Do not judge a cell by its cover—diversity of CNS resident, adjoining and infiltrating myeloid cells in inflammation

Induction of endogenous Type I interferon within the central nervous system plays a protective role in experimental autoimmune encephalomyelitis

(2015) Reza Khorooshi et al.   ACTA NEUROPATHOLOGICA

Dynamic Changes of Microglia/Macrophage M1 and M2 Polarization in Theiler's Murine Encephalomyelitis

(2015) Vanessa Herder et al.   BRAIN PATHOLOGY

Advances in the immunopathogenesis of multiple sclerosis

(2015) Sudhir K. Yadav et al.   CURRENT OPINION IN NEUROLOGY

USP18 lack in microglia causes destructive interferonopathy of the mouse brain

(2015) T. Goldmann et al.   EMBO JOURNAL

Dynamic changes in meningeal inflammation correspond to clinical exacerbations in a murine model of relapsing–remitting multiple sclerosis

(2015) Margaret E. Walker-Caulfield et al.   JOURNAL OF NEUROIMMUNOLOGY

Immunization with a Myelin-Derived Antigen Activates the Brain's Choroid Plexus for Recruitment of Immunoregulatory Cells to the CNS and Attenuates Disease Progression in a Mouse Model of ALS

(2015) G. Kunis et al.   JOURNAL OF NEUROSCIENCE

Extensive grey matter pathology in the cerebellum in multiple sclerosis is linked to inflammation in the subarachnoid space

(2015) Owain W. Howell et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Cell types in the mouse cortex and hippocampus revealed by single-cell RNA-seq

(2015) A. Zeisel et al.   SCIENCE

Development of the choroid plexus and blood-CSF barrier

(2015) Shane A. Liddelow   Frontiers in Neuroscience

IFNβ secreted by microglia mediates clearance of myelin debris in CNS autoimmunity

(2015) Magdalena Kocur et al.   Acta Neuropathologica Communications

Microglia: unique and common features with other tissue macrophages

(2014) Marco Prinz et al.   ACTA NEUROPATHOLOGICA

Macrophage subsets and microglia in multiple sclerosis

(2014) Jeroen F. J. Bogie et al.   ACTA NEUROPATHOLOGICA

Transcription and enhancer profiling in human monocyte subsets

(2014) C. Schmidl et al.   BLOOD

In acute experimental autoimmune encephalomyelitis, infiltrating macrophages are immune activated, whereas microglia remain immune suppressed

(2014) I. D. Vainchtein et al.   GLIA

Genetic targeting of microglia

(2014) Peter Wieghofer et al.   GLIA

Embryonic and Adult-Derived Resident Cardiac Macrophages Are Maintained through Distinct Mechanisms at Steady State and during Inflammation

(2014) Slava Epelman et al.   IMMUNITY

Origin and Functions of Tissue Macrophages

(2014) Slava Epelman et al.   IMMUNITY

A macrophage revolution-and beyond

(2014) Gwendalyn J. Randolph   IMMUNOLOGICAL REVIEWS

Macrophages: A double-edged sword in experimental autoimmune encephalomyelitis

(2014) Zhilong Jiang et al.   IMMUNOLOGY LETTERS

Antiviral drug ganciclovir is a potent inhibitor of microglial proliferation and neuroinflammation

(2014) Zhaoqing Ding et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Progressive replacement of embryo-derived cardiac macrophages with age

(2014) Kaaweh Molawi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Differential roles of microglia and monocytes in the inflamed central nervous system

(2014) Ryo Yamasaki et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Macrophages and CNS remyelination

(2014) Veronique E. Miron et al.   JOURNAL OF NEUROCHEMISTRY

Expression of the Mannose Receptor CD206 in HIV and SIV Encephalitis: A Phenotypic Switch of Brain Perivascular Macrophages with Virus Infection

(2014) Gerard E. Holder et al.   Journal of Neuroimmune Pharmacology

RNA sequencing of microglia and monocyte-derived macrophages from mice with experimental autoimmune encephalomyelitis illustrates a changing phenotype with disease course

(2014) Nuruddeen D. Lewis et al.   JOURNAL OF NEUROIMMUNOLOGY

Mapping the accumulation of co-infiltrating CNS dendritic cells and encephalitogenic T cells during EAE

(2014) Benjamin D. Clarkson et al.   JOURNAL OF NEUROIMMUNOLOGY

Comparison of microglia and infiltrating CD11c+ cells as antigen presenting cells for T cell proliferation and cytokine response

(2014) Agnieszka Wlodarczyk et al.   Journal of Neuroinflammation

Conditional Ablation of Astroglial CCL2 Suppresses CNS Accumulation of M1 Macrophages and Preserves Axons in Mice with MOG Peptide EAE

(2014) M. Moreno et al.   JOURNAL OF NEUROSCIENCE

Constant replenishment from circulating monocytes maintains the macrophage pool in the intestine of adult mice

(2014) Calum C Bain et al.   NATURE IMMUNOLOGY

Deficient neuron-microglia signaling results in impaired functional brain connectivity and social behavior

(2014) Yang Zhan et al.   NATURE NEUROSCIENCE

Microglia and brain macrophages in the molecular age: from origin to neuropsychiatric disease

(2014) Marco Prinz et al.   NATURE REVIEWS NEUROSCIENCE

Macrophages in cardiac homeostasis, injury responses and progenitor cell mobilisation

(2014) Alexander R. Pinto et al.   Stem Cell Research

Microglial diversity by responses and responders

(2014) Ulla Gertig et al.   Frontiers in Cellular Neuroscience

Nr4a1-Dependent Ly6Clow Monocytes Monitor Endothelial Cells and Orchestrate Their Disposal

(2013) Leo M. Carlin et al.   CELL

Role of Microglia in CNS Autoimmunity

(2013) Tobias Goldmann et al.   Clinical & Developmental Immunology

The resolution of neuroinflammation in neurodegeneration: leukocyte recruitment via the choroid plexus

(2013) Michal Schwartz et al.   EMBO JOURNAL

Minimal Differentiation of Classical Monocytes as They Survey Steady-State Tissues and Transport Antigen to Lymph Nodes

(2013) Claudia Jakubzick et al.   IMMUNITY

Tissue-Resident Macrophages Self-Maintain Locally throughout Adult Life with Minimal Contribution from Circulating Monocytes

(2013) Daigo Hashimoto et al.   IMMUNITY

The Kinetics of Myelin Antigen Uptake by Myeloid Cells in the Central Nervous System during Experimental Autoimmune Encephalomyelitis

(2013) R. A. Sosa et al.   JOURNAL OF IMMUNOLOGY

The Blood-Brain Barrier

(2013) Felix Dyrna et al.   Journal of Neuroimmune Pharmacology

MHC class I–restricted myelin epitopes are cross-presented by Tip-DCs that promote determinant spreading to CD8+ T cells

(2013) Qingyong Ji et al.   NATURE IMMUNOLOGY

A new type of microglia gene targeting shows TAK1 to be pivotal in CNS autoimmune inflammation

(2013) Tobias Goldmann et al.   NATURE NEUROSCIENCE

Microglia emerge from erythromyeloid precursors via Pu.1- and Irf8-dependent pathways

(2013) Katrin Kierdorf et al.   NATURE NEUROSCIENCE

Identification of a unique TGF-β–dependent molecular and functional signature in microglia

(2013) Oleg Butovsky et al.   NATURE NEUROSCIENCE

M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination

(2013) Veronique E Miron et al.   NATURE NEUROSCIENCE

The microglial sensome revealed by direct RNA sequencing

(2013) Suzanne E Hickman et al.   NATURE NEUROSCIENCE

Modeling the heterogeneity of multiple sclerosis in animals

(2013) Sarah B. Simmons et al.   TRENDS IN IMMUNOLOGY

The three human monocyte subsets: implications for health and disease

(2012) Kok Loon Wong et al.   IMMUNOLOGIC RESEARCH

All-trans-retinoic acid ameliorates experimental allergic encephalomyelitis by affecting dendritic cell and monocyte development

(2012) Xiao-Xia Zhan et al.   IMMUNOLOGY

Mast cell activation and neutrophil recruitment promotes early and robust inflammation in the meninges in EAE

(2012) Alison L. Christy et al.   JOURNAL OF AUTOIMMUNITY

Brain leukocyte infiltration initiated by peripheral inflammation or experimental autoimmune encephalomyelitis occurs through pathways connected to the CSF-filled compartments of the forebrain and midbrain

(2012) Charlotte Schmitt et al.   Journal of Neuroinflammation

Wild-type microglia arrest pathology in a mouse model of Rett syndrome

(2012) Noël C. Derecki et al.   NATURE

Deciphering the transcriptional network of the dendritic cell lineage

(2012) Jennifer C Miller et al.   NATURE IMMUNOLOGY

Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages

(2012) Emmanuel L Gautier et al.   NATURE IMMUNOLOGY

Immune surveillance in the central nervous system

(2012) Shalina S Ousman et al.   NATURE NEUROSCIENCE

A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells

(2012) C. Schulz et al.   SCIENCE

Cell trafficking through the choroid plexus

(2012) Rick B. Meeker et al.   Cell Adhesion & Migration

Gene expression profiling reveals the defining features of the classical, intermediate, and nonclassical human monocyte subsets

(2011) K. L. Wong et al.   BLOOD

Posttraumatic Invasion of Monocytes across the Blood—Cerebrospinal Fluid Barrier

(2011) Joanna Szmydynger-Chodobska et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Flt3L controls the development of radiosensitive dendritic cells in the meninges and choroid plexus of the steady-state mouse brain

(2011) Niroshana Anandasabapathy et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis

(2011) Stephen Sawcer et al.   NATURE

A reversible form of axon damage in experimental autoimmune encephalomyelitis and multiple sclerosis

(2011) Ivana Nikić et al.   NATURE MEDICINE

Infiltrating monocytes trigger EAE progression, but do not contribute to the resident microglia pool

(2011) Bahareh Ajami et al.   NATURE NEUROSCIENCE

Heterogeneity of CNS myeloid cells and their roles in neurodegeneration

(2011) Marco Prinz et al.   NATURE NEUROSCIENCE

Inflammatory Cortical Demyelination in Early Multiple Sclerosis

(2011) Claudia F. Lucchinetti et al.   NEW ENGLAND JOURNAL OF MEDICINE

Synaptic Pruning by Microglia Is Necessary for Normal Brain Development

(2011) R. C. Paolicelli et al.   SCIENCE

CD11c-expressing cells reside in the juxtavascular parenchyma and extend processes into the glia limitans of the mouse nervous system

(2010) Carolin Prodinger et al.   ACTA NEUROPATHOLOGICA

The role of antigen presenting cells in multiple sclerosis

(2010) Emily M.L. Chastain et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Central memory CD4+ T cells dominate the normal cerebrospinal fluid

(2010) Marieke T. de Graaf et al.   CYTOMETRY PART B-CLINICAL CYTOMETRY

Differentiation and function of mouse monocyte-derived dendritic cells in steady state and inflammation

(2010) Pilar M. Domínguez et al.   IMMUNOLOGICAL REVIEWS

Tickets to the brain: Role of CCR2 and CX3CR1 in myeloid cell entry in the CNS

(2010) Marco Prinz et al.   JOURNAL OF NEUROIMMUNOLOGY

Novel Characterization of Monocyte-Derived Cell Populations in the Meninges and Choroid Plexus and Their Rates of Replenishment in Bone Marrow Chimeric Mice

(2010) Holly R. Chinnery et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Role of Cytokines as Mediators and Regulators of Microglial Activity in Inflammatory Demyelination of the CNS

(2010) Tobias D. Merson et al.   NEUROMOLECULAR MEDICINE

Selective Chemokine Receptor Usage by Central Nervous System Myeloid Cells in CCR2-Red Fluorescent Protein Knock-In Mice

(2010) Noah Saederup et al.   PLoS One

Development of Monocytes, Macrophages, and Dendritic Cells

(2010) F. Geissmann et al.   SCIENCE

Microglial Interactions with Synapses Are Modulated by Visual Experience

(2010) Marie-Ève Tremblay et al.   PLOS BIOLOGY

Circulating Ly-6C+ myeloid precursors migrate to the CNS and play a pathogenic role during autoimmune demyelinating disease

(2009) I. L. King et al.   BLOOD

The choroid plexus response to a repeated peripheral inflammatory stimulus

(2009) Fernanda Marques et al.   BMC NEUROSCIENCE

CCR2+Ly-6Chi monocytes are crucial for the effector phase of autoimmunity in the central nervous system

(2009) Alexander Mildner et al.   BRAIN

Kinetic Profile of the Transcriptome Changes Induced in the Choroid Plexus by Peripheral Inflammation

(2009) Fernanda Marques et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Mice deficient for CCR6 fail to control chronic experimental autoimmune encephalomyelitis

(2009) Adam Elhofy et al.   JOURNAL OF NEUROIMMUNOLOGY

Effector T cell interactions with meningeal vascular structures in nascent autoimmune CNS lesions

(2009) Ingo Bartholomäus et al.   NATURE

C-C chemokine receptor 6–regulated entry of TH-17 cells into the CNS through the choroid plexus is required for the initiation of EAE

(2009) Andrea Reboldi et al.   NATURE IMMUNOLOGY

Gaining entry to an uninflamed brain

(2009) Robert C Axtell et al.   NATURE IMMUNOLOGY

Localizing central nervous system immune surveillance: Meningeal antigen-presenting cells activate T cells during experimental autoimmune encephalomyelitis

(2008) Pia Kivisäkk et al.   ANNALS OF NEUROLOGY

Debris clearance by microglia: an essential link between degeneration and regeneration

(2008) H. Neumann et al.   BRAIN

Distinct and Nonredundant In Vivo Functions of IFNAR on Myeloid Cells Limit Autoimmunity in the Central Nervous System

(2008) Marco Prinz et al.   IMMUNITY

Involvement of the choroid plexus in multiple sclerosis autoimmune inflammation: A neuropathological study

(2008) Marco Vercellino et al.   JOURNAL OF NEUROIMMUNOLOGY

Induction and effector functions of TH17 cells

(2008) Estelle Bettelli et al.   NATURE

Abundant extracellular myelin in the meninges of patients with multiple sclerosis

(2008) E.-J. Kooi et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY