Lipid disequilibrium disrupts ER proteostasis by impairing ERAD substrate glycan trimming and dislocation

Endoplasmic Reticulum–Associated Degradation and Lipid Homeostasis

(2016) Julian Stevenson et al.   Annual Review of Nutrition

Autoubiquitination of the Hrd1 Ligase Triggers Protein Retrotranslocation in ERAD

(2016) Ryan D. Baldridge et al.   CELL

N-linked glycosylation and homeostasis of the endoplasmic reticulum

(2016) Natalia Cherepanova et al.   CURRENT OPINION IN CELL BIOLOGY

Protein misfolding specifies recruitment to cytoplasmic inclusion bodies

(2016) Kirill Bersuker et al.   JOURNAL OF CELL BIOLOGY

Lipid droplet–mediated ER homeostasis regulates autophagy and cell survival during starvation

(2016) Ariadna P. Velázquez et al.   JOURNAL OF CELL BIOLOGY

Protein misfolding in the endoplasmic reticulum as a conduit to human disease

(2016) Miao Wang et al.   NATURE

Subcellular Fractionation Analysis of the Extraction of Ubiquitinated Polytopic Membrane Substrate during ER-Associated Degradation

(2016) Kunio Nakatsukasa et al.   PLoS One

Perilipin2 plays a positive role in adipocytes during lipolysis by escaping proteasomal degradation

(2016) Yu Takahashi et al.   Scientific Reports

Diacylglycerol Metabolism and Signaling Is a Driving Force Underlying FASN Inhibitor Sensitivity in Cancer Cells

(2015) Daniel I. Benjamin et al.   ACS Chemical Biology

Multiple Mechanisms of Unfolded Protein Response–Induced Cell Death

(2015) Nobuhiko Hiramatsu et al.   AMERICAN JOURNAL OF PATHOLOGY

Targeting the AAA ATPase p97 as an Approach to Treat Cancer through Disruption of Protein Homeostasis

(2015) Daniel J. Anderson et al.   CANCER CELL

Lipid-dependent regulation of the unfolded protein response

(2015) Romain Volmer et al.   CURRENT OPINION IN CELL BIOLOGY

The life cycle of lipid droplets

(2015) Hayaa F Hashemi et al.   CURRENT OPINION IN CELL BIOLOGY

Lipid Droplets Are Essential for Efficient Clearance of Cytosolic Inclusion Bodies

(2015) Ofer Moldavski et al.   DEVELOPMENTAL CELL

Role for Lipid Droplet Biogenesis and Microlipophagy in Adaptation to Lipid Imbalance in Yeast

(2015) Jason D. Vevea et al.   DEVELOPMENTAL CELL

Fatty Acid Trafficking in Starved Cells: Regulation by Lipid Droplet Lipolysis, Autophagy, and Mitochondrial Fusion Dynamics

(2015) Angelika S. Rambold et al.   DEVELOPMENTAL CELL

Glycosylation-directed quality control of protein folding

(2015) Chengchao Xu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Glycan regulation of ER-associated degradation through compartmentalization

(2015) Ron Benyair et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Key Steps in ERAD of Luminal ER Proteins Reconstituted with Purified Components

(2014) Alexander Stein et al.   CELL

Metabolic Profiling Reveals PAFAH1B3 as a Critical Driver of Breast Cancer Pathogenicity

(2014) Melinda M. Mulvihill et al.   CHEMISTRY & BIOLOGY

Biogenesis of the multifunctional lipid droplet: Lipids, proteins, and sites

(2014) Albert Pol et al.   JOURNAL OF CELL BIOLOGY

Cleaning up in the endoplasmic reticulum: ubiquitin in charge

(2014) John C Christianson et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Opposing unfolded-protein-response signals converge on death receptor 5 to control apoptosis

(2014) M. Lu et al.   SCIENCE

Desnutrin/ATGL Activates PPARδ to Promote Mitochondrial Function for Insulin Secretion in Islet β Cells

(2013) Tianyi Tang et al.   Cell Metabolism

Cellular Fatty Acid Metabolism and Cancer

(2013) Erin Currie et al.   Cell Metabolism

Acyl-CoA synthetase 3 promotes lipid droplet biogenesis in ER microdomains

(2013) Adam Kassan et al.   JOURNAL OF CELL BIOLOGY

Palmitoylation is the switch that assigns calnexin to quality control or ER Ca2+ signaling

(2013) E. M. Lynes et al.   JOURNAL OF CELL SCIENCE

ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death

(2013) Jaeseok Han et al.   NATURE CELL BIOLOGY

Der1 promotes movement of misfolded proteins through the endoplasmic reticulum membrane

(2013) Martin Mehnert et al.   NATURE CELL BIOLOGY

Targeting the unfolded protein response in disease

(2013) Claudio Hetz et al.   NATURE REVIEWS DRUG DISCOVERY

Deglycosylation-dependent fluorescent proteins provide unique tools for the study of ER-associated degradation

(2013) Jeff E. Grotzke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Spatial regulation of UBXD8 and p97/VCP controls ATGL-mediated lipid droplet turnover

(2013) James A. Olzmann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ether lipid generating enzyme AGPS alters the balance of structural and signaling lipids to fuel cancer pathogenicity

(2013) D. I. Benjamin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Membrane lipid saturation activates endoplasmic reticulum unfolded protein response transducers through their transmembrane domains

(2013) R. Volmer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lipid Droplets and Cellular Lipid Metabolism

(2012) Tobias C. Walther et al.   Annual Review of Biochemistry

Palmitoylated calnexin is a key component of the ribosome-translocon complex

(2012) Asvin KK Lakkaraju et al.   EMBO JOURNAL

RING finger palmitoylation of the endoplasmic reticulum Gp78 E3 ubiquitin ligase

(2012) Maria Fairbank et al.   FEBS LETTERS

Unassembled CD147 is an endogenous endoplasmic reticulum–associated degradation substrate

(2012) Ryan E. Tyler et al.   MOLECULAR BIOLOGY OF THE CELL

Derlin-1 and UBXD8 are engaged in dislocation and degradation of lipidated ApoB-100 at lipid droplets

(2012) Michitaka Suzuki et al.   MOLECULAR BIOLOGY OF THE CELL

Ancient ubiquitous protein-1 mediates sterol-induced ubiquitination of 3-hydroxy-3-methylglutaryl CoA reductase in lipid droplet–associated endoplasmic reticulum membranes

(2012) Youngah Jo et al.   MOLECULAR BIOLOGY OF THE CELL

The Membrane Stress Response Buffers Lethal Effects of Lipid Disequilibrium by Reprogramming the Protein Homeostasis Network

(2012) Guillaume Thibault et al.   MOLECULAR CELL

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

The unfolded protein response: controlling cell fate decisions under ER stress and beyond

(2012) Claudio Hetz   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Delicate Balance Between Secreted Protein Folding and Endoplasmic Reticulum-Associated Degradation in Human Physiology

(2012) Christopher J. Guerriero et al.   PHYSIOLOGICAL REVIEWS

The Mammalian Endoplasmic Reticulum-Associated Degradation System

(2012) J. A. Olzmann et al.   Cold Spring Harbor Perspectives in Biology

A novel role for lipid droplets in the organismal antibacterial response

(2012) Preetha Anand et al.   eLife

Palmitoylated TMX and calnexin target to the mitochondria-associated membrane

(2011) Emily M Lynes et al.   EMBO JOURNAL

Ligand-switchable Substrates for a Ubiquitin-Proteasome System

(2011) Emily L. Egeler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characterization of Early EDEM1 Protein Maturation Events and Their Functional Implications

(2011) Taku Tamura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting Acyl-CoA:Diacylglycerol Acyltransferase 1 (DGAT1) with Small Molecule Inhibitors for the Treatment of Metabolic Diseases

(2011) Jingsong Cao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dual Role of Ancient Ubiquitous Protein 1 (AUP1) in Lipid Droplet Accumulation and Endoplasmic Reticulum (ER) Protein Quality Control

(2011) Elizabeth J. Klemm et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lipid Droplet Formation Is Dispensable for Endoplasmic Reticulum-associated Degradation

(2011) James A. Olzmann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The yeast lipin orthologue Pah1p is important for biogenesis of lipid droplets

(2011) Oludotun Adeyo et al.   JOURNAL OF CELL BIOLOGY

DGAT enzymes are required for triacylglycerol synthesis and lipid droplets in adipocytes

(2011) Charles A. Harris et al.   JOURNAL OF LIPID RESEARCH

Aberrant lipid metabolism disrupts calcium homeostasis causing liver endoplasmic reticulum stress in obesity

(2011) Suneng Fu et al.   NATURE

Defining human ERAD networks through an integrative mapping strategy

(2011) John C. Christianson et al.   NATURE CELL BIOLOGY

ATGL-mediated fat catabolism regulates cardiac mitochondrial function via PPAR-α and PGC-1

(2011) Guenter Haemmerle et al.   NATURE MEDICINE

Derlin-1 is a rhomboid pseudoprotease required for the dislocation of mutant α-1 antitrypsin from the endoplasmic reticulum

(2011) Ethan J Greenblatt et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation

(2011) P. Walter et al.   SCIENCE

Specificity of Intramembrane Protein-Lipid Interactions

(2011) F.-X. Contreras et al.   Cold Spring Harbor Perspectives in Biology

Retrotranslocation of a Misfolded Luminal ER Protein by the Ubiquitin-Ligase Hrd1p

(2010) Pedro Carvalho et al.   CELL

Ancient Ubiquitous Protein 1 (AUP1) Localizes to Lipid Droplets and Binds the E2 Ubiquitin Conjugase G2 (Ube2g2) via Its G2 Binding Region

(2010) Johanna Spandl et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sterol-induced Dislocation of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase from Endoplasmic Reticulum Membranes into the Cytosol through a Subcellular Compartment Resembling Lipid Droplets

(2010) Isamu Z. Hartman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Basis for Oligosaccharide Recognition of Misfolded Glycoproteins by OS-9 in ER-Associated Degradation

(2010) Tadashi Satoh et al.   MOLECULAR CELL

Efficient hepatitis C virus particle formation requires diacylglycerol acyltransferase-1

(2010) Eva Herker et al.   NATURE MEDICINE

Conditions of endoplasmic reticulum stress stimulate lipid droplet formation inSaccharomyces cerevisiae

(2009) Weihua Fei et al.   BIOCHEMICAL JOURNAL

IRE1α Kinase Activation Modes Control Alternate Endoribonuclease Outputs to Determine Divergent Cell Fates

(2009) Dan Han et al.   CELL

Sterol and Diacylglycerol Acyltransferase Deficiency Triggers Fatty Acid-mediated Cell Death

(2009) Jeanne Garbarino et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Good Fat, Essential Cellular Requirements for Triacylglycerol Synthesis to Maintain Membrane Homeostasis in Yeast

(2009) Julia Petschnigg et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting sequences of UBXD8 and AAM-B reveal that the ER has a direct role in the emergence and regression of lipid droplets

(2009) J. K. Zehmer et al.   JOURNAL OF CELL SCIENCE

Proteomic insights into an expanded cellular role for cytoplasmic lipid droplets

(2009) Brittany D. M. Hodges et al.   JOURNAL OF LIPID RESEARCH

Cdk1/Cdc28-Dependent Activation of the Major Triacylglycerol Lipase Tgl4 in Yeast Links Lipolysis to Cell-Cycle Progression

(2009) Christoph F. Kurat et al.   MOLECULAR CELL

Divergent Effects of PERK and IRE1 Signaling on Cell Viability

(2009) Jonathan H. Lin et al.   PLoS One

Comprehensive Characterization of Genes Required for Protein Folding in the Endoplasmic Reticulum

(2009) M. C. Jonikas et al.   SCIENCE

Human XTP3-B Forms an Endoplasmic Reticulum Quality Control Scaffold with the HRD1-SEL1L Ubiquitin Ligase Complex and BiP

(2008) Nobuko Hosokawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An Unconventional Diacylglycerol Kinase That Regulates Phospholipid Synthesis and Nuclear Membrane Growth

(2008) Gil-Soo Han et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of Sec61p in the ER-associated degradation of short-lived transmembrane proteins

(2008) Daniel C. Scott et al.   JOURNAL OF CELL BIOLOGY

Thematic Review Series: Glycerolipids.DGAT enzymes and triacylglycerol biosynthesis

(2008) Chi-Liang Eric Yen et al.   JOURNAL OF LIPID RESEARCH

Gp78 Cooperates with RMA1 in Endoplasmic Reticulum-associated Degradation of CFTRΔF508

(2008) Daisuke Morito et al.   MOLECULAR BIOLOGY OF THE CELL

OS-9 and GRP94 deliver mutant α1-antitrypsin to the Hrd1–SEL1L ubiquitin ligase complex for ERAD

(2008) John C. Christianson et al.   NATURE CELL BIOLOGY

SEL1L nucleates a protein complex required for dislocation of misfolded glycoproteins

(2008) B. Mueller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA