A Small Molecule Angiotensin II Type 2 Receptor (AT2R) Antagonist Produces Analgesia in a Rat Model of Neuropathic Pain by Inhibition of p38 Mitogen-Activated Protein Kinase (MAPK) and p44/p42 MAPK Activation in the Dorsal Root Ganglia

Small Molecule Angiotensin II Type 2 Receptor (AT2R) Antagonists as Novel Analgesics for Neuropathic Pain: Comparative Pharmacokinetics, Radioligand Binding, and Efficacy in Rats

(2013) Maree T. Smith et al.   PAIN MEDICINE

Analgesic efficacy and safety of the novel p38 MAP kinase inhibitor, losmapimod, in patients with neuropathic pain following peripheral nerve injury: a double-blind, placebo-controlled study

(2012) T. Ostenfeld et al.   EUROPEAN JOURNAL OF PAIN

Clinical trial of the p38 MAP kinase inhibitor dilmapimod in neuropathic pain following nerve injury

(2011) Praveen Anand et al.   EUROPEAN JOURNAL OF PAIN

NaV1.7 accumulates and co-localizes with phosphorylated ERK1/2 within transected axons in early experimental neuromas

(2011) Anna-Karin Persson et al.   EXPERIMENTAL NEUROLOGY

MAPK inhibitor shows promise in clinical trial for neuropathic pain

(2011) Katie Kingwell   Nature Reviews Neurology

Bilateral downregulation of Nav1.8 in dorsal root ganglia of rats with bone cancer pain induced by inoculation with Walker 256 breast tumor cells

(2010) Xue-Rong Miao et al.   BMC CANCER

ERK1/2 Mitogen-Activated Protein Kinase Phosphorylates Sodium Channel Nav1.7 and Alters Its Gating Properties

(2010) S. Stamboulian et al.   JOURNAL OF NEUROSCIENCE

Fyn is involved in angiotensin II type 2 receptor-induced neurite outgrowth, but not in p42/p44mapk in NG108-15 cells

(2010) M.-O. Guimond et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

The evidence for pharmacological treatment of neuropathic pain

(2010) Nanna Brix Finnerup et al.   PAIN

Intraneuronal angiotensinergic system in rat and human dorsal root ganglia

(2010) Jaspal Patil et al.   REGULATORY PEPTIDES

The angiotensin II type 2 (AT2) receptor: an enigmatic seven transmembrane receptor

(2009) Enzo et al.   Frontiers in Bioscience-Landmark

p38MAPK: stress responses from molecular mechanisms to therapeutics

(2009) Lydia R. Coulthard et al.   TRENDS IN MOLECULAR MEDICINE

Ectopic discharge in Aβ afferents as a source of neuropathic pain

(2009) Marshall Devor   EXPERIMENTAL BRAIN RESEARCH

Multiple sodium channel isoforms and mitogen-activated protein kinases are present in painful human neuromas

(2008) Joel A. Black et al.   ANNALS OF NEUROLOGY

Estrogen Elicits Dorsal Root Ganglion Axon Sprouting via a Renin-Angiotensin System

(2008) Anuradha Chakrabarty et al.   ENDOCRINOLOGY

Phosphorylation of Sodium Channel Nav1.8 by p38 Mitogen-Activated Protein Kinase Increases Current Density in Dorsal Root Ganglion Neurons

(2008) A. Hudmon et al.   JOURNAL OF NEUROSCIENCE

Fire in the hole: pore dilation of the capsaicin receptor TRPV1

(2008) Diana Bautista et al.   NATURE NEUROSCIENCE