The brain metastatic niche

Exercise maintains blood–brain barrier integrity during early stages of brain metastasis formation

(2015) Gretchen Wolff et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Neuronal Activity Promotes Glioma Growth through Neuroligin-3 Secretion

(2015) Humsa S. Venkatesh et al.   CELL

Blocking the Adhesion Cascade at the Premetastatic Niche for Prevention of Breast Cancer Metastasis

(2015) Shin-Ae Kang et al.   MOLECULAR THERAPY

Structural and functional features of central nervous system lymphatic vessels

(2015) Antoine Louveau et al.   NATURE

Breast-cancer-secreted miR-122 reprograms glucose metabolism in premetastatic niche to promote metastasis

(2015) Miranda Y. Fong et al.   NATURE CELL BIOLOGY

Brain metastatic cancer cells release microRNA-181c-containing extracellular vesicles capable of destructing blood–brain barrier

(2015) Naoomi Tominaga et al.   Nature Communications

Reactive Astrocytes Protect Melanoma Cells from Chemotherapy by Sequestering Intracellular Calcium through Gap Junction Communication Channels

(2015) Qingtang Lin et al.   NEOPLASIA

Astrocytes Upregulate Survival Genes in Tumor Cells and Induce Protection from Chemotherapy

(2015) Sun-Jin Kim et al.   NEOPLASIA

Role of the Neural Niche in Brain Metastatic Cancer

(2014) J. Termini et al.   CANCER RESEARCH

Serpins Promote Cancer Cell Survival and Vascular Co-Option in Brain Metastasis

(2014) Manuel Valiente et al.   CELL

Analysis of tumour- and stroma-supplied proteolytic networks reveals a brain-metastasis-promoting role for cathepsin S

(2014) Lisa Sevenich et al.   NATURE CELL BIOLOGY

Role of the endothelin axis in astrocyte- and endothelial cell-mediated chemoprotection of cancer cells

(2014) Seung Wook Kim et al.   NEURO-ONCOLOGY

Tumor microenvironment-based feed-forward regulation of NOS2 in breast cancer progression

(2014) J. L. Heinecke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human breast cancer metastases to the brain display GABAergic properties in the neural niche

(2014) J. Neman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nitric Oxide-Mediated Tumoricidal Activity of Murine Microglial Cells

(2014) Emily C. Brantley et al.   Translational Oncology

Insights into cell-to-cell and cell-to-blood-vessel communications in the brain: in vivo multiphoton microscopy

(2013) Matthias Osswald et al.   CELL AND TISSUE RESEARCH

 B-Crystallin: A Novel Regulator of Breast Cancer Metastasis to the Brain

(2013) D. Malin et al.   CLINICAL CANCER RESEARCH

Reactive astrocytes promote the metastatic growth of breast cancer stem-like cells by activating Notch signalling in brain

(2013) Fei Xing et al.   EMBO Molecular Medicine

Gap Junction Intercellular Communication Mediated by Connexin43 in Astrocytes Is Essential for Their Resistance to Oxidative Stress

(2013) Hoa T. Le et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Angiopoietin-2 mediates blood-brain barrier impairment and colonization of triple-negative breast cancer cells in brain

(2013) Hava Karsenty Avraham et al.   JOURNAL OF PATHOLOGY

The perivascular niche regulates breast tumour dormancy

(2013) Cyrus M. Ghajar et al.   NATURE CELL BIOLOGY

Brain metastases: pathobiology and emerging targeted therapies

(2012) Matthias Preusser et al.   ACTA NEUROPATHOLOGICA

The blood-brain barrier in health and disease

(2012) Richard Daneman   ANNALS OF NEUROLOGY

Characterization of the inflammatory response to solid cancer metastases in the human brain

(2012) Anna Sophie Berghoff et al.   CLINICAL & EXPERIMENTAL METASTASIS

Toward determining the lifetime occurrence of metastatic brain tumors estimated from 2007 United States cancer incidence data

(2012) Faith G. Davis et al.   NEURO-ONCOLOGY

Neurotrophin-3 modulates breast cancer cells and the microenvironment to promote the growth of breast cancer brain metastasis

(2012) E Louie et al.   ONCOGENE

Integrin β4 Signaling Promotes Mammary Tumor Cell Adhesion to Brain Microvascular Endothelium by Inducing ErbB2-Mediated Secretion of VEGF

(2011) Jie Fan et al.   ANNALS OF BIOMEDICAL ENGINEERING

Pemetrexed and cisplatin as first-line chemotherapy for advanced non-small-cell lung cancer (NSCLC) with asymptomatic inoperable brain metastases: a multicenter phase II trial (GFPC 07-01)

(2011) F. Barlesi et al.   ANNALS OF ONCOLOGY

Glioma Stem Cell Proliferation and Tumor Growth Are Promoted by Nitric Oxide Synthase-2

(2011) Christine E. Eyler et al.   CELL

Tissue concentration of systemically administered antineoplastic agents in human brain tumors

(2011) Marshall W. Pitz et al.   JOURNAL OF NEURO-ONCOLOGY

Perivascular instruction of cell genesis and fate in the adult brain

(2011) Steven A Goldman et al.   NATURE NEUROSCIENCE

Premetastatic Lung "Niche": Is Vascular Endothelial Growth Factor Receptor 1 Activation Required?

(2010) D. G. Duda et al.   CANCER RESEARCH

Perivascular Nitric Oxide Activates Notch Signaling and Promotes Stem-like Character in PDGF-Induced Glioma Cells

(2010) Nikki Charles et al.   Cell Stem Cell

Heterogeneous Blood-Tumor Barrier Permeability Determines Drug Efficacy in Experimental Brain Metastases of Breast Cancer

(2010) P. R. Lockman et al.   CLINICAL CANCER RESEARCH

Therapy and prophylaxis of brain metastases

(2010) Yvonne Kienast et al.   Expert Review of Anticancer Therapy

Induction of glioma apoptosis by microglia-secreted molecules: The role of nitric oxide and cathepsin B

(2009) So-Young Hwang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Imaging glioma cell invasionin vivoreveals mechanisms of dissemination and peritumoral angiogenesis

(2009) Frank Winkler et al.   GLIA

Genes that mediate breast cancer metastasis to the brain

(2009) Paula D. Bos et al.   NATURE

Real-time imaging reveals the single steps of brain metastasis formation

(2009) Yvonne Kienast et al.   NATURE MEDICINE

Vascular niche factor PEDF modulates Notch-dependent stemness in the adult subependymal zone

(2009) Celia Andreu-Agulló et al.   NATURE NEUROSCIENCE

The Vascular Basement Membrane as “Soil” in Brain Metastasis

(2009) W. Shawn Carbonell et al.   PLoS One

Activation of tumor cell integrin  v 3 controls angiogenesis and metastatic growth in the brain

(2009) M. Lorger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation of Notch Signaling in a Xenograft Model of Brain Metastasis

(2008) D.-H. Nam et al.   CLINICAL CANCER RESEARCH

PI3K pathway regulates survival of cancer stem cells residing in the perivascular niche following radiation in medulloblastoma in vivo

(2008) D. Hambardzumyan et al.   GENES & DEVELOPMENT

Inhibition of melanoma brain metastasis by targeting melanotransferrin at the cell surface

(2008) Yannève Rolland et al.   Pigment Cell & Melanoma Research