Mode of action and pharmacogenomic biomarkers for exceptional responders to didemnin B

Small molecule Mcl-1 inhibitors for the treatment of cancer

(2015) Johannes Belmar et al.   PHARMACOLOGY & THERAPEUTICS

Does bafilomycin A1block the fusion of autophagosomes with lysosomes?

(2014) Daniel J. Klionsky et al.   Autophagy

Cell and Molecular Determinants of In Vivo Efficacy of the BH3 Mimetic ABT-263 against Pediatric Acute Lymphoblastic Leukemia Xenografts

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Highly homologous eEF1A1 and eEF1A2 exhibit differential post-translationalmodification with significant enrichment around localised sites of sequence variation

(2013) Dinesh C Soares et al.   Biology Direct

The role, mechanism and potentially therapeutic application of microRNA-29 family in acute myeloid leukemia

(2013) J-N Gong et al.   CELL DEATH AND DIFFERENTIATION

Multicenter phase II study of plitidepsin in patients with relapsed/refractory non-Hodgkin's lymphoma

(2013) V. Ribrag et al.   HAEMATOLOGICA

Discoipyrroles A–D: Isolation, Structure Determination, and Synthesis of Potent Migration Inhibitors from Bacillus hunanensis

(2013) Youcai Hu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Downregulation of miR-383 promotes glioma cell invasion by targeting insulin-like growth factor 1 receptor

(2013) Zhanwen He et al.   MEDICAL ONCOLOGY

MicroRNA-497 increases apoptosis in MYCN amplified neuroblastoma cells by targeting the key cell cycle regulator WEE1

(2013) Laura Creevey et al.   Molecular Cancer

Using Functional Signature Ontology (FUSION) to Identify Mechanisms of Action for Natural Products

(2013) M. B. Potts et al.   Science Signaling

Epigenetic silencing of microRNA-193a contributes to leukemogenesis in t(8;21) acute myeloid leukemia by activating the PTEN/PI3K signal pathway

(2012) Y. Li et al.   BLOOD

Natural Products As Sources of New Drugs over the 30 Years from 1981 to 2010

(2012) David J. Newman et al.   JOURNAL OF NATURAL PRODUCTS

The Role of Ceroid Lipofuscinosis Neuronal Protein 5 (CLN5) in Endosomal Sorting

(2012) A. Mamo et al.   MOLECULAR AND CELLULAR BIOLOGY

Didemnins, tamandarins and related natural products

(2012) Jisun Lee et al.   NATURAL PRODUCT REPORTS

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity

(2012) Jordi Barretina et al.   NATURE

MicroRNA-497 targets insulin-like growth factor 1 receptor and has a tumour suppressive role in human colorectal cancer

(2012) S T Guo et al.   ONCOGENE

S6 Kinase 2 Promotes Breast Cancer Cell Survival via Akt

(2011) S. Sridharan et al.   CANCER RESEARCH

Eukaryotic elongation factor-2 (eEF2): its regulation and peptide chain elongation

(2011) Gautam Kaul et al.   CELL BIOCHEMISTRY AND FUNCTION

The cancerous translation apparatus

(2011) Craig R Stumpf et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Bacterial Production of the Tunicate-Derived Antitumor Cyclic Depsipeptide Didemnin B

(2011) Moriya Tsukimoto et al.   JOURNAL OF NATURAL PRODUCTS

Functionally recurrent rearrangements of the MAST kinase and Notch gene families in breast cancer

(2011) Dan R Robinson et al.   NATURE MEDICINE

Phosphoproteomic Analysis Identifies Grb10 as an mTORC1 Substrate That Negatively Regulates Insulin Signaling

(2011) Y. Yu et al.   SCIENCE

The mTOR-Regulated Phosphoproteome Reveals a Mechanism of mTORC1-Mediated Inhibition of Growth Factor Signaling

(2011) P. P. Hsu et al.   SCIENCE

The CNK1 scaffold binds cytohesins and promotes insulin pathway signaling

(2010) J. Lim et al.   GENES & DEVELOPMENT

Lung Cancer Cell Lines as Tools for Biomedical Discovery and Research

(2010) Adi F. Gazdar et al.   JNCI-Journal of the National Cancer Institute

Alteration of microRNA expression correlates to fatty acid-mediated insulin resistance in mouse myoblasts

(2010) Zhen-Ya Li et al.   Molecular BioSystems

CNK1 is a novel Akt interaction partner that promotes cell proliferation through the Akt-FoxO signalling axis

(2010) R D Fritz et al.   ONCOGENE

microRNA-7 Inhibits the Epidermal Growth Factor Receptor and the Akt Pathway and Is Down-regulated in Glioblastoma

(2008) B. Kefas et al.   CANCER RESEARCH

Integrated analysis of homozygous deletions, focal amplifications, and sequence alterations in breast and colorectal cancers

(2008) R. J. Leary et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA