Cellular and population level processes influence the rate, accumulation and observed frequency of inherited and somatic mtDNA mutations

Parsing the life-shortening effects of dietary protein: effects of individual amino acids

(2017) Sara Arganda et al.   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Nutritional strategies to optimise cognitive function in the aging brain

(2016) Devin Wahl et al.   AGEING RESEARCH REVIEWS

Gene by environmental interactions affecting oxidative phosphorylation and thermal sensitivity

(2016) Tara Z. Baris et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Homeostatic Responses Regulate Selfish Mitochondrial Genome Dynamics in C. elegans

(2016) Bryan L. Gitschlag et al.   Cell Metabolism

Human mitochondrial DNA replication machinery and disease

(2016) Matthew J Young et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Ketogenic diets: from cancer to mitochondrial diseases and beyond

(2016) Ana F. Branco et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Functional role of mitochondrial reactive oxygen species in physiology

(2016) Plamena R. Angelova et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mitochondrial DNA damage induced autophagy cell death and disease

(2016) Bennett Van Houten   Frontiers in Bioscience-Landmark

Segregation of Naturally Occurring Mitochondrial DNA Variants in a Mini-Pig Model

(2016) G. Cagnone et al.   GENETICS

Mitochondrial-Nuclear Interactions Mediate Sex-Specific Transcriptional Profiles in Drosophila

(2016) J. A. Mossman et al.   GENETICS

Demographic History of the GenusPanInferred from Whole Mitochondrial Genome Reconstructions

(2016) Irene Lobon et al.   Genome Biology and Evolution

Mitochondrial haplogroup M9a1a1c1b is associated with hypoxic adaptation in the Tibetans

(2016) Qian Li et al.   JOURNAL OF HUMAN GENETICS

Selection on Mitochondrial Variants Occurs between and within Individuals in an Expanding Invasion

(2016) Lee A. Rollins et al.   MOLECULAR BIOLOGY AND EVOLUTION

Mitochondria and Cancer

(2016) Wei-Xing Zong et al.   MOLECULAR CELL

Maintenance and propagation of a deleterious mitochondrial genome by the mitochondrial unfolded protein response

(2016) Yi-Fan Lin et al.   NATURE

Mitochondrial DNA exhibits resistance to induced point and deletion mutations

(2016) William J. Valente et al.   NUCLEIC ACIDS RESEARCH

Review: can diet influence the selective advantage of mitochondrial DNA haplotypes?

(2015) J. W. O. Ballard et al.   BIOSCIENCE REPORTS

The impact of low-protein high-carbohydrate diets on aging and lifespan

(2015) David G. Le Couteur et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Defects in Mitochondrial Efficiency and H2O2Emissions in Obese Women Are Restored to a Lean Phenotype With Aerobic Exercise Training

(2015) Adam R. Konopka et al.   DIABETES

Skeletal muscle mitochondrial DNA deletions are not increased in CuZn-superoxide dismutase deficient mice

(2015) Jonathan Wanagat et al.   EXPERIMENTAL GERONTOLOGY

Mechanisms linking mtDNA damage and aging

(2015) Milena Pinto et al.   FREE RADICAL BIOLOGY AND MEDICINE

Differential Expression of Genes that Control Respiration Contribute to Thermal Adaptation in Redband Trout ( Oncorhynchus mykiss gairdneri )

(2015) Michael R. Garvin et al.   Genome Biology and Evolution

Germline mutation rates and the long-term phenotypic effects of mutation accumulation in wild-type laboratory mice and mutator mice

(2015) Arikuni Uchimura et al.   GENOME RESEARCH

Mitochondrial DNA maintenance: an appraisal

(2015) Alexander T. Akhmedov et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Asymmetric Context-Dependent Mutation Patterns Revealed through Mutation–Accumulation Experiments

(2015) Way Sung et al.   MOLECULAR BIOLOGY AND EVOLUTION

The rate of adaptive evolution in animal mitochondria

(2015) Jennifer E. James et al.   MOLECULAR ECOLOGY

The dynamics of mitochondrial DNA heteroplasmy: implications for human health and disease

(2015) James B. Stewart et al.   NATURE REVIEWS GENETICS

Extensive tissue-related and allele-related mtDNA heteroplasmy suggests positive selection for somatic mutations

(2015) Mingkun Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genomic determinants of coral heat tolerance across latitudes

(2015) G. B. Dixon et al.   SCIENCE

Complementation between polymerase- and exonuclease-deficient mitochondrial DNA polymerase mutants in genomically engineered flies

(2015) Ana Bratic et al.   Nature Communications

When man got his mtDNA deletions?

(2014) Konstantin Popadin et al.   AGING CELL

The Ratio of Macronutrients, Not Caloric Intake, Dictates Cardiometabolic Health, Aging, and Longevity in Ad Libitum-Fed Mice

(2014) Samantha M. Solon-Biet et al.   Cell Metabolism

Superoxide Dismutases and Superoxide Reductases

(2014) Yuewei Sheng et al.   CHEMICAL REVIEWS

Exercise training decreases activation of the mitochondrial fission protein dynamin-related protein-1 in insulin-resistant human skeletal muscle

(2014) Ciaran E. Fealy et al.   JOURNAL OF APPLIED PHYSIOLOGY

Differential high-altitude adaptation and restricted gene flow across a mid-elevation hybrid zone in Andean tit-tyrant flycatchers

(2014) Shane G. DuBay et al.   MOLECULAR ECOLOGY

Selective propagation of functional mitochondrial DNA during oogenesis restricts the transmission of a deleterious mitochondrial variant

(2014) Jahda H Hill et al.   NATURE GENETICS

Transmission of mitochondrial mutations and action of purifying selection in Drosophila melanogaster

(2014) Hansong Ma et al.   NATURE GENETICS

AFLPs and Mitochondrial Haplotypes Reveal Local Adaptation to Extreme Thermal Environments in a Freshwater Gastropod

(2014) María Quintela et al.   PLoS One

Thermal adaptation and clinal mitochondrial DNA variation of European anchovy

(2014) G. Silva et al.   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Strong male bias drives germline mutation in chimpanzees

(2014) O. Venn et al.   SCIENCE

mtDNA Segregation in Heteroplasmic Tissues Is Common In Vivo and Modulated by Haplotype Differences and Developmental Stage

(2014) Joerg Patrick Burgstaller et al.   Cell Reports

Oxidative Stress Is Not a Major Contributor to Somatic Mitochondrial DNA Mutations

(2014) Leslie S. Itsara et al.   PLoS Genetics

Clonal Expansion of Early to Mid-Life Mitochondrial DNA Point Mutations Drives Mitochondrial Dysfunction during Human Ageing

(2014) Laura C. Greaves et al.   PLoS Genetics

In vivo male fertility is affected by naturally occurring mitochondrial haplotypes

(2013) Winston K.W. Yee et al.   CURRENT BIOLOGY

Coexistence of Minicircular and a Highly Rearranged mtDNA Molecule Suggests That Recombination Shapes Mitochondrial Genome Organization

(2013) Meng Mao et al.   MOLECULAR BIOLOGY AND EVOLUTION

No recombination of mtDNA after heteroplasmy for 50 generations in the mouse maternal germline

(2013) E. Hagstrom et al.   NUCLEIC ACIDS RESEARCH

Mitochondrial DNA replication proceeds via a ‘bootlace’ mechanism involving the incorporation of processed transcripts

(2013) Aurelio Reyes et al.   NUCLEIC ACIDS RESEARCH

Analysis of Replication Intermediates Indicates That Drosophila melanogaster Mitochondrial DNA Replicates by a Strand-Coupled Theta Mechanism

(2013) Priit Jõers et al.   PLoS One

Overexpression of Twinkle-helicase protects cardiomyocytes from genotoxic stress caused by reactive oxygen species

(2013) J. L. O. Pohjoismaki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial DNA Genetics and the Heteroplasmy Conundrum in Evolution and Disease

(2013) D. C. Wallace et al.   Cold Spring Harbor Perspectives in Biology

Mitophagy is triggered by mild oxidative stress in a mitochondrial fission dependent manner

(2012) Magdalena Frank et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

mtDNA lineage analysis of mouse L-cell lines reveals the accumulation of multiple mtDNA mutants and intermolecular recombination

(2012) W. Fan et al.   GENES & DEVELOPMENT

Paternal leakage of mitochondrial DNA in experimental crosses of populations of the potato cyst nematode Globodera pallida

(2012) Angelique H. Hoolahan et al.   GENETICA

The Effects of Deleterious Mutations on Evolution at Linked Sites

(2012) Brian Charlesworth   GENETICS

Paternal transmission of mitochondrial DNA as an integral part of mitochondrial inheritance in metapopulations of Drosophila simulans

(2012) J N Wolff et al.   HEREDITY

Universal heteroplasmy of human mitochondrial DNA

(2012) B. A. I. Payne et al.   HUMAN MOLECULAR GENETICS

PGC-1β mediates adaptive chemoresistance associated with mitochondrial DNA mutations

(2012) Z Yao et al.   ONCOGENE

Intestinal development and differentiation

(2011) Taeko K. Noah et al.   EXPERIMENTAL CELL RESEARCH

Evolutionary Patterns of the Mitochondrial Genome in Metazoa: Exploring the Role of Mutation and Selection in Mitochondrial Protein–Coding Genes

(2011) S. Castellana et al.   Genome Biology and Evolution

During autophagy mitochondria elongate, are spared from degradation and sustain cell viability

(2011) Ligia C. Gomes et al.   NATURE CELL BIOLOGY

Ultra-Deep Sequencing of Mouse Mitochondrial DNA: Mutational Patterns and Their Origins

(2011) Adam Ameur et al.   PLoS Genetics

Direct Measure of the De Novo Mutation Rate in Autism and Schizophrenia Cohorts

(2010) Philip Awadalla et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Somatic Mitochondrial DNA Mutations in Mammalian Aging

(2010) Nils-Göran Larsson   Annual Review of Biochemistry

Linking the mitochondrial genotype to the organismal phenotype

(2010) J. W. O. BALLARD et al.   MOLECULAR ECOLOGY

Rate, molecular spectrum, and consequences of human mutation

(2010) M. Lynch   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Analysis of Genetic Inheritance in a Family Quartet by Whole-Genome Sequencing

(2010) J. C. Roach et al.   SCIENCE

Effects of a sex-ratio distorting endosymbiont on mtDNA variation in a global insect pest

(2009) Ana M Delgado et al.   BMC EVOLUTIONARY BIOLOGY

Sensitivity of Lipid Metabolism and Insulin Signaling to Genetic Alterations in Hepatic Peroxisome Proliferator-Activated Receptor-  Coactivator-1  Expression

(2009) J. L. Estall et al.   DIABETES

Comparative Genomics of Drosophila mtDNA: Novel Features of Conservation and Change Across Functional Domains and Lineages

(2009) Kristi L. Montooth et al.   JOURNAL OF MOLECULAR EVOLUTION

Mitochondrial DNA as a marker of molecular diversity: a reappraisal

(2009) N. GALTIER et al.   MOLECULAR ECOLOGY

Mitochondrial Dynamics in Mammalian Health and Disease

(2009) Marc Liesa et al.   PHYSIOLOGICAL REVIEWS

Mutation Patterns in the Human Genome: More Variable Than Expected

(2009) Laurent Duret   PLOS BIOLOGY

Genomics and Evolution of Heritable Bacterial Symbionts

(2008) Nancy A. Moran et al.   Annual Review of Genetics

How many species are infected with Wolbachia? – a statistical analysis of current data

(2008) Kirsten Hilgenboecker et al.   FEMS MICROBIOLOGY LETTERS

Single-nucleotide mutation rate increases close to insertions/deletions in eukaryotes

(2008) Dacheng Tian et al.   NATURE

The mitochondrial DNA genetic bottleneck results from replication of a subpopulation of genomes

(2008) Timothy Wai et al.   NATURE GENETICS

A reduction of mitochondrial DNA molecules during embryogenesis explains the rapid segregation of genotypes

(2008) Lynsey M Cree et al.   NATURE GENETICS

Purifying selection of mtDNA and its implications for understanding evolution and mitochondrial disease

(2008) James Bruce Stewart et al.   NATURE REVIEWS GENETICS

Wolbachia: master manipulators of invertebrate biology

(2008) John H. Werren et al.   NATURE REVIEWS MICROBIOLOGY

Genotype-dependent variation of mitochondrial transcriptional profiles in interpopulation hybrids

(2008) C. K. Ellison et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lifespan and reproduction in Drosophila: New insights from nutritional geometry

(2008) K. P. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial DNA mutations and aging: devils in the details?

(2008) Konstantin Khrapko et al.   TRENDS IN GENETICS

Strong Purifying Selection in Transmission of Mammalian Mitochondrial DNA

(2008) James Bruce Stewart et al.   PLOS BIOLOGY

Direct Estimation of the Mitochondrial DNA Mutation Rate in Drosophila melanogaster

(2008) Cathy Haag-Liautard et al.   PLOS BIOLOGY

Mutation and Evolutionary Rates in Adélie Penguins from the Antarctic

(2008) Craig D. Millar et al.   PLoS Genetics