Sensitivity of Mitochondrial Transcription and Resistance of RNA Polymerase II Dependent Nuclear Transcription to Antiviral Ribonucleosides

Human Mitochondrial RNA Polymerase: Evaluation of the Single-Nucleotide-Addition Cycle on Synthetic RNA/DNA Scaffolds

(2011) Eric D. Smidansky et al.   BIOCHEMISTRY

New nucleoside analogs for patients with hematological malignancies

(2011) Tadeusz Robak   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Interaction of RNA Polymerase II Fork Loop 2 with Downstream Non-template DNA Regulates Transcription Elongation

(2011) Maria L. Kireeva et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nucleoside Triphosphate Pool Asymmetry in Mammalian Mitochondria

(2011) Linda J. Wheeler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure of human mitochondrial RNA polymerase

(2011) Rieke Ringel et al.   NATURE

Review article: specifically targeted anti-viral therapy for hepatitis C - a new era in therapy

(2010) C. M. Lange et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Turning Hepatitis C into a Real Virus

(2010) Catherine L. Murray et al.   Annual Review of Microbiology

Sustained Viral Response in a Hepatitis C Virus-Infected Chimpanzee via a Combination of Direct-Acting Antiviral Agents

(2010) David B. Olsen et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Novel Hepatitis C Virus Reporter Replicon Cell Lines Enable Efficient Antiviral Screening against Genotype 1a

(2010) M. Robinson et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

PSI-7851, a Pronucleotide of  -D-2'-Deoxy-2'-Fluoro-2'-C-Methyluridine Monophosphate, Is a Potent and Pan-Genotype Inhibitor of Hepatitis C Virus Replication

(2010) A. M. Lam et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Identification of Multiple Rate-limiting Steps during the Human Mitochondrial Transcription Cyclein Vitro

(2010) Maria F. Lodeiro et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Discovery of a β-d-2′-Deoxy-2′-α-fluoro-2′-β-C-methyluridine Nucleotide Prodrug (PSI-7977) for the Treatment of Hepatitis C Virus

(2010) Michael J. Sofia et al.   JOURNAL OF MEDICINAL CHEMISTRY

A transient kinetic approach to investigate nucleoside inhibitors of mitochondrial DNA polymerase γ

(2010) Karen S. Anderson   METHODS

Comparison of HCV NS3 protease and NS5B polymerase inhibitor activity in 1a, 1b and 2a replicons and 2a infectious virus

(2009) Matthew S. Paulson et al.   ANTIVIRAL RESEARCH

Progress towards improving antiviral therapy for hepatitis C with hepatitis C virus polymerase inhibitors. Part I: Nucleoside analogues

(2009) Nathaniel A Brown   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Millisecond phase kinetic analysis of elongation catalyzed by human, yeast, and Escherichia coli RNA polymerase

(2009) Maria Kireeva et al.   METHODS

Nucleotide Analogue Prodrug Tenofovir Disoproxil Enhances Lymphoid Cell Loading following Oral Administration in Monkeys

(2009) Lucie Durand-Gasselin et al.   MOLECULAR PHARMACEUTICS

Robust Antiviral Efficacy upon Administration of a Nucleoside Analog to Hepatitis C Virus-Infected Chimpanzees

(2008) S. S. Carroll et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY