Chemokine and chemokine receptor structure and interactions: implications for therapeutic strategies

Chemokines and Chemokine Receptors: Positioning Cells for Host Defense and Immunity

(2014) Jason W. Griffith et al.   Annual Review of Immunology

Interaction of Chemokines with their Receptors – From Initial Chemokine Binding to Receptor Activating Steps

(2014) Stefanie Thiele et al.   CURRENT MEDICINAL CHEMISTRY

Multiple Glycosaminoglycan-binding Epitopes of Monocyte Chemoattractant Protein-3/CCL7 Enable It to Function as a Non-oligomerizing Chemokine

(2014) Catherina L. Salanga et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of Monocyte Chemoattractant Protein-1 Ameliorates Rat Adjuvant-Induced Arthritis

(2014) S. Shahrara et al.   JOURNAL OF IMMUNOLOGY

Structural Analysis of a Novel Small Molecule Ligand Bound to the CXCL12 Chemokine

(2014) Emmanuel W. Smith et al.   JOURNAL OF MEDICINAL CHEMISTRY

Molecular Recognition of CCR5 by an HIV-1 gp120 V3 Loop

(2014) Phanourios Tamamis et al.   PLoS One

Stoichiometry and geometry of the CXC chemokine receptor 4 complex with CXC ligand 12: Molecular modeling and experimental validation

(2014) Irina Kufareva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CCR5/CD4/CXCR4 oligomerization prevents HIV-1 gp120IIIB binding to the cell surface

(2014) L. Martinez-Munoz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Basis of Receptor Sulfotyrosine Recognition by a CC Chemokine: The N-Terminal Region of CCR3 Bound to CCL11/Eotaxin-1

(2014) Christopher J. Millard et al.   STRUCTURE

Breast Cancer: Coordinated Regulation of CCL2 Secretion by Intracellular Glycosaminoglycans and Chemokine Motifs

(2014) Yaeli Lebel-Haziv et al.   NEOPLASIA

Molecular Recognition of CXCR4 by a Dual Tropic HIV-1 gp120 V3 Loop

(2013) Phanourios Tamamis et al.   BIOPHYSICAL JOURNAL

In vivo regulation of chemokine activity by post-translational modification

(2013) Eva AV Moelants et al.   IMMUNOLOGY AND CELL BIOLOGY

Using Glycosaminoglycan/Chemokine Interactions for the Long-Term Delivery of 5P12-RANTES in HIV Prevention

(2013) Nick X. Wang et al.   MOLECULAR PHARMACEUTICS

HIV-1 exploits CCR5 conformational heterogeneity to escape inhibition by chemokines

(2013) Philippe Colin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of the CCR5 Chemokine Receptor-HIV Entry Inhibitor Maraviroc Complex

(2013) Q. Tan et al.   SCIENCE

Interstitial Dendritic Cell Guidance by Haptotactic Chemokine Gradients

(2013) M. Weber et al.   SCIENCE

Crystal Structure of a Soluble Cleaved HIV-1 Envelope Trimer

(2013) J.-P. Julien et al.   SCIENCE

The heterodimerization of platelet-derived chemokines

(2012) James Carlson et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Structure-based design of decoy chemokines as a way to explore the pharmacological potential of glycosaminoglycans

(2012) Tiziana Adage et al.   BRITISH JOURNAL OF PHARMACOLOGY

Heparin Oligosaccharides Inhibit Chemokine (CXC Motif) Ligand 12 (CXCL12) Cardioprotection by Binding Orthogonal to the Dimerization Interface, Promoting Oligomerization, and Competing with the Chemokine (CXC Motif) Receptor 4 (CXCR4) N Terminus

(2012) Joshua J. Ziarek et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Locked, Dimeric CXCL12 Variant Effectively Inhibits Pulmonary Metastasis of CXCR4-Expressing Melanoma Cells Due to Enhanced Serum Stability

(2012) T. Takekoshi et al.   MOLECULAR CANCER THERAPEUTICS

Unliganded HIV-1 gp120 core structures assume the CD4-bound conformation with regulation by quaternary interactions and variable loops

(2012) Y. D. Kwon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pharmacological modulation of chemokine receptor function

(2011) DJ Scholten et al.   BRITISH JOURNAL OF PHARMACOLOGY

Anti-Inflammatory Gene Therapy for Cardiovascular Disease

(2011) Tetsuya Matoba et al.   CURRENT GENE THERAPY

Chemokine oligomerization and interactions with receptors and glycosaminoglycans: The role of structural dynamics in function

(2011) C.L. Salanga et al.   EXPERIMENTAL CELL RESEARCH

Highly Potent Chimeric Inhibitors Targeting Two Steps of HIV Cell Entry

(2011) Bo Zhao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Allosteric Model of Maraviroc Binding to CC Chemokine Receptor 5 (CCR5)

(2011) Javier Garcia-Perez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dendritic cell chemotaxis in 3D under defined chemokine gradients reveals differential response to ligands CCL21 and CCL19

(2011) U. Haessler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oligomeric Structure of the Chemokine CCL5/RANTES from NMR, MS, and SAXS Data

(2011) Xu Wang et al.   STRUCTURE

Functional divergence between 2 chemokines is conferred by single amino acid change

(2010) A. Dubrac et al.   BLOOD

Polymerization of MIP-1 chemokine (CCL3 and CCL4) and clearance of MIP-1 by insulin-degrading enzyme

(2010) Min Ren et al.   EMBO JOURNAL

The Epstein-Barr Virus-encoded G Protein-coupled Receptor BILF1 Hetero-oligomerizes with Human CXCR4, Scavenges GαiProteins, and Constitutively Impairs CXCR4 Functioning

(2010) Saskia Nijmeijer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Monomeric Rhodopsin Is Sufficient for Normal Rhodopsin Kinase (GRK1) Phosphorylation and Arrestin-1 Binding

(2010) Timothy H. Bayburt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Antagonism of the chemokine Ccl5 ameliorates experimental liver fibrosis in mice

(2010) Marie-Luise Berres et al.   JOURNAL OF CLINICAL INVESTIGATION

Structures of the CXCR4 Chemokine GPCR with Small-Molecule and Cyclic Peptide Antagonists

(2010) B. Wu et al.   SCIENCE

Anti-inflammatory therapy by intravenous delivery of non-heparan sulfate-binding CXCL12

(2009) Graeme O'Boyle et al.   FASEB JOURNAL

Structural Basis of the Interaction between Chemokine Stromal Cell-derived Factor-1/CXCL12 and Its G-protein-coupled Receptor CXCR4

(2009) Yutaka Kofuku et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differential Activation and Regulation of CXCR1 and CXCR2 by CXCL8 Monomer and Dimer

(2009) M. W. Nasser et al.   JOURNAL OF IMMUNOLOGY

Topically Applied Recombinant Chemokine Analogues Fully Protect Macaques from Vaginal Simian‐Human Immunodeficiency Virus Challenge

(2009) Ronald S. Veazey et al.   JOURNAL OF INFECTIOUS DISEASES

Chemokine CCL5/RANTES inhibition reduces myocardial reperfusion injury in atherosclerotic mice

(2009) Vincent Braunersreuther et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Structure of HIV-1 gp120 with gp41-interactive region reveals layered envelope architecture and basis of conformational mobility

(2009) M. Pancera et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Novel RANTES Antagonist Prevents Progression of Established Atherosclerotic Lesions in Mice

(2008) Vincent Braunersreuther et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

An engineered monomer of CCL2 has anti-inflammatory properties emphasizing the importance of oligomerization for chemokine activity in vivo

(2008) Tracy M. Handel et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The Relative Activity of "Function Sparing" HIV-1 Entry Inhibitors on Viral Entry and CCR5 Internalization: Is Allosteric Functional Selectivity a Valuable Therapeutic Property?

(2008) V. M. Muniz-Medina et al.   MOLECULAR PHARMACOLOGY

Highly potent, fully recombinant anti-HIV chemokines: Reengineering a low-cost microbicide

(2008) H. Gaertner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interconversion between two unrelated protein folds in the lymphotactin native state

(2008) Robbyn L. Tuinstra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Basis of CXCR4 Sulfotyrosine Recognition by the Chemokine SDF-1/CXCL12

(2008) C. T. Veldkamp et al.   Science Signaling