Mutually Exclusive Roles of SHARPIN in Integrin Inactivation and NF-κB Signaling

PTEN: Multiple Functions in Human Malignant Tumors

(2015) Michele Milella et al.   Frontiers in Oncology

A catalytic-independent role for the LUBAC in NF- B activation upon antigen receptor engagement and in lymphoma cells

(2014) S. M. Dubois et al.   BLOOD

Activation of nuclear factor κB pathway and downstream targets survivin and livin by SHARPIN contributes to the progression and metastasis of prostate cancer

(2014) Yiming Zhang et al.   CANCER

SIPL1-facilitated PTEN ubiquitination contributes to its association with PTEN

(2014) Jason De Melo et al.   CELLULAR SIGNALLING

The integrin adhesome: from genes and proteins to human disease

(2014) Sabina E. Winograd-Katz et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

SHANK3Gene Mutations Associated with Autism Facilitate Ligand Binding to the Shank3 Ankyrin Repeat Region

(2013) Marie Germaine Mameza et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Integrin inactivators: balancing cellular functions in vitro and in vivo

(2013) Daniel Bouvard et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Longin and GAF Domains: Structural Evolution and Adaptation to the Subcellular Trafficking Machinery

(2013) Nicola De Franceschi et al.   TRAFFIC

SHARPIN Regulates Uropod Detachment in Migrating Lymphocytes

(2013) Jeroen Pouwels et al.   Cell Reports

Structural Analysis of SHARPIN, a Subunit of a Large Multi-protein E3 Ubiquitin Ligase, Reveals a Novel Dimerization Function for the Pleckstrin Homology Superfold

(2012) Benjamin Stieglitz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sharpin Contributes to TNFα Dependent NFκB Activation and Anti-Apoptotic Signalling in Hepatocytes

(2012) Sabrina Sieber et al.   PLoS One

SHARPIN is a component of the NF-κB-activating linear ubiquitin chain assembly complex

(2011) Fuminori Tokunaga et al.   NATURE

SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis

(2011) Fumiyo Ikeda et al.   NATURE

Linear ubiquitination prevents inflammation and regulates immune signalling

(2011) Björn Gerlach et al.   NATURE

SHARPIN is an endogenous inhibitor of β1-integrin activation

(2011) Juha K. Rantala et al.   NATURE CELL BIOLOGY

Shank-interacting protein–like 1 promotes tumorigenesis via PTEN inhibition in human tumor cells

(2010) Lizhi He et al.   JOURNAL OF CLINICAL INVESTIGATION

Newly identified tumor-associated role of human Sharpin

(2010) Jinyoung Jung et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Sipl1 and Rbck1 Are Novel Eya1-Binding Proteins with a Role in Craniofacial Development

(2010) K. Landgraf et al.   MOLECULAR AND CELLULAR BIOLOGY

Kindlin-1 and -2 Directly Bind the C-terminal Region of β Integrin Cytoplasmic Tails and Exert Integrin-specific Activation Effects

(2009) David S. Harburger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Involvement of linear polyubiquitylation of NEMO in NF-κB activation

(2009) Fuminori Tokunaga et al.   NATURE CELL BIOLOGY

Quantification of integrin receptor agonism by fluorescence lifetime imaging

(2008) M. Parsons et al.   JOURNAL OF CELL SCIENCE

Kindlin-3 is essential for integrin activation and platelet aggregation

(2008) Markus Moser et al.   NATURE MEDICINE