Survivin inhibitor YM155 induces mitochondrial dysfunction, autophagy, DNA damage and apoptosis in Bcl-xL silenced glioma cell lines

AML sensitivity to YM155 is modulated through AKT and Mcl-1

(2015) Rosalia de Necochea-Campion et al.   CANCER LETTERS

YM155 suppresses cell proliferation and induces cell death in human adult T-cell leukemia/lymphoma cells

(2015) Ryousei Sasaki et al.   LEUKEMIA RESEARCH

Dual induction of apoptotic and autophagic cell death by targeting survivin in head neck squamous cell carcinoma

(2015) L Zhang et al.   Cell Death & Disease

Preclinical efficacy of sepantronium bromide (YM155) in multiple myeloma is conferred by down regulation of Mcl-1

(2015) Verena Wagner et al.   Oncotarget

Apoptosis-related BCL2-family Members: Key Players in Chemotherapy

(2014) Christos Kontos et al.   Anti-Cancer Agents in Medicinal Chemistry

Bcl-2 family members: Dual regulators of apoptosis and autophagy

(2014) Beth Levine et al.   Autophagy

Phase II, multicenter, open-label, randomized study of YM155 plus docetaxel as first-line treatment in patients with HER2-negative metastatic breast cancer

(2014) Michael R. Clemens et al.   BREAST CANCER RESEARCH AND TREATMENT

YM155 down-regulates survivin and XIAP, modulates autophagy and induces autophagy-dependent DNA damage in breast cancer cells

(2014) S M Cheng et al.   BRITISH JOURNAL OF PHARMACOLOGY

Molecular characterizations of glioblastoma, targeted therapy, and clinical results to date

(2014) Jayson I. L. Bastien et al.   CANCER

Targeted Therapy in Gliomas

(2014) Mohamed Ali Hamza et al.   Current Oncology Reports

Bcl-2 Family Proteins Are Involved in the Signal Crosstalk between Endoplasmic Reticulum Stress and Mitochondrial Dysfunction in Tumor Chemotherapy Resistance

(2014) Jing Su et al.   Biomed Research International

Induction of autophagy-dependent cell death by the survivin suppressant YM155 in salivary adenoid cystic carcinoma

(2013) Yu-Fan Wang et al.   APOPTOSIS

Novel approaches to glioma drug design and drug screening

(2013) Shivaputra A Patil et al.   Expert Opinion on Drug Discovery

YM-155 Potentiates the Effect of ABT-737 in Malignant Human Glioma Cells via Survivin and Mcl-1 Downregulation in an EGFR-Dependent Context

(2013) E. P. Jane et al.   MOLECULAR CANCER THERAPEUTICS

DNA repair and cytotoxic drugs: the potential role of RAD51 in clinical outcome of non-small-cell lung cancer patients

(2013) Augusto Nogueira et al.   PHARMACOGENOMICS

The Bcl-2 proteins Noxa and Bcl-xL co-ordinately regulate oxidative stress-induced apoptosis

(2012) Colins O. Eno et al.   BIOCHEMICAL JOURNAL

Targeting the DNA damage response in oncology

(2012) Bristi Basu et al.   CURRENT OPINION IN ONCOLOGY

Drug Resistance in Glioblastoma: A Mini Review

(2012) Catherine P. Haar et al.   NEUROCHEMICAL RESEARCH

A phase II study of YM155, a novel small-molecule suppressor of survivin, in castration-resistant taxane-pretreated prostate cancer

(2011) A. W. Tolcher et al.   ANNALS OF ONCOLOGY

Mcl-1 downregulation by YM155 contributes to its synergistic anti-tumor activities with ABT-263

(2011) Haikuo Tang et al.   BIOCHEMICAL PHARMACOLOGY

Induction of autophagy-dependent apoptosis by the survivin suppressant YM155 in prostate cancer cells

(2011) Qinwen Wang et al.   CANCER LETTERS

The Beclin 1 network regulates autophagy and apoptosis

(2011) R Kang et al.   CELL DEATH AND DIFFERENTIATION

Evolving strategies: future treatment of glioblastoma

(2011) Marc Chamberlain   Expert Review of Neurotherapeutics

Bcl-xLregulates mitochondrial energetics by stabilizing the inner membrane potential

(2011) Ying-bei Chen et al.   JOURNAL OF CELL BIOLOGY

Identification of Chemosensitivity Nodes for Vinblastine through Small Interfering RNA High-Throughput Screens

(2011) C. A. Kitchens et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Bortezomib-induced sensitization of malignant human glioma cells to vorinostat-induced apoptosis depends on reactive oxygen species production, mitochondrial dysfunction, Noxa upregulation, Mcl-1 cleavage, and DNA damage

(2011) Daniel R. Premkumar et al.   MOLECULAR CARCINOGENESIS

Broad spectrum and potent antitumor activities of YM155, a novel small-molecule survivin suppressant, in a wide variety of human cancer cell lines and xenograft models

(2010) Takahito Nakahara et al.   CANCER SCIENCE

Functional genomic analysis of glioblastoma multiforme through short interfering RNA screening: a paradigm for therapeutic development

(2010) Nikhil G. Thaker et al.   Neurosurgical Focus

Survivin: A new target for anti-cancer therapy

(2009) Bríd M. Ryan et al.   CANCER TREATMENT REVIEWS

Molecularly targeted therapies for malignant glioma: rationale for combinatorial strategies

(2009) Nikhil G Thaker et al.   Expert Review of Neurotherapeutics

Rad51 Protein Expression and Survival in Patients with Glioblastoma Multiforme

(2009) James W. Welsh et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Multicenter Phase II Trial of YM155, a Small-Molecule Suppressor of Survivin, in Patients With Advanced, Refractory, Non–Small-Cell Lung Cancer

(2009) Giuseppe Giaccone et al.   JOURNAL OF CLINICAL ONCOLOGY

Designing, optimizing, and implementing high-throughput siRNA genomic screening with glioma cells for the discovery of survival genes and novel drug targets

(2009) Nikhil G. Thaker et al.   JOURNAL OF NEUROSCIENCE METHODS

Dasatinib-induced autophagy is enhanced in combination with temozolomide in glioma

(2009) V. Milano et al.   MOLECULAR CANCER THERAPEUTICS

Identification of Survival Genes in Human Glioblastoma Cells by Small Interfering RNA Screening

(2009) N. G. Thaker et al.   MOLECULAR PHARMACOLOGY

Proteasome inhibitors activate autophagy as a cytoprotective response in human prostate cancer cells

(2009) K Zhu et al.   ONCOGENE

Caspase-mediated cleavage of ATG6/Beclin-1 links apoptosis to autophagy in HeLa cells

(2008) Dong-Hyung Cho et al.   CANCER LETTERS

Bcl-xLand UVRAG Cause a Monomer-Dimer Switch in Beclin1

(2008) Christian G. Noble et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Involvement of Protective Autophagy in TRAIL Resistance of Apoptosis-defective Tumor Cells

(2008) Jie Han et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phase I and Pharmacokinetic Study of YM155, a Small-Molecule Inhibitor of Survivin

(2008) Anthony W. Tolcher et al.   JOURNAL OF CLINICAL ONCOLOGY