Beyond dsRNA: Toll-like receptor 3 signalling in RNA-induced immune responses

The Clathrin-Mediated Endocytic Pathway Participates in dsRNA-Induced IFN-  Production

(2014) K. Itoh et al.   JOURNAL OF IMMUNOLOGY

Double-Stranded RNA of Intestinal Commensal but Not Pathogenic Bacteria Triggers Production of Protective Interferon-β

(2013) Tadaomi Kawashima et al.   IMMUNITY

Innate immune detection of microbial nucleic acids

(2013) Claudia Gürtler et al.   TRENDS IN MICROBIOLOGY

Toll-like receptor 3 recognizes incomplete stem structures in single-stranded viral RNA

(2013) Megumi Tatematsu et al.   Nature Communications

Single-stranded DNA oligonucleotides inhibit TLR3-mediated responses in human monocyte-derived dendritic cells and in vivo in cynomolgus macaques

(2012) A. E. Skold et al.   BLOOD

Activation of Innate Immunity Is Required for Efficient Nuclear Reprogramming

(2012) Jieun Lee et al.   CELL

Proteolytic Processing Regulates Toll-like Receptor 3 Stability and Endosomal Localization

(2012) Rongsu Qi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cleaved/Associated TLR3 Represents the Primary Form of the Signaling Receptor

(2012) F. Toscano et al.   JOURNAL OF IMMUNOLOGY

Uptake of Extracellular Double-Stranded RNA by SID-2

(2012) Deborah L. McEwan et al.   MOLECULAR CELL

Ultraviolet radiation damages self noncoding RNA and is detected by TLR3

(2012) Jamie J Bernard et al.   NATURE MEDICINE

A rule of seven in Watson-Crick base-pairing of mismatched sequences

(2012) Ibrahim I Cisse et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

DEC-205 is a cell surface receptor for CpG oligonucleotides

(2012) M. H. Lahoud et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cleavage of Toll-like receptor 3 by cathepsins B and H is essential for signaling

(2012) A. Garcia-Cattaneo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Age-Dependent TLR3 Expression of the Intestinal Epithelium Contributes to Rotavirus Susceptibility

(2012) Johanna Pott et al.   PLoS Pathogens

Cross-priming for antitumor CTL induced by soluble Ag + polyI:C depends on the TICAM-1 pathway in mouse CD11c+/CD8α+dendritic cells

(2012) Masahiro Azuma et al.   OncoImmunology

Raftlin Is Involved in the Nucleocapture Complex to Induce Poly(I:C)-mediated TLR3 Activation

(2011) Ayako Watanabe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Herpes simplex encephalitis in children with autosomal recessive and dominant TRIF deficiency

(2011) Vanessa Sancho-Shimizu et al.   JOURNAL OF CLINICAL INVESTIGATION

Nucleic acid recognition by Toll-like receptors is coupled to stepwise processing by cathepsins and asparagine endopeptidase

(2011) Sarah E. Ewald et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Herpes simplex virus encephalitis in a patient with complete TLR3 deficiency: TLR3 is otherwise redundant in protective immunity

(2011) Yiqi Guo et al.   JOURNAL OF EXPERIMENTAL MEDICINE

TLR3-Specific Double-Stranded RNA Oligonucleotide Adjuvants Induce Dendritic Cell Cross-Presentation, CTL Responses, and Antiviral Protection

(2011) I. Jelinek et al.   JOURNAL OF IMMUNOLOGY

The TLR3/TICAM-1 Pathway Is Mandatory for Innate Immune Responses to Poliovirus Infection

(2011) Hiroyuki Oshiumi et al.   JOURNAL OF IMMUNOLOGY

The Toll-Like Receptor 3-Mediated Antiviral Response Is Important for Protection against Poliovirus Infection in Poliovirus Receptor Transgenic Mice

(2011) Y. Abe et al.   JOURNAL OF VIROLOGY

Antiviral responses induced by the TLR3 pathway

(2011) Misako Matsumoto et al.   REVIEWS IN MEDICAL VIROLOGY

Dimerization of Toll-like Receptor 3 (TLR3) Is Required for Ligand Binding

(2010) Yan Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human CD141+(BDCA-3)+dendritic cells (DCs) represent a unique myeloid DC subset that cross-presents necrotic cell antigens

(2010) Sarah L. Jongbloed et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Superior antigen cross-presentation and XCR1 expression define human CD11c+CD141+cells as homologues of mouse CD8+dendritic cells

(2010) Annabell Bachem et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Identification of a polyI:C-inducible membrane protein that participates in dendritic cell–mediated natural killer cell activation

(2010) Takashi Ebihara et al.   JOURNAL OF EXPERIMENTAL MEDICINE

An Accessory to the ‘Trinity’: SR-As Are Essential Pathogen Sensors of Extracellular dsRNA, Mediating Entry and Leading to Subsequent Type I IFN Responses

(2010) Stephanie J. DeWitte-Orr et al.   PLoS Pathogens

The extrinsic RNA-sensing pathway for adjuvant immunotherapy of cancer

(2009) Tsukasa Seya et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Antiviral immunity in Drosophila requires systemic RNA interference spread

(2009) Maria-Carla Saleh et al.   NATURE

TLR3: Interferon induction by double-stranded RNA including poly(I:C)☆

(2008) M MATSUMOTO et al.   ADVANCED DRUG DELIVERY REVIEWS

Hepatitis C virus–infected hepatocytes extrinsically modulate dendritic cell maturation to activate T cells and natural killer cells

(2008) Takashi Ebihara et al.   HEPATOLOGY

Modulation of Double-stranded RNA Recognition by the N-terminal Histidine-rich Region of the Human Toll-like Receptor 3

(2008) Kotaro Fukuda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TLR3 is an endogenous sensor of tissue necrosis during acute inflammatory events

(2008) Karen A. Cavassani et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid–inducible gene-I and melanoma differentiation–associated gene 5

(2008) Hiroki Kato et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A second binding site for double-stranded RNA in TLR3 and consequences for interferon activation

(2008) Nina Pirher et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The TLR3 signaling complex forms by cooperative receptor dimerization

(2008) J. N. Leonard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A critical link between Toll-like receptor 3 and type II interferon signaling pathways in antiviral innate immunity

(2008) H. Negishi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Basis of Toll-Like Receptor 3 Signaling with Double-Stranded RNA

(2008) L. Liu et al.   SCIENCE

Scavenger receptor class-A is a novel cell surface receptor for double-stranded RNA

(2007) Gino V. Limmon et al.   FASEB JOURNAL