Article
Endocrinology & Metabolism
Fei Luo, Chao Xing, Sumeet K. Asrani, Shili Li, Guosheng Liang, Helen H. Hobbs, Jonathan C. Cohen
Summary: This study identified a missense variant in the insulin receptor associated with fatty liver disease in a four generation family, but experiments in mice failed to show a causal relationship between this variant and the disease or any impact on hepatic triglyceride metabolism.
MOLECULAR METABOLISM
(2021)
Article
Gastroenterology & Hepatology
Janine Dywicki, Laura Elisa Buitrago-Molin, Fatih Noyan, Ana C. Davalos-Misslitz, Katharina L. Hupa-Breier, Maren Lieber, Martin Hapke, Jerome Schlue, Christine S. Falk, Solaiman Raha, Immo Prinz, Christian Koenecke, Michael P. Manns, Heiner Wedemeyer, Matthias Hardtke-Wolenski, Elmar Jaeckel
Summary: Studies have shown that feeding NASH-resistant BALB/c mice with a high-fat high-carbohydrate diet can activate intrahepatic T cells, while the absence of the adaptive immune response has a significant impact on NASH. The increase in intrahepatic Treg numbers in NASH patients did not improve NASH and unexpected had negative effects when Treg transfer or anti-CD3 therapy were attempted.
HEPATOLOGY COMMUNICATIONS
(2022)
Review
Pharmacology & Pharmacy
Linda Vanessa Marquez-Quiroga, Jaime Arellanes-Robledo, Veronica Rocio Vasquez-Garzon, Saul Villa-Trevino, Pablo Muriel
Summary: NASH is a major risk factor for HCC, and current experimental models provide valuable tools for studying and evaluating new drugs for chronic liver diseases. These models show promise in replicating liver alterations and promoting liver injury progression, but there is still room for improvement in simulating the progression from NASH to HCC.
BIOCHEMICAL PHARMACOLOGY
(2022)
Review
Endocrinology & Metabolism
Bing Yang, Liqing Lu, Dongmei Zhou, Wei Fan, Lucia Barbier-Torres, Justin Steggerda, Heping Yang, Xi Yang
Summary: Fatty liver disease is a complex liver pathology with various pathogenesis and lack of effective treatments. Hepatokines play important roles in the development of NAFLD and NASH and interact with cytokines or peptides secreted from muscle, adipose tissue, and hepatic stellate cells.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Nutrition & Dietetics
Danijela Ristic-Medic, Marijana Kovacic, Marija Takic, Aleksandra Arsic, Snjezana Petrovic, Marija Paunovic, Maja Jovicic, Vesna Vucic
Summary: This study evaluated the effects of calorie-restricted Mediterranean and low-fat diets on patients with NAFLD. Both diets resulted in significant weight loss and improvements in liver status and cardiometabolic markers. The Mediterranean diet may have additional benefits compared to the low-fat diet by improving fatty acid profiles and FLI in NAFLD patients.
Article
Nutrition & Dietetics
Jui-Ting Yang, Yu-Jen Chen, Chao-Wei Huang, Ya-Chin Wang, Harry J. Mersmann, Pei-Hwa Wang, Shih-Torng Ding
Summary: The study demonstrates that DHA negatively regulates the adipogenic TN in both pigs in vivo and in humans/pigs in vitro, potentially through SREBP-1c or FoxO. This down-regulation of TN associated with fibrinolysis and adipogenesis could contribute to the beneficial effects of DHA on alleviating obesity-induced metabolic syndromes.
Review
Biochemistry & Molecular Biology
Chuanfei Zeng, Mingkai Chen
Summary: This paper comprehensively introduces the role of the SIRT family in regulating mitochondrial biogenesis in the liver in NAFLD. SIRT family members play an important role in regulating hepatic fatty acid oxidation metabolism and mitochondrial energy metabolism through various pathways and mechanisms, potentially playing a key role in improving NAFLD.
Article
Biochemistry & Molecular Biology
Hao Han, Xiaoyu Li, Yan Guo, Mingming Zheng, Tingli Xue, Linqi Wang
Summary: The study focused on exploring the beneficial effects of plant sterol ester of alpha-linolenic acid (PS-ALA) in treating NAFLD through AMPK signaling, demonstrating its ability to improve mitochondrial function and reduce oxidative stress.
Article
Pharmacology & Pharmacy
Jing Quan, Ann M. Bode, Xiangjian Luo
Summary: The deregulation of fatty acid metabolism is associated with cancer development, with ACSL family members playing different roles in cancer progression, some promoting cancer and some having inhibitory effects, while also participating in cell death processes. ACSLs may serve as important therapeutic targets and biomarkers for cancer treatment.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Cell Biology
Da-Hye Lee, So-Hyun Park, Jiyun Ahn, Seung Pyo Hong, Eunyoung Lee, Young-Jin Jang, Tae-Youl Ha, Yang Hoon Huh, Seung-Yeon Ha, Tae-Il Jeon, Chang Hwa Jung
Summary: The study revealed that inhibition of Mir214-3p expression alleviated fatty liver disease by increasing autophagic activity through upregulation of Ulk1. Mir214-3p is a potential therapeutic target for nonalcoholic fatty liver disease.
Article
Nutrition & Dietetics
Tiia N. K. Makela, Tomi-Pekka Tuomainen, Sari Hantunen, Jyrki K. Virtanen
Summary: This study investigated the associations between serum n-3 and n-6 polyunsaturated fatty acids (PUFAs) and nonalcoholic fatty liver disease (NAFLD) in middle-aged and older men and women from eastern Finland. The results showed that higher serum concentrations of total n-6 PUFAs and linoleic acid were associated with lower risk for future NAFLD.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2022)
Review
Biochemistry & Molecular Biology
Maria Notarnicola, Alberto Ruben Osella, Maria Gabriella Caruso, Pasqua Letizia Pesole, Antonio Lippolis, Valeria Tutino, Caterina Bonfiglio, Valentina De Nunzio, Maria Principia Scavo, Antonella Mirizzi, Isabella Franco, Tamara Lippolis, Rosalba D'Alessandro, Maria Grazia Refolo, Caterina Messa
Summary: NAFLD is considered as a hepatic manifestation of metabolic syndrome, characterized by excessive lipid accumulation and oxidative stress leading to liver injury. The identification of genetic and epigenetic modifications contributing to NAFLD pathogenesis is crucial, while lifestyle modifications remain the main prevention and treatment approach.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Gastroenterology & Hepatology
Danijela Ristic-Medic, Joanna Bajerska, Vesna Vucic
Summary: The prevalence of nonalcoholic fatty liver disease (NAFLD) is rising worldwide, paralleling the epidemic of obesity. Nutrition can manage hepatic and cardiometabolic complications of NAFLD.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Endocrinology & Metabolism
Christopher L. Axelrod, Ingeborg Langohr, Wagner S. Dantas, Elizabeth C. Heintz, Bolormaa Vandanmagsar, Shengping Yang, Elizabeth R. M. Zunica, R. Leigh Townsend, Vance L. Albaugh, Hans-Rudolf Berthoud, John P. Kirwan
Summary: Obesity is a driver of non-alcoholic fatty liver disease, and interventions that decrease body weight, such as bariatric surgery and/or calorie restriction, may serve as effective therapies. This study compared the effects of Roux-en-Y gastric bypass surgery and calorie restriction on hepatic function in mice with obesity and NAFLD. The results showed that gastric bypass surgery reduced hepatic lipid content and adiposity while increasing energy expenditure and lean body mass. Gastric bypass surgery also activated enterohepatic signaling and genes regulating hepatic lipid homeostasis.
Review
Nutrition & Dietetics
Ling Pan, Jing Sui, Ying Xu, Qun Zhao
Summary: This meta-analysis examines the relationship between nut consumption and the risk of NAFLD. The results indicate a significant negative correlation between nut intake and NAFLD, particularly in females.
Article
Environmental Sciences
Maja Czerwinska-Rogowska, Karolina Skonieczna-Zydecka, Krzysztof Kaseja, Karolina Jakubczyk, Joanna Palma, Marta Bott-Olejnik, Slawomir Brzozowski, Ewa Stachowska
Summary: Strokes are the second highest cause of death in the world and the most common cause of permanent disability in adults. This study found that stroke patients should be administered with industrial diets enriched with fiber to improve gut barrier integrity and nutritional parameters.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Nutrition & Dietetics
Malgorzata Kaczkan, Sylwia Czaja-Stolc, Malgorzata Szczuko, Arleta Drozd, Przemyslaw Rutkowski, Alicja Debska-Slizien, Sylwia Malgorzewicz
Summary: The concentration of water-soluble vitamins is often not measured in hemodialysis patients, leading to undiagnosed deficiencies. This study compared the blood concentration of water-soluble vitamins in hemodialysis patients with healthy subjects and assessed the impact of diabetes mellitus on these vitamins. The study found significantly lower levels of vitamin B-1, B-6, and B-12 in the hemodialysis group.
Article
Nutrition & Dietetics
Beata Loniewska, Magda Fraszczyk-Tousty, Piotr Tousty, Karolina Skonieczna-Zydecka, Dominika Maciejewska-Markiewicz, Igor Loniewski
Summary: This study analyzed 456 fecal samples from 86 children to investigate the influence of perinatal factors on the concentrations of fecal short-chain fatty acids (SCFAs) during the first two years of life. The results showed that SCFA concentrations increased until 12 months and then stabilized. Factors such as antibiotic treatment during pregnancy, mode of delivery, feeding formula, and maternal weight gain were found to be associated with changes in SCFA concentrations. Higher SCFA levels were observed in infants born to mothers with normal pre-pregnancy weight and adequate weight gain. Additionally, female infants had higher levels of acetic acid at 2 years old. The study suggests the need for further long-term epidemiological studies in this area.
Article
Chemistry, Multidisciplinary
Katarzyna Janda-Milczarek, Kinga Szymczykowska, Karolina Jakubczyk, Patrycja Kupnicka, Karolina Skonieczna-Zydecka, Bogumila Pilarczyk, Agnieszka Tomza-Marciniak, Alicja Ligenza, Ewa Stachowska, Bartosz Dalewski
Summary: The study aimed to explore the effect of supplement form (tablet and powder) and cultivation method (organic and conventional) on the mineral content of spirulina supplements. The findings showed that both supplement form and cultivation method had an impact on the mineral content, with powder supplements containing higher amounts of important elements and organic spirulina supplements being a richer dietary source of iron and potassium.
APPLIED SCIENCES-BASEL
(2023)
Article
Biochemistry & Molecular Biology
Arleta Drozd, Dariusz Kotlega, Krzysztof Dmytrow, Malgorzata Szczuko
Summary: The main aim of this study was to investigate the impact of cigarette smoking on selected derivatives of arachidonic acid, linoleic acid, DHA, and EPA, which may serve as markers for post-stroke inflammation. The eicosanoid profile was compared between smokers and non-smokers, both with and without gender division. The results revealed that non-smokers had higher levels of the linolenic acid derivative (LA) 9S HODE than smokers. However, when the results were further divided by gender, it was found that non-smoking women had higher levels of this derivative compared to smoking women, while no difference was observed in the group of men. Similarly, the level of the arachidonic acid metabolite LTX A4 differed only in the group of women. Moreover, a number of statistically significant correlations were identified between the analyzed groups, with smokers showing fewer correlations compared to non-smokers. This study highlights the importance of smoking cessation in reducing inflammation mediated by lipid mediators in both genders.
Article
Biochemistry & Molecular Biology
Dominika Maciejewska-Markiewicz, Joanna Kochman, Karolina Jakubczyk, Piotr Bargiel, Zbigniew Szlosser, Ewa Stachowska, Marta Markowska, Anna Bucka, Norbert Czapla, Jan Petriczko, Anna Surowka, Sonia Hertman, Piotr Puchalski, Piotr Prowans
Summary: This study aimed to assess the concentration of vitamin D and its metabolites in patients before thyroidectomy. The results showed that patients undergoing thyroidectomy have a marked vitamin D deficiency, which may affect their subsequent convalescence and prognosis. Therefore, determining vitamin D levels prior to thyroidectomy may be useful for considering supplementation in the clinical management of these patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Nutrition & Dietetics
Anna Gudan, Katarzyna Kozlowska-Petriczko, Ewa Wunsch, Tomasz Bodnarczuk, Ewa Stachowska
Summary: Non-alcoholic fatty liver disease (NAFLD) is a chronic liver disease characterized by lipid accumulation in the liver. Insulin resistance is common among NAFLD patients. Obesity is a major risk factor for lipid accumulation, but normal-weight individuals can also develop NAFLD. Obesity, with or without NAFLD, is associated with a higher incidence of small intestinal bacterial overgrowth (SIBO), while NAFLD patients also show increased intestinal permeability. SIBO can lead to malabsorption disorders and impair liver function, but more research is needed to understand its impact on liver dysfunction, intestinal barrier integrity, inflammation, endotoxemia, and bacterial translocation.
Review
Nutrition & Dietetics
Dominika Jamiol-Milc, Anna Gudan, Karolina Kazmierczak-Siedlecka, Joanna Holowko-Ziolek, Dominika Maciejewska-Markiewicz, Katarzyna Janda-Milczarek, Ewa Stachowska
Summary: The liver plays a crucial role in the metabolism of nutrients and the storage of micronutrients, but chronic liver diseases can lead to nutritional deficiencies and poor prognosis. This review focuses on the dietary therapy for patients with chronic liver diseases, including those eligible for liver transplantation and in the postoperative period.
Article
Chemistry, Multidisciplinary
Weronika Jacunska, Wioletta Biel, Robert Witkowicz, Dominika Maciejewska-Markiewicz, Ewa Piatkowska
Summary: A balanced diet is essential for a dog's energy, growth, immunity, and overall health. Customizing the diet based on the dog's age, size, and activity level is crucial. This study evaluated the nutrient content of puppy diets containing EPA and DHA fatty acids. The diets met the protein and fat requirements, but varied in terms of essential fatty acid levels. None of the diets fulfilled the claims for EPA and DHA, and all contained trans fat.
APPLIED SCIENCES-BASEL
(2023)
Article
Medicine, General & Internal
Katarzyna Kotfis, Arleta Wojciechowska, Malgorzata Zimny, Dominika Jamiol-Milc, Aleksandra Szylinska, Sebastian Kwiatkowski, Karolina Kaim, Barbara Dolegowska, Ewa Stachowska, Maciej Zukowski, Maria Pankowiak, Andrzej Torbe, Paul Wischmeyer
Summary: This study compared the effectiveness of oral carbohydrate loading (CHO) with standard fasting in patients undergoing elective cesarean delivery (CD). The results showed that the incidence of vomiting or dry retching within 24 hours after CD was lower in the CHO group compared to the standard fasting group. Additionally, CHO supplementation reduced preoperative feelings of hunger and thirst, enhancing the comfort of pregnant women.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Medicine, Research & Experimental
Anna Gudan, Ewa Stachowska
Summary: The microscopic intestinal barrier is an important part of the human intestinal tract, responsible for nutrient absorption and protection against pathogens and toxins. The gut microbiota interacts with the human host, and animal-product based diets can impact the composition of gut microbiota. The ketogenic diet, which is high in animal fats, has been shown to have both metabolic and neurodegenerative therapeutic properties, with effects depending on the gut microbiota.
POSTEPY HIGIENY I MEDYCYNY DOSWIADCZALNEJ
(2022)
Article
Gastroenterology & Hepatology
Ewa Stachowska, Dominika Maciejewska, Joanna Palma, Dominika Jamiol-Milc, Malgorzata Szczuko, Wojciech Marlicz, Ewa Wunsch, Karolina Skonieczna-Zydecka
Summary: Regular intake of a snack containing soluble fiber improves SCFA synthesis and bowel habits in sedentary individuals without adverse gastrointestinal symptoms.
GASTROENTEROLOGY REVIEW-PRZEGLAD GASTROENTEROLOGICZNY
(2022)
