Article
Cardiac & Cardiovascular Systems
Luca Liberale, Yustina M. Puspitasari, Stefano Ministrini, Alexander Akhmedov, Simon Kraler, Nicole R. Bonetti, Georgia Beer, Ana Vukolic, Dario Bongiovanni, Jiaying Han, Kilian Kirmes, Isabell Bernlochner, Jaroslav Pelisek, Jurg H. Beer, Zheng-Gen Jin, Daniela Pedicino, Giovanna Liuzzo, Konstantinos Stellos, Fabrizio Montecucco, Filippo Crea, Thomas F. Luscher, Giovanni G. Camici
Summary: JCAD promotes arterial thrombosis by modulating coagulation and fibrinolysis. Knockout of JCAD reduces thrombogenicity in mice, and silencing of JCAD inhibits the expression of coagulation factors and fibrinolysis factors. These findings suggest JCAD as a potential therapeutic target for atherothrombosis.
EUROPEAN HEART JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Shahid Karim, Abdulhadi S. Burzangi, Aftab Ahmad, Nasir Ali Siddiqui, Ibrahim M. Ibrahim, Priyanka Sharma, Walaa A. Abualsunun, Gamal A. Gabr
Summary: This study found that thymoquinone inhibits glycolytic metabolism in colorectal cancer cells by modulating the PI3/AKT axis and inhibiting the glycolytic enzyme HK2. Overexpression of HK2 is essential for fueling glycolytic metabolism and sustaining tumorigenicity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Medicinal
Pengzhan He, Yang He, Jingjing Ma, Yinghui Liu, Chuan Liu, Yu Baoping, Weiguo Dong
Summary: In this study, it was found that thymoquinone inhibited the proliferation of gastric cancer cells and induced concentration-dependent apoptosis and autophagy. These effects were mediated through the inhibition of the PI3K/Akt/mTOR pathway. The findings provide new insights into the specific mechanism of thymoquinone as an anti-gastric cancer drug.
PHYTOTHERAPY RESEARCH
(2023)
Article
Plant Sciences
Ruixue Dong, Xi Zhang, Yadi Liu, Tingting Zhao, Zhongyan Sun, Peiyu Liu, Qian Xiang, Jianfeng Xiong, Xinwen Du, Xifei Yang, Dingkun Gui, Youhua Xu
Summary: This study aimed to investigate the renoprotective effect of Rutin in diabetic kidney disease (DKD) and explore its potential molecular mechanisms. The results showed that Rutin can improve kidney function and structure in DKD by restoring autophagy through inhibiting HDAC1 via the PI3K/AKT/mTOR pathway, thereby alleviating endothelial-to-mesenchymal transition (EndMT). These findings have important implications for the treatment and prevention of DKD.
Review
Chemistry, Medicinal
Syarifah Aisyah Syed Abd Halim, Norhashima Abd Rashid, Choy Ker Woon, Nahdia Afiifah Abdul Jalil
Summary: This scoping review summarizes the effects of natural products targeting PI3K/AKT in MIRI. The review identifies various natural compounds that reduce MIRI by regulating the PI3K/AKT signaling pathway. 14 research publications meeting the inclusion and exclusion criteria were shortlisted, demonstrating that natural products effectively improve cardiac functions through antioxidant regulation and apoptosis modulation. This review provides evidence supporting the potential of natural products in treating MIRI due to their diverse biological activities and drug-like properties.
Article
Biochemistry & Molecular Biology
Lan Yao, Xianhui Liang, Yamin Liu, Bingyu Li, Mei Hong, Xin Wang, Bohan Chen, Zhangsuo Liu, Pei Wang
Summary: Diabetic tubulopathy is a crucial pathology of diabetic kidney disease, in which mitochondria play a vital role. Finerenone, a novel non-steroidal mineralocorticoid receptor antagonist, attenuates kidney inflammation and fibrosis in DKD through the PI3K/Akt/eNOS signaling pathway. Finerenone reduces oxidative stress, mitochondrial fragmentation, and restores mitophagy to rescue mitochondrial function.
Review
Pharmacology & Pharmacy
Amin Iranpanah, Leila Kooshki, Seyed Zachariah Moradi, Luciano Saso, Sajad Fakhri, Haroon Khan
Summary: As a major public health concern, neurological diseases and neurodegenerative diseases significantly impact the growing aging population, leading to disability and mortality. Apoptosis, inflammation, and oxidative stress play crucial roles in the development of neurodegenerative diseases, with the phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt)/mammalian target of rapamycin (mTOR) pathway being a key player. The blood-brain barrier poses challenges for drug delivery, but exosomes have emerged as potential nano-sized vehicles for central nervous system drug delivery due to their ability to cross the blood-brain barrier and their unique characteristics such as low immunogenicity and great tissue/cell penetration capabilities. This systematic review highlights the therapeutic potential of exosomes targeting the PI3K/Akt/mTOR signaling pathway in the context of neurodegenerative diseases and neurological diseases.
Article
Chemistry, Medicinal
Futoon Abedrabbu Al-Rawashde, Abdullah Saleh Al-wajeeh, Mansoureh Nazari Vishkaei, Hanan Kamel M. Saad, Muhammad Farid Johan, Wan Rohani Wan Taib, Imilia Ismail, Hamid Ali Nagi Al-Jamal
Summary: This study explores the inhibitory effect of thymoquinone (TQ) on the JAK/STAT and PI3K/Akt/mTOR pathways in acute myeloid leukemia (AML) and chronic myeloid leukemia (CML) cells. TQ showed a dose and time dependent inhibition of cell proliferation and downregulated PI3K, Akt, and mTOR genes while upregulating PTEN gene expression. TQ also inhibited JAK/STAT and PI3K/Akt/mTOR signaling pathways. These findings suggest that TQ has potential anti-leukemic effects on both AML and CML cells.
Article
Biochemistry & Molecular Biology
Sandy Winfield Jere, Nicolette Nadene Houreld, Heidi Abrahamse
Summary: This study investigated the mechanism of action of photobiomodulation (PBM) in the treatment of diabetic wounds. The results showed that PBM can enhance the therapeutic effects of diabetic wound healing by activating the PI3K/AKT cell signaling pathway and downstream signaling proteins.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
(2022)
Article
Plant Sciences
Xian Wang, Ling Jiang, Xue-qi Liu, Yue-bo Huang, An-li Wang, Han-xu Zeng, Li Gao, Qi-Jin Zhu, Ling -ling Xia, Yong-gui Wu
Summary: This study explores the specific mechanism of Paeoniflorin (PF) in protecting podocyte injury in diabetic kidney disease (DKD). The results show that PF restores autophagy and inhibits apoptosis by targeting the VEGFR2-mediated PI3K-AKT pathway, improving renal injury in DKD.
Article
Biochemistry & Molecular Biology
Amjad Husain, Arogya Khadka, Allen Ehrlicher, Magali Saint-Geniez, Ramaswamy Krishnan
Summary: The study reveals the underlying role of the PI3K/Akt/mTOR signaling pathway in regulating vascular endothelial growth factor-A (VEGF-A) mediated signaling and functions. The pathway is activated on stiffer substrates, amplified by VEGF-A stimulation, and correlated with enhanced endothelial cell (EC) proliferation, contraction, pro-angiogenic secretion, and capillary-like tube formation. These findings have important implications for understanding age-related macular degeneration and provide insight into potential therapeutic pathways.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Pharmacology & Pharmacy
Mingjun Han, Jie Lin, Yi Yang, Yumei Ding, Wenjun Ge, Haoran Fan, Ce Wang, Wen Xie
Summary: The medicated serum of Xinshuaining preparation increased cell viability and suppressed apoptosis and oxidative stress via the PI3K/Akt/Nrf-2 signaling pathway.
CLINICAL AND EXPERIMENTAL HYPERTENSION
(2022)
Article
Food Science & Technology
Chengkai Wu, Bosai He, Xiao Wang, Yang Zou, Ruixin Ma, Yanting Gu, Jian Huang, Songping Li, Jinhui Wang, Jiahong Wang
Summary: This study demonstrated that Salvianolic acid A (Sal A) effectively attenuates vascular injury caused by chronic kidney disease. Its mechanisms of action involve activation of the PI3K/Akt/Nrf2/HO-1 signaling pathway for antioxidant effects and suppression of the SIRT1/TLR4/NF-kappa B/P38 signaling pathway for anti-inflammatory effects.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Review
Cell Biology
Sakshi Gupta, Mukund Kumar, Soumi Chaudhuri, Arun Kumar
Summary: The PI3K-AKT-MTOR signaling pathway is essential for various cellular functions and has been found to be involved in nuclear processes such as DNA replication, transcription, DNA repair, maintenance of genomic integrity, chromatin architecture, and cell cycle control. Effector molecules of this pathway can translocate to the nucleus and regulate nuclear signaling.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Cell Biology
Kuang-Chen Hung, Ni Tien, Da-Tian Bau, Chun-Hsu Yao, Chan-Hung Chen, Jiun-Long Yang, Meng-Liang Lin, Shih-Shun Chen
Summary: The aberrant activation of signaling pathways contributes to cancer cells with metabolic reprogramming. Thus, targeting signaling modulators is considered a potential therapeutic strategy for cancer. Subcellular fractionation, coimmunoprecipitation, biochemical analysis, and gene manipulation experiments revealed that decreasing the interaction of KRAS with p110 alpha in lipid rafts with the use of naringenin (NGN), a citrus flavonoid, causes lipid raft-associated phosphatidylinositol 3-kinase (PI3K)-GTP-ras-related C3 botulinum toxin substrate 1 (Rac1)-protein kinase B (Akt)-regulated metabolic dysfunction of glycolysis and mitochondrial oxidative phosphorylation (OXPHOS), leading to apoptosis in human nasopharyngeal carcinoma (NPC) cells.
