A tethering complex drives the terminal stage of SNARE-dependent membrane fusion

HOPS catalyzes the interdependent assembly of each vacuolar SNARE into a SNARE complex

(2017) Amy Orr et al.   MOLECULAR BIOLOGY OF THE CELL

Multivalent Rab interactions determine tether-mediated membrane fusion

(2017) Anna Lürick et al.   MOLECULAR BIOLOGY OF THE CELL

Steric hindrance of SNARE transmembrane domain organization impairs the hemifusion‐to‐fusion transition

(2016) Massimo D'Agostino et al.   EMBO REPORTS

Stability, folding dynamics, and long-range conformational transition of the synaptic t-SNARE complex

(2016) Xinming Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional homologies in vesicle tethering

(2015) Anne Kuhlee et al.   FEBS LETTERS

Vacuolar SNARE Protein Transmembrane Domains Serve as Nonspecific Membrane Anchors with Unequal Roles in Lipid Mixing

(2015) Michel Pieren et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reconstituting Intracellular Vesicle Fusion Reactions: The Essential Role of Macromolecular Crowding

(2015) Haijia Yu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Yeast vacuolar HOPS, regulated by its kinase, exploits affinities for acidic lipids and Rab:GTP for membrane binding and to catalyze tethering and fusion

(2015) Amy Orr et al.   MOLECULAR BIOLOGY OF THE CELL

Sec17 can trigger fusion oftrans-SNARE paired membranes without Sec18

(2015) Michael Zick et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A direct role for the Sec1/Munc18-family protein Vps33 as a template for SNARE assembly

(2015) R. W. Baker et al.   SCIENCE

Multiple conformations of a single SNAREpin between two nanodisc membranes reveal diverse pre-fusion states

(2014) Jaeil Shin et al.   BIOCHEMICAL JOURNAL

What Macromolecular Crowding Can Do to a Protein

(2014) Irina Kuznetsova et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Expansion of the fusion stalk and its implication for biological membrane fusion

(2014) H. J. Risselada et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Variable cooperativity in SNARE-mediated membrane fusion

(2014) J. M. Hernandez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The tethering complex HOPS catalyzes assembly of the soluble SNARE Vam7 into fusogenic trans-SNARE complexes

(2013) Michael Zick et al.   MOLECULAR BIOLOGY OF THE CELL

Teardrop shapes minimize bending energy of fusion pores connecting planar bilayers

(2013) Rolf J. Ryham et al.   PHYSICAL REVIEW E

The Membrane Fusion Enigma: SNAREs, Sec1/Munc18 Proteins, and Their Accomplices—Guilty as Charged?

(2012) Josep Rizo et al.   Annual Review of Cell and Developmental Biology

SNAREs, HOPS and regulatory lipids control the dynamics of vacuolar actin during homotypic fusion in S. cerevisiae

(2012) S. Karunakaran et al.   JOURNAL OF CELL SCIENCE

Cell-free reconstitution of vacuole membrane fragmentation reveals regulation of vacuole size and number by TORC1

(2012) Lydie Michaillat et al.   MOLECULAR BIOLOGY OF THE CELL

Molecular architecture of the multisubunit homotypic fusion and vacuole protein sorting (HOPS) tethering complex

(2012) C. Brocker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Single Reconstituted Neuronal SNARE Complexes Zipper in Three Distinct Stages

(2012) Y. Gao et al.   SCIENCE

Caught in the Act: Visualization of SNARE-Mediated Fusion Events in Molecular Detail

(2011) Herre Jelger Risselada et al.   CHEMBIOCHEM

Regulation of exocytosis by the exocyst subunit Sec6 and the SM protein Sec1

(2011) Francesca Morgera et al.   MOLECULAR BIOLOGY OF THE CELL

At the junction of SNARE and SM protein function

(2010) Chavela M Carr et al.   CURRENT OPINION IN CELL BIOLOGY

HOPS prevents the disassembly of trans-SNARE complexes by Sec17p/Sec18p during membrane fusion

(2010) Hao Xu et al.   EMBO JOURNAL

g_wham—A Free Weighted Histogram Analysis Implementation Including Robust Error and Autocorrelation Estimates

(2010) Jochen S. Hub et al.   Journal of Chemical Theory and Computation

The SM protein Vps33 and the t-SNARE Habc domain promote fusion pore opening

(2010) Michel Pieren et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Defined Subunit Arrangement and Rab Interactions Are Required for Functionality of the HOPS Tethering Complex

(2010) Clemens W. Ostrowicz et al.   TRAFFIC

Capture and release of partially zipped trans-SNARE complexes on intact organelles

(2009) Matthew L. Schwartz et al.   JOURNAL OF CELL BIOLOGY

Minimum Membrane Bending Energies of Fusion Pores

(2009) Meyer B. Jackson   JOURNAL OF MEMBRANE BIOLOGY

Yeast Sec1p Functions before and after Vesicle Docking

(2009) Kristina Hashizume et al.   MOLECULAR BIOLOGY OF THE CELL

Vps41 Phosphorylation and the Rab Ypt7 Control the Targeting of the HOPS Complex to Endosome–Vacuole Fusion Sites

(2009) Margarita Cabrera et al.   MOLECULAR BIOLOGY OF THE CELL

The MARTINI Coarse-Grained Force Field: Extension to Proteins

(2008) Luca Monticelli et al.   Journal of Chemical Theory and Computation

GROMACS 4:  Algorithms for Highly Efficient, Load-Balanced, and Scalable Molecular Simulation

(2008) Berk Hess et al.   Journal of Chemical Theory and Computation

The Anchor-Away Technique: Rapid, Conditional Establishment of Yeast Mutant Phenotypes

(2008) Hirohito Haruki et al.   MOLECULAR CELL