Aspergillus fumigatus morphology and dynamic host interactions

A mast cell-ILC2-Th9 pathway promotes lung inflammation in cystic fibrosis

(2017) Silvia Moretti et al.   Nature Communications

Voriconazole-Susceptible and Voriconazole-ResistantAspergillus fumigatusCoinfection

(2016) Eva Kolwijck et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Calcineurin Orchestrates Lateral Transfer of Aspergillus fumigatus during Macrophage Cell Death

(2016) Anand Shah et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Melanin targets LC3-associated phagocytosis (LAP): A novel pathogenetic mechanism in fungal disease

(2016) Georgios Chamilos et al.   Autophagy

Regulatory T Cell Specificity Directs Tolerance versus Allergy against Aeroantigens in Humans

(2016) Petra Bacher et al.   CELL

Aspergillus Cell Wall Melanin Blocks LC3-Associated Phagocytosis to Promote Pathogenicity

(2016) Tonia Akoumianaki et al.   Cell Host & Microbe

Noncanonical Fungal Autophagy Inhibits Inflammation in Response to IFN-γ via DAPK1

(2016) Vasilis Oikonomou et al.   Cell Host & Microbe

Diverse Regulation of the CreA Carbon Catabolite Repressor in Aspergillus nidulans

(2016) Laure N. A. Ries et al.   GENETICS

Pulmonary Th17 Antifungal Immunity Is Regulated by the Gut Microbiome

(2016) Jeremy P. McAleer et al.   JOURNAL OF IMMUNOLOGY

The contribution of Aspergillus fumigatus stress responses to virulence and antifungal resistance

(2016) Neil A. Brown et al.   JOURNAL OF MICROBIOLOGY

Identification ofAspergillus fumigatusmultidrug transporter genes and their potential involvement in antifungal resistance

(2016) Isabelle Meneau et al.   MEDICAL MYCOLOGY

Broad defects in the energy metabolism of leukocytes underlie immunoparalysis in sepsis

(2016) Shih-Chin Cheng et al.   NATURE IMMUNOLOGY

Volatile Compounds Emitted by Pseudomonas aeruginosa Stimulate Growth of the Fungal Pathogen Aspergillus fumigatus

(2016) Benoit Briard et al.   mBio

Gliotoxin Suppresses Macrophage Immune Function by Subverting Phosphatidylinositol 3,4,5-Trisphosphate Homeostasis

(2016) Daniel Schlam et al.   mBio

Aspergillus Cell Wall Chitin Induces Anti- and Proinflammatory Cytokines in Human PBMCs via the Fc-γ Receptor/Syk/PI3K Pathway

(2016) K. L. Becker et al.   mBio

IL-1 receptor antagonist ameliorates inflammasome-dependent inflammation in murine and human cystic fibrosis

(2016) Rossana G. Iannitti et al.   Nature Communications

Reducing hypoxia and inflammation during invasive pulmonary aspergillosis by targeting the Interleukin-1 receptor

(2016) Mark S. Gresnigt et al.   Scientific Reports

Diverse Regulation of the CreA Carbon Catabolite Repressor in Aspergillus nidulans

(2016) Laure N. A. Ries et al.   GENETICS

Concerted Activation of the AIM2 and NLRP3 Inflammasomes Orchestrates Host Protection against Aspergillus Infection

(2015) Rajendra Karki et al.   Cell Host & Microbe

Pattern recognition pathways leading to a Th2 cytokine bias in allergic bronchopulmonary aspergillosis patients

(2015) K. L. Becker et al.   CLINICAL AND EXPERIMENTAL ALLERGY

PTX3Polymorphisms and Invasive Mold Infections After Solid Organ Transplant: Figure 1.

(2015) Agnieszka Wójtowicz et al.   CLINICAL INFECTIOUS DISEASES

Virulence determinants of the human pathogenic fungusAspergillus fumigatusprotect against soil amoeba predation

(2015) Falk Hillmann et al.   ENVIRONMENTAL MICROBIOLOGY

Human Neutrophils Use Different Mechanisms To KillAspergillus fumigatusConidia and Hyphae: Evidence from Phagocyte Defects

(2015) Roel P. Gazendam et al.   JOURNAL OF IMMUNOLOGY

High osmolarity glycerol response PtcB phosphatase is important forAspergillus fumigatusvirulence

(2015) Lizziane K. Winkelströter et al.   MOLECULAR MICROBIOLOGY

Nanoscale biophysical properties of the cell surface galactosaminogalactan from the fungal pathogen Aspergillus fumigatus

(2015) Audrey Beaussart et al.   Nanoscale

Molecular characterization of LC3-associated phagocytosis reveals distinct roles for Rubicon, NOX2 and autophagy proteins

(2015) Jennifer Martinez et al.   NATURE CELL BIOLOGY

Pseudomonas aeruginosa manipulates redox and iron homeostasis of its microbiota partner Aspergillus fumigatus via phenazines

(2015) Benoit Briard et al.   Scientific Reports

CD103+ Dendritic Cells Control Th17 Cell Function in the Lung

(2015) Teresa Zelante et al.   Cell Reports

Recognition of Aspergillus fumigatus Hyphae by Human Plasmacytoid Dendritic Cells Is Mediated by Dectin-2 and Results in Formation of Extracellular Traps

(2015) Flávio V. Loures et al.   PLoS Pathogens

The Fungal Exopolysaccharide Galactosaminogalactan Mediates Virulence by Enhancing Resistance to Neutrophil Extracellular Traps

(2015) Mark J. Lee et al.   PLoS Pathogens

Different Stress-Induced Calcium Signatures Are Reported by Aequorin-Mediated Calcium Measurements in Living Cells of Aspergillus fumigatus

(2015) Alberto Muñoz et al.   PLoS One

Interferon-gamma as adjunctive immunotherapy for invasive fungal infections: a case series

(2014) Corine E Delsing et al.   BMC INFECTIOUS DISEASES

Functional duality of the cell wall

(2014) Jean-Paul Latgé et al.   CURRENT OPINION IN MICROBIOLOGY

The Janus transcription factor HapX controls fungal adaptation to both iron starvation and iron excess

(2014) F. Gsaller et al.   EMBO JOURNAL

Induction of A. fumigatus-specific CD4-positive T cells in patients recovering from invasive aspergillosis

(2014) H. Jolink et al.   HAEMATOLOGICA

Distinct and complementary roles for Aspergillus fumigatus -specific Tr1 and Foxp3+ regulatory T cells in humans and mice

(2014) Tanja Bedke et al.   IMMUNOLOGY AND CELL BIOLOGY

NADPH Oxidase Promotes Neutrophil Extracellular Trap Formation in Pulmonary Aspergillosis

(2014) Marc Röhm et al.   INFECTION AND IMMUNITY

A Polysaccharide Virulence Factor of a Human Fungal Pathogen Induces Neutrophil Apoptosis via NK Cells

(2014) P. Robinet et al.   JOURNAL OF IMMUNOLOGY

Identification of Immunogenic Antigens fromAspergillus fumigatusby Direct Multiparameter Characterization of Specific Conventional and Regulatory CD4+T Cells

(2014) Petra Bacher et al.   JOURNAL OF IMMUNOLOGY

Multispecific Aspergillus T Cells Selected by CD137 or CD154 Induce Protective Immune Responses Against the Most Relevant Mold Infections

(2014) Claudia Stuehler et al.   JOURNAL OF INFECTIOUS DISEASES

Aspergillus Cell Wall and Biofilm

(2014) Anne Beauvais et al.   MYCOPATHOLOGIA

Neutrophils sense microbe size and selectively release neutrophil extracellular traps in response to large pathogens

(2014) Nora Branzk et al.   NATURE IMMUNOLOGY

Genetic PTX3 Deficiency and Aspergillosis in Stem-Cell Transplantation

(2014) Cristina Cunha et al.   NEW ENGLAND JOURNAL OF MEDICINE

Bioengineering T cells to target carbohydrate to treat opportunistic fungal infection

(2014) P. R. Kumaresan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IL-1 receptor blockade restores autophagy and reduces inflammation in chronic granulomatous disease in mice and in humans

(2014) Antonella de Luca et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antifungal innate immunity: recognition and inflammatory networks

(2014) Katharina L. Becker et al.   Seminars in Immunopathology

IL-37 Inhibits Inflammasome Activation and Disease Severity in Murine Aspergillosis

(2014) Silvia Moretti et al.   PLoS Pathogens

A Polysaccharide Virulence Factor from Aspergillus fumigatus Elicits Anti-inflammatory Effects through Induction of Interleukin-1 Receptor Antagonist

(2014) Mark S. Gresnigt et al.   PLoS Pathogens

ChIP-seq and In Vivo Transcriptome Analyses of the Aspergillus fumigatus SREBP SrbA Reveals a New Regulator of the Fungal Hypoxia Response and Virulence

(2014) Dawoon Chung et al.   PLoS Pathogens

Population-Based Survey of Filamentous Fungi and Antifungal Resistance in Spain (FILPOP Study)

(2013) A. Alastruey-Izquierdo et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The ZrfC alkaline zinc transporter is required forAspergillus fumigatusvirulence and its growth in the presence of the Zn/Mn-chelating protein calprotectin

(2013) Jorge Amich et al.   CELLULAR MICROBIOLOGY

Immunotherapy in Invasive Fungal Infection - Focus on Invasive Aspergillosis

(2013) Thomas Lehrnbecher et al.   CURRENT PHARMACEUTICAL DESIGN

Adhesins in Human Fungal Pathogens: Glue with Plenty of Stick

(2013) Piet W. J. de Groot et al.   EUKARYOTIC CELL

Corticosteroids Block Autophagy Protein Recruitment in Aspergillus fumigatus Phagosomes via Targeting Dectin-1/Syk Kinase Signaling

(2013) I. Kyrmizi et al.   JOURNAL OF IMMUNOLOGY

The RodA Hydrophobin on Aspergillus fumigatus Spores Masks Dectin-1- and Dectin-2-Dependent Responses and Enhances Fungal Survival In Vivo

(2013) S. d. J. Carrion et al.   JOURNAL OF IMMUNOLOGY

Aspergillus fumigatus-Induced IL-22 Is Not Restricted to a Specific Th Cell Subset and Is Dependent on Complement Receptor 3

(2013) M. S. Gresnigt et al.   JOURNAL OF IMMUNOLOGY

Activation of neutrophils by autocrine IL-17A–IL-17RC interactions during fungal infection is regulated by IL-6, IL-23, RORγt and dectin-2

(2013) Patricia R Taylor et al.   NATURE IMMUNOLOGY

Interaction ofAspergillus fumigatusconidia withAcanthamoeba castellaniiparallels macrophage-fungus interactions

(2013) Lieven Van Waeyenberghe et al.   Environmental Microbiology Reports

Aspergillus Galactosaminogalactan Mediates Adherence to Host Constituents and Conceals Hyphal β-Glucan from the Immune System

(2013) Fabrice N. Gravelat et al.   PLoS Pathogens

Aspergillus fumigatus—What Makes the Species a Ubiquitous Human Fungal Pathogen?

(2013) Kyung J. Kwon-Chung et al.   PLoS Pathogens

Deletion of the α-(1,3)-Glucan Synthase Genes Induces a Restructuring of the Conidial Cell Wall Responsible for the Avirulence of Aspergillus fumigatus

(2013) Anne Beauvais et al.   PLoS Pathogens

Pattern recognition receptors and their role in invasive aspergillosis

(2012) Mark S. Gresnigt et al.   Annals of the New York Academy of Sciences

Transcriptomic and proteomic analyses of the Aspergillus fumigatus hypoxia response using an oxygen-controlled fermenter

(2012) Bridget M Barker et al.   BMC GENOMICS

Dsc Orthologs Are Required for Hypoxia Adaptation, Triazole Drug Responses, and Fungal Virulence in Aspergillus fumigatus

(2012) Sven D. Willger et al.   EUKARYOTIC CELL

Dectin-1-triggered Recruitment of Light Chain 3 Protein to Phagosomes Facilitates Major Histocompatibility Complex Class II Presentation of Fungal-derived Antigens

(2012) Jun Ma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CD4+ T cell vaccination overcomes defective cross-presentation of fungal antigens in a mouse model of chronic granulomatous disease

(2012) Antonella De Luca et al.   JOURNAL OF CLINICAL INVESTIGATION

Species-Specific Recognition of Aspergillus fumigatus by Toll-like Receptor 1 and Toll-like Receptor 6

(2012) Ivana Rubino et al.   JOURNAL OF INFECTIOUS DISEASES

Aspergillus fumigatusmitochondrial electron transport chain mediates oxidative stress homeostasis, hypoxia responses and fungal pathogenesis

(2012) Nora Grahl et al.   MOLECULAR MICROBIOLOGY

Hidden Killers: Human Fungal Infections

(2012) G. D. Brown et al.   Science Translational Medicine

Sensing of mammalian IL-17A regulates fungal adaptation and virulence

(2012) Teresa Zelante et al.   Nature Communications

Iron – A Key Nexus in the Virulence of Aspergillus fumigatus

(2012) Hubertus Haas   Frontiers in Microbiology

TLR3 essentially promotes protective class I-restricted memory CD8+ T-cell responses to Aspergillus fumigatus in hematopoietic transplanted patients

(2011) A. Carvalho et al.   BLOOD

Molecular mechanism of Aspergillus fumigatus adherence to host constituents

(2011) Donald C Sheppard   CURRENT OPINION IN MICROBIOLOGY

Dectin-1-Dependent Interleukin-22 Contributes to Early Innate Lung Defense against Aspergillus fumigatus

(2011) Melissa A. Gessner et al.   INFECTION AND IMMUNITY

Shaping the fungal adaptome – Stress responses of Aspergillus fumigatus

(2011) Thomas Hartmann et al.   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

Identification and Characterization of an Aspergillus fumigatus "Supermater" Pair

(2011) J. A. Sugui et al.   mBio

In vivo Hypoxia and a Fungal Alcohol Dehydrogenase Influence the Pathogenesis of Invasive Pulmonary Aspergillosis

(2011) Nora Grahl et al.   PLoS Pathogens

Galactosaminogalactan, a New Immunosuppressive Polysaccharide of Aspergillus fumigatus

(2011) Thierry Fontaine et al.   PLoS Pathogens

Profiling theAspergillus fumigatusProteome in Response to Caspofungin

(2010) Steven E. Cagas et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Role of complement and Fc  receptors in the protective activity of the long pentraxin PTX3 against Aspergillus fumigatus

(2010) F. Moalli et al.   BLOOD

In vivo bioluminescence imaging and histopathopathologic analysis reveal distinct roles for resident and recruited immune effector cells in defense against invasive aspergillosis

(2010) Oumaïma Ibrahim-Granet et al.   BMC MICROBIOLOGY

Dectin-2 Recognition of α-Mannans and Induction of Th17 Cell Differentiation Is Essential for Host Defense against Candida albicans

(2010) Shinobu Saijo et al.   IMMUNITY

Vitamin D3 attenuates Th2 responses to Aspergillus fumigatus mounted by CD4+ T cells from cystic fibrosis patients with allergic bronchopulmonary aspergillosis

(2010) James L. Kreindler et al.   JOURNAL OF CLINICAL INVESTIGATION

Inhibition of neutrophil function following exposure to the Aspergillus fumigatus toxin fumagillin

(2010) J. P. Fallon et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Aspergillusspecies intrinsically resistant to antifungal agents

(2010) Jan W. M. Van Der Linden et al.   MEDICAL MYCOLOGY

NETs formed by human neutrophils inhibit growth of the pathogenic mold Aspergillus fumigatus

(2010) Allison McCormick et al.   MICROBES AND INFECTION

Divergent Protein Kinase A isoforms co-ordinately regulate conidial germination, carbohydrate metabolism and virulence in Aspergillus fumigatus

(2010) Kevin K. Fuller et al.   MOLECULAR MICROBIOLOGY

Aspergillus fumigatus Stimulates the NLRP3 Inflammasome through a Pathway Requiring ROS Production and the Syk Tyrosine Kinase

(2010) Najwane Saïd-Sadier et al.   PLoS One

Fungal hydrophobins form a sheath preventing immune recognition of airborne conidia

(2010) Vishukumar Aimanianda et al.   Virulence

HapX-Mediated Adaption to Iron Starvation Is Crucial for Virulence of Aspergillus fumigatus

(2010) Markus Schrettl et al.   PLoS Pathogens

Production of Extracellular Traps against Aspergillus fumigatus In Vitro and in Infected Lung Tissue Is Dependent on Invading Neutrophils and Influenced by Hydrophobin RodA

(2010) Sandra Bruns et al.   PLoS Pathogens

Restoration of NET formation by gene therapy in CGD controls aspergillosis

(2009) M. Bianchi et al.   BLOOD

Aspergillus fumigatus inhibits angiogenesis through the production of gliotoxin and other secondary metabolites

(2009) R. Ben-Ami et al.   BLOOD

In vivobiofilm composition ofAspergillus fumigatus

(2009) Céline Loussert et al.   CELLULAR MICROBIOLOGY

Aspergillus fumigatus Conidial Melanin Modulates Host Cytokine Response

(2009) Louis Y.A. Chai et al.   IMMUNOBIOLOGY

Anti-Aspergillushuman host defence relies on type 1 T helper (Th1), rather than type 17 T helper (Th17), cellular immunity

(2009) Louis Y. A. Chai et al.   IMMUNOLOGY

Exogenous Pentraxin 3 Restores Antifungal Resistance and Restrains Inflammation in Murine Chronic Granulomatous Disease

(2009) C. D'Angelo et al.   JOURNAL OF IMMUNOLOGY

Requisite Role for the Dectin-1  -Glucan Receptor in Pulmonary Defense against Aspergillus fumigatus

(2009) J. L. Werner et al.   JOURNAL OF IMMUNOLOGY

Surface hydrophobin prevents immune recognition of airborne fungal spores

(2009) Vishukumar Aimanianda et al.   NATURE

Aspergillus fumigatus: virulence genes in a street-smart mold

(2008) David S Askew   CURRENT OPINION IN MICROBIOLOGY

SreA-mediated iron regulation in Aspergillus fumigatus

(2008) Markus Schrettl et al.   MOLECULAR MICROBIOLOGY

Discovery of a sexual cycle in the opportunistic fungal pathogen Aspergillus fumigatus

(2008) Céline M. O’Gorman et al.   NATURE

Emergence of Azole Resistance in Aspergillus fumigatus and Spread of a Single Resistance Mechanism

(2008) Eveline Snelders et al.   PLOS MEDICINE

Sub-Telomere Directed Gene Expression during Initiation of Invasive Aspergillosis

(2008) Andrew McDonagh et al.   PLoS Pathogens

A Sterol-Regulatory Element Binding Protein Is Required for Cell Polarity, Hypoxia Adaptation, Azole Drug Resistance, and Virulence in Aspergillus fumigatus

(2008) Sven D. Willger et al.   PLoS Pathogens

Invasive pulmonary aspergillosis in neutropenic patients and the influence of hospital renovation

(2007) Gabriella Pini et al.   MYCOSES