Article
Pharmacology & Pharmacy
Rasool Haddadi, Mohammad Cheraghi-poor
Summary: This study investigated the analgesic and anti-inflammatory effects of naproxen and pioglitazone, and found that their combined treatment enhanced these effects. The involvement of PPAR-gamma receptor was also noted. Additionally, these drugs reduced the release of inflammatory cytokines and myeloperoxidase activity.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2023)
Article
Biology
Catarina Teixeira, Andre P. Sousa, Ines Santos, Ana Catarina Rocha, Ines Alencastre, Ana Claudia Pereira, Daniela Martins-Mendes, Pedro Barata, Pilar Baylina, Ruben Fernandes
Summary: This study demonstrates that pioglitazone enhances adipocyte differentiation and secretome production, making it an excellent model for studying adiposity. The study also proposes an improved method for adipocyte secretome production, which can be used for experimental biology studies to understand the molecular mechanisms underlying the influence of adiposity on other cells.
Article
Medicine, Research & Experimental
Yuichi Igarashi, Shiho Iida, Jian Dai, Jia Huo, Xiaoran Cui, Jinko Sawashita, Masayuki Mori, Hiroki Miyahara, Keiichi Higuchi
Summary: Long-term supplementation of Glavonoid-rich oil (GRO) derived from licorice root in obese and diabetic mice improved metabolic disorders by reducing body weight and white adipose tissue weight, lowering serum triglycerides and cholesterol levels, and enhancing glucose tolerance. The improved lipid profiles were attributed to reduced de novo lipogenesis in the liver and white adipose tissue, while glucose metabolism may benefit from increased glycolysis in the liver.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Multidisciplinary Sciences
Huibin Tian, Huimin Niu, Jun Luo, Weiwei Yao, Wenchang Gao, Yang Wen, Min Cheng, Anmin Lei, Jinlian Hua
Summary: The aim of this study was to evaluate the effects of SCD1 on embryo development and lipid synthesis using a knockout mice model generated by the CRISPR/Cas9 system. The results showed that microinjection during the S phase had the highest zygote survival rate, and Scd1 knockout reduced blastocyst formation rates. In addition, in the knockout mice, the protein level of SCD1 decreased, and body weight and serum TAG and cholesterol contents were reduced.
Article
Genetics & Heredity
Liangjie Lu, Lijun Wang, Jiqiong Wu, Minjie Yang, Binhui Chen, Huihan Wang, Kaifeng Gan
Summary: This study reveals that DNMT3a promotes osteoblast differentiation through the methylation regulation of PPAR gamma. PPAR gamma inhibits osteoblast differentiation by upregulating SCD1 and downregulating GLUT1 expression. Inhibition of PPAR gamma reduces SCD1 expression and increases GLUT1 expression, thus alleviating postmenopausal osteoporosis.
Review
Biochemistry & Molecular Biology
Yanhao Qiu, Mailin Gan, Xingyu Wang, Tianci Liao, Qiuyang Chen, Yuhang Lei, Lei Chen, Jinyong Wang, Ye Zhao, Lili Niu, Yan Wang, Shunhua Zhang, Li Zhu, Linyuan Shen
Summary: Excessive expansion of adipocytes can lead to ectopic fat deposition, increasing the risk of metabolic diseases. Peroxisome proliferator-activated receptor gamma (PPARγ) plays a crucial role in fat cell differentiation and adipogenesis.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Rheumatology
Sarfaraz Hasni, Yenealem Temesgen-Oyelakin, Michael Davis, Jun Chu, Elaine Poncio, Mohammad Naqi, Sarthak Gupta, Xinghao Wang, Christopher Oliveira, Dillon Claybaugh, Amit Dey, Shajia Lu, Philip Carlucci, Monica Purmalek, Zerai G. Manna, Yinghui Shi, Isabel Ochoa-Navas, Jinguo Chen, Amrita Mukherjee, Kyu Lee Han, Foo Cheung, Galina Koroleva, Yasmine Belkaid, John S. Tsang, Richard Apps, Donald E. Thomas, Theo Heller, Massimo Gadina, Martin P. Playford, Xiaobai Li, Nehal N. Mehta, Mariana J. Kaplan
Summary: The study aimed to investigate the effects of the peroxisome proliferator activated receptor-gamma agonist pioglitazone (PGZ) on vascular function and cardiometabolic parameters in SLE patients. The results showed that PGZ significantly improved vascular stiffness and metabolic parameters in SLE patients.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Engineering, Environmental
Clementine Garoche, Abdelhay Boulahtouf, Marina Grimaldi, Barbara Chiavarina, Lucia Toporova, Marjo J. den Broeder, Juliette Legler, William Bourguet, Patrick Balaguer
Summary: This study demonstrated the interspecies differences in PPAR gamma activities among human, mouse, zebrafish, and xenopus, highlighting the importance of using species-specific models to study endocrine and metabolism disruption by environmental chemicals.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2021)
Article
Microbiology
Yi-Hsin Lai, Tai-Chieh Wu, Bo-Yang Tsai, Yuan-Pin Hung, Hsiao-Ju Lin, Yau-Sheng Tsai, Wen-Chien Ko, Pei-Jane Tsai
Summary: PPAR-γ plays an important role in the pathogenesis of CDI by regulating colonic inflammation and integrity.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Neurosciences
May A. Abd El Fattah, Yasmine A. Abdelhamid, Mohammed F. Elyamany, Osama A. Badary, Ola A. Heikal
Summary: RBE administration was found to protect against the LPS-induced inflammatory effects by decreasing the inflammatory mediator expression in mice brains, potentially through PPAR-gamma activation. Additionally, RBE also decreased PPAR-gamma sumoylation.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Si-ping Xiong, Hai-jian Sun, Xu Cao, Zhi-yuan Wu, Meng-yuan Zhu, Lei Cao, Xiao-wei Nie, Jin-song Bian
Summary: In this study, the therapeutic effects of polysulfide in diabetic cardiomyopathy were investigated using Na2S4. The results showed that Na2S4 protected cardiomyocytes against high glucose-induced injury and improved pathological changes. Mechanistically, Na2S4 exerted its protective effects by sulfhydrating PPAR gamma and SIRT-3. These findings suggest that polysulfide may be a potential agent for treating diabetic cardiomyopathy.
ANTIOXIDANTS & REDOX SIGNALING
(2023)
Review
Endocrinology & Metabolism
Samuel M. Lee, Jose Muratalla, Marta Sierra-Cruz, Jose Cordoba-Chacon
Summary: Peroxisome proliferator-activated receptor ? (PPAR?) is a lipid sensor that plays a role in regulating glucose and lipid metabolism. Thiazolidinediones (TZDs) are insulin sensitizers that target PPAR? and have potential benefits in treating non-alcoholic fatty liver disease (NAFLD). However, studies in mouse models suggest that PPAR? activation in hepatocytes may limit the therapeutic potential of TZDs against NAFLD. This review provides an overview of PPAR isoforms, their tissue-specific expression, the pathogenesis of NAFLD, and potential therapeutics.
JOURNAL OF ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Toru Iizaka, Eriko Kodama, Kentaro Mikura, Tatsuya Iida, Hideyuki Imai, Mai Hashizume, Yasuyoshi Kigawa, Chiho Sugisawa, Rie Tadokoro, Kei Endo, Fumiko Otsuka, Masayo Isoda, Ken Ebihara, Shun Ishibashi, Shoichiro Nagasaka
Summary: This article reports the first pedigree of familial partial lipodystrophy (FPLD 3) in Japanese patients. The diagnosis of FPLD 3 was made based on the patient's clinical manifestations, imaging studies, and genetic analysis. It emphasizes the importance of considering lipodystrophy syndromes in non-obese diabetic patients with features of insulin resistance.
Article
Pathology
Shinji Kaba, Yoshitaka Kawai, Yuki Tanigami, Hiroe Ohnishi, Tomoko Kita, Masayoshi Yoshimatsu, Koichi Omori, Yo Kishimoto
Summary: This study aimed to evaluate the effects of pioglitazone on macrophage phenotype and fibrosis following vocal fold injury. The results showed that pioglitazone reduced the expression of Ccl2, inhibited the accumulation of inflammatory macrophages, and improved tissue repair in a PPARy-dependent manner, resulting in decreased fibrosis.
AMERICAN JOURNAL OF PATHOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Zhen Wang, Shu Yang, Yan Li, Yongying Zhou, Daoquan Liu, Jianmin Liu, Michael E. DiSanto, Xinhua Zhang
Summary: BPH is a common disease in elderly men and is closely related to MetS. This study demonstrates that SV can modulate cell proliferation, apoptosis, tissue fibrosis, and the EMT process in the prostate through crosstalk between PPAR gamma and WNT/beta-catenin pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Editorial Material
Endocrinology & Metabolism
Michael R. Lewis, Robert C. Macauley, Patricia R. Sheehan, Myrlene A. Staten, Lawrence S. Phillips, Neda Rasouli, Anastassios G. Pittas
Article
Endocrinology & Metabolism
Yunjiao J. Wang, Stacey Seggelke, R. Matthew Hawkins, Joanna Gibbs, Mark Lindsay, Ingrid Hazlett, Cecilia C. Low Wang, Neda Rasouli, Kendra A. Young, Boris Draznin
ENDOCRINE PRACTICE
(2016)
Article
Endocrinology & Metabolism
Kristen E. Boyle, Jacob E. Friedman, Rachel C. Janssen, Chantal Underkofler, Joseph A. Houmard, Neda Rasouli
HORMONE AND METABOLIC RESEARCH
(2017)
Article
Endocrinology & Metabolism
Helen M. Lawler, Chantal M. Underkofler, Philip A. Kern, Christopher Erickson, Brooke Bredbeck, Neda Rasouli
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2016)
Article
Medicine, General & Internal
Neda Rasouli
JOURNAL OF INVESTIGATIVE MEDICINE
(2016)
Article
Cell Biology
Tyler J. Kirby, R. Grace Walton, Brian Finlin, Beibei Zhu, Resat Unal, Neda Rasouli, Charlotte A. Peterson, Philip A. Kern
PHYSIOLOGICAL GENOMICS
(2016)
Article
Endocrinology & Metabolism
Paresh Dandona, Chantai Mathieu, Moshe Phillip, Lars Hansen, Steven C. Griffen, Diethelm Tschope, Fredrik Thoren, John Xu, Anna Maria Langkilde
LANCET DIABETES & ENDOCRINOLOGY
(2017)
Article
Endocrinology & Metabolism
Daniel S. Hsia, Neda Rasouli, Anastassios G. Pittas, Christine W. Lary, Anne Peters, Michael R. Lewis, Sangeeta R. Kashyap, Karen C. Johnson, Erin S. LeBlanc, Lawrence S. Phillips, James M. Hempe, Cyrus Desouza
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2020)
Editorial Material
Endocrinology & Metabolism
Neda Rasouli
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2020)
Editorial Material
Endocrinology & Metabolism
Kendra A. Young, Neda Rasouli
JOURNAL OF DIABETES AND ITS COMPLICATIONS
(2020)
Article
Endocrinology & Metabolism
Neda Rasouli, Naji Younes, Kristina M. Utzschneider, Silvio E. Inzucchi, Ashok Balasubramanyam, Andrea L. Cherrington, Faramarz Ismail-Beigi, Robert M. Cohen, Darin E. Olson, Ralph A. DeFronzo, William H. Herman, John M. Lachin, Steven E. Kahn
Summary: The study found that women had higher beta-cell function than men but similar insulin sensitivity. Beta-cell function differed by race, with Black/African Americans having the highest oral disposition index (DI) followed by American Indians/Alaska Natives, Asians, and Whites. Differences in HbA(1c) were observed among different races but not between sexes. Age, BMI, and TG/HDL-C were associated with both beta-cell function and insulin sensitivity.
Article
Endocrinology & Metabolism
Neda Rasouli, Irwin G. Brodsky, Ranee Chatterjee, Sun H. Kim, Richard E. Pratley, Myrlene A. Staten, Anastassios G. Pittas
Summary: Supplementation with vitamin D-3 for 24 months did not improve beta-cell function in people with prediabetes, but showed benefits in those with very low baseline vitamin D levels.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Rodica Pop-Busui, James L. Januzzi, Dennis Bruemmer, Sonia Butalia, Jennifer B. Green, William B. Horton, Colette Knight, Moshe Levi, Neda Rasouli, Caroline R. Richardson
Summary: Heart failure is a common complication of diabetes, even in the absence of other cardiovascular diseases. With the increasing prevalence of diabetes globally, particularly type 2 diabetes, the burden of heart failure on the healthcare system is expected to rise. This consensus report aims to provide clear guidance to practitioners on screening and diagnosing heart failure in individuals with diabetes.
Letter
Endocrinology & Metabolism
Neda Rasouli, Anastassios G. Pittas
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Medicine, General & Internal
Jean Chen, Amy Diesburg-Stanwood, Geza Bodor, Neda Rasouli
JOURNAL OF INVESTIGATIVE MEDICINE HIGH IMPACT CASE REPORTS
(2016)