The Tribbles 2 (TRB2) pseudokinase binds to ATP and autophosphorylates in a metal-independent manner

Going for broke: targeting the human cancer pseudokinome

(2015) Fiona P. Bailey et al.   BIOCHEMICAL JOURNAL

ProKinO: A Unified Resource for Mining the Cancer Kinome

(2015) Daniel Ian McSkimming et al.   HUMAN MUTATION

Regulation of Trib2 by an E2F1-C/EBP  feedback loop in AML cell proliferation

(2014) L. Rishi et al.   BLOOD

Development and Applications of CRISPR-Cas9 for Genome Engineering

(2014) Patrick D. Hsu et al.   CELL

Loss of Tribbles pseudokinase-3 promotes Akt-driven tumorigenesis via FOXO inactivation

(2014) M Salazar et al.   CELL DEATH AND DIFFERENTIATION

RETRACTED: An ATP-Competitive Inhibitor Modulates the Allosteric Function of the HER3 Pseudokinase

(2014) Peter Littlefield et al.   CHEMISTRY & BIOLOGY

Conformation-Selective ATP-Competitive Inhibitors Control Regulatory Interactions and Noncatalytic Functions of Mitogen-Activated Protein Kinases

(2014) Sanjay B. Hari et al.   CHEMISTRY & BIOLOGY

Identification of a Major Determinant for Serine-Threonine Kinase Phosphoacceptor Specificity

(2014) Catherine Chen et al.   MOLECULAR CELL

Pharmacological targeting of the pseudokinase Her3

(2014) Ting Xie et al.   Nature Chemical Biology

Drosophila Tribbles Antagonizes Insulin Signaling-Mediated Growth and Metabolism via Interactions with Akt Kinase

(2014) Rahul Das et al.   PLoS One

Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death

(2014) Joanne M. Hildebrand et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chloride Sensing by WNK1 Involves Inhibition of Autophosphorylation

(2014) A. T. Piala et al.   Science Signaling

Day of the dead: pseudokinases and pseudophosphatases in physiology and disease

(2014) Veronika Reiterer et al.   TRENDS IN CELL BIOLOGY

The structures of the kinase domain and UBA domain of MPK38 suggest the activation mechanism for kinase activity

(2014) Yong-Soon Cho et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Kinase Drug Discovery – What’s Next in the Field?

(2013) Philip Cohen et al.   ACS Chemical Biology

Direct Comparison of a Genetically Encoded Sensor and Small Molecule Indicator: Implications for Quantification of Cytosolic Zn2+

(2013) Yan Qin et al.   ACS Chemical Biology

Structure-Guided Inhibitor Design Expands the Scope of Analog-Sensitive Kinase Technology

(2013) Chao Zhang et al.   ACS Chemical Biology

Insights into the evolution of divergent nucleotide-binding mechanisms among pseudokinases revealed by crystal structures of human and mouse MLKL

(2013) James M. Murphy et al.   BIOCHEMICAL JOURNAL

A robust methodology to subclassify pseudokinases based on their nucleotide-binding properties

(2013) James M. Murphy et al.   BIOCHEMICAL JOURNAL

The functionally diverse roles of tribbles

(2013) Fiona Lohan et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Techniques to examine nucleotide binding by pseudokinases: Table 1

(2013) Isabelle S. Lucet et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Pseudokinase drug intervention: a potentially poisoned chalice

(2013) Jeroen Claus et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Pseudokinases from a structural perspective

(2013) Susan S. Taylor et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Receptor tyrosine kinases with intracellular pseudokinase domains

(2013) Jeannine M. Mendrola et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Dawn of the dead: protein pseudokinases signal new adventures in cell biology

(2013) Patrick A. Eyers et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Structural and evolutionary adaptation of rhoptry kinases and pseudokinases, a family of coccidian virulence factors

(2013) Eric Talevich et al.   BMC EVOLUTIONARY BIOLOGY

Developing Irreversible Inhibitors of the Protein Kinase Cysteinome

(2013) Qingsong Liu et al.   CHEMISTRY & BIOLOGY

The kinase domain of Drosophila Tribbles is required for turnover of fly C/EBP during cellmigration

(2013) Venessa Masoner et al.   DEVELOPMENTAL BIOLOGY

The Pseudokinase MLKL Mediates Necroptosis via a Molecular Switch Mechanism

(2013) James M. Murphy et al.   IMMUNITY

Recurrent deletions of ULK4 in schizophrenia: a gene crucial for neuritogenesis and neuronal motility

(2013) B. Lang et al.   JOURNAL OF CELL SCIENCE

TRIB2 Acts Downstream of Wnt/TCF in Liver Cancer Cells to Regulate YAP and C/EBPα Function

(2013) Jiayi Wang et al.   MOLECULAR CELL

High throughput kinase inhibitor screens reveal TRB3 and MAPK-ERK/TGF  pathways as fundamental Notch regulators in breast cancer

(2013) J. Izrailit et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Affinity Profiling of the Cellular Kinome for the Nucleotide Cofactors ATP, ADP, and GTP

(2012) Isabelle Becher et al.   ACS Chemical Biology

A public-private partnership to unlock the untargeted kinome

(2012) Stefan Knapp et al.   Nature Chemical Biology

Java bioinformatics analysis web services for multiple sequence alignment--JABAWS:MSA

(2011) P. V. Troshin et al.   BIOINFORMATICS

A Conserved Glu–Arg Salt Bridge Connects Coevolved Motifs That Define the Eukaryotic Protein Kinase Fold

(2011) Jie Yang et al.   JOURNAL OF MOLECULAR BIOLOGY

A Raf-induced allosteric transition of KSR stimulates phosphorylation of MEK

(2011) Damian F. Brennan et al.   NATURE

Comprehensive analysis of kinase inhibitor selectivity

(2011) Mindy I Davis et al.   NATURE BIOTECHNOLOGY

Common variation at 3p22.1 and 7p15.3 influences multiple myeloma risk

(2011) Peter Broderick et al.   NATURE GENETICS

The pseudokinase domain of JAK2 is a dual-specificity protein kinase that negatively regulates cytokine signaling

(2011) Daniela Ungureanu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Overexpression of TRIB2 in human lung cancers contributes to tumorigenesis through downregulation of C/EBPα

(2011) K B Grandinetti et al.   ONCOGENE

ProKinO: An Ontology for Integrative Analysis of Protein Kinases in Cancer

(2011) Gurinder Gosal et al.   PLoS One

Mutation that blocks ATP binding creates a pseudokinase stabilizing the scaffolding function of kinase suppressor of Ras, CRAF and BRAF

(2011) J. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chemical genetic strategy for targeting protein kinases based on covalent complementarity

(2011) A. L. Garske et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Congenital Hydrocephalus in Genetically Engineered Mice

(2011) P. Vogel et al.   VETERINARY PATHOLOGY

The minimal kinome of Giardia lamblia illuminates early kinase evolution and unique parasite biology

(2011) Gerard Manning et al.   GENOME BIOLOGY

Trib1 links the MEK1/ERK pathway in myeloid leukemogenesis

(2010) T. Yokoyama et al.   BLOOD

Differential ability of Tribbles family members to promote degradation of C/EBP  and induce acute myelogenous leukemia

(2010) P. H. Dedhia et al.   BLOOD

Transformation by Tribbles homolog 2 (Trib2) requires both the Trib2 kinase domain and COP1 binding

(2010) K. Keeshan et al.   BLOOD

Pseudokinases-remnants of evolution or key allosteric regulators?

(2010) Elton Zeqiraj et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

mTOR regulation of autophagy

(2010) Chang Hwa Jung et al.   FEBS LETTERS

The (un)targeted cancer kinome

(2010) Oleg Fedorov et al.   Nature Chemical Biology

Human TRIB2 is a repressor of FOXO that contributes to the malignant phenotype of melanoma cells

(2010) F Zanella et al.   ONCOGENE

ErbB3/HER3 intracellular domain is competent to bind ATP and catalyze autophosphorylation

(2010) Fumin Shi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protein denaturation and protein:drugs interactions from intrinsic protein fluorescence measurements at the nanolitre scale

(2010) Gaudet Matthieu et al.   PROTEIN SCIENCE

Evolution of CASK into a Mg2+-Sensitive Kinase

(2010) K. Mukherjee et al.   Science Signaling

Resiliency and Vulnerability in the HER2-HER3 Tumorigenic Driver

(2010) D. N. Amin et al.   Science Translational Medicine

A Quantitative Comparison of Wild-Type and Gatekeeper Mutant Cdk2 for Chemical Genetic Studies with ATP Analogues

(2009) Lucy M. Elphick et al.   CHEMBIOCHEM

Autophagy genes as tumor suppressors

(2009) Chengyu Liang et al.   CURRENT OPINION IN CELL BIOLOGY

Discovery and Exploitation of Inhibitor-resistant Aurora and Polo Kinase Mutants for the Analysis of Mitotic Networks

(2009) Paul J. Scutt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PKC maturation is promoted by nucleotide pocket occupation independently of intrinsic kinase activity

(2009) Angus J M Cameron et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure of the LKB1-STRAD-MO25 Complex Reveals an Allosteric Mechanism of Kinase Activation

(2009) E. Zeqiraj et al.   SCIENCE

Pseudokinases: Functional Insights Gleaned from Structure

(2009) Alexandr P. Kornev et al.   STRUCTURE

Structure of the Pseudokinase VRK3 Reveals a Degraded Catalytic Site, a Highly Conserved Kinase Fold, and a Putative Regulatory Binding Site

(2009) Eric D. Scheeff et al.   STRUCTURE

ATP and MO25α Regulate the Conformational State of the STRADα Pseudokinase and Activation of the LKB1 Tumour Suppressor

(2009) Elton Zeqiraj et al.   PLOS BIOLOGY

Rethinking Pseudokinases

(2008) Natarajan Kannan et al.   CELL

CASK Functions as a Mg2+-Independent Neurexin Kinase

(2008) Konark Mukherjee et al.   CELL

A helix scaffold for the assembly of active protein kinases

(2008) A. P. Kornev et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA