Pyrrolo[2,3-d ]pyrimidine (7-deazapurine) as a privileged scaffold in design of antitumor and antiviral nucleosides

Ibulocydine sensitizes human hepatocellular carcinoma cells to TRAIL-induced apoptosis via calpain-mediated Bax cleavage

(2017) Seok Soon Park et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Synthesis and Cytostatic and Antiviral Profiling of Thieno-Fused 7-Deazapurine Ribonucleosides

(2017) Michal Tichý et al.   JOURNAL OF MEDICINAL CHEMISTRY

5-Substituted Pyrimidine and 7-Substituted 7-Deazapurine dNTPs as Substrates for DNA Polymerases in Competitive Primer Extension in the Presence of Natural dNTPs

(2016) Hana Cahová et al.   ACS Chemical Biology

Design, synthesis, and in vitro biological evaluation of novel 6-methyl-7-substituted-7-deaza purine nucleoside analogs as anti-influenza A agents

(2016) Cai Lin et al.   ANTIVIRAL RESEARCH

Structure-activity relationships of nucleoside analogues for inhibition of tick-borne encephalitis virus

(2016) Luděk Eyer et al.   ANTIVIRAL RESEARCH

In vitro antiviral activity of adenosine analog NITD008 against tick-borne flaviviruses

(2016) Michael K. Lo et al.   ANTIVIRAL RESEARCH

A phase I study of the investigational NEDD8-activating enzyme inhibitor pevonedistat (TAK-924/MLN4924) in patients with metastatic melanoma

(2016) Shailender Bhatia et al.   INVESTIGATIONAL NEW DRUGS

Nucleoside Inhibitors of Zika Virus

(2016) Luděk Eyer et al.   JOURNAL OF INFECTIOUS DISEASES

South (S)- and North (N)-Methanocarba-7-Deazaadenosine Analogues as Inhibitors of Human Adenosine Kinase

(2016) Kiran S. Toti et al.   JOURNAL OF MEDICINAL CHEMISTRY

Exploiting Protein Conformational Change to Optimize Adenosine-Derived Inhibitors of HSP70

(2016) Matthew D. Cheeseman et al.   JOURNAL OF MEDICINAL CHEMISTRY

7-(2-Thienyl)-7-Deazaadenosine (AB61), a New Potent Nucleoside Cytostatic with a Complex Mode of Action

(2016) P. Perlikova et al.   MOLECULAR CANCER THERAPEUTICS

Novel genomic island modifies DNA with 7-deazaguanine derivatives

(2016) Jennifer J. Thiaville et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Viral Polymerase Inhibitor 7-Deaza-2’-C-Methyladenosine Is a Potent Inhibitor of In Vitro Zika Virus Replication and Delays Disease Progression in a Robust Mouse Infection Model

(2016) Joanna Zmurko et al.   PLoS Neglected Tropical Diseases

Nucleoside Inhibitors of Tick-Borne Encephalitis Virus

(2015) Luděk Eyer et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Combined treatment of adenosine nucleoside inhibitor NITD008 and histone deacetylase inhibitor vorinostat represents an immunotherapy strategy to ameliorate West Nile virus infection

(2015) Jacob Nelson et al.   ANTIVIRAL RESEARCH

Synthesis and biological profiling of 6- or 7-(het)aryl-7-deazapurine 4′-C-methylribonucleosides

(2015) Petr Nauš et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Pevonedistat (MLN4924), a First-in-Class NEDD8-activating enzyme inhibitor, in patients with acute myeloid leukaemia and myelodysplastic syndromes: a phase 1 study

(2015) Ronan T. Swords et al.   BRITISH JOURNAL OF HAEMATOLOGY

Synthetic Entries to and Biological Activity of Pyrrolopyrimidines

(2015) Laurens M. De Coen et al.   CHEMICAL REVIEWS

2-Substituted 6-(Het)aryl-7-deazapurine Ribonucleosides: Synthesis, Inhibition of Adenosine Kinases, and Antimycobacterial Activity

(2015) Vincent Malnuit et al.   ChemMedChem

Phase I Study of the Novel Investigational NEDD8-Activating Enzyme Inhibitor Pevonedistat (MLN4924) in Patients with Relapsed/Refractory Multiple Myeloma or Lymphoma

(2015) J. J. Shah et al.   CLINICAL CANCER RESEARCH

Phase I Study of the Investigational NEDD8-Activating Enzyme Inhibitor Pevonedistat (TAK-924/MLN4924) in Patients with Advanced Solid Tumors

(2015) J. Sarantopoulos et al.   CLINICAL CANCER RESEARCH

Synthesis and Evaluation of the Antiproliferative Properties of a Tethered Tubercidin-Platinum(II) Complex

(2015) Stefano D'Errico et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Structural basis for RNA replication by the hepatitis C virus polymerase

(2015) T. C. Appleby et al.   SCIENCE

Identification of anti-proliferative kinase inhibitors as potential therapeutic agents to treat canine osteosarcoma

(2015) Ulrike Mauchle et al.   VETERINARY JOURNAL

Synthesis and cytostatic activity of 7-arylsulfanyl-7-deazapurine bases and ribonucleosides

(2015) Martin Klečka et al.   MedChemComm

7-Aryl-7-deazaadenine 2′-Deoxyribonucleoside Triphosphates (dNTPs): Better Substrates for DNA Polymerases than dATP in Competitive Incorporations

(2014) Pavel Kielkowski et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

An adenosine nucleoside analogue NITD008 inhibits EV71 proliferation

(2014) Luqing Shang et al.   ANTIVIRAL RESEARCH

Identification of a chemical inhibitor for nuclear speckle formation: Implications for the function of nuclear speckles in regulation of alternative pre-mRNA splicing

(2014) Yutaro Kurogi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Sangivamycin induces apoptosis by suppressing Erk signaling in primary effusion lymphoma cells

(2014) Kazufumi Wakao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Synthesis of Purine and 7-Deazapurine Nucleoside Analogues of 6-N-(4-Nitrobenzyl)adenosine; Inhibition of Nucleoside Transport and Proliferation of Cancer Cells

(2014) Ramanjaneyulu Rayala et al.   ChemMedChem

Trifluoromethylated Nucleosides: A Building Block Approach to Cytotoxic Adenosine Analogues

(2014) Johannes Drexler et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

The Synthesis and Evaluation of New Carbocyclic Pyrrolo[2,3-d]pyrimidine Nucleoside Analogs

(2014) Hakjune Rhee et al.   HETEROCYCLES

Structural Basis for Inhibition of Mycobacterial and Human Adenosine Kinase by 7-Substituted 7-(Het)aryl-7-deazaadenine Ribonucleosides

(2014) Jan Snášel et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, Cytostatic, Antimicrobial, and Anti-HCV Activity of 6-Substituted 7-(Het)aryl-7-deazapurine Ribonucleosides

(2014) Petr Nauš et al.   JOURNAL OF MEDICINAL CHEMISTRY

Ibulocydine sensitizes human cancers to radiotherapy by induction of mitochondria-mediated apoptosis

(2014) Seok Soon Park et al.   RADIOTHERAPY AND ONCOLOGY

Multiple Classes of Antiviral Agents ExhibitIn VitroActivity against Human Rhinovirus Type C

(2013) Chris Mello et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Synthesis and biological activity of benzo-fused 7-deazaadenosine analogues. 5- and 6-substituted 4-amino- or 4-alkylpyrimido[4,5-b]indole ribonucleosides

(2013) Michal Tichý et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and evaluation of Janus type nucleosides as potential HCV NS5B polymerase inhibitors

(2013) Longhu Zhou et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and Cytostatic and Antiviral Activities of 2′-Deoxy-2′,2′-difluororibo- and 2′-Deoxy-2′-fluororibonucleosides Derived from 7-(Het)aryl-7-deazaadenines

(2013) Pavla Perlíková et al.   ChemMedChem

Apoptosis is Induced in Cancer Cells via the Mitochondrial Pathway by the Novel Xylocydine-Derived Compound JRS-15

(2013) Chao Sun et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Evaluation of Novel Acyclic Nucleoside Phosphonates against Human and Animal Gammaherpesviruses Revealed an Altered Metabolism of Cyclic Prodrugs upon Epstein-Barr Virus Reactivation in P3HR-1 Cells

(2013) N. Coen et al.   JOURNAL OF VIROLOGY

Identification of 5-Iodotubercidin as a Genotoxic Drug with Anti-Cancer Potential

(2013) Xin Zhang et al.   PLoS One

6-Alkyl-, 6-aryl- or 6-hetaryl-7-deazapurine ribonucleosides as inhibitors of human or MTB adenosine kinase and potential antimycobacterial agents

(2013) Pavla Perlíková et al.   MedChemComm

Sugar-modified derivatives of cytostatic 7-(het)aryl-7-deazaadenosines: 2′-C-methylribonucleosides, 2′-deoxy-2′-fluoroarabinonucleosides, arabinonucleosides and 2′-deoxyribonucleosides

(2012) Petr Nauš et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and antiviral properties of novel 7-heterocyclic substituted 7-deaza-adenine nucleoside inhibitors of Hepatitis C NS5B polymerase

(2012) M. Emilia Di Francesco et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and antiviral activity of 4,6-disubstituted pyrimido[4,5-b]indole ribonucleosides

(2012) Michal Tichý et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and evaluation against hepatitis C virus of 7-deaza analogues of 2′-C-methyl-6-O-methyl guanosine nucleoside and l-Alanine ester phosphoramidates

(2012) Claire Bourdin et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Biosynthesis of pyrrolopyrimidines

(2012) Reid M. McCarty et al.   BIOORGANIC CHEMISTRY

Conformational Adaptation Drives Potent, Selective and Durable Inhibition of the Human Protein Methyltransferase DOT1L

(2012) Aravind Basavapathruni et al.   Chemical Biology & Drug Design

Sangivamycin-like Molecule 6 Exhibits Potent Anti-Multiple Myeloma Activity through Inhibition of Cyclin-Dependent Kinase-9

(2012) N. G. Dolloff et al.   MOLECULAR CANCER THERAPEUTICS

Synthesis and Antiviral Properties of Novel Tetracyclic Nucleoside Inhibitors of Hepatitis C NS5B Polymerase

(2012) M. Emilia Di Francesco et al.   NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS

Synthesis of 2′-deoxy-2′-fluororibo- and 2′-deoxy-2′,2′-difluororibonucleosides derived from 6-(het)aryl-7-deazapurines

(2012) Pavla Perlíková et al.   TETRAHEDRON

Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors

(2012) Wenyu Yu et al.   Nature Communications

Identification of Toyocamycin, an agent cytotoxic for multiple myeloma cells, as a potent inhibitor of ER stress-induced XBP1 mRNA splicing

(2012) M Ri et al.   Blood Cancer Journal

Sensitivity of Mitochondrial Transcription and Resistance of RNA Polymerase II Dependent Nuclear Transcription to Antiviral Ribonucleosides

(2012) Jamie J. Arnold et al.   PLoS Pathogens

Synthesis of 6-(het) ary Xylocydine analogues and evaluating their inhibitory activities of CDK1 and CDK2 in vitro

(2011) Chuan Xiao et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and anti-HIV-1 activity of 4-substituted-7-(2′-deoxy-2′-fluoro-4′-azido-β-d-ribofuranosyl)pyrrolo[2,3-d]pyrimidine analogues

(2011) Xiaohe Guo et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and antiviral activity of 2′-deoxy-2′-fluoro-2′-C-methyl-7-deazapurine nucleosides, their phosphoramidate prodrugs and 5′-triphosphates

(2011) Junxing Shi et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Selective Killing of Mixed Lineage Leukemia Cells by a Potent Small-Molecule DOT1L Inhibitor

(2011) Scott R. Daigle et al.   CANCER CELL

Combination of Farnesyltransferase and Akt Inhibitors Is Synergistic in Breast Cancer Cells and Causes Significant Breast Tumor Regression in ErbB2 Transgenic Mice

(2011) M. E. Balasis et al.   CLINICAL CANCER RESEARCH

Ibulocydine Is a Novel Prodrug Cdk Inhibitor That Effectively Induces Apoptosis in Hepatocellular Carcinoma Cells

(2011) Seung-Ju Cho et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Synthesis and Significant Cytostatic Activity of 7-Hetaryl-7-deazaadenosines

(2011) Aurelie Bourderioux et al.   JOURNAL OF MEDICINAL CHEMISTRY

Expedient Total Synthesis of Triciribine and Its Prodrugs

(2011) Wei Shen et al.   SYNTHETIC COMMUNICATIONS

Sustained Viral Response in a Hepatitis C Virus-Infected Chimpanzee via a Combination of Direct-Acting Antiviral Agents

(2010) David B. Olsen et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Inhibition of Dengue Virus RNA Synthesis by an Adenosine Nucleoside

(2010) Y.-L. Chen et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Inhibition of Dengue Virus by an Ester Prodrug of an Adenosine Analog

(2010) Y.-L. Chen et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Biochemical characterization of the inhibition of the dengue virus RNA polymerase by beta-d-2′-ethynyl-7-deaza-adenosine triphosphate

(2010) Derek R. Latour et al.   ANTIVIRAL RESEARCH

Phosphoramidate pronucleotides of cytostatic 6-aryl-7-deazapurine ribonucleosides

(2010) Pavla Perlíková et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and anti-HCV activity of a new 2′-deoxy-2′-fluoro-2′-C-methyl nucleoside analogue

(2010) Weidong Hu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Cell cycle arrest and cytochrome c-mediated apoptotic induction by MCS-5A is associated with up-regulation of p16INK4a in HL-60 cells

(2010) Bu Young Choi et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Novel anticancer compounds induce apoptosis in melanoma cells

(2010) Uppoor G. Bhat et al.   CELL CYCLE

CycloSal-phosphate Pronucleotides of Cytostatic 6-(Het)aryl-7-deazapurine Ribonucleosides: Synthesis, Cytostatic Activity, and Inhibition of Adenosine Kinases

(2010) Pavla Spáčilová et al.   ChemMedChem

Elimination of hepatitis C virus by short term NS3-4A and NS5B inhibitor combination therapy in human hepatocyte chimeric mice

(2010) Eiji Ohara et al.   JOURNAL OF HEPATOLOGY

Synthesis of a 6-Methyl-7-deaza Analogue of Adenosine That Potently Inhibits Replication of Polio and Dengue Viruses

(2010) Runzhi Wu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of a β-d-2′-Deoxy-2′-α-fluoro-2′-β-C-methyluridine Nucleotide Prodrug (PSI-7977) for the Treatment of Hepatitis C Virus

(2010) Michael J. Sofia et al.   JOURNAL OF MEDICINAL CHEMISTRY

ARC Synergizes with ABT-737 to Induce Apoptosis in Human Cancer Cells

(2010) U. G. Bhat et al.   MOLECULAR CANCER THERAPEUTICS

ARC (NSC 188491) has identical activity to Sangivamycin (NSC 65346) including inhibition of both P-TEFb and PKC

(2009) Luke H Stockwin et al.   BMC CANCER

Xylocydine, a novel Cdk inhibitor, is an effective inducer of apoptosis in hepatocellular carcinoma cells in vitro and in vivo

(2009) Seung-Ju Cho et al.   CANCER LETTERS

6-(Het)aryl-7-Deazapurine Ribonucleosides as Novel Potent Cytostatic Agents

(2009) Petr Nauš et al.   JOURNAL OF MEDICINAL CHEMISTRY

An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer

(2009) Teresa A. Soucy et al.   NATURE

An adenosine nucleoside inhibitor of dengue virus

(2009) Z. Yin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Robust Antiviral Efficacy upon Administration of a Nucleoside Analog to Hepatitis C Virus-Infected Chimpanzees

(2008) S. S. Carroll et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Dual Targeting of HSC70 and HSP72 Inhibits HSP90 Function and Induces Tumor-Specific Apoptosis

(2008) Marissa V. Powers et al.   CANCER CELL

Synthesis and Anti-Hepatitis B Virus and Anti-Hepatitis C Virus Activities of 7-Deazaneplanocin A Analogues in Vitro

(2008) Hyo-Joong Kim et al.   JOURNAL OF MEDICINAL CHEMISTRY

Biochemical and biological properties of 5-bromotubercidin: Differential effects on cellular DNA-directed and viral RNA-directed RNA synthesis

(2007) Branko Brdar et al.   BIOORGANIC & MEDICINAL CHEMISTRY