Subcellular Fractionation Analysis of the Extraction of Ubiquitinated Polytopic Membrane Substrate during ER-Associated Degradation

The yeast ERAD-C ubiquitin ligase Doa10 recognizes an intramembrane degron

(2015) Gregor Habeck et al.   JOURNAL OF CELL BIOLOGY

The Ubiquitin Ligase SCFUcc1 Acts as a Metabolic Switch for the Glyoxylate Cycle

(2015) Kunio Nakatsukasa et al.   MOLECULAR CELL

Key Steps in ERAD of Luminal ER Proteins Reconstituted with Purified Components

(2014) Alexander Stein et al.   CELL

ER-associated degradation: Protein quality control and beyond

(2014) Annamaria Ruggiano et al.   JOURNAL OF CELL BIOLOGY

SGTA regulates the cytosolic quality control of hydrophobic substrates

(2014) L. Wunderley et al.   JOURNAL OF CELL SCIENCE

Protein quality control at the inner nuclear membrane

(2014) Anton Khmelinskii et al.   NATURE

A stalled retrotranslocation complex reveals physical linkage between substrate recognition and proteasomal degradation during ER-associated degradation

(2013) Kunio Nakatsukasa et al.   MOLECULAR BIOLOGY OF THE CELL

Sterol-induced dislocation of 3-hydroxy-3-methylglutaryl coenzyme A reductase from membranes of permeabilized cells

(2013) Rania Elsabrouty et al.   MOLECULAR BIOLOGY OF THE CELL

Spatial sequestration of misfolded proteins by a dynamic chaperone pathway enhances cellular fitness during stress

(2013) Stéphanie Escusa-Toret et al.   NATURE CELL BIOLOGY

Previously unknown role for the ubiquitin ligase Ubr1 in endoplasmic reticulum-associated protein degradation

(2013) A. Stolz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sterol homeostasis requires regulated degradation of squalene monooxygenase by the ubiquitin ligase Doa10/Teb4

(2013) Ombretta Foresti et al.   eLife

Cleaning Up: ER-Associated Degradation to the Rescue

(2012) Jeffrey L. Brodsky   CELL

Finding the will and the way of ERAD substrate retrotranslocation

(2012) Randolph Y Hampton et al.   CURRENT OPINION IN CELL BIOLOGY

Design Principles of Protein Biosynthesis-Coupled Quality Control

(2012) Monica C. Rodrigo-Brenni et al.   DEVELOPMENTAL CELL

BAG6/BAT3: emerging roles in quality control for nascent polypeptides

(2012) H. Kawahara et al.   JOURNAL OF BIOCHEMISTRY

Aberrant substrate engagement of the ER translocon triggers degradation by the Hrd1 ubiquitin ligase

(2012) Eric M. Rubenstein et al.   JOURNAL OF CELL BIOLOGY

Ancient ubiquitous protein-1 mediates sterol-induced ubiquitination of 3-hydroxy-3-methylglutaryl CoA reductase in lipid droplet–associated endoplasmic reticulum membranes

(2012) Youngah Jo et al.   MOLECULAR BIOLOGY OF THE CELL

The Delicate Balance Between Secreted Protein Folding and Endoplasmic Reticulum-Associated Degradation in Human Physiology

(2012) Christopher J. Guerriero et al.   PHYSIOLOGICAL REVIEWS

SGTA Recognizes a Noncanonical Ubiquitin-like Domain in the Bag6-Ubl4A-Trc35 Complex to Promote Endoplasmic Reticulum-Associated Degradation

(2012) Yue Xu et al.   Cell Reports

The Cdc48 machine in endoplasmic reticulum associated protein degradation

(2011) Dieter H. Wolf et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Cooperative and independent activities of Sgt2 and Get5 in the targeting of tail-anchored proteins

(2011) Christian Kohl et al.   BIOLOGICAL CHEMISTRY

Dual Role of Ancient Ubiquitous Protein 1 (AUP1) in Lipid Droplet Accumulation and Endoplasmic Reticulum (ER) Protein Quality Control

(2011) Elizabeth J. Klemm et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lipid Droplet Formation Is Dispensable for Endoplasmic Reticulum-associated Degradation

(2011) James A. Olzmann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Structural Model of the Sgt2 Protein and Its Interactions with Chaperones and the Get4/Get5 Complex

(2011) Justin W. Chartron et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Ubiquitin Ligase-Associated Chaperone Holdase Maintains Polypeptides in Soluble States for Proteasome Degradation

(2011) Qiuyan Wang et al.   MOLECULAR CELL

Protein targeting and degradation are coupled for elimination of mislocalized proteins

(2011) Tara Hessa et al.   NATURE

The Cdc48 ATPase modulates the interaction between two proteolytic factors Ufd2 and Rad23

(2011) G. H. Baek et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Enzymatic Blockade of the Ubiquitin-Proteasome Pathway

(2011) Robert Ernst et al.   PLOS BIOLOGY

Protein dislocation from the ER

(2010) Katrin Bagola et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Retrotranslocation of a Misfolded Luminal ER Protein by the Ubiquitin-Ligase Hrd1p

(2010) Pedro Carvalho et al.   CELL

Control of cholesterol synthesis through regulated ER-associated degradation of HMG CoA reductase

(2010) Youngah Jo et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Crystal Structure of Get4-Get5 Complex and Its Interactions with Sgt2, Get3, and Ydj1

(2010) Yi-Wei Chang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sterol-induced Dislocation of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase from Endoplasmic Reticulum Membranes into the Cytosol through a Subcellular Compartment Resembling Lipid Droplets

(2010) Isamu Z. Hartman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Chaperone Cascade Sorts Proteins for Posttranslational Membrane Insertion into the Endoplasmic Reticulum

(2010) Fei Wang et al.   MOLECULAR CELL

ERAD substrate recognition in budding yeast

(2010) Wei Xie et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Protein Quality Control as a Strategy for Cellular Regulation: Lessons from Ubiquitin-Mediated Regulation of the Sterol Pathway

(2009) Randolph Y. Hampton et al.   CHEMICAL REVIEWS

Sterol and Diacylglycerol Acyltransferase Deficiency Triggers Fatty Acid-mediated Cell Death

(2009) Jeanne Garbarino et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Good Fat, Essential Cellular Requirements for Triacylglycerol Synthesis to Maintain Membrane Homeostasis in Yeast

(2009) Julia Petschnigg et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

In VitroAnalysis of Hrd1p-mediated Retrotranslocation of Its Multispanning Membrane Substrate 3-Hydroxy-3-methylglutaryl (HMG)-CoA Reductase

(2009) Renee M. Garza et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dislocation of HMG-CoA Reductase and Insig-1, Two Polytopic Endoplasmic Reticulum Proteins, En Route to Proteasomal Degradation

(2009) Gil S. Leichner et al.   MOLECULAR BIOLOGY OF THE CELL

Misfolded Membrane Proteins Are Specifically Recognized by the Transmembrane Domain of the Hrd1p Ubiquitin Ligase

(2009) Brian K. Sato et al.   MOLECULAR CELL

Dissecting the ER-Associated Degradation of a Misfolded Polytopic Membrane Protein

(2008) Kunio Nakatsukasa et al.   CELL

Degradation of a Cytosolic Protein Requires Endoplasmic Reticulum-associated Degradation Machinery

(2008) Meredith Boyle Metzger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Misfolded proteins partition between two distinct quality control compartments

(2008) Daniel Kaganovich et al.   NATURE