Article
Nutrition & Dietetics
Kieran Shay Struebin Abbotts, Taylor Russell Ewell, Hannah Michelle Butterklee, Matthew Charles Bomar, Natalie Akagi, Gregory P. Dooley, Christopher Bell
Summary: The study found significant pharmacokinetic differences between commercial CBD formulations, CBD is unlikely to affect the caloric cost of eating, but may benefit initial metabolic responses, consuming CBD with food alters the dynamics of CBD metabolism and increases systemic availability, low-dose CBD may not pose a risk to normal liver function.
Article
Endocrinology & Metabolism
Emmanuel Quaye, Shaji Chacko, Stephanie T. Chung, Robert J. Brychta, Kong Y. Chen, Rebecca J. Brown
Summary: This study demonstrates that gluconeogenesis accounts for a significant portion of energy expenditure in patients with insulin resistance, potentially one-third of resting energy expenditure. Prediction equations may underestimate caloric needs in these individuals.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2021)
Article
Cell Biology
Heegu Jin, Hyun-Ji Oh, Boo-Yong Lee
Summary: Sarcopenic obesity, characterized by obesity and muscle wasting, is common in the elderly and has become an increasing public health burden. This condition has a greater impact on metabolic disease compared to obesity or sarcopenia alone. The underlying mechanisms of sarcopenic obesity are complex and not fully understood, highlighting the need for effective treatments. This study investigates the potential therapeutic use of Gamma-aminobutyric acid (GABA) in preventing age-related sarcopenic obesity and related metabolic diseases.
Review
Endocrinology & Metabolism
Lili Huang, Lin Gao, Chen Chen
Summary: This review focuses on the metabolic role of MCFAs in modulating cellular signaling and regulating key circulating metabolites and hormones, as well as the potential of MCFAs in treating various metabolic diseases in a clinical setting.
TRENDS IN ENDOCRINOLOGY AND METABOLISM
(2021)
Article
Biochemistry & Molecular Biology
Qianhui Zeng, Nannan Wang, Yaru Zhang, Yuxuan Yang, Shuangshuang Li, Rong Zheng, Jin Chai, Tong Qiao, Siwen Jiang
Summary: The study demonstrates that Zfp217 plays a modulatory role in energy metabolism and may offer new insights into obesity treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Endocrinology & Metabolism
Alison D. McNeilly, Adonis Yianakas, Jennifer G. Gallagher, Jamie Tarlton, Michael L. J. Ashford, Rory J. McCrimmon
Summary: The study reveals the significant role of central IL-6Ra signaling in regulating glucose and energy homeostasis through mechanisms such as food intake, energy expenditure, fuel flexibility, and insulin secretion.
MOLECULAR METABOLISM
(2022)
Article
Endocrinology & Metabolism
Rongya Tao, Oliver Stohr, Caixia Wang, Wei Qiu, Kyle D. Copps, Morris F. White
Summary: This study found that disruption of hepatic insulin signaling can reduce adipose mass and increase energy expenditure in mice, preventing obesity. Moreover, a protein called Fst produced by the liver was found to regulate energy expenditure through its effects on muscles, revealing the important communication between the liver and muscles in controlling energy balance and obesity.
MOLECULAR METABOLISM
(2023)
Article
Endocrinology & Metabolism
Sonar Soni Panigoro, Noorwati Sutandyo, Fiastuti Witjaksono, Nurjati Chairani Siregar, Ramadhan Ramli, Ririn Hariani, Eko Adhi Pangarsa, Yan Wisnu Prajoko, Niken Puruhita, William Hamdani, Dimas Bayu, Mardiana Madjid, Dedy Yulidar, Jane Estherina Fransiska, Retno Widyawati, Effif Syofra Tripriadi, F. W. Wiwit Ade, Dewi Krisna Yunda, Raymond Pranata
Summary: The study revealed a nonlinear dose-response association between TyG index and breast cancer risk, showing that higher TyG index was linked to an increased risk of breast cancer.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Lifang Liu, Xiaoyu Hou, An Song, Yunpeng Guan, Peipei Tian, Chao Wang, Luping Ren, Yong Tang, Ling Gao, Xiaoping Xing, Guangyao Song
Summary: This study investigated the impact of lipid metabolism disorders on insulin sensitivity and beta-cell function in individuals with normal glucose tolerance. The results showed that as lipid metabolism deteriorated, insulin sensitivity and beta-cell function gradually decreased, with both fasting and postprandial triglyceride concentrations affecting these functions. Postprandial triglyceride concentrations were identified as independent risk factors for impaired beta-cell function and insulin resistance in individuals with normal glucose tolerance.
JOURNAL OF DIABETES INVESTIGATION
(2022)
Article
Endocrinology & Metabolism
Xi Chen, Enrique Maldonado, Ralph A. DeFronzo, Devjit Tripathy
Summary: The study revealed that there is a relationship between plasma glucagon levels and insulin sensitivity and insulin secretion in obese individuals. As glucose intolerance worsens, the insulin-mediated suppression of glucagon secretion is impaired, which corresponds to the severity of insulin resistance and beta-cell dysfunction.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Multidisciplinary Sciences
Aiyun Li, Wenjuan Shi, Jin Wang, Xuejiao Wang, Yan Zhang, Zhandong Lei, Xiang-Ying Jiao
Summary: This study found that AT1aR deficiency delays obesity development in high-fat diet rats by promoting adipose lipolysis, possibly through the cAMP/PKA pathway. These findings reveal the role of Ang II in the formation of obesity and provide new insights for the treatment of obesity and related metabolic diseases.
Article
Multidisciplinary Sciences
Aiyun Li, Wenjuan Shi, Jin Wang, Xuejiao Wang, Yan Zhang, Zhandong Lei, Xiang-Ying Jiao
Summary: The study found that AT1aR deficiency promoted adipose lipolysis in high-fat diet rats by activating lipolysis-related enzymes and increasing the levels of NEFAs and glycerol released from adipose tissue, without affecting triglycerides synthesis. Additionally, AT1aR knockout enhanced energy expenditure and fatty acids oxidation in adipose tissue. Increased cAMP levels and PKA phosphorylation in adipose tissue of AT1aR(-/-) rats fed with high-fat diet were observed, which led to improved adipose histomorphology and insulin sensitivity.
Article
Endocrinology & Metabolism
Karen D. Corbin, Elvis A. Carnero, Timothy D. Allerton, Joachim Tillner, Christopher P. Bock, Pierre-Philippe Luyet, Britta Gobel, Kevin D. Hall, Stephanie A. Parsons, Eric Ravussin, Steven R. Smith
Summary: This study aimed to test the hypothesis that treatment with the glucagon-like peptide-1/glucagon receptor agonist SAR425899 would result in less metabolic adaptation and increased lipid oxidation. The results showed that SAR425899 led to a smaller reduction in body composition-adjusted sleeping metabolic rate (SMR) and increased fat oxidation, which are beneficial for weight loss and weight-loss maintenance.
Article
Psychology, Biological
Gregory N. Ruegsegger, Chapin Rappaport, Justin J. Hill, Kelly A. Jochum, Erik S. Challeen, Michael C. Roth
Summary: Short-term consumption of SFA leads to worsened cognitive performance in obese men, associated with increased IR.
PHYSIOLOGY & BEHAVIOR
(2022)
Article
Nutrition & Dietetics
Annaliese Widmer, Margaret G. Mercante, Heidi J. Silver
Summary: This study aimed to determine the contribution of cardiometabolic biomarkers to the variation in resting energy expenditure (REE) in individuals with different body mass index (BMI) categories and to assess their contribution in predicting REE based on glycemic and metabolic syndrome status. The results showed that the TG/HDL ratio is an independent predictor of REE. Calculating the TG/HDL ratio can help healthcare providers identify patients with impaired lipid metabolism and optimize REE estimation for weight and disease management goals.
Article
Biochemistry & Molecular Biology
Rachel B. Wilson, Richard Zhang, Yun Jin Chen, Kia M. Peters, Cynthia G. Sawyez, Brian G. Sutherland, Krisha Patel, John P. Kennelly, Kelly-Ann Leonard, Rene L. Jacobs, Rennian Wang, Nica M. Borradaile
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Endocrinology & Metabolism
Jesus M. Pradillo, Macarena Hernandez-Jimenez, Maria E. Fernandez-Valle, Violeta Medina, Juan E. Ortuno, Stuart M. Allan, Spencer D. Proctor, Juan M. Garcia-Segura, Maria J. Ledesma-Carbayo, Andres Santos, Maria A. Moro, Ignacio Lizasoain
Summary: The study found that stroke outcomes and angiogenesis/vasculogenesis in old rats are negatively affected by the co-morbidities present in the corpulent genotype. DCE-MRI may be a useful technique for non-invasive evaluation of vascular function and angiogenesis processes.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Article
Cell Biology
Irene Anastasia, Nicolo Ilacqua, Andrea Raimondi, Philippe Lemieux, Rana Ghandehari-Alavijeh, Guilhem Faure, Sergei L. Mekhedov, Kevin J. Williams, Federico Caicci, Giorgio Valle, Marta Giacomello, Ariel D. Quiroga, Richard Lehner, Michael J. Miksis, Katalin Toth, Thomas Q. de Aguiar Vallim, Eugene Koonin, Luca Scorrano, Luca Pellegrini
Summary: The study reveals that liver wrappER-mitochondria contacts participate in VLDL biology, suggesting an involvement of inter-organelle contacts in systemic lipid homeostasis.
Article
Microbiology
Craig Resch, Mihir Parikh, J. Alejandro Austria, Spencer D. Proctor, Thomas Netticadan, Heather Blewett, Grant N. Pierce
Summary: Research indicates that an HFHS diet leads to dysbiosis in the gut microbiota, and gender, diet, and flaxseed supplementation all play a role in influencing the composition and diversity of the microbiota.
Article
Nutrition & Dietetics
Jenneffer Rayane Braga Tibaes, Jessy Azarcoya-Barrera, Bethany Wollin, Hellen Veida-Silva, Alexander Makarowski, Donna Vine, Sue Tsai, Rene Jacobs, Caroline Richard
Summary: The study found that male rats gained more weight than females and females on a high-fat diet showed better cytokine production. Sex differences modulate immune function in the context of high-fat feeding.
JOURNAL OF NUTRITION
(2022)
Article
Biochemistry & Molecular Biology
Mihir Parikh, Branislav Kura, Bhavana Garg, J. Alejandro Austria, Liping Yu, Thane G. Maddaford, Spencer D. Proctor, Thomas Netticadan, Grant N. Pierce
Summary: The research indicates that dietary flaxseed can protect obese rats from myocardial ischemic lesions and reduce the occurrence of cardiac lesions; a high-fat, high-sucrose diet increases the frequency of myocardial ischemic lesions, but dietary flaxseed can lower the frequency of cardiac lesions and improve heart function.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2021)
Article
Nutrition & Dietetics
Karen E. Christensen, Olga V. Malysheva, Stephanie Carlin, Fernando Matias, Amanda J. MacFarlane, Rene L. Jacobs, Marie A. Caudill, Rima Rozen
Summary: Folate and choline are metabolically interconnected. Choline deficiency may interact with the MTHFD1 R653Q SNP and increase health risks. This study assessed the effects of choline deficiency on maternal one-carbon metabolism and reproductive outcomes in a mouse model for MTHFD1 R653Q. The results showed that mild choline deficiency and Mthfd1S(+/-) genotype alter maternal one-carbon metabolism and increase the incidence of developmental defects.
Article
Microbiology
Vijay P. Singh, Melanie A. Fontaine, Rabban Mangat, Janelle M. Fouhse, Abdoulaye Diane, Benjamin P. Willing, Spencer D. Proctor
Summary: High-fat diets can influence gut microbial composition, while beef fat rich in vaccenic acid may have insulin-sensitizing effects, increase HDL cholesterol, reduce postprandial plasma TG, and protect against high-fat diet-induced changes in gut microbial composition in low birth weight pigs. Further research is needed to understand the mechanisms behind natural trans fats' effects on gut dysbiosis.
Review
Nutrition & Dietetics
Yongbo She, Rabban Mangat, Sue Tsai, Spencer D. Proctor, Caroline Richard
Summary: Obesity is strongly linked to inflammation, impaired insulin signaling, lipid metabolism, and immune function. Recent research has provided insights into the mechanisms of immune dysfunction in obesity, using various animal and clinical models. Nutritional strategies, particularly those involving choline-rich foods, are emerging as potential ways to improve immune function in the context of obesity.
FRONTIERS IN NUTRITION
(2022)
Article
Microbiology
Edward C. Deehan, Zhengxiao Zhang, Alessandra Riva, Anissa M. Armet, Maria Elisa Perez-Munoz, Nguyen K. Nguyen, Jacqueline A. Krysa, Benjamin Seethaler, Yuan-Yuan Zhao, Janis Cole, Fuyong Li, Bela Hausmann, Andreas Spittler, Julie-Anne Nazare, Nathalie M. Delzenne, Jonathan M. Curtis, Wendy Wismer, Spencer D. Proctor, Jeffrey A. Bakal, Stephan C. Bischoff, Dan Knights, Catherine J. Field, David Berry, Carla M. Prado, Jens Walter
Summary: This study demonstrates the efficacy of purified dietary fibers when used as supplements and suggests that the satiating effects of AX may be linked to bacterial taxa that ferment the fiber or utilize breakdown products.
Article
Nutrition & Dietetics
Yongbo She, Kun Wang, Alexander Makarowski, Rabban Mangat, Sue Tsai, Benjamin P. Willing, Spencer D. Proctor, Caroline Richard
Summary: This study investigated the impact of dairy and dairy fat on cardiometabolic risk factors and immune function using a low birthweight swine model. The results showed that consuming high-fat dairy products improved fasting plasma glucose concentrations compared to low-fat dairy, while dairy consumption had a neutral effect on fasting lipid profile. Furthermore, consuming low-fat dairy significantly improved the production of certain cytokines, indicating enhanced immune function.
FRONTIERS IN NUTRITION
(2022)
Article
Nutrition & Dietetics
Yongbo She, Kun Wang, Alexander Makarowski, Rabban Mangat, Sue Tsai, Benjamin P. Willing, Spencer D. Proctor, Caroline Richard
Summary: This study investigated the effects of consuming high-fat and low-fat dairy products on postprandial cardiometabolic risk factors and intestinal immune function using a low birthweight swine model. The results showed that dairy consumption, regardless of fat content, did not have an impact on postprandial cardiometabolic risk factors. However, low-fat dairy products were found to significantly improve intestinal T cell function compared to high-fat dairy products in this model of obesity and insulin resistance.
EUROPEAN JOURNAL OF NUTRITION
(2023)
Article
Agriculture, Dairy & Animal Science
Kun Wang, Yongbo She, Rabban Mangat, Alexander Makarowski, Bimol C. Roy, Heather L. Bruce, Michael K. Dyck, Caroline Richard, Spencer D. Proctor
Summary: Increasing dairy intake can enhance the absorption of fatty acids into pork. Low-birth weight (LBW) swine fed a high-fat diet are susceptible to insulin resistance and excessive lipid absorption, but increasing dairy intake can alleviate these issues. Additionally, increasing dairy intake can increase the healthy fatty acid content in pork and improve carcass lean yield.
JOURNAL OF ANIMAL SCIENCE
(2023)
Article
Gastroenterology & Hepatology
John P. Kennelly, Stephanie Carlin, Tingting Ju, Jelske N. van der Veen, Randal C. Nelson, Jean Buteau, Aducio Thiesen, Caroline Richard, Ben P. Willing, Rene L. Jacobs
Summary: The study found that the loss of CT alpha in intestinal epithelial cells leads to decreased colonic PC concentrations and rapid, spontaneous colitis development in adult mice, which is linked to an endoplasmic reticulum stress response. These results highlight the crucial role of IEC phospholipid equilibrium in colonic homeostasis.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Pediatrics
Jacqueline A. Krysa, Geoff D. C. Ball, Donna F. Vine, Mary Jetha, Spencer D. Proctor
Summary: This study examined the association between obesity and cardiovascular risk factors in youth, finding that obesity was linked to higher levels of fasting and non-fasting apoB48-remnants compared to non-obese individuals. Additionally, fasting apoB48-remnants were positively correlated with non-fasting apoB48 response as well as other cardiometabolic risk factors, suggesting that they may serve as potential biomarkers for cardiovascular disease risk in youth.
Article
Biochemistry & Molecular Biology
Xinyu Wang, Jun Huang, Huan Li, Yanlong Li, Shuang Cai, Bangxin Xue, Zhekun Zhu, Xiangzhou Zeng, Xiangfang Zeng
Summary: Embryo development plays a crucial role in pregnancy outcome and lifelong health. A high throughput screening cell model was established to select nutrients that can enhance embryonic development. Resveratrol was identified as a potential candidate for promoting embryo development.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Ren Yoshitomi, Motofumi Kumazoe, Kwan-Woo Lee, Yuki Marugame, Yoshinori Fujimura, Hirofumi Tachibana
Summary: This study investigated the connection between food components and circular RNA (circRNA), as well as the regulatory effect of (-)-Epigallocatechin-3-O-gallate (EGCG) on circRNA expression in the liver. The results showed that EGCG treatment altered the expression of circRNAs in mice livers, and one upregulated circRNA (mmu_circRNA_011775) affected the expression of genes related to liver fibrosis and the cardiovascular system.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
ViVi Tang Kang Wee, Hitoshi Shirakawa, Sung-Ling Yeh, Chiu-Li Yeh
Summary: This study investigated the effects of fermented rice bran (FRB) on modulating intestinal aryl hydrocarbon receptor (AhR) expression, innate lymphoid cell (ILC)3 populations, the fecal microbiota distribution, and their associations with dextran sodium sulfate (DSS)-induced acute colitis. The results showed that FRB supplementation can improve gut health, alleviate colitis symptoms, and have anti-colitis effects by enhancing ILC3 and AhR functions.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Xinzhuang Ma, Xijuan Ren, Xuemin Zhang, Guangyin Wang, Hui Liu, Li Wang
Summary: The study demonstrates that rutin can ameliorate kidney damage caused by PFOA exposure by improving oxidative stress and regulating lipid metabolism.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Ya-Jie Ding, Xue-Ning Li, Zhe Xiao, Chen-Yang Li, Li-Hong Jia
Summary: This study investigates the impact of maternal vitamin D levels during pregnancy on infantile eczema. The findings suggest that lower prenatal maternal vitamin D levels increase the risk of eczema in infants aged 0-1 year. Furthermore, the study indicates that infants with eczema have lower expression of the Foxp3 gene in cord blood and decreased placental FOXP3 protein expression. These results suggest that vitamin D may affect the development of infantile eczema through the regulation of gene and protein expression in cord blood and placenta.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Shujing Liu, Shiyu Song, Shuan Wang, Tonghui Cai, Lian Qin, Xinzhuang Wang, Guangming Zhu, Haibo Wang, Wenqi Yang, Chunlu Fang, Yuan Wei, Fu Zhou, Yang Yu, Shaozhang Lin, Shuang Peng, Liangming Li
Summary: Long-term consumption of a high-fat diet disrupts energy balance and leads to weight gain. The fat mass and obesity-associated (FTO) gene is involved in high-fat diet-induced obesity. The hypothalamus plays a crucial role in regulating energy balance, and high-fat diet-induced hypothalamic leptin resistance contributes to obesity. The study reveals that FTO is associated with hypothalamic leptin resistance and provides new insight into its role in obesity.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Shuang Liu, Xiaoling Chen, Jun He, Yuheng Luo, Ping Zheng, Bing Yu, Daiwen Chen, Zhiqing Huang
Summary: This study found that oleanolic acid promotes the transformation of fast muscle fibers to slow muscle fibers through the TGR5-mediated CaN/NFATc1 signaling pathway.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Huijuan Hu, Fan Li, Shaoli Cheng, Tingting Qu, Fanqi Shen, Jie Cheng, Lina Chen, Zhenghang Zhao, Hao Hu
Summary: Long-term alternate-day fasting can ameliorate obesity-induced anxiety-like behavior and hippocampal damage, but it can cause anxiety in normal-weight mice. Short-term alternate-day fasting does not produce adverse emotional reactions in normal-weight mice.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Jannis Ulke, Christian Schwedler, Janine Krueger, Vanessa Stein, Peter Geserick, Andre Kleinridders, Kai Kappert
Summary: This study characterized the glycosylation pattern of PTPRJ in the liver and found that high-fat diet-induced obesity altered the glycosylation pattern of PTPRJ. These findings provide new insights into the role of glycosylation in metabolic disorders.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Shuang Liu, Marii Mochizuki, Yasuyuki Suzuki, Erika Takemasa, Akiko Yano, Matome Imai, Masaki Mogi
Summary: This study evaluated the feasibility and efficacy of leucine supplementation in offsetting immune dysfunction in sarcopenia. The results showed that leucine supplementation not only improved muscle mass and restored mitochondrial respiratory function, but also reduced inflammation levels. These findings are important for the rational design and optimization of leucine supplementation in patients with sarcopenia and autoimmune diseases.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Review
Biochemistry & Molecular Biology
Zhan Su, Jun Fang, Bin Yao, Gang Liu
Summary: Osteoporosis is a serious skeletal disorder that can be prevented and treated by polyphenols, which have antioxidant and anti-allergy properties. Polyphenols affect bone metabolism and density by inhibiting oxidative stress and exhibiting antibacterial effects. This article provides an overview of the preventive and therapeutic effects of polyphenols on osteoporosis and discusses the mechanisms involved.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Qian Zhang, Xinhua Xiao, Jia Zheng, Ming Li, Miao Yu, Fan Ping, Tong Wang, Xiaojing Wang
Summary: Maternal high-fat diet can affect the structure and function of offspring's pancreas, leading to weight gain, glucose metabolism disorders, and insulin secretion defects. The study found that this may be related to DNA methylation of specific genes in the pancreas.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Hanaa Mousa, Aisha Al Saei, Rozaimi Mohamad Razali, Susu M. Zughaier
Summary: Vitamin D deficiency and dyslipidemia have significant implications for human health. This study investigates the proteomic profiles of individuals with and without these conditions, revealing decreased HDL-associated apolipoproteins and increased acute-phase proteins. Pathway analysis highlights inflammatory and cancer pathways associated with vitamin D deficiency and dyslipidemia.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Qi-Lan Jiang, Tao Li, Qin Xu, Yang Zeng, Wei Wang, Bo-Tao Zhang, Qing-Ping Yao, Rui Jiang, Jun Jiang
Summary: Environmental factors, especially dietary habits, play a significant role in the susceptibility and progression of cardiovascular diseases through epigenetic modification. This study found that a methyl donor diet can attenuate balloon injury-induced intimal hyperplasia in rat carotid arteries, potentially by influencing the composition and function of the extracellular matrix.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Review
Biochemistry & Molecular Biology
Jiayi Cai, Yajie Qiao, Lingbin Chen, Youguang Lu, Dali Zheng
Summary: The Notch signaling pathway plays a regulatory role in normal biological processes such as cellular differentiation, apoptosis, and stem cell self-renewal. Dysregulation of this pathway is associated with various types of cancer. Natural products targeting the Notch pathway have shown potential as chemopreventive and anti-cancer agents, providing a feasible solution to fight against cancer by either alone or in combination with current therapeutic agents.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)