Yeast vacuolar HOPS, regulated by its kinase, exploits affinities for acidic lipids and Rab:GTP for membrane binding and to catalyze tethering and fusion

Fusion Proteins and Select Lipids Cooperate as Membrane Receptors for the SolubleN-Ethylmaleimide-sensitive Factor Attachment Protein Receptor (SNARE) Vam7p

(2013) Vidya Karunakaran et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The tethering complex HOPS catalyzes assembly of the soluble SNARE Vam7 into fusogenic trans-SNARE complexes

(2013) Michael Zick et al.   MOLECULAR BIOLOGY OF THE CELL

Lipid-Anchored SNAREs Lacking Transmembrane Regions Fully Support Membrane Fusion during Neurotransmitter Release

(2013) Peng Zhou et al.   NEURON

Phosphorylation of the Rab exchange factor Sec2p directs a switch in regulatory binding partners

(2013) D. Stalder et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sec1/Munc18 protein Vps33 binds to SNARE domains and the quaternary SNARE complex

(2012) Braden T. Lobingier et al.   MOLECULAR BIOLOGY OF THE CELL

Phosphorylation of the effector complex HOPS by the vacuolar kinase Yck3p confers Rab nucleotide specificity for vacuole docking and fusion

(2012) Michael Zick et al.   MOLECULAR BIOLOGY OF THE CELL

N-terminal domain of vacuolar SNARE Vam7p promotes trans-SNARE complex assembly

(2012) H. Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The yeast vacuolar Rab GTPase Ypt7p has an activity beyond membrane recruitment of the homotypic fusion and protein sorting–Class C Vps complex

(2011) Christopher Stroupe   BIOCHEMICAL JOURNAL

HOPS drives vacuole fusion by binding the vacuolar SNARE complex and the Vam7 PX domain via two distinct sites

(2011) Lukas Krämer et al.   MOLECULAR BIOLOGY OF THE CELL

Membrane fusion catalyzed by a Rab, SNAREs, and SNARE chaperones is accompanied by enhanced permeability to small molecules and by lysis

(2011) Paola C. Zucchi et al.   MOLECULAR BIOLOGY OF THE CELL

Membrane Fusion: Five Lipids, Four SNAREs, Three Chaperones, Two Nucleotides, and a Rab, All Dancing in a Ring on Yeast Vacuoles

(2010) William Wickner   Annual Review of Cell and Developmental Biology

HOPS prevents the disassembly of trans-SNARE complexes by Sec17p/Sec18p during membrane fusion

(2010) Hao Xu et al.   EMBO JOURNAL

Phosphorylation of a membrane curvature–sensing motif switches function of the HOPS subunit Vps41 in membrane tethering

(2010) Margarita Cabrera et al.   JOURNAL OF CELL BIOLOGY

HOPS Initiates Vacuole Docking by Tethering Membranes before trans-SNARE Complex Assembly

(2010) Christopher M. Hickey et al.   MOLECULAR BIOLOGY OF THE CELL

The Major Role of the Rab Ypt7p in Vacuole Fusion Is Supporting HOPS Membrane Association

(2009) Christopher M. Hickey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Capture and release of partially zipped trans-SNARE complexes on intact organelles

(2009) Matthew L. Schwartz et al.   JOURNAL OF CELL BIOLOGY

Minimal membrane docking requirements revealed by reconstitution of Rab GTPase-dependent membrane fusion from purified components

(2009) C. Stroupe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reconstituted membrane fusion requires regulatory lipids, SNAREs and synergistic SNARE chaperones

(2008) Joji Mima et al.   EMBO JOURNAL

Efficient termination of vacuolar Rab GTPase signaling requires coordinated action by a GAP and a protein kinase

(2008) Christopher L. Brett et al.   JOURNAL OF CELL BIOLOGY

HOPS Proofreads the trans-SNARE Complex for Yeast Vacuole Fusion

(2008) Vincent J. Starai et al.   MOLECULAR BIOLOGY OF THE CELL