Is Palmitoleic Acid a Plausible Nonpharmacological Strategy to Prevent or Control Chronic Metabolic and Inflammatory Disorders?

A Macadamia Nut-Rich Diet Reduces Total and LDL-Cholesterol in Mildly Hypercholesterolemic Men and Women

(2018) Amy E. Griel et al.   JOURNAL OF NUTRITION

Vaccenic acid suppresses intestinal inflammation by increasing anandamide and relatedN-acylethanolamines in the JCR:LA-cp rat

(2016) Miriam Jacome-Sosa et al.   JOURNAL OF LIPID RESEARCH

Serum palmitoleate acts as a lipokine in subjects at high cardiometabolic risk

(2016) J. Merino et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

Prevention of atherosclerosis by bioactive palmitoleate through suppression of organelle stress and inflammasome activation

(2016) Ismail Çimen et al.   Science Translational Medicine

The Macrophage Switch in Obesity Development

(2016) Angela Castoldi et al.   Frontiers in Immunology

Red Blood Cell Fatty Acids and Incident Diabetes Mellitus in the Women’s Health Initiative Memory Study

(2016) William S. Harris et al.   PLoS One

Marine omega-3 fatty acids and inflammatory processes: Effects, mechanisms and clinical relevance

(2015) Philip C. Calder   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Fatty acid profile of plasma NEFA does not reflect adipose tissue fatty acid profile

(2015) Celia G. Walker et al.   BRITISH JOURNAL OF NUTRITION

Adipose Tissue Inflammation in the Pathogenesis of Type 2 Diabetes

(2015) Ayano Kohlgruber et al.   Current Diabetes Reports

Palmitoleate Reverses High Fat-induced Proinflammatory Macrophage Polarization via AMP-activated Protein Kinase (AMPK)

(2015) Kenny L. Chan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional Roles of Fatty Acids and Their Effects on Human Health

(2015) Philip C. Calder   JOURNAL OF PARENTERAL AND ENTERAL NUTRITION

Fatty acid changes help to better understand regression of nonalcoholic fatty liver disease

(2015) Dominika Maciejewska   WORLD JOURNAL OF GASTROENTEROLOGY

The Pattern of Fatty Acids Displaced by EPA and DHA Following 12 Months Supplementation Varies between Blood Cell and Plasma Fractions

(2015) Celia Walker et al.   Nutrients

Circulating Unsaturated Fatty Acids Delineate the Metabolic Status of Obese Individuals

(2015) Yan Ni et al.   EBioMedicine

Palmitoleic acid (n-7) increases white adipocytes GLUT4 content and glucose uptake in association with AMPK activation

(2015) Andressa Bolsoni-Lopes et al.   Lipids in Health and Disease

Palmitoleic acid is elevated in fatty liver disease and reflects hepatic lipogenesis

(2014) Joseph J Lee et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Prospective association of fatty acids in the de novo lipogenesis pathway with risk of type 2 diabetes: the Cardiovascular Health Study

(2014) Wenjie Ma et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

AMPK—Sensing Energy while Talking to Other Signaling Pathways

(2014) D. Grahame Hardie   Cell Metabolism

AMPK: A cellular metabolic and redox sensor. A minireview

(2014) Najeeb Shirwany   Frontiers in Bioscience-Landmark

The opposite associations of long-chain versus very long-chain monounsaturated fatty acids with mortality among patients with coronary artery disease

(2014) Zhongxia Li et al.   HEART

Purified palmitoleic acid for the reduction of high-sensitivity C-reactive protein and serum lipids: A double-blinded, randomized, placebo controlled study

(2014) Adam M. Bernstein et al.   Journal of Clinical Lipidology

Diets enriched in trans-11 vaccenic acid alleviate ectopic lipid accumulation in a rat model of NAFLD and metabolic syndrome

(2014) M. Miriam Jacome-Sosa et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Macadamia Oil Supplementation Attenuates Inflammation and Adipocyte Hypertrophy in Obese Mice

(2014) Edson A. Lima et al.   MEDIATORS OF INFLAMMATION

Palmitoleic acid prevents palmitic acid-induced macrophage activation and consequent p38 MAPK-mediated skeletal muscle insulin resistance

(2014) Nicola A. Talbot et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Associations of erythrocyte membrane fatty acids with the concentrations of C-reactive protein, interleukin 1 receptor antagonist and adiponectin in 1373 men

(2014) M.J. Takkunen et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

New Insight into Adiponectin Role in Obesity and Obesity-Related Diseases

(2014) Ersilia Nigro et al.   Biomed Research International

Palmitoleic acid reduces intramuscular lipid and restores insulin sensitivity in obese sheep

(2014) Susan Duckett et al.   Diabetes Metabolic Syndrome and Obesity-Targets and Therapy

Oral administration of omega-7 palmitoleic acid induces satiety and the release of appetite-related hormones in male rats

(2013) Zhi-Hong Yang et al.   APPETITE

Associations of erythrocyte fatty acids in the de novo lipogenesis pathway with risk of metabolic syndrome in a cohort study of middle-aged and older Chinese

(2013) Geng Zong et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Palmitoleic acid (n-7) increases white adipocyte lipolysis and lipase content in a PPARα-dependent manner

(2013) Andressa Bolsoni-Lopes et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Plasma fatty acid composition, estimated desaturase activities, and their relation with the metabolic syndrome in a population at high risk of cardiovascular disease

(2013) Jordi Mayneris-Perxachs et al.   CLINICAL NUTRITION

Is there something special about palmitoleate?

(2013) Leanne Hodson et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Dietary anhydrous milk fat naturally enriched with conjugated linoleic acid and vaccenic acid modify cardiovascular risk biomarkers in spontaneously hypertensive rats

(2013) M. S. Herrera-Meza et al.   INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION

Individual Saturated and Monounsaturated Fatty Acids Trigger Distinct Transcriptional Networks in Differentiated 3T3-L1 Preadipocytes

(2013) Brittany Shaw et al.   Journal of Nutrigenetics and Nutrigenomics

Mechanisms of Chronic State of Inflammation as Mediators That Link Obese Adipose Tissue and Metabolic Syndrome

(2013) Eduardo Fuentes et al.   MEDIATORS OF INFLAMMATION

Red Blood Cell Membrane Concentration of cis-Palmitoleic and cis-Vaccenic Acids and Risk of Coronary Heart Disease

(2012) Luc Djoussé et al.   AMERICAN JOURNAL OF CARDIOLOGY

Associations of erythrocyte palmitoleic acid with adipokines, inflammatory markers, and the metabolic syndrome in middle-aged and older Chinese

(2012) Geng Zong et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Plasma Phospholipid Concentration of Cis -Palmitoleic Acid and Risk of Heart Failure

(2012) Luc Djoussé et al.   Circulation-Heart Failure

Gluteofemoral Adipose Tissue Plays a Major Role in Production of the Lipokine Palmitoleate in Humans

(2012) K. E. Pinnick et al.   DIABETES

Supplemental palmitoleic (C16:1 cis-9) acid reduces lipogenesis and desaturation in bovine adipocyte cultures1

(2012) T. A. Burns et al.   JOURNAL OF ANIMAL SCIENCE

Saturated fatty acids activate TLR-mediated proinflammatory signaling pathways

(2012) Shurong Huang et al.   JOURNAL OF LIPID RESEARCH

Palmitoleic (16:1 cis-9) and cis-Vaccenic (18:1 cis-11) Acid Alter Lipogenesis in Bovine Adipocyte Cultures

(2012) T. A. Burns et al.   LIPIDS

AMPK regulation of fatty acid metabolism and mitochondrial biogenesis: Implications for obesity

(2012) Hayley M. O’Neill et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human

(2012) Atsuhiko Ichimura et al.   NATURE

AMPK: a nutrient and energy sensor that maintains energy homeostasis

(2012) D. Grahame Hardie et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

High levels of stearic acid, palmitoleic acid, and dihomo-γ-linolenic acid and low levels of linoleic acid in serum cholesterol ester are associated with high insulin resistance

(2012) Kayo Kurotani et al.   NUTRITION RESEARCH

Palmitoleate Induces Hepatic Steatosis but Suppresses Liver Inflammatory Response in Mice

(2012) Xin Guo et al.   PLoS One

Fatty acids in the de novo lipogenesis pathway and risk of coronary heart disease: the Cardiovascular Health Study

(2011) Jason HY Wu et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Insulin sensitivity is not associated with palmitoleate availability in obese humans

(2011) Elisa Fabbrini et al.   JOURNAL OF LIPID RESEARCH

Chronic administration of palmitoleic acid reduces insulin resistance and hepatic lipid accumulation in KK-Ay Mice with genetic type 2 diabetes

(2011) Zhi-Hong Yang et al.   Lipids in Health and Disease

Adipose tissue palmitoleic acid and obesity in humans: does it behave as a lipokine?

(2010) Jian Gong et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Circulating palmitoleic acid and risk of metabolic abnormalities and new-onset diabetes

(2010) Dariush Mozaffarian et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Role of hepatic desaturases in obesity-related metabolic disorders

(2010) Helena Bjermo et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Inflammatory markers and cardiovascular risk in the metabolic syndrome

(2010) Christine Espinola-Klein   Frontiers in Bioscience-Landmark

TNF-α Antagonism with Etanercept Decreases Glucose and Increases the Proportion of High Molecular Weight Adiponectin in Obese Subjects with Features of the Metabolic Syndrome

(2010) Takara L. Stanley et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Role of fatty acid elongases in determination of de novo synthesized monounsaturated fatty acid species

(2010) Christopher D. Green et al.   JOURNAL OF LIPID RESEARCH

Omega-3 Fatty Acids and Inflammatory Processes

(2010) Philip C. Calder   Nutrients

Human health benefits of vaccenic acid

(2009) Catherine J. Field et al.   Applied Physiology Nutrition and Metabolism

Vaccenic acid favourably alters immune function in obese JCR:LA- cp rats

(2009) Heather J. Blewett et al.   BRITISH JOURNAL OF NUTRITION

AMPK: An Emerging Drug Target for Diabetes and the Metabolic Syndrome

(2009) Bei B. Zhang et al.   Cell Metabolism

Circulating Palmitoleate Strongly and Independently Predicts Insulin Sensitivity in Humans

(2009) N. Stefan et al.   DIABETES CARE

The plasma lipidomic signature of nonalcoholic steatohepatitis

(2009) Puneet Puri et al.   HEPATOLOGY

Dietary Vaccenic Acid Has Antiatherogenic Effects in LDLr−/− Mice

(2009) Chantal M. C. Bassett et al.   JOURNAL OF NUTRITION

IL-1 antagonism reduces hyperglycemia and tissue inflammation in the type 2 diabetic GK rat

(2009) J. A. Ehses et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The key roles of elongases and desaturases in mammalian fatty acid metabolism: Insights from transgenic mice

(2009) Hervé Guillou et al.   PROGRESS IN LIPID RESEARCH

Identification of a Lipokine, a Lipid Hormone Linking Adipose Tissue to Systemic Metabolism

(2008) Haiming Cao et al.   CELL

Inhibition of Stearoyl-Coenzyme A Desaturase 1 Dissociates Insulin Resistance and Obesity From Atherosclerosis

(2008) J. Mark Brown et al.   CIRCULATION

Use of Salsalate to Target Inflammation in the Treatment of Insulin Resistance and Type 2 Diabetes

(2008) Allison B. Goldfine et al.   CTS-Clinical and Translational Science

Stearoyl-Coenzyme A Desaturase 1 Gene Expression Increases after Pioglitazone Treatment and Is Associated with Peroxisomal Proliferator-Activated Receptor-γ Responsiveness

(2008) Aiwei Yao-Borengasser et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Effects of Dietary Palmitoleic Acid on Plasma Lipoprotein Profile and Aortic Cholesterol Accumulation Are Similar to Those of Other Unsaturated Fatty Acids in the F1B Golden Syrian Hamster

(2008) Nirupa R. Matthan et al.   JOURNAL OF NUTRITION

Plasma palmitoleic acid, a product of stearoyl-coA desaturase activity, is an independent marker of triglyceridemia and abdominal adiposity

(2008) François Paillard et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

Effects of four-week high-fructose diet on gene expression in skeletal muscle of healthy men

(2007) K.-A. Lê et al.   DIABETES & METABOLISM