Mitochondrial DNA exhibits resistance to induced point and deletion mutations

Tissue-specific in vivo genetic toxicity of nine polycyclic aromatic hydrocarbons assessed using the Muta™Mouse transgenic rodent assay

(2016) Alexandra S. Long et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Subacute calorie restriction and rapamycin discordantly alter mouse liver proteome homeostasis and reverse aging effects

(2015) Pabalu P. Karunadharma et al.   AGING CELL

Mitochondrial DNA copy number - but not a mitochondrial tandem CC to TT transition - is increased in sun-exposed skin

(2014) Daniel Gebhard et al.   EXPERIMENTAL DERMATOLOGY

Formation and repair of oxidative damage in the mitochondrial DNA

(2014) Meltem Muftuoglu et al.   MITOCHONDRION

MMS Exposure Promotes Increased MtDNA Mutagenesis in the Presence of Replication-Defective Disease-Associated DNA Polymerase γ Variants

(2014) Jeffrey D. Stumpf et al.   PLoS Genetics

Oxidative Stress Is Not a Major Contributor to Somatic Mitochondrial DNA Mutations

(2014) Leslie S. Itsara et al.   PLoS Genetics

Targeted enrichment and high-resolution digital profiling of mitochondrial DNA deletions in human brain

(2013) Sean D. Taylor et al.   AGING CELL

Alkyladenine DNA glycosylase (AAG) localizes to mitochondria and interacts with mitochondrial single-stranded binding protein (mtSSB)

(2013) Barbara van Loon et al.   DNA REPAIR

Translesion Synthesis Past Acrolein-derived DNA Adducts by Human Mitochondrial DNA Polymerase γ

(2013) Rajesh Kasiviswanathan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial Common Deletion, a Potential Biomarker for Cancer Occurrence, Is Selected against in Cancer Background: A Meta-Analysis of 38 Studies

(2013) Hezhongrong Nie et al.   PLoS One

Ultra-Sensitive Sequencing Reveals an Age-Related Increase in Somatic Mitochondrial Mutations That Are Inconsistent with Oxidative Damage

(2013) Scott R. Kennedy et al.   PLoS Genetics

Primer-BLAST: A tool to design target-specific primers for polymerase chain reaction

(2012) Jian Ye et al.   BMC BIOINFORMATICS

In vivo repair of alkylating and oxidative DNA damage in the mitochondrial and nuclear genomes of wild-type and glycosylase-deficient Caenorhabditis elegans

(2012) Senyene E. Hunter et al.   DNA REPAIR

Human mitochondrial DNA: roles of inherited and somatic mutations

(2012) Eric A. Schon et al.   NATURE REVIEWS GENETICS

Minimizing the damage: repair pathways keep mitochondrial DNA intact

(2012) Lawrence Kazak et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mitochondrial dynamics and autophagy aid in removal of persistent mitochondrial DNA damage in Caenorhabditis elegans

(2012) Amanda S. Bess et al.   NUCLEIC ACIDS RESEARCH

Decreased Mitochondrial DNA Mutagenesis in Human Colorectal Cancer

(2012) Nolan G. Ericson et al.   PLoS Genetics

Evaluation of a Droplet Digital Polymerase Chain Reaction Format for DNA Copy Number Quantification

(2011) Leonardo B. Pinheiro et al.   ANALYTICAL CHEMISTRY

High-Throughput Droplet Digital PCR System for Absolute Quantitation of DNA Copy Number

(2011) Benjamin J. Hindson et al.   ANALYTICAL CHEMISTRY

Simultaneous measurement of benzo[a]pyrene-induced Pig-a and lacZ mutations, micronuclei and dna adducts in mutaTMmouse

(2011) Christine L. Lemieux et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

A random mutation capture assay to detect genomic point mutations in mouse tissue

(2011) Jocelyn H. Wright et al.   NUCLEIC ACIDS RESEARCH

Mitochondrial DNA Mutations Regulate Metastasis of Human Breast Cancer Cells

(2011) Hirotake Imanishi et al.   PLoS One

Somatic mutations of mitochondrial DNA in aging and cancer progression

(2010) Hsin-Chen Lee et al.   AGEING RESEARCH REVIEWS

The mitochondrial transcription factor A functions in mitochondrial base excision repair

(2010) Chandrika Canugovi et al.   DNA REPAIR

The DNA glycosylase Ogg1 defends against oxidant-induced mtDNA damage and apoptosis in pulmonary artery endothelial cells

(2010) Mykhaylo V. Ruchko et al.   FREE RADICAL BIOLOGY AND MEDICINE

The QPCR assay for analysis of mitochondrial DNA damage, repair, and relative copy number

(2010) Senyene E. Hunter et al.   METHODS

Quantification of mitochondrial DNA mutation load

(2009) Laura C. Greaves et al.   AGING CELL

Chemical biology of mutagenesis and DNA repair: cellular responses to DNA alkylation

(2009) N. Shrivastav et al.   CARCINOGENESIS

Overexpression of Catalase Targeted to Mitochondria Attenuates Murine Cardiac Aging

(2009) Dao-Fu Dai et al.   CIRCULATION

Novel DNA mismatch-repair activity involving YB-1 in human mitochondria

(2009) Nadja C. de Souza-Pinto et al.   DNA REPAIR

Mice expressing an error-prone DNA polymerase in mitochondria display elevated replication pausing and chromosomal breakage at fragile sites of mitochondrial DNA

(2009) Laura J. Bailey et al.   NUCLEIC ACIDS RESEARCH

Analysis of differential DNA damage in the mitochondrial genome employing a semi-long run real-time PCR approach

(2009) Oliver Rothfuss et al.   NUCLEIC ACIDS RESEARCH

Oxidative stress induces degradation of mitochondrial DNA

(2009) Inna Shokolenko et al.   NUCLEIC ACIDS RESEARCH

The long amplicon quantitative PCR for DNA damage assay as a sensitive method of assessing DNA damage in the environmental model, Atlantic killifish (Fundulus heteroclitus)

(2008) Dawoon Jung et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY

Quantification of random mutations in the mitochondrial genome

(2008) Marc Vermulst et al.   METHODS

Single molecule PCR in mtDNA mutational analysis: Genuine mutations vs. damage bypass-derived artifacts

(2008) Y. Kraytsberg et al.   METHODS

What causes mitochondrial DNA deletions in human cells?

(2008) Kim J Krishnan et al.   NATURE GENETICS

DNA deletions and clonal mutations drive premature aging in mitochondrial mutator mice

(2008) Marc Vermulst et al.   NATURE GENETICS