Functional homologies in vesicle tethering

Yeast vacuolar HOPS, regulated by its kinase, exploits affinities for acidic lipids and Rab:GTP for membrane binding and to catalyze tethering and fusion

(2015) Amy Orr et al.   MOLECULAR BIOLOGY OF THE CELL

Toward a Comprehensive Map of the Effectors of Rab GTPases

(2014) Alison K. Gillingham et al.   DEVELOPMENTAL CELL

Structural Identification of the Vps18 β-Propeller Reveals a Critical Role in the HOPS Complex Stability and Function

(2014) Heide Behrmann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The specificity of vesicle traffic to the Golgi is encoded in the golgin coiled-coil proteins

(2014) M. Wong et al.   SCIENCE

Mammalian CORVET Is Required for Fusion and Conversion of Distinct Early Endosome Subpopulations

(2014) Enrico D. Perini et al.   TRAFFIC

Molecular mechanism for Rabex-5 GEF activation by Rabaptin-5

(2014) Zhe Zhang et al.   eLife

The exocyst at the interface between cytoskeleton and membranes in eukaryotic cells

(2014) Lukáš Synek et al.   Frontiers in Plant Science

Self-Assembly of VPS41 Promotes Sorting Required for Biogenesis of the Regulated Secretory Pathway

(2013) Cédric S. Asensio et al.   DEVELOPMENTAL CELL

CORVET and HOPS tethering complexes - coordinators of endosome and lysosome fusion

(2013) H. J. k. Balderhaar et al.   JOURNAL OF CELL SCIENCE

Arl8/ARL-8 functions in apoptotic cell removal by mediating phagolysosome formation in Caenorhabditis elegans

(2013) Ayaka Sasaki et al.   MOLECULAR BIOLOGY OF THE CELL

Crystal Structures of the Sec1/Munc18 (SM) Protein Vps33, Alone and Bound to the Homotypic Fusion and Vacuolar Protein Sorting (HOPS) Subunit Vps16*

(2013) Richard W. Baker et al.   PLoS One

Syntaxin1a variants lacking an N-peptide or bearing the LE mutation bind to Munc18a in a closed conformation

(2013) K. N. Colbert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural basis of Vps33A recruitment to the human HOPS complex by Vps16

(2013) S. C. Graham et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

hVps41 and VAMP7 function in direct TGN to late endosome transport of lysosomal membrane proteins

(2013) Maaike S. Pols et al.   Nature Communications

Trans-Golgi proteins participate in the control of lipid droplet and chylomicron formation

(2012) Deike Hesse et al.   BIOSCIENCE REPORTS

How SNARE molecules mediate membrane fusion: Recent insights from molecular simulations

(2012) Herre Jelger Risselada et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Sec1/Munc18 protein Vps33 binds to SNARE domains and the quaternary SNARE complex

(2012) Braden T. Lobingier et al.   MOLECULAR BIOLOGY OF THE CELL

Phosphorylation of the effector complex HOPS by the vacuolar kinase Yck3p confers Rab nucleotide specificity for vacuole docking and fusion

(2012) Michael Zick et al.   MOLECULAR BIOLOGY OF THE CELL

Molecular architecture of the multisubunit homotypic fusion and vacuole protein sorting (HOPS) tethering complex

(2012) C. Brocker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The DSL1 Complex: The Smallest but Not the Least CATCHR

(2012) Anne Spang   TRAFFIC

Exorcising the Exocyst Complex

(2012) Margaret R. Heider et al.   TRAFFIC

The Structure of the Nuclear Pore Complex

(2011) André Hoelz et al.   Annual Review of Biochemistry

Lysosomal Trafficking, Antigen Presentation, and Microbial Killing Are Controlled by the Arf-like GTPase Arl8b

(2011) Salil Garg et al.   IMMUNITY

The Dsl1 Protein Tethering Complex Is a Resident Endoplasmic Reticulum Complex, Which Interacts with Five Soluble NSF (N-Ethylmaleimide-sensitive Factor) Attachment Protein Receptors (SNAREs)

(2011) Christoph T. A. Meiringer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Clathrin-dependent mechanisms modulate the subcellular distribution of class C Vps/HOPS tether subunits in polarized and nonpolarized cells

(2011) Stephanie A. Zlatic et al.   MOLECULAR BIOLOGY OF THE CELL

HOPS drives vacuole fusion by binding the vacuolar SNARE complex and the Vam7 PX domain via two distinct sites

(2011) Lukas Krämer et al.   MOLECULAR BIOLOGY OF THE CELL

Subunit organization and Rab interactions of Vps-C protein complexes that control endolysosomal membrane traffic

(2011) Rachael L. Plemel et al.   MOLECULAR BIOLOGY OF THE CELL

Regulation of exocytosis by the exocyst subunit Sec6 and the SM protein Sec1

(2011) Francesca Morgera et al.   MOLECULAR BIOLOGY OF THE CELL

Primordial neurosecretory apparatus identified in the choanoflagellate Monosiga brevicollis

(2011) P. Burkhardt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of Golgi Transport Proteins

(2011) D. Kummel et al.   Cold Spring Harbor Perspectives in Biology

The Golgin Coiled-Coil Proteins of the Golgi Apparatus

(2011) S. Munro   Cold Spring Harbor Perspectives in Biology

Tethering Factors as Organizers of Intracellular Vesicular Traffic

(2010) I-Mei Yu et al.   Annual Review of Cell and Developmental Biology

Structure of Coatomer Cage Proteins and the Relationship among COPI, COPII, and Clathrin Vesicle Coats

(2010) Changwook Lee et al.   CELL

The Mon1-Ccz1 Complex Is the GEF of the Late Endosomal Rab7 Homolog Ypt7

(2010) Mirjana Nordmann et al.   CURRENT BIOLOGY

HOPS prevents the disassembly of trans-SNARE complexes by Sec17p/Sec18p during membrane fusion

(2010) Hao Xu et al.   EMBO JOURNAL

Phosphorylation of a membrane curvature–sensing motif switches function of the HOPS subunit Vps41 in membrane tethering

(2010) Margarita Cabrera et al.   JOURNAL OF CELL BIOLOGY

TRAPP complexes in membrane traffic: convergence through a common Rab

(2010) Jemima Barrowman et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Molecular organization of the COG vesicle tethering complex

(2010) Joshua A Lees et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural basis for the wobbler mouse neurodegenerative disorder caused by mutation in the Vps54 subunit of the GARP complex

(2010) F. J. Perez-Victoria et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of a C-terminal fragment of its Vps53 subunit suggests similarity of Golgi-associated retrograde protein (GARP) complex to a family of tethering complexes

(2010) N. Vasan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transport according to GARP: receiving retrograde cargo at the trans-Golgi network

(2010) Juan S. Bonifacino et al.   TRENDS IN CELL BIOLOGY

A Structure-Based Mechanism for Vesicle Capture by the Multisubunit Tethering Complex Dsl1

(2009) Yi Ren et al.   CELL

Vps-C complexes: gatekeepers of endolysosomal traffic

(2009) Daniel P Nickerson et al.   CURRENT OPINION IN CELL BIOLOGY

A Link between ER Tethering and COP-I Vesicle Uncoating

(2009) Sabrina Zink et al.   DEVELOPMENTAL CELL

Direct interaction between the COG complex and the SM protein, Sly1, is required for Golgi SNARE pairing

(2009) Orly Laufman et al.   EMBO JOURNAL

Role of vesicle tethering factors in the ER-Golgi membrane traffic

(2009) Elizabeth Sztul et al.   FEBS LETTERS

Amphipathic helices and membrane curvature

(2009) Guillaume Drin et al.   FEBS LETTERS

The Major Role of the Rab Ypt7p in Vacuole Fusion Is Supporting HOPS Membrane Association

(2009) Christopher M. Hickey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural and Functional Analysis of the Globular Head Domain of p115 Provides Insight into Membrane Tethering

(2009) Yu An et al.   JOURNAL OF MOLECULAR BIOLOGY

Remote Homology between Munc13 MUN Domain and Vesicle Tethering Complexes

(2009) Jimin Pei et al.   JOURNAL OF MOLECULAR BIOLOGY

Dual Roles of the Mammalian GARP Complex in Tethering and SNARE Complex Assembly at the trans-Golgi Network

(2009) F. J. Perez-Victoria et al.   MOLECULAR AND CELLULAR BIOLOGY

HOPS Interacts with Apl5 at the Vacuole Membrane and Is Required for Consumption of AP-3 Transport Vesicles

(2009) Cortney G. Angers et al.   MOLECULAR BIOLOGY OF THE CELL

Vps41 Phosphorylation and the Rab Ypt7 Control the Targeting of the HOPS Complex to Endosome–Vacuole Fusion Sites

(2009) Margarita Cabrera et al.   MOLECULAR BIOLOGY OF THE CELL

The Exo70 Subunit of the Exocyst Is an Effector for Both Cdc42 and Rho3 Function in Polarized Exocytosis

(2009) Hao Wu et al.   MOLECULAR BIOLOGY OF THE CELL

Rab GTPases as coordinators of vesicle traffic

(2009) Harald Stenmark   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Structural characterization of Tip20p and Dsl1p, subunits of the Dsl1p vesicle tethering complex

(2009) Arati Tripathi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Unusual Armadillo Fold in the Human General Vesicular Transport Factor p115

(2009) Harald Striegl et al.   PLoS One

Structural basis for a human glycosylation disorder caused by mutation of the COG4 gene

(2009) B. C. Richardson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Membrane Fusion: Grappling with SNARE and SM Proteins

(2009) T. C. Sudhof et al.   SCIENCE

Golgins and GRASPs: Holding the Golgi together

(2009) Irene Barinaga-Rementeria Ramirez et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Rab and Arl GTPase Family Members Cooperate in the Localization of the Golgin GCC185

(2008) Alondra Schweizer Burguete et al.   CELL

Munc18a controls SNARE assembly through its interaction with the syntaxin N-peptide

(2008) Pawel Burkhardt et al.   EMBO JOURNAL

Golgi coiled-coil proteins contain multiple binding sites for Rab family G proteins

(2008) Rita Sinka et al.   JOURNAL OF CELL BIOLOGY

Efficient termination of vacuolar Rab GTPase signaling requires coordinated action by a GAP and a protein kinase

(2008) Christopher L. Brett et al.   JOURNAL OF CELL BIOLOGY

Requirement of the Human GARP Complex for Mannose 6-phosphate-receptor-dependent Sorting of Cathepsin D to Lysosomes

(2008) F. Javier Pérez-Victoria et al.   MOLECULAR BIOLOGY OF THE CELL

elipsa is an early determinant of ciliogenesis that links the IFT particle to membrane-associated small GTPase Rab8

(2008) Yoshihiro Omori et al.   NATURE CELL BIOLOGY

Asymmetric Tethering of Flat and Curved Lipid Membranes by a Golgin

(2008) G. Drin et al.   SCIENCE

Structural Evidence for Common Ancestry of the Nuclear Pore Complex and Vesicle Coats

(2008) S. G. Brohawn et al.   SCIENCE