Activation of the Liver X Receptor by Agonist TO901317 Improves Hepatic Insulin Resistance via Suppressing Reactive Oxygen Species and JNK Pathway

FFA-induced hepatic insulin resistance in vivo is mediated by PKCδ, NADPH oxidase, and oxidative stress

(2014) Sandra Pereira et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Liver X receptor: from metabolism to cancer

(2014) Nicolas Venteclef et al.   BIOCHEMICAL JOURNAL

Liver X receptor agonist treatment attenuates cardiac dysfunction in type 2 diabetic db/db mice

(2014) Qing He et al.   Cardiovascular Diabetology

Activation of Liver-X-Receptor α But Not Liver-X-Receptor β Protects Against Myocardial Ischemia/Reperfusion Injury

(2014) Qing He et al.   Circulation-Heart Failure

Inhibiting CB1 receptors improves lipogenesis in an in vitro non-alcoholic fatty liver disease model

(2014) Dongmei Shi et al.   Lipids in Health and Disease

Nrf2-Inducing Anti-Oxidation Stress Response in the Rat Liver - New Beneficial Effect of Lansoprazole

(2014) Yasunobu Yamashita et al.   PLoS One

Arsenic induces diabetic effects through beta-cell dysfunction and increased gluconeogenesis in mice

(2014) Su Liu et al.   Scientific Reports

Skeletal muscle as a target of LXR agonist after long-term treatment: focus on lipid homeostasis

(2013) Amena Archer et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

The chemistry and biological activities of N-acetylcysteine

(2013) Yuval Samuni et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Oral supplementation with glycine reduces oxidative stress in patients with metabolic syndrome, improving their systolic blood pressure

(2013) Margarita Díaz-Flores et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Potential Impact of Genetic Variants in Nrf2 Regulated Antioxidant Genes and Risk Prediction of Diabetes and Associated Cardiac Complications

(2013) T. Ramprasath et al.   CURRENT MEDICINAL CHEMISTRY

Targeting liver X receptors in inflammation

(2013) Knut R Steffensen et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Increased oxidative stress in obesity: Implications for metabolic syndrome, diabetes, hypertension, dyslipidemia, atherosclerosis, and cancer

(2013) Morihiro Matsuda et al.   Obesity Research & Clinical Practice

The Liver X Receptor Agonist T0901317 Protects Mice from High Fat Diet-Induced Obesity and Insulin Resistance

(2012) Mingming Gao et al.   AAPS Journal

Grape Polyphenols Prevent Fructose-Induced Oxidative Stress and Insulin Resistance in First-Degree Relatives of Type 2 Diabetic Patients

(2012) M. Hokayem et al.   DIABETES CARE

Inhibition of hepatic sulfatase-2 In Vivo: A novel strategy to correct diabetic dyslipidemia

(2012) H. Carlijne Hassing et al.   HEPATOLOGY

Pre-Diabetes, Metabolic Syndrome, and Cardiovascular Risk

(2012) Scott M. Grundy   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Liver X Receptor Agonist Alleviated High Glucose-Induced Endothelial Progenitor Cell Dysfunction via Inhibition of Reactive Oxygen Species and Activation of AMP-Activated Protein Kinase

(2012) XIAOXIA LI et al.   MICROCIRCULATION

Role of inhibitory κB kinase and c-Jun NH2-terminal kinase in the development of hepatic insulin resistance in critical illness diabetes

(2011) Shaoning Jiang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Diabetic Downregulation of Nrf2 Activity via ERK Contributes to Oxidative Stress-Induced Insulin Resistance in Cardiac Cells In Vitro and In Vivo

(2011) Y. Tan et al.   DIABETES

Fatty acids acutely enhance insulin-induced oxidative stress and cause insulin resistance by increasing mitochondrial reactive oxygen species (ROS) generation and nuclear factor-κB inhibitor (IκB)–nuclear factor-κB (NFκB) activation in rat muscle, in the absence of mitochondrial dysfunction

(2011) R. Barazzoni et al.   DIABETOLOGIA

Obesity, insulin resistance and free fatty acids

(2011) Guenther Boden   Current Opinion in Endocrinology Diabetes and Obesity

Molecular biology and functional genomics of liver X receptors (LXR) in relationship to metabolic diseases

(2010) Malin Hedengran Faulds et al.   CURRENT OPINION IN PHARMACOLOGY

Oltipraz upregulates the nuclear respiratory factor 2 alpha subunit (NRF2) antioxidant system and prevents insulin resistance and obesity induced by a high-fat diet in C57BL/6J mice

(2010) Z. Yu et al.   DIABETOLOGIA

mTORC1 activates SREBP-1c and uncouples lipogenesis from gluconeogenesis: Fig. 1.

(2010) Mathieu Laplante et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

LXRβ is the dominant LXR subtype in skeletal muscle regulating lipogenesis and cholesterol efflux

(2009) N. P. Hessvik et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Activation of the Liver X Receptor Prevents Lipopolysaccharide-induced Lung Injury

(2009) Haibiao Gong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Palmitate Induces Insulin Resistance in H4IIEC3 Hepatocytes through Reactive Oxygen Species Produced by Mitochondria

(2009) Seiji Nakamura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Selective versus Total Insulin Resistance: A Pathogenic Paradox

(2008) Michael S. Brown et al.   Cell Metabolism

Increased oxidative stress precedes the onset of high-fat diet–induced insulin resistance and obesity

(2008) Naoto Matsuzawa-Nagata et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes

(2008) Adilson Guilherme et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Dietary fats and prevention of type 2 diabetes

(2008) U RISERUS et al.   PROGRESS IN LIPID RESEARCH