S. Miyamoto et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

n-3 Fatty acids, inflammation and immunity: new mechanisms to explain old actions

(2013) Philip C. Calder   PROCEEDINGS OF THE NUTRITION SOCIETY

Ectopic fat, insulin resistance and non-alcoholic fatty liver disease

(2013) Christopher D. Byrne   PROCEEDINGS OF THE NUTRITION SOCIETY

Diagnosis and Management of Nonalcoholic Fatty Liver Disease and Its Hemostatic/Thrombotic and Vascular Complications

(2013) Christopher Byrne et al.   SEMINARS IN THROMBOSIS AND HEMOSTASIS

The Glucagon-Like Peptide-1 Receptor Agonist, Liraglutide, Attenuates the Progression of Overt Diabetic Nephropathy in Type 2 Diabetic Patients

(2013) Shigeki Imamura et al.   TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE

Association between Nonalcoholic Liver Disease and Chronic Kidney Disease: An Ultrasound Analysis from NHANES 1988–1994

(2012) Jeffrey C. Sirota et al.   AMERICAN JOURNAL OF NEPHROLOGY

Adiponectin: Key Player in the Adipose Tissue-Liver Crosstalk

(2012) A. R. Moschen et al.   CURRENT MEDICINAL CHEMISTRY

Non-alcoholic fatty liver disease: a new and important cardiovascular risk factor?

(2012) Lokpal S. Bhatia et al.   EUROPEAN HEART JOURNAL

Targeting chemokines in proteinuria-induced renal disease

(2012) Juan Antonio Moreno et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Statins Are Associated With a Reduced Risk of Hepatocellular Cancer: A Systematic Review and Meta-analysis

(2012) Siddharth Singh et al.   GASTROENTEROLOGY

Liver vitamin D receptor, CYP2R1, and CYP27A1 expression: relationship with liver histology and vitamin D3 levels in patients with nonalcoholic steatohepatitis or hepatitis C virus

(2012) Ilaria Barchetta et al.   HEPATOLOGY

The diagnosis and management of non-alcoholic fatty liver disease: Practice Guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association

(2012) Naga Chalasani et al.   HEPATOLOGY

p-Cresyl Sulfate Promotes Insulin Resistance Associated with CKD

(2012) L. Koppe et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Exenatide Reduces Urinary Transforming Growth Factor-ß1 and Type IV Collagen Excretion in Patients with Type 2 Diabetes and Microalbuminuria

(2012) Hong Zhang et al.   KIDNEY & BLOOD PRESSURE RESEARCH

A metagenome-wide association study of gut microbiota in type 2 diabetes

(2012) Junjie Qin et al.   NATURE

Implications of worse renal dysfunction and medical comorbidities in patients with NASH undergoing liver transplant evaluation: impact on MELD and more

(2011) Chan W. Park et al.   CLINICAL TRANSPLANTATION

Frequency and Outcomes of Liver Transplantation for Nonalcoholic Steatohepatitis in the United States

(2011) Michael R. Charlton et al.   GASTROENTEROLOGY

Shedding of syndecan-1 from human hepatocytes alters very low density lipoprotein clearance

(2011) Yiping Deng et al.   HEPATOLOGY

Diagnostic accuracy and reliability of ultrasonography for the detection of fatty liver: A meta-analysis

(2011) Ruben Hernaez et al.   HEPATOLOGY

Impaired renal function in morbid obese patients with nonalcoholic fatty liver disease

(2011) Mariana V. Machado et al.   LIVER INTERNATIONAL

Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease

(2011) Zeneng Wang et al.   NATURE

Measuring the population burden of chronic kidney disease: a systematic literature review of the estimated prevalence of impaired kidney function

(2011) Keith McCullough et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Relationship between Kidney Function and Liver Histology in Subjects with Nonalcoholic Steatohepatitis

(2010) G. Targher et al.   Clinical Journal of the American Society of Nephrology

Non-alcoholic fatty liver disease is independently associated with an increased prevalence of chronic kidney disease and retinopathy in type 1 diabetic patients

(2010) G. Targher et al.   DIABETOLOGIA

Galectin-3 ablation protects mice from diet-induced NASH: A major scavenging role for galectin-3 in liver

(2010) Carla Iacobini et al.   JOURNAL OF HEPATOLOGY

Mechanisms Linking Obesity, Chronic Kidney Disease, and Fatty Liver Disease: The Roles of Fetuin-A, Adiponectin, and AMPK

(2010) J. H. Ix et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Safety and efficacy of long-term statin treatment for cardiovascular events in patients with coronary heart disease and abnormal liver tests in the Greek Atorvastatin and Coronary Heart Disease Evaluation (GREACE) Study: a post-hoc analysis

(2010) Vasilios G Athyros et al.   LANCET

Microalbuminuria in nondiabetic patients with nonalcoholic fatty liver disease: association with liver fibrosis

(2010) Yusuf Yilmaz et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Nonalcoholic steatohepatitis and increased risk of chronic kidney disease

(2010) Kohichiroh Yasui et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

p-Cresyl sulphate and indoxyl sulphate predict progression of chronic kidney disease

(2010) I.-W. Wu et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Pioglitazone, Vitamin E, or Placebo for Nonalcoholic Steatohepatitis

(2010) Arun J. Sanyal et al.   NEW ENGLAND JOURNAL OF MEDICINE

Risk of Cardiovascular Disease in Patients with Nonalcoholic Fatty Liver Disease

(2010) Giovanni Targher et al.   NEW ENGLAND JOURNAL OF MEDICINE

Gut Microbiota in Human Adults with Type 2 Diabetes Differs from Non-Diabetic Adults

(2010) Nadja Larsen et al.   PLoS One

Metabolic disturbances in non-alcoholic fatty liver disease

(2009) Christopher D. Byrne et al.   CLINICAL SCIENCE

Serum Lipopolysaccharide Activity Is Associated With the Progression of Kidney Disease in Finnish Patients With Type 1 Diabetes

(2009) M. Nymark et al.   DIABETES CARE

Role of oxidants/inflammation in declining renal function in chronic kidney disease and normal aging

(2009) Helen Vlassara et al.   KIDNEY INTERNATIONAL

Emerging risk factors and markers of chronic kidney disease progression

(2009) Florian Kronenberg   Nature Reviews Nephrology

The Role of Oxidative Stress in Chronic Kidney Disease

(2009) Ziad A. Massy et al.   SEMINARS IN DIALYSIS

Angiotensin-receptor blockers as therapy for mild-to-moderate hypertension-associated non-alcoholic steatohepatitis

(2009) Eugen Florin Georgescu et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Fibroblast Growth Factor 21 Reverses Hepatic Steatosis, Increases Energy Expenditure, and Improves Insulin Sensitivity in Diet-Induced Obese Mice

(2008) J. Xu et al.   DIABETES

Causes and Metabolic Consequences of Fatty Liver

(2008) Norbert Stefan et al.   ENDOCRINE REVIEWS

Increased Risk of CKD among Type 2 Diabetics with Nonalcoholic Fatty Liver Disease

(2008) G. Targher et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Nonalcoholic fatty liver disease predicts chronic kidney disease in nonhypertensive and nondiabetic Korean men

(2008) Yoosoo Chang et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Nontraditional risk factors for cardiovascular disease in patients with chronic kidney disease

(2008) Jessica Kendrick et al.   Nature clinical practice. Nephrology