Protein tyrosine phosphatases as potential therapeutic targets

Phosphatase of regenerating liver: a novel target for cancer therapy

(2014) Amanda M Campbell et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

PRL2/PTP4A2 Phosphatase Is Important for Hematopoietic Stem Cell Self-Renewal

(2014) Michihiro Kobayashi et al.   STEM CELLS

Kinase Drug Discovery – What’s Next in the Field?

(2013) Philip Cohen et al.   ACS Chemical Biology

Targeting SHP2 for EGFR inhibitor resistant non-small cell lung carcinoma

(2013) Jie Xu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Anti-CD45 radioimmunotherapy using 211At with bone marrow transplantation prolongs survival in a disseminated murine leukemia model

(2013) J. J. Orozco et al.   BLOOD

Roles of the protein tyrosine phosphatase PTPN22 in immunity and autoimmunity

(2013) Georgia Fousteri et al.   CLINICAL IMMUNOLOGY

A novel single nucleotide polymorphism in the protein tyrosine phosphatase N22 gene (PTPN22) is associated with Type 1 diabetes in a Chinese population

(2013) Z. Pei et al.   DIABETIC MEDICINE

Phosphatase of Regenerating Liver 2 (PRL2) Deficiency Impairs Kit Signaling and Spermatogenesis

(2013) Yuanshu Dong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metastasis-associated PRL-3 induces EGFR activation and addiction in cancer cells

(2013) Abdul Qader Omer Al-aidaroos et al.   JOURNAL OF CLINICAL INVESTIGATION

Identification of Cryptotanshinone as an Inhibitor of Oncogenic Protein Tyrosine Phosphatase SHP2 (PTPN11)

(2013) Wei Liu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Overexpression of PTP1B in human colorectal cancer and its association with tumor progression and prognosis

(2013) Queting Chen et al.   JOURNAL OF MOLECULAR HISTOLOGY

Phosphatase of Regenerating Liver 3 (PRL3) Provokes a Tyrosine Phosphoproteome to Drive Prometastatic Signal Transduction

(2013) Chad D. Walls et al.   MOLECULAR & CELLULAR PROTEOMICS

Targeting Protein Tyrosine Phosphatase SHP2 for the Treatment of PTPN11-Associated Malignancies

(2013) B. Yu et al.   MOLECULAR CANCER THERAPEUTICS

Irreversible kinase inhibitors gain traction

(2013) Katharine Sanderson   NATURE REVIEWS DRUG DISCOVERY

The Differential Regulation of p38α by the Neuronal Kinase Interaction Motif Protein Tyrosine Phosphatases, a Detailed Molecular Study

(2013) Dana May Francis et al.   STRUCTURE

Role of SHP2 phosphatase in KIT-induced transformation: identification of SHP2 as a druggable target in diseases involving oncogenic KIT

(2012) R. S. Mali et al.   BLOOD

Diversity and specificity of the mitogen-activated protein kinase phosphatase-1 functions

(2012) Ahmed Lawan et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Small molecule tools for functional interrogation of protein tyrosine phosphatases

(2012) Rongjun He et al.   FEBS Journal

Molecular mechanisms of the PRL phosphatases

(2012) Pablo Rios et al.   FEBS Journal

Protein tyrosine phosphatases - from housekeeping enzymes to master regulators of signal transduction

(2012) Nicholas K. Tonks   FEBS Journal

Phosphatase of Regenerating Liver 2 (PRL2) Is Essential for Placental Development by Down-regulating PTEN (Phosphatase and Tensin Homologue Deleted on Chromosome 10) and Activating Akt Protein

(2012) Yuanshu Dong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Irreversible Protein Kinase Inhibitors: Balancing the Benefits and Risks

(2012) Tjeerd Barf et al.   JOURNAL OF MEDICINAL CHEMISTRY

LYP inhibits T-cell activation when dissociated from CSK

(2012) Torkel Vang et al.   Nature Chemical Biology

Tyrosine phosphatase SHP2 promotes breast cancer progression and maintains tumor-initiating cells via activation of key transcription factors and a positive feedback signaling loop

(2012) Nicola Aceto et al.   NATURE MEDICINE

The tyrosine phosphatase STEP: implications in schizophrenia and the molecular mechanism underlying antipsychotic medications

(2012) N C Carty et al.   Translational Psychiatry

Anti-CD45 pretargeted radioimmunotherapy using bismuth-213: high rates of complete remission and long-term survival in a mouse myeloid leukemia xenograft model

(2011) J. M. Pagel et al.   BLOOD

Let-7 and miR-200 microRNAs: Guardians against pluripotency and cancer progression

(2011) Marcus E. Peter   CELL CYCLE

Discovery of a Novel Series of Inhibitors of Lymphoid Tyrosine Phosphatase with Activity in Human T Cells

(2011) Stephanie M. Stanford et al.   JOURNAL OF MEDICINAL CHEMISTRY

The autoimmune disease–associated PTPN22 variant promotes calpain-mediated Lyp/Pep degradation associated with lymphocyte and dendritic cell hyperresponsiveness

(2011) Jinyi Zhang et al.   NATURE GENETICS

Metastasis-associated phosphatase PRL-2 regulates tumor cell migration and invasion

(2011) Y Wang et al.   ONCOGENE

Alcohol inhibition of the NMDA receptor function, long-term potentiation, and fear learning requires striatal-enriched protein tyrosine phosphatase

(2011) T. R. Hicklin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Overexpression of the Protein Tyrosine Phosphatase PRL-2 Correlates with Breast Tumor Formation and Progression

(2010) S. Hardy et al.   CANCER RESEARCH

The role of STEP in Alzheimer's disease

(2010) Pradeep Kurup et al.   Channels

Salicylic Acid Based Small Molecule Inhibitor for the Oncogenic Src Homology-2 Domain Containing Protein Tyrosine Phosphatase-2 (SHP2)

(2010) Xian Zhang et al.   JOURNAL OF MEDICINAL CHEMISTRY

A -Mediated NMDA Receptor Endocytosis in Alzheimer's Disease Involves Ubiquitination of the Tyrosine Phosphatase STEP61

(2010) P. Kurup et al.   JOURNAL OF NEUROSCIENCE

Mkp1 Is a c-Jun Target Gene That Antagonizes JNK-Dependent Apoptosis in Sympathetic Neurons

(2010) M. Kristiansen et al.   JOURNAL OF NEUROSCIENCE

Phosphatase of Regenerating Liver-1 Promotes Cell Migration and Invasion and Regulates Filamentous Actin Dynamics

(2010) M. Nakashima et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

mir-200c Regulates Induction of Apoptosis through CD95 by Targeting FAP-1

(2010) Robert Schickel et al.   MOLECULAR CELL

A negative regulator of MAP kinase causes depressive behavior

(2010) Vanja Duric et al.   NATURE MEDICINE

The MAP kinase phosphatase MKP-1 regulates BDNF-induced axon branching

(2010) Freddy Jeanneteau et al.   NATURE NEUROSCIENCE

PRL1 Promotes Cell Migration and Invasion by Increasing MMP2 and MMP9 Expression through Src and ERK1/2 Pathways†

(2009) Yong Luo et al.   BIOCHEMISTRY

The two faces of PTP1B in cancer

(2009) Laurent Lessard et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Leukemogenic Ptpn11 causes fatal myeloproliferative disorder via cell-autonomous effects on multiple stages of hematopoiesis

(2009) G. Chan et al.   BLOOD

Mitogen-Activated Protein Kinase Phosphatase-1 in Human Breast Cancer Independently Predicts Prognosis and Is Repressed by Doxorubicin

(2009) F. Rojo et al.   CLINICAL CANCER RESEARCH

Recent Advances in the Discovery of Competitive Protein Tyrosine Phosphatase 1B Inhibitors for the Treatment of Diabetes, Obesity, and Cancer

(2009) Andrew P. Combs   JOURNAL OF MEDICINAL CHEMISTRY

Downregulation of p53 by phosphatase of regenerating liver 3 is mediated by MDM2 and PIRH2

(2009) Sang-Hyun Min et al.   LIFE SCIENCES

PRL-3 promotes the motility, invasion, and metastasis of LoVo colon cancer cells through PRL-3-integrin β1-ERK1/2 and-MMP2 signaling

(2009) Lirong Peng et al.   Molecular Cancer

Modulation of STAT5 Interaction with LMW-PTP during Early Megakaryocyte Differentiation

(2008) Stefania Rigacci et al.   BIOCHEMISTRY

The p38α mitogen-activated protein kinase as a central nervous system drug discovery target

(2008) Aaron S Borders et al.   BMC NEUROSCIENCE

The tyrosine phosphatase Shp2 (PTPN11) in cancer

(2008) Gordon Chan et al.   CANCER AND METASTASIS REVIEWS

PTPL1: a large phosphatase with a split personality

(2008) Ogan D. Abaan et al.   CANCER AND METASTASIS REVIEWS

PRL PTPs: mediators and markers of cancer progression

(2008) Darrell C. Bessette et al.   CANCER AND METASTASIS REVIEWS

Dual-specificity MAP kinase phosphatases (MKPs) and cancer

(2008) Stephen M. Keyse   CANCER AND METASTASIS REVIEWS

Modulation of Src Activity by Low Molecular Weight Protein Tyrosine Phosphatase During Osteoblast Differentiation

(2008) Willian F. Zambuzzi et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Activating PTPN11 mutants promote hematopoietic progenitor cell-cycle progression and survival

(2008) Zhenyun Yang et al.   EXPERIMENTAL HEMATOLOGY

Gold(I)-Mediated Inhibition of Protein Tyrosine Phosphatases: A Detailed in Vitro and Cellular Study

(2008) Divya Krishnamurthy et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Tyrosine Phosphatase STEP Mediates AMPA Receptor Endocytosis after Metabotropic Glutamate Receptor Stimulation

(2008) Y. Zhang et al.   JOURNAL OF NEUROSCIENCE

Small interfering RNA-mediated knockdown of PRL phosphatases results in altered Akt phosphorylation and reduced clonogenicity of pancreatic cancer cells

(2008) B. Stephens et al.   MOLECULAR CANCER THERAPEUTICS

The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1

(2008) Philip A. Gregory et al.   NATURE CELL BIOLOGY

Isolation of a distinct class of gain-of-function SHP-2 mutants with oncogenic RAS-like transforming activity from solid tumors

(2008) D Miyamoto et al.   ONCOGENE

New p53 target, phosphatase of regenerating liver 1 (PRL-1) downregulates p53

(2008) S-H Min et al.   ONCOGENE

Knockout of STriatal enriched protein tyrosine phosphatase in mice results in increased ERK1/2 phosphorylation

(2008) Deepa V. Venkitaramani et al.   SYNAPSE