Viruses and Multiple Sclerosis: From Mechanisms and Pathways to Translational Research Opportunities

Cocapture of cognate and bystander antigens can activate autoreactive B cells

(2017) Nicholas S. R. Sanderson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A human brain microphysiological system derived from induced pluripotent stem cells to study neurological diseases and toxicity

(2017) David Pamies   ALTEX-Alternatives to Animal Experimentation

Brain-to-stomach transfer of α-synuclein via vagal preganglionic projections

(2016) Ayse Ulusoy et al.   ACTA NEUROPATHOLOGICA

Vascular, glial, and lymphatic immune gateways of the central nervous system

(2016) Britta Engelhardt et al.   ACTA NEUROPATHOLOGICA

Multiple sclerosis: experimental models and reality

(2016) Hans Lassmann et al.   ACTA NEUROPATHOLOGICA

T cell epitope redundancy: cross-conservation of the TCR face between pathogens and self and its implications for vaccines and autoimmunity

(2016) Leonard Moise et al.   Expert Review of Vaccines

Immunopathology of Japanese macaque encephalomyelitis is similar to multiple sclerosis

(2016) Tiffany C. Blair et al.   JOURNAL OF NEUROIMMUNOLOGY

Transgenic expression of non-structural genes of Theiler’s virus suppresses initial viral replication and pathogenesis of demyelination

(2016) Hyun Seok Kang et al.   Journal of Neuroinflammation

Antibodies specific for Epstein-Barr virus nuclear antigen-1 cross-react with human heterogeneous nuclear ribonucleoprotein L

(2016) J.William Lindsey et al.   MOLECULAR IMMUNOLOGY

LINGO-1-Fc-Transduced Neural Stem Cells Are Effective Therapy for Chronic Stage Experimental Autoimmune Encephalomyelitis

(2016) Xing Li et al.   MOLECULAR NEUROBIOLOGY

Access of protective antiviral antibody to neuronal tissues requires CD4 T-cell help

(2016) Norifumi Iijima et al.   NATURE

Viral evasion of intracellular DNA and RNA sensing

(2016) Ying Kai Chan et al.   NATURE REVIEWS MICROBIOLOGY

Multiple Sclerosis Epidemiology in East Asia, South East Asia and South Asia: A Systematic Review

(2016) Sharareh Eskandarieh et al.   NEUROEPIDEMIOLOGY

Vagus nerve stimulation inhibits cytokine production and attenuates disease severity in rheumatoid arthritis

(2016) Frieda A. Koopman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epidemiology of multiple sclerosis

(2016) E. Leray et al.   REVUE NEUROLOGIQUE

Transkingdom control of viral infection and immunity in the mammalian intestine

(2016) J. K. Pfeiffer et al.   SCIENCE

Alterations of the human gut microbiome in multiple sclerosis

(2016) Sushrut Jangi et al.   Nature Communications

Host Gut Motility Promotes Competitive Exclusion within a Model Intestinal Microbiota

(2016) Travis J Wiles et al.   PLOS BIOLOGY

Next-generation sequencing reveals broad down-regulation of microRNAs in secondary progressive multiple sclerosis CD4+ T cells

(2016) Katherine A. Sanders et al.   Clinical Epigenetics

Multiple sclerosis patients have a distinct gut microbiota compared to healthy controls

(2016) Jun Chen et al.   Scientific Reports

Brain microbiota disruption within inflammatory demyelinating lesions in multiple sclerosis

(2016) W. G. Branton et al.   Scientific Reports

Time trends in the incidence and prevalence of multiple sclerosis in Norway during eight decades

(2015) N. Grytten et al.   ACTA NEUROLOGICA SCANDINAVICA

Disease-Specific Alterations in the Enteric Virome in Inflammatory Bowel Disease

(2015) Jason M. Norman et al.   CELL

Variation in the Human Immune System Is Largely Driven by Non-Heritable Influences

(2015) Petter Brodin et al.   CELL

Mouse Models of Multiple Sclerosis: Lost in Translation?

(2015) David Baker et al.   CURRENT PHARMACEUTICAL DESIGN

The Gut Microbiome in Multiple Sclerosis

(2015) Daniel W. Mielcarz et al.   Current Treatment Options in Neurology

Animal models of Multiple Sclerosis

(2015) Claudio Procaccini et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

MSPrecise: A molecular diagnostic test for multiple sclerosis using next generation sequencing

(2015) William H. Rounds et al.   GENE

A review of genome-wide association studies for multiple sclerosis: classical and hypothesis-driven approaches

(2015) V. V. Bashinskaya et al.   HUMAN GENETICS

A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules

(2015) Aleksanteri Aspelund et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Opportunistic DNA Recombination With Epstein-Barr Virus at Sites of Control Region Rearrangements Mediating JC Virus Neurovirulence

(2015) Margaret J. Wortman et al.   JOURNAL OF INFECTIOUS DISEASES

The immune response in the CNS in Theiler’s virus induced demyelinating disease switches from an early adaptive response to a chronic innate-like response

(2015) Francesca Gilli et al.   JOURNAL OF NEUROVIROLOGY

Depletion of Olig2 in oligodendrocyte progenitor cells infected by Theiler’s murine encephalomyelitis virus

(2015) Bayleigh Benner et al.   JOURNAL OF NEUROVIROLOGY

Environmental risk factors and multiple sclerosis: an umbrella review of systematic reviews and meta-analyses

(2015) Lazaros Belbasis et al.   LANCET NEUROLOGY

Treatment Against Human Endogenous Retrovirus: A Possible Personalized Medicine Approach for Multiple Sclerosis

(2015) François Curtin et al.   Molecular Diagnosis & Therapy

Structural and functional features of central nervous system lymphatic vessels

(2015) Antoine Louveau et al.   NATURE

Multiple sclerosis: getting personal with induced pluripotent stem cells

(2015) A Di Ruscio et al.   Cell Death & Disease

Autoimmune encephalitis in humans: how closely does it reflect multiple sclerosis ?

(2015) Romana Höftberger et al.   Acta Neuropathologica Communications

The Effect of Disease Modifying Therapies on Disease Progression in Patients with Relapsing-Remitting Multiple Sclerosis: A Systematic Review and Meta-Analysis

(2015) Georgios Tsivgoulis et al.   PLoS One

Cross-reactivity between human cytomegalovirus peptide 981-1003 and myelin oligodendroglia glycoprotein peptide 35-55 in experimental autoimmune encephalomyelitis in Lewis rats

(2014) Mei-Mei Zheng et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Retrovirus/Superantigen Hypothesis of Multiple Sclerosis

(2014) Alexander Emmer et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Promoting remyelination: utilizing a viral model of demyelination to assess cell-based therapies

(2014) Brett S Marro et al.   Expert Review of Neurotherapeutics

Microbial view of central nervous system autoimmunity

(2014) Kerstin Berer et al.   FEBS LETTERS

Acute disseminated encephalomyelitis progressing to multiple sclerosis: Are infectious triggers involved?

(2014) Daniel S. Smyk et al.   IMMUNOLOGIC RESEARCH

Epstein–Barr virus and Mycobacterium avium subsp. paratuberculosis peptides are cross recognized by anti-myelin basic protein antibodies in multiple sclerosis patients

(2014) Giuseppe Mameli et al.   JOURNAL OF NEUROIMMUNOLOGY

Atlas of Multiple Sclerosis 2013: A growing global problem with widespread inequity

(2014) P. Browne et al.   NEUROLOGY

Immunoglobulin class-switched B cells form an active immune axis between CNS and periphery in multiple sclerosis

(2014) A. Palanichamy et al.   Science Translational Medicine

B cells populating the multiple sclerosis brain mature in the draining cervical lymph nodes

(2014) J. N. H. Stern et al.   Science Translational Medicine

A novel model of demyelination and remyelination in a GFP-transgenic zebrafish

(2014) Y. Fang et al.   Biology Open

EAE is not a useful model for demyelinating disease

(2014) Peter O. Behan et al.   Multiple Sclerosis and Related Disorders

Recent Advances and Future Challenges in the Genetics of Multiple Sclerosis

(2014) Christina M. Lill   Frontiers in Neurology

Incidence and prevalence of multiple sclerosis in Europe: a systematic review

(2013) Elaine Kingwell et al.   BMC Neurology

Multiple sclerosis

(2013) Matthew F. Cusick et al.   CURRENT OPINION IN RHEUMATOLOGY

Role of Pathogens in Multiple Sclerosis

(2013) Jane E. Libbey et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

Antibiotic treatment expands the resistance reservoir and ecological network of the phage metagenome

(2013) Sheetal R. Modi et al.   NATURE

Possible Role of Human Herpesvirus 6 as a Trigger of Autoimmune Disease

(2013) Francesco Broccolo et al.   TheScientificWorldJOURNAL

Commensal gut flora and brain autoimmunity: a love or hate affair?

(2012) Kerstin Berer et al.   ACTA NEUROPATHOLOGICA

Network Analysis of Randomized Controlled Trials in Multiple Sclerosis

(2012) Elias Zintzaras et al.   CLINICAL THERAPEUTICS

Viruses and Multiple Sclerosis

(2012) Jussi Oskari Virtanen et al.   CNS & Neurological Disorders-Drug Targets

Mesenchymal stem cells protect CNS neurons against glutamate excitotoxicity by inhibiting glutamate receptor expression and function

(2012) A. Voulgari-Kokota et al.   EXPERIMENTAL NEUROLOGY

Genomic Characterization of Japanese Macaque Rhadinovirus, a Novel Herpesvirus Isolated from a Nonhuman Primate with a Spontaneous Inflammatory Demyelinating Disease

(2012) R. D. Estep et al.   JOURNAL OF VIROLOGY

Common values in assessing health outcomes from disease and injury: disability weights measurement study for the Global Burden of Disease Study 2010

(2012) Joshua A Salomon et al.   LANCET

Resurrection of endogenous retroviruses in antibody-deficient mice

(2012) George R. Young et al.   NATURE

Deep Sequencing for the Detection of Virus-Like Sequences in the Brains of Patients with Multiple Sclerosis: Detection of GBV-C in Human Brain

(2012) John D. Kriesel et al.   PLoS One

Rare variants in the CYP27B1 gene are associated with multiple sclerosis

(2011) Sreeram V. Ramagopalan et al.   ANNALS OF NEUROLOGY

Combinatorial antibody library from multiple sclerosis patients reveals antibodies that cross-react with myelin basic protein and EBV antigen

(2011) Alexander G. Gabibov et al.   FASEB JOURNAL

Role of CD8 T cell subsets in the pathogenesis of multiple sclerosis

(2011) A. Saxena et al.   FEBS LETTERS

Epstein–Barr and other viral mimicry of autoantigens, myelin and vitamin D-related proteins and of EIF2B, the cause of vanishing white matter disease: massive mimicry of multiple sclerosis relevant proteins by theSynechococcusphage

(2011) C. J. Carter   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

Commensal microbiota and myelin autoantigen cooperate to trigger autoimmune demyelination

(2011) Kerstin Berer et al.   NATURE

Viruses and Multiple Sclerosis

(2011) G. P. Owens et al.   NEUROSCIENTIST

Evidence for Viral Etiology of Multiple Sclerosis

(2011) Alexandros Tselis   SEMINARS IN NEUROLOGY

Neural differentiation of patient specific iPS cells as a novel approach to study the pathophysiology of multiple sclerosis

(2011) Bi Song et al.   Stem Cell Research

Experimental in vivo and in vitro models of multiple sclerosis: EAE and beyond

(2011) Markus Kipp et al.   Multiple Sclerosis and Related Disorders

Viral triggers of multiple sclerosis

(2010) Kristina Kakalacheva et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Different Strains of Theiler's Murine Encephalomyelitis Virus Antagonize Different Sites in the Type I Interferon Pathway

(2010) S. Stavrou et al.   JOURNAL OF VIROLOGY

Genome, epigenome and RNA sequences of monozygotic twins discordant for multiple sclerosis

(2010) Sergio E. Baranzini et al.   NATURE

Viruses in the faecal microbiota of monozygotic twins and their mothers

(2010) Alejandro Reyes et al.   NATURE

Proinflammatory T-cell responses to gut microbiota promote experimental autoimmune encephalomyelitis

(2010) Y. K. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The cuprizone animal model: new insights into an old story

(2009) Markus Kipp et al.   ACTA NEUROPATHOLOGICA

Neuropathogenesis of Theiler’s Murine Encephalomyelitis Virus Infection, An Animal Model for Multiple Sclerosis

(2009) Ikuo Tsunoda et al.   Journal of Neuroimmune Pharmacology

Mechanisms of Primary Axonal Damage in a Viral Model of Multiple Sclerosis

(2009) J. Das Sarma et al.   JOURNAL OF NEUROSCIENCE

The phylogeny of invertebrates and the evolution of myelin

(2009) Betty I. Roots   Neuron Glia Biology

On the Origin of The Immune System

(2009) J. Travis   SCIENCE

Multiple sclerosis – a response-to-damage model

(2009) Bert A. ‘t Hart et al.   TRENDS IN MOLECULAR MEDICINE

Transplanted neural stem/progenitor cells generate myelinating oligodendrocytes and Schwann cells in spinal cord demyelination and dysmyelination

(2008) Andrea J. Mothe et al.   EXPERIMENTAL NEUROLOGY

Experimental Optic Neuritis Induced by a Demyelinating Strain of Mouse Hepatitis Virus

(2008) K. S. Shindler et al.   JOURNAL OF VIROLOGY

Proteomic analysis of active multiple sclerosis lesions reveals therapeutic targets

(2008) May H. Han et al.   NATURE