Reducing hypoxia and inflammation during invasive pulmonary aspergillosis by targeting the Interleukin-1 receptor

Hypoxic Epithelial Necrosis Triggers Neutrophilic Inflammation via IL-1 Receptor Signaling in Cystic Fibrosis Lung Disease

(2015) Benedikt Fritzsching et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

SnapShot: Hypoxia-Inducible Factors

(2015) Kyoung Eun Lee et al.   CELL

IL-1 receptor antagonist reduces endotoxin-induced airway inflammation in healthy volunteers

(2015) Michelle L. Hernandez et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Interferon-gamma Immunotherapy in a Patient With Refractory Disseminated Candidiasis

(2015) Emilie P. Buddingh et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

IL-1α Signaling Is Critical for Leukocyte Recruitment after Pulmonary Aspergillus fumigatus Challenge

(2015) Alayna K. Caffrey et al.   PLoS Pathogens

Compartment-Specific and Sequential Role of MyD88 and CARD9 in Chemokine Induction and Innate Defense during Respiratory Fungal Infection

(2015) Anupam Jhingran et al.   PLoS Pathogens

Interferon-gamma as adjunctive immunotherapy for invasive fungal infections: a case series

(2014) Corine E Delsing et al.   BMC INFECTIOUS DISEASES

Immunotherapy

(2014) Bart-Jan Kullberg et al.   CURRENT OPINION IN INFECTIOUS DISEASES

Two C4-sterol methyl oxidases (Erg25) catalyse ergosterol intermediate demethylation and impact environmental stress adaptation in Aspergillus fumigatus

(2014) S. J. Blosser et al.   MICROBIOLOGY-SGM

IL-1 receptor blockade restores autophagy and reduces inflammation in chronic granulomatous disease in mice and in humans

(2014) Antonella de Luca et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Myeloid Derived Hypoxia Inducible Factor 1-alpha Is Required for Protection against Pulmonary Aspergillus fumigatus Infection

(2014) Kelly M. Shepardson et al.   PLoS Pathogens

ChIP-seq and In Vivo Transcriptome Analyses of the Aspergillus fumigatus SREBP SrbA Reveals a New Regulator of the Fungal Hypoxia Response and Virulence

(2014) Dawoon Chung et al.   PLoS Pathogens

Th17/Treg Imbalance in Murine Cystic Fibrosis Is Linked to Indoleamine 2,3-Dioxygenase Deficiency but Corrected by Kynurenines

(2013) Rossana G. Iannitti et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Hypoxia-Induced Inflammation in the Lung

(2013) Stephen Fröhlich et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Assessment of Efficacy of Antifungals against Aspergillus fumigatus: Value of Real-Time Bioluminescence Imaging

(2013) Célimène Galiger et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Immunotherapy in Invasive Fungal Infection - Focus on Invasive Aspergillosis

(2013) Thomas Lehrnbecher et al.   CURRENT PHARMACEUTICAL DESIGN

Aspergillus fumigatus Invasion Increases with Progressive Airway Ischemia

(2013) Joe L. Hsu et al.   PLoS One

The Interleukin-1α Precursor is Biologically Active and is Likely a Key Alarmin in the IL-1 Family of Cytokines

(2013) Busun Kim et al.   Frontiers in Immunology

Inflammation in aspergillosis: the good, the bad, and the therapeutic

(2012) Agostinho Carvalho et al.   Annals of the New York Academy of Sciences

Dsc Orthologs Are Required for Hypoxia Adaptation, Triazole Drug Responses, and Fungal Virulence in Aspergillus fumigatus

(2012) Sven D. Willger et al.   EUKARYOTIC CELL

Fungi and allergic lower respiratory tract diseases

(2012) Alan P. Knutsen et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Aspergillus fumigatusmitochondrial electron transport chain mediates oxidative stress homeostasis, hypoxia responses and fungal pathogenesis

(2012) Nora Grahl et al.   MOLECULAR MICROBIOLOGY

Treating inflammation by blocking interleukin-1 in a broad spectrum of diseases

(2012) Charles A. Dinarello et al.   NATURE REVIEWS DRUG DISCOVERY

In Vivo Imaging and Quantification of Carbonic Anhydrase IX Expression as an Endogenous Biomarker of Tumor Hypoxia

(2012) Bagna Bao et al.   PLoS One

Hidden Killers: Human Fungal Infections

(2012) G. D. Brown et al.   Science Translational Medicine

The transcription of the alarmin cytokine interleukin-1 alpha is controlled by hypoxia inducible factors 1 and 2 alpha in hypoxic cells

(2012) Peleg Rider et al.   Frontiers in Immunology

Targeting Tumor Hypoxia: Suppression of Breast Tumor Growth and Metastasis by Novel Carbonic Anhydrase IX Inhibitors

(2011) Y. Lou et al.   CANCER RESEARCH

Allergic Bronchopulmonary Aspergillosis in Asthma and Cystic Fibrosis

(2011) Alan P. Knutsen et al.   Clinical & Developmental Immunology

Hypoxia and Inflammation

(2011) Holger K. Eltzschig et al.   NEW ENGLAND JOURNAL OF MEDICINE

In vivo Hypoxia and a Fungal Alcohol Dehydrogenase Influence the Pathogenesis of Invasive Pulmonary Aspergillosis

(2011) Nora Grahl et al.   PLoS Pathogens

Inflammasome activation in NADPH oxidase defective mononuclear phagocytes from patients with chronic granulomatous disease

(2010) F. Meissner et al.   BLOOD

Human NLRP3 inflammasome activation is Nox1-4 independent

(2010) R. van Bruggen et al.   BLOOD

In vivo bioluminescence imaging and histopathopathologic analysis reveal distinct roles for resident and recruited immune effector cells in defense against invasive aspergillosis

(2010) Oumaïma Ibrahim-Granet et al.   BMC MICROBIOLOGY

Prospective Surveillance for Invasive Fungal Infections in Hematopoietic Stem Cell Transplant Recipients, 2001–2006: Overview of the Transplant‐Associated Infection Surveillance Network (TRANSNET) Database

(2010) Dimitrios P. Kontoyiannis et al.   CLINICAL INFECTIOUS DISEASES

Carbonic Anhydrase IX as an Anticancer Therapy Target: Preclinical Evaluation of Internalizing Monoclonal Antibody Directed to Catalytic Domain

(2010) M. Zatovicova et al.   CURRENT PHARMACEUTICAL DESIGN

Vitamin D3 attenuates Th2 responses to Aspergillus fumigatus mounted by CD4+ T cells from cystic fibrosis patients with allergic bronchopulmonary aspergillosis

(2010) James L. Kreindler et al.   JOURNAL OF CLINICAL INVESTIGATION

Reactive oxygen species-independent activation of the IL-1  inflammasome in cells from patients with chronic granulomatous disease

(2010) F. L. van de Veerdonk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hypoxia and metabolic phenotypes during breast carcinogenesis: expression of HIF-1α, GLUT1, and CAIX

(2010) Chi-Long Chen et al.   VIRCHOWS ARCHIV

Aspergillus fumigatus inhibits angiogenesis through the production of gliotoxin and other secondary metabolites

(2009) R. Ben-Ami et al.   BLOOD

Essential Role for Neutrophils but not Alveolar Macrophages at Early Time Points followingAspergillus fumigatusInfection

(2009) Monica M. Mircescu et al.   JOURNAL OF INFECTIOUS DISEASES

Bioluminescent Aspergillus fumigatus, a New Tool for Drug Efficiency Testing and In Vivo Monitoring of Invasive Aspergillosis

(2008) M. Brock et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Epidemiology of Invasive Mold Infections in Allogeneic Stem Cell Transplant Recipients: Biological Risk Factors for Infection According to Time after Transplantation

(2008) Carol Garcia‐Vidal et al.   CLINICAL INFECTIOUS DISEASES

Invasive aspergillosis in glucocorticoid-treated patients

(2008) Russell E. Lewis et al.   MEDICAL MYCOLOGY

Real-time luminescence monitoring of cell-cycle and respiratory oscillations in yeast

(2008) J. B. Robertson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hyperinflammation in chronic granulomatous disease and anti-inflammatory role of the phagocyte NADPH oxidase

(2008) Michela G. Schäppi et al.   Seminars in Immunopathology

A Sterol-Regulatory Element Binding Protein Is Required for Cell Polarity, Hypoxia Adaptation, Azole Drug Resistance, and Virulence in Aspergillus fumigatus

(2008) Sven D. Willger et al.   PLoS Pathogens