Roles of AMP-activated Protein Kinase in Alzheimer’s Disease

An Integrated and Unifying Hypothesis for the Metabolic Basis of Sporadic Alzheimer's Disease

(2017) Adnan Erol   JOURNAL OF ALZHEIMERS DISEASE

Alzheimer's Disease: A General Introduction and Pathomechanism

(2017) Verena H. Finder   JOURNAL OF ALZHEIMERS DISEASE

mTOR's role in ageing: protein synthesis or autophagy?

(2016) Sarah L. Hands et al.   Aging-US

Protein kinase A is a target for aging and the aging heart

(2016) Linda C Enns et al.   Aging-US

Atypical antipsychotic drugs perturb AMPK-dependent regulation of hepatic lipid metabolism

(2011) Kyoung-Jin Oh et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Systems biology of the autophagy-lysosomal pathway

(2011) Anil G. Jegga et al.   Autophagy

The autophagy initiating kinase ULK1 is regulated via opposing phosphorylation by AMPK and mTOR

(2011) Dan Egan et al.   Autophagy

AMP-activated protein kinase (AMPK) is a tau kinase, activated in response to amyloid β-peptide exposure

(2011) Claire Thornton et al.   BIOCHEMICAL JOURNAL

LKB1/AMPK/mTOR signaling pathway in hematological malignancies: From metabolism to cancer cell biology

(2011) Alexa S. Green et al.   CELL CYCLE

AMPK Activates Autophagy by Phosphorylating ULK1

(2011) Kai Mao et al.   CIRCULATION RESEARCH

Family Caregiving in Dementia: The Asian Perspective of a Global Problem

(2011) Sally Wai-Chi Chan   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

AMP-activated Protein Kinase (AMPK) Activation and Glycogen Synthase Kinase-3β (GSK-3β) Inhibition Induce Ca2+-independent Deposition of Tight Junction Components at the Plasma Membrane

(2011) Li Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nuclear translocation of AMPK-α1 potentiates striatal neurodegeneration in Huntington’s disease

(2011) Tz-Chuen Ju et al.   JOURNAL OF CELL BIOLOGY

AMP-activated protein kinase: a potential player in Alzheimer’s disease

(2011) Antero Salminen et al.   JOURNAL OF NEUROCHEMISTRY

Post-Stroke Hypothermia Provides Neuroprotection through Inhibition of AMP-Activated Protein Kinase

(2011) Jun Li et al.   JOURNAL OF NEUROTRAUMA

Molecular mechanisms linking diabetes mellitus and Alzheimer disease: beta-amyloid peptide, insulin signaling, and neuronal function

(2011) Shuko Takeda et al.   Molecular BioSystems

Tyrosine Phosphorylation of Tau by the Src Family Kinases Lck and Fyn

(2011) Timothy ME Scales et al.   Molecular Neurodegeneration

Lifespan extension induced by AMPK and calcineurin is mediated by CRTC-1 and CREB

(2011) William Mair et al.   NATURE

Lysosome positioning coordinates mTORC1 activity and autophagy

(2011) Christian Poüs et al.   NATURE CELL BIOLOGY

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

Peripheral insulin-sensitizer drug metformin ameliorates neuronal insulin resistance and Alzheimer’s-like changes

(2011) Amit Gupta et al.   NEUROPHARMACOLOGY

A conserved mechanism of autoinhibition for the AMPK kinase domain: ATP-binding site and catalytic loop refolding as a means of regulation

(2010) Dene R. Littler et al.   Acta Crystallographica Section F-Structural Biology and Crystallization Communications

Brain aging and Aβ1–42 neurotoxicity converge via deterioration in autophagy–lysosomal system: a conditional Drosophila model linking Alzheimer’s neurodegeneration with aging

(2010) Daijun Ling et al.   ACTA NEUROPATHOLOGICA

AMPK is abnormally activated in tangle- and pre-tangle-bearing neurons in Alzheimer’s disease and other tauopathies

(2010) Valérie Vingtdeux et al.   ACTA NEUROPATHOLOGICA

Dysregulation of lipolysis and lipid metabolism in visceral and subcutaneous adipocytes by high-fat diet: role of ATGL, HSL, and AMPK

(2010) Mandeep P. Gaidhu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

ER stress negatively regulates AKT/TSC/mTOR pathway to enhance autophagy

(2010) Liang Qin et al.   Autophagy

Involvement of AMP-activated-protein-kinase (AMPK) in neuronal amyloidogenesis

(2010) Je-Seong Won et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Role of amyloid beta in lipid homeostasis

(2010) Sven Grösgen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

AMPK-independent induction of autophagy by cytosolic Ca2+ increase

(2010) Antje Grotemeier et al.   CELLULAR SIGNALLING

DAP1, a Novel Substrate of mTOR, Negatively Regulates Autophagy

(2010) Itay Koren et al.   CURRENT BIOLOGY

Anti-Amyloidogenic and Anti-Apoptotic Role of Melatonin in Alzheimer Disease

(2010) Hongwen He et al.   Current Neuropharmacology

Potential Predictors of Hippocampal Atrophy in Alzheimerʼs Disease

(2010) Vikas Dhikav et al.   DRUGS & AGING

Regulation of mitochondrial biogenesis

(2010) François R. Jornayvaz et al.   Essays in Biochemistry

Novel synthetic small-molecule activators of AMPK as enhancers of autophagy and amyloid-β peptide degradation

(2010) Valérie Vingtdeux et al.   FASEB JOURNAL

Dementia and Stroke: The Present and Future Epidemic

(2010) Toby Cumming et al.   International Journal of Stroke

Resveratrol Modulates Tumor Cell Proliferation and Protein Translation via SIRT1-Dependent AMPK Activation

(2010) Jia-Ni Lin et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

AMP-activated Protein Kinase Signaling Activation by Resveratrol Modulates Amyloid-β Peptide Metabolism

(2010) Valérie Vingtdeux et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Interplay between Mammalian Target of Rapamycin (mTOR), Amyloid-β, and Tau

(2010) Antonella Caccamo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effects of AMP-Activated Protein Kinase in Cerebral Ischemia

(2010) Jun Li et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state

(2010) Marc Foretz et al.   JOURNAL OF CLINICAL INVESTIGATION

Melatonin Potentiates the Neuroprotective Properties of Resveratrol Against Beta-Amyloid-Induced Neurodegeneration by Modulating AMP-Activated Protein Kinase Pathways

(2010) Kyoung Ja Kwon et al.   Journal of Clinical Neurology

Liver AMP/ATP ratio and fructokinase expression are related to gender differences in AMPK activity and glucose intolerance in rats ingesting liquid fructose

(2010) Laia Vilà et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Quercetin activates AMP-activated protein kinase by reducing PP2C expression protecting old mouse brain against high cholesterol-induced neurotoxicity

(2010) Jun Lu et al.   JOURNAL OF PATHOLOGY

AMP-activated protein kinase: ‘a cup of tea’ against cholesterol-induced neurotoxicity

(2010) Pablo Blanco Martínez de Morentin et al.   JOURNAL OF PATHOLOGY

Disrupted energy metabolism and neuronal circuit dysfunction in cognitive impairment and Alzheimer's disease

(2010) Dimitrios Kapogiannis et al.   LANCET NEUROLOGY

Metformin in Cancer Therapy: A New Perspective for an Old Antidiabetic Drug?

(2010) I. Ben Sahra et al.   MOLECULAR CANCER THERAPEUTICS

Metformin suppresses azoxymethane-induced colorectal aberrant crypt foci by activating AMP-activated protein kinase

(2010) Kunihiro Hosono et al.   MOLECULAR CARCINOGENESIS

Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin

(2010) William L Holland et al.   NATURE MEDICINE

Homologous posttranscriptional regulation of insulin-like growth factor-I receptor level via glycogen synthase kinase-3β and mammalian target of rapamycin in adrenal chromaffin cells: Effect on tau phosphorylation

(2010) Takayuki Nemoto et al.   NEUROPHARMACOLOGY

Adenosine monophosphate activated protein kinase inhibition is protective in both sexes after experimental stroke

(2010) Jun Li et al.   NEUROSCIENCE LETTERS

β-Amyloid precursor protein metabolism: focus on the functions and degradation of its intracellular domain

(2010) Erica Buoso et al.   PHARMACOLOGICAL RESEARCH

Inhibition of mTOR by Rapamycin Abolishes Cognitive Deficits and Reduces Amyloid-β Levels in a Mouse Model of Alzheimer's Disease

(2010) Patricia Spilman et al.   PLoS One

The Association of AMPK with ULK1 Regulates Autophagy

(2010) Jong Woo Lee et al.   PLoS One

ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS

(2010) A. Alexander et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biguanide metformin acts on tau phosphorylation via mTOR/protein phosphatase 2A (PP2A) signaling

(2010) E. Kickstein et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

AMP-activated protein kinase: a core signalling pathway in the heart

(2009) A. S. Kim et al.   Acta Physiologica

Cerebrospinal Fluid β-Amyloid 42 and Tau Proteins as Biomarkers of Alzheimer-Type Pathologic Changes in the Brain

(2009) Tero Tapiola et al.   ARCHIVES OF NEUROLOGY

mTOR regulates autophagy-associated genes downstream of p73

(2009) Jennifer M. Rosenbluth et al.   Autophagy

Leptin regulates tau phosphorylation and amyloid through AMPK in neuronal cells

(2009) Steven J. Greco et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Translational responses to growth factors and stress

(2009) Megan Cully et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Expanding roles for AMP-activated protein kinase in neuronal survival and autophagy

(2009) Jeroen Poels et al.   BIOESSAYS

Amyloid- (1-42), Total Tau, and Phosphorylated Tau as Cerebrospinal Fluid Biomarkers for the Diagnosis of Alzheimer Disease

(2009) C. Mulder et al.   CLINICAL CHEMISTRY

Pioglitazone stimulates AMP-activated protein kinase signalling and increases the expression of genes involved in adiponectin signalling, mitochondrial function and fat oxidation in human skeletal muscle in vivo: a randomised trial

(2009) D. K. Coletta et al.   DIABETOLOGIA

Targeting the AMPK pathway for the treatment of Type 2 diabetes

(2009) Benoit Viollet   Frontiers in Bioscience-Landmark

Tau fragmentation, aggregation and clearance: the dual role of lysosomal processing

(2009) Yipeng Wang et al.   HUMAN MOLECULAR GENETICS

PKR, a cognitive decline biomarker, can regulate translationviatwo consecutive molecular targets p53 and Redd1 in lymphocytes of AD patients

(2009) Milena Damjanac et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

AMPK in the brain: its roles in energy balance and neuroprotection

(2009) Gabriele V. Ronnett et al.   JOURNAL OF NEUROCHEMISTRY

Protection against cognitive deficits and markers of neurodegeneration by long-term oral administration of melatonin in a transgenic model of Alzheimer disease

(2009) James M. Olcese et al.   JOURNAL OF PINEAL RESEARCH

Simian Virus 40 Small T Antigen Activates AMPK and Triggers Autophagy To Protect Cancer Cells from Nutrient Deprivation

(2009) S. H. Kumar et al.   JOURNAL OF VIROLOGY

The JNK pathway amplifies and drives subcellular changes in tau phosphorylation

(2009) J. Vogel et al.   NEUROPHARMACOLOGY

Leptin inhibits glycogen synthase kinase-3β to prevent tau phosphorylation in neuronal cells

(2009) Steven J. Greco et al.   NEUROSCIENCE LETTERS

AICAR (5-aminoimidazole-4-carboxamide-1-β-4-ribofuranoside) increases the production of toxic molecules and affects the profile of cytokines release in LPS-stimulated rat primary microglial cultures

(2009) Krzysztof Łabuzek et al.   NEUROTOXICOLOGY

Chondrocyte autophagy is stimulated by HIF-1 dependent AMPK activation and mTOR suppression

(2009) Jolene Bohensky et al.   PEDIATRIC NEPHROLOGY

AMPK in Health and Disease

(2009) Gregory R. Steinberg et al.   PHYSIOLOGICAL REVIEWS

Protection of synapses against Alzheimer's-linked toxins: Insulin signaling prevents the pathogenic binding of Aβ oligomers

(2009) Fernanda G. De Felice et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antidiabetic drug metformin (GlucophageR) increases biogenesis of Alzheimer's amyloid peptides via up-regulating BACE1 transcription

(2009) Y. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Active-Site Inhibitors of mTOR Target Rapamycin-Resistant Outputs of mTORC1 and mTORC2

(2009) Morris E Feldman et al.   PLOS BIOLOGY

Metformina e AMPK: um antigo fármaco e uma nova enzima no contexto da síndrome metabólica

(2008) Augusto Cézar Santomauro Jún et al.   Arquivos Brasileiros de Endocrinologia e Metabologia

Lithium blocks ethanol-induced modulation of protein kinases in the developing brain

(2008) Goutam Chakraborty et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Akt activation protects pancreatic beta cells from AMPK-mediated death through stimulation of mTOR

(2008) Ying Cai et al.   BIOCHEMICAL PHARMACOLOGY

Therapeutic potential of resveratrol in Alzheimer's disease

(2008) Valérie Vingtdeux et al.   BMC NEUROSCIENCE

Hyperphosphorylation of Microtubule-Associated Protein Tau: A Promising Therapeutic Target for Alzheimer Disease

(2008) C.-X. Gong et al.   CURRENT MEDICINAL CHEMISTRY

AMPK: a key regulator of energy balance in the single cell and the whole organism

(2008) D G Hardie   INTERNATIONAL JOURNAL OF OBESITY

Phosphorylation Regulates Tau Interactions with Src Homology 3 Domains of Phosphatidylinositol 3-Kinase, Phospholipase Cγ1, Grb2, and Src Family Kinases

(2008) C. Hugh Reynolds et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Role of Amyloid Precursor Protein Processing by BACE1, the β-Secretase, in Alzheimer Disease Pathophysiology

(2008) Sarah L. Cole et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

AMP-activated Protein Kinase Activation Increases Phosphorylation of Glycogen Synthase Kinase 3β and Thereby Reduces cAMP-responsive Element Transcriptional Activity and Phosphoenolpyruvate Carboxykinase C Gene Expression in the Liver

(2008) Nanao Horike et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

mTOR-dependent signalling in Alzheimer's disease

(2008) Jin-Jing Pei et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Autophagy Induction and Autophagosome Clearance in Neurons: Relationship to Autophagic Pathology in Alzheimer's Disease

(2008) B. Boland et al.   JOURNAL OF NEUROSCIENCE

The mTOR pathway and its role in human genetic diseases

(2008) M ROSNER et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

The autophagy-lysosomal degradation pathway: role in neurodegenerative disease and therapy

(2007) John et al.   Frontiers in Bioscience-Landmark

Dissociation of Akt/PKB and ribosomal S6 kinase signaling markers in a transgenic mouse model of Alzheimer’s disease

(2007) Milena Damjanac et al.   NEUROBIOLOGY OF DISEASE